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Aliases for MIR147B Gene

Subcategory (RNA class) for MIR147B Gene

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Quality Score for this RNA gene is

3

Aliases for MIR147B Gene

  • MicroRNA 147b 2 3 5
  • Hsa-Mir-147b 3
  • Mir-147b 3
  • MIRN147B 3

External Ids for MIR147B Gene

ORGUL Members for MIR147B Gene

Previous HGNC Symbols for MIR147B Gene

  • MIRN147B

Previous GeneCards Identifiers for MIR147B Gene

  • GC15P043514
  • GC15P045725

Summaries for MIR147B Gene

Entrez Gene Summary for MIR147B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR147B Gene

MIR147B (MicroRNA 147b) is an RNA Gene, and is affiliated with the undefined RNA class.

Additional gene information for MIR147B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR147B Gene

Genomics for MIR147B Gene

GeneHancer (GH) Regulatory Elements for MIR147B Gene

Promoters and enhancers for MIR147B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I045431 Enhancer 0.5 ENCODE 550.8 -1.5 -1476 0.9 RXRA GLIS1 HNF4A ZIC2 PRDM4 EZH2 MIR147B GC15P045434 C15orf48 LOC100533853 ENSG00000259342
GH15I045454 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +23.8 23782 5.1 ARNT SIN3A FEZF1 IRF4 ZNF143 ZNF207 FOS SP3 JUNB ZHX2 C15orf48 LOC100533853 SPATA5L1 MIR147B SLC30A4 SQOR BLOC1S6 GC15P045452 ENSG00000259354 LOC105376714
GH15I045434 Enhancer 0.3 dbSUPER 0.8 +2.6 2574 1.9 GATA3 GC15P045436 LOC100533853 SPATA5L1 MIR147B C15orf48 ENSG00000259342
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR147B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR147B Gene

Genomic Locations for MIR147B Gene
chr15:45,433,050-45,433,129
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr15:45,725,248-45,725,327
(GRCh37/hg19)

Genomic View for MIR147B Gene

Genes around MIR147B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR147B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR147B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR147B Gene

Proteins for MIR147B Gene

Post-translational modifications for MIR147B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR147B Gene

Domains & Families for MIR147B Gene

Gene Families for MIR147B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR147B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR147B Gene

Function for MIR147B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR147B Gene

Localization for MIR147B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR147B Gene

Pathways & Interactions for MIR147B Gene

SuperPathways for MIR147B Gene

No Data Available

Interacting Proteins for MIR147B Gene

Gene Ontology (GO) - Biological Process for MIR147B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR147B Gene

Drugs & Compounds for MIR147B Gene

No Compound Related Data Available

Transcripts for MIR147B Gene

mRNA/cDNA for MIR147B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR147B Gene

No ASD Table

Relevant External Links for MIR147B Gene

GeneLoc Exon Structure for
MIR147B
ECgene alternative splicing isoforms for
MIR147B

Expression for MIR147B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR147B Gene

mRNA differential expression in normal tissues according to GTEx for MIR147B Gene

This gene is overexpressed in Colon - Transverse (x25.2), Esophagus - Mucosa (x5.4), and Small Intestine - Terminal Ileum (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR147B Gene:

MIR147B
genes like me logo Genes that share expression patterns with MIR147B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR147B Gene

Orthologs for MIR147B Gene

Evolution for MIR147B Gene

ENSEMBL:
Gene Tree for MIR147B (if available)
TreeFam:
Gene Tree for MIR147B (if available)

No data available for Orthologs for MIR147B Gene

Paralogs for MIR147B Gene

No data available for Paralogs for MIR147B Gene

Variants for MIR147B Gene

Sequence variations from dbSNP and Humsavar for MIR147B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000447671 -- 45,432,608(+) T/C upstream_transcript_variant
rs1000711452 -- 45,431,311(+) C/T upstream_transcript_variant
rs1006200314 -- 45,432,289(+) T/A/C upstream_transcript_variant
rs1006706852 -- 45,431,865(+) G/C upstream_transcript_variant
rs1008640800 -- 45,432,931(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR147B Gene

Variant ID Type Subtype PubMed ID
esv3569553 CNV gain 25503493
esv3892684 CNV gain 25118596
nsv1160292 CNV duplication 26073780
nsv469721 CNV gain 16826518
nsv569315 CNV gain 21841781

Additional Variant Information for MIR147B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR147B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR147B Gene

Disorders for MIR147B Gene

Additional Disease Information for MIR147B

No disorders were found for MIR147B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR147B Gene

Publications for MIR147B Gene

  1. Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis. (PMID: 27821806) Kleemann M … Otte K (Oncotarget 2017) 3 58
  2. MicroRNAs 146a and 147b biomarkers for colorectal tumor's localization. (PMID: 24800242) Omrane I … Benammar-Elgaaied A (BioMed research international 2014) 3 58
  3. MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression. (PMID: 25333931) Chatterjee V … Yuan SY (PloS one 2014) 3 58
  4. "Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity. (PMID: 23028679) Bertero T … Mari B (PloS one 2012) 3 58
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58

Products for MIR147B Gene

Sources for MIR147B Gene

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