microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR147A Gene

Data sources for MIR147A Gene:

Subcategory (RNA class) for MIR147A Gene

miRNA

Aliases for MIR147A Gene

External Ids for MIR147A Gene

Previous HGNC Symbols for MIR147A Gene

  • MIRN147
  • MIR147

Previous GeneCards Identifiers for MIR147A Gene

  • GC09M123008
  • GC09M123010
  • GC09M123013

Summaries for MIR147A Gene

Entrez Gene Summary for MIR147A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR147A Gene

MIR147A (MicroRNA 147a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR147A include Acute Promyelocytic Leukemia and Leukemia, Acute Myeloid.

Rfam classification for MIR147A Gene

Additional gene information for MIR147A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR147A Gene

Genomics for MIR147A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR147A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J120264 Enhancer 0.3 ENCODE 12.2 -20.5 -20496 1.5 ZNF366 MIR147A RF00017-7852 HSALNG0074106 CDK5RAP2 BRINP1
GH09J120073 Enhancer 0.3 Ensembl 9.2 +171.1 171149 0.2 HLF MIR147A piR-36756-091 piR-46847-289 CDK5RAP2 BRINP1
GH09J120091 Enhancer 0.2 FANTOM5 10.3 +153.8 153824 0 MIR147A piR-46847-289 LOC107987124 HSALNG0074106 CDK5RAP2 BRINP1
GH09J120221 Enhancer 0.2 FANTOM5 0.3 +23.3 23279 0.1 MIR147A piR-58929-117 HSALNG0074106 CDK5RAP2 BRINP1
GH09J120284 Enhancer 0.2 ENCODE 0.3 -39.8 -39848 0.2 RF00017-7852 MIR147A HSALNG0074106 CDK5RAP2 BRINP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR147A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR147A Gene

Latest Assembly
chr9:120,244,979-120,245,050
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand

Previous Assembly
chr9:123,007,257-123,007,328
(GRCh37/hg19 by Entrez Gene)
Size:
72 bases
Orientation:
Minus strand

chr9:123,007,257-123,007,328
(GRCh37/hg19 by Ensembl)
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR147A Gene

Genes around MIR147A on UCSC Golden Path with GeneCards custom track
MIR147A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR147A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR147A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR147A Gene

Proteins for MIR147A Gene

Post-translational modifications for MIR147A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR147A Gene

Domains & Families for MIR147A Gene

Gene Families for MIR147A Gene

genes like me logo Genes that share domains with MIR147A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR147A Gene

Function for MIR147A Gene

Phenotypes From GWAS Catalog for MIR147A Gene

Gene Ontology (GO) - Molecular Function for MIR147A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 21982160
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA, HDA 21982160
genes like me logo Genes that share ontologies with MIR147A: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR147A Gene

Localization for MIR147A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR147A gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR147A Gene

Pathways & Interactions for MIR147A Gene

PathCards logo

SuperPathways for MIR147A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR147A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA, IEA, HDA --
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process IDA 21982160
GO:1904046 negative regulation of vascular endothelial growth factor production HMP 18320040
genes like me logo Genes that share ontologies with MIR147A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR147A Gene

Drugs & Compounds for MIR147A Gene

No Compound Related Data Available

Transcripts for MIR147A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR147A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006A0D68_9606 pre_miRNA 72 4

RefSeq: NR_029604,

Ensembl: ENST00000385079 (view in UCSC) ,

miRBase: MI0000262,

Rfam: RF00693,

URS00002849B7_9606 miRNA 20 4

RefSeq: NR_029604,

LncBase: hsa-miR-147a,

miRBase: MIMAT0000251,

TarBase: hsa-miR-147a,

MIR147A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR147A Gene

No ASD Table

Relevant External Links for MIR147A Gene

GeneLoc Exon Structure for
MIR147A

No data available for mRNA/cDNA for MIR147A Gene

Expression for MIR147A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR147A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR147A

genes like me logo Genes that share expression patterns with MIR147A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR147A Gene

Orthologs for MIR147A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR147A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-147a 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-147b 31
  • 68 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 65 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-147 31
  • 43 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-147 31
  • 79 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-147 31
  • 64 (a)
OneToMany
Species where no ortholog for MIR147A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR147A Gene

ENSEMBL:
Gene Tree for MIR147A (if available)
TreeFam:
Gene Tree for MIR147A (if available)

Paralogs for MIR147A Gene

No data available for Paralogs for MIR147A Gene

Variants for MIR147A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR147A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR147A Gene

Variant ID Type Subtype PubMed ID
nsv1048345 CNV loss 25217958
nsv7434 OTHER inversion 18451855

Additional Variant Information for MIR147A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR147A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR147A Gene

Disorders for MIR147A Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR147A Gene - From: MID

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR147A

genes like me logo Genes that share disorders with MIR147A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR147A Gene

Publications for MIR147A Gene

  1. Downregulation of microR-147b represses the proliferation and invasion of thyroid carcinoma cells by inhibiting Wnt/β-catenin signaling via targeting SOX15. (PMID: 31760045) Xu C … Zhang S (Molecular and cellular endocrinology 2020) 3
  2. Ectopic Expression of miR-147 Inhibits Stem Cell Marker and Epithelial-Mesenchymal Transition (EMT)-Related Protein Expression in Colon Cancer Cells. (PMID: 29426374) Ning X … Wang K (Oncology research 2019) 3
  3. The Long Noncoding RNA MEG3 and its Target miR-147 Regulate JAK/STAT Pathway in Advanced Chronic Myeloid Leukemia. (PMID: 30072211) Li ZY … Luo JM (EBioMedicine 2018) 3
  4. MiR-147b influences vascular smooth muscle cell proliferation and migration via targeting YY1 and modulating Wnt/β-catenin activities. (PMID: 30060075) Yue Y … Kang W (Acta biochimica et biophysica Sinica 2018) 3
  5. microRNA profiling: increased expression of miR-147a and miR-518e in progressive supranuclear palsy (PSP). (PMID: 27052995) Tatura R … Müller U (Neurogenetics 2016) 3

Products for MIR147A Gene

Sources for MIR147A Gene