microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR148A Gene

RNA type for MIR148A Gene

miRNA

Aliases for MIR148A Gene

External Ids for MIR148A Gene

Previous HGNC Symbols for MIR148A Gene

  • MIRN148
  • MIRN148A

Previous GeneCards Identifiers for MIR148A Gene

  • GC07M025957
  • GC07M025990

Summaries for MIR148A Gene

Entrez Gene Summary for MIR148A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR148A Gene

MIR148A (MicroRNA 148a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR148A include Cholangiocarcinoma and Esophageal Cancer. Among its related pathways are Metastatic brain tumor and miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma.

Rfam classification for MIR148A Gene

  • mir-148/mir-152 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR148A Gene

Genomics for MIR148A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR148A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR148A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR148A Gene

Latest Assembly
chr7:25,949,910-25,949,995
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand

Previous Assembly
chr7:25,989,539-25,989,606
(GRCh37/hg19 by Entrez Gene)
Size:
68 bases
Orientation:
Minus strand

chr7:25,989,539-25,989,606
(GRCh37/hg19 by Ensembl)
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR148A Gene

Genes around MIR148A on UCSC Golden Path with GeneCards custom track
MIR148A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR148A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR148A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR148A Gene

Proteins for MIR148A Gene

Post-translational modifications for MIR148A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR148A Gene

Domains & Families for MIR148A Gene

Gene Families for MIR148A Gene

genes like me logo Genes that share domains with MIR148A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR148A Gene

Function for MIR148A Gene

Phenotypes From GWAS Catalog for MIR148A Gene

Gene Ontology (GO) - Molecular Function for MIR148A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IGI 30451334
genes like me logo Genes that share ontologies with MIR148A: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR148A Gene

Localization for MIR148A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR148A gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR148A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR148A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR148A Gene

Pathways & Interactions for MIR148A Gene

genes like me logo Genes that share pathways with MIR148A: view

Pathways by source for MIR148A Gene

Gene Ontology (GO) - Biological Process for MIR148A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010985 negative regulation of lipoprotein particle clearance ISS --
GO:0010989 negative regulation of low-density lipoprotein particle clearance IDA 26437365
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 18268015
GO:0042632 cholesterol homeostasis ISS --
genes like me logo Genes that share ontologies with MIR148A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR148A Gene

Drugs & Compounds for MIR148A Gene

No Compound Related Data Available

Transcripts for MIR148A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR148A Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003BBF48_9606 miRNA 22 6

RefSeq: NR_029597,

LncBase: hsa-miR-148a-3p,

miRBase: MIMAT0000243,

MirGeneDB: Hsa-Mir-148-P1_3p,

TarBase: hsa-miR-148a-3p,

ENA: LM378885.1:1..22:ncRNA, LM608330.1:44..65:ncRNA,

URS00003E16E5_9606 miRNA 22 6

RefSeq: NR_029597,

LncBase: hsa-miR-148a-5p,

miRBase: MIMAT0004549,

MirGeneDB: Hsa-Mir-148-P1_5p,

TarBase: hsa-miR-148a-5p,

ENA: LM380228.1:1..22:ncRNA, LM608330.1:6..27:ncRNA,

URS00004C7B32_9606 pre_miRNA 68 4

RefSeq: NR_029597,

Ensembl: ENST00000362215 (view in UCSC) ,

miRBase: MI0000253,

ENA: LM608330.1:1..68:precursor_RNA,

URS00006F5700_9606 pre_miRNA 86 1

Rfam: RF00248,

URS0001BC2D07_9606 pre_miRNA 86 1

Rfam: RF00248,

MIR148A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR148A Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR148A Gene

No ASD Table

Relevant External Links for MIR148A Gene

GeneLoc Exon Structure for
MIR148A

Expression for MIR148A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR148A

Evidence on tissue expression from TISSUES for MIR148A Gene

  • Blood(2.2)
  • Liver(2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR148A Gene

Orthologs for MIR148A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR148A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-148a 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-148a 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-148a 30
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-148 30
  • 74 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir148a 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-148a 30
  • 88 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-148a 30
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BX546447.1 30
  • 67 (a)
ManyToMany
Species where no ortholog for MIR148A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR148A Gene

ENSEMBL:
Gene Tree for MIR148A (if available)
TreeFam:
Gene Tree for MIR148A (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR148A

Paralogs for MIR148A Gene

No data available for Paralogs for MIR148A Gene

Variants for MIR148A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR148A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR148A Gene

Variant ID Type Subtype PubMed ID
nsv1126776 CNV deletion 24896259
nsv606432 CNV gain 21841781
nsv7393 OTHER inversion 18451855

Additional Variant Information for MIR148A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR148A
Leiden Open Variation Database (LOVD)
MIR148A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR148A Gene

Disorders for MIR148A Gene

MalaCards: The human disease database

(49) MalaCards diseases for MIR148A Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cholangiocarcinoma, susceptibility to
esophageal cancer
  • esophageal cancer, somatic
asthma
  • asthma, susceptibility to
miyoshi muscular dystrophy 1
  • mmd1
dermatomyositis
  • amyopathic dermatomyositis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR148A

genes like me logo Genes that share disorders with MIR148A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR148A Gene

Publications for MIR148A Gene

  1. MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma. (PMID: 20628822) Hummel R … Watson DI (Annals of surgical oncology 2011) 3 72
  2. LncRNA XIST knockdown suppresses the malignancy of human nasopharyngeal carcinoma through XIST/miRNA-148a-3p/ADAM17 pathway in vitro and in vivo. (PMID: 31810117) Shi J … Wang Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  3. LncRNA HOXA11-AS promotes migration and invasion through modulating miR-148a/WNT1/β-catenin pathway in gastric cancer. (PMID: 32009419) Guo T … Xu AM (Neoplasma 2020) 3
  4. From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia. (PMID: 32337535) Frazier S … Graham D (Clinical science (London, England : 1979) 2020) 3
  5. Regulation of aberrantly expressed SERPINH1 by antitumor miR-148a-5p inhibits cancer cell aggressiveness in gastric cancer. (PMID: 32235846) Kawagoe K … Seki N (Journal of human genetics 2020) 3

Products for MIR148A Gene

Sources for MIR148A Gene