microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR146B Gene

RNA type for MIR146B Gene

miRNA

Aliases for MIR146B Gene

External Ids for MIR146B Gene

Previous HGNC Symbols for MIR146B Gene

  • MIRN146B

Previous GeneCards Identifiers for MIR146B Gene

  • GC10P104187
  • GC10P104196

Summaries for MIR146B Gene

Entrez Gene Summary for MIR146B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR146B Gene

MIR146B (MicroRNA 146b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146B include Glioma and Breast Cancer. Among its related pathways are Cell Differentiation - Index.

Rfam classification for MIR146B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR146B Gene

Genomics for MIR146B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR146B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102438 Promoter 0.4 Ensembl 250.7 +1.8 1796 0.2 SMAD5 HSALNG0080294 MIR146B lnc-FBXL15-2-001 lnc-FBXL15-2-002 C10orf95-AS1 CUEDC2 L13705-001 C10orf95
GH10J102595 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +164.2 164241 11.3 MYC ZNF654 IKZF1 NCOR1 SSRP1 JUND ZNF592 CEBPA ATF3 NFIC HSALNG0080304 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B
GH10J102462 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.6 +27.0 27002 1.7 IKZF1 ZIC2 YY1 BHLHE40 TBP MNT SIN3A RAD51 FOXA2 SMAD4 MFSD13A MIR146B CUEDC2 PSD FBXL15 SUFU RNU6-43P NFKB2 ELOVL3 HSALNG0080295
GH10J102478 Enhancer 1.1 Ensembl ENCODE 11.6 +42.5 42496 1.6 BCLAF1 ZNF654 ZNF600 SSRP1 MXD4 CTCF REST KLF11 DEK TRIM22 NONHSAG006759.2 MFSD13A SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 ENSG00000273262 ACTR1A
GH10J102467 Enhancer 0.6 ENCODE 12.1 +31.6 31616 1.1 ZNF600 IKZF1 NFIC ZFP91 SPI1 ZNF384 ZBTB40 HDAC1 DPF2 ARID1B piR-46501-010 MFSD13A MIR146B CUEDC2 SUFU NFKB2 RNU6-43P FBXL15 PSD ELOVL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR146B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR146B Gene

Latest Assembly
chr10:102,436,505-102,436,593
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand

Previous Assembly
chr10:104,196,269-104,196,341
(GRCh37/hg19 by Entrez Gene)
Size:
73 bases
Orientation:
Plus strand

chr10:104,196,269-104,196,341
(GRCh37/hg19 by Ensembl)
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR146B Gene

Genes around MIR146B on UCSC Golden Path with GeneCards custom track
MIR146B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR146B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146B Gene

Proteins for MIR146B Gene

Post-translational modifications for MIR146B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146B Gene

Domains & Families for MIR146B Gene

Gene Families for MIR146B Gene

genes like me logo Genes that share domains with MIR146B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR146B Gene

Function for MIR146B Gene

Phenotypes From GWAS Catalog for MIR146B Gene

Gene Ontology (GO) - Molecular Function for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 30362152
genes like me logo Genes that share ontologies with MIR146B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146B Gene

Localization for MIR146B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR146B gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA --
genes like me logo Genes that share ontologies with MIR146B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR146B Gene

Pathways & Interactions for MIR146B Gene

PathCards logo

SuperPathways for MIR146B Gene

SuperPathway Contained pathways
1 Cell Differentiation - Index
genes like me logo Genes that share pathways with MIR146B: view

Pathways by source for MIR146B Gene

1 BioSystems pathway for MIR146B Gene

Gene Ontology (GO) - Biological Process for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP --
GO:0010764 negative regulation of fibroblast migration IDA --
GO:0032700 negative regulation of interleukin-17 production IDA 30362152
GO:0034121 regulation of toll-like receptor signaling pathway IDA --
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR146B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR146B Gene

Drugs & Compounds for MIR146B Gene

No Compound Related Data Available

Transcripts for MIR146B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR146B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075C2A0_9606 pre_miRNA 73 4

RefSeq: NR_030169,

Ensembl: ENST00000365699 (view in UCSC) ,

miRBase: MI0003129,

ENA: LM609460.1:1..73:precursor_RNA,

URS0000D52743_9606 miRNA 22 3

RefSeq: NR_030169,

miRBase: MIMAT0004766,

MirGeneDB: Hsa-Mir-146-P2_3p,

URS000075DF95_9606 miRNA 23 2

RefSeq: NR_030169,

miRBase: MIMAT0002809,

URS000050CCE0_9606 miRNA 22 3

LncBase: hsa-miR-146b-3p,

TarBase: hsa-miR-146b-3p,

ENA: LM380383.1:1..22:ncRNA, LM609460.1:45..66:ncRNA,

URS000061B694_9606 miRNA 22 3

LncBase: hsa-miR-146b-5p,

TarBase: hsa-miR-146b-5p,

ENA: AY882276.1:1..22:ncRNA, LM379768.1:1..22:ncRNA, LM609460.1:9..30:ncRNA,

MIR146B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR146B Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146B Gene

No ASD Table

Relevant External Links for MIR146B Gene

GeneLoc Exon Structure for
MIR146B

Expression for MIR146B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR146B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR146B

Evidence on tissue expression from TISSUES for MIR146B Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR146B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146B Gene

Orthologs for MIR146B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR146B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-146b 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-146b 30
  • 84 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-146b 30
  • 80 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-146b 30
  • 66 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir146b 30
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-146b 30
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-146b 30
  • 50 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-146a 30
  • 55 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-146a 30
  • 39 (a)
OneToOne
Species where no ortholog for MIR146B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR146B Gene

ENSEMBL:
Gene Tree for MIR146B (if available)
TreeFam:
Gene Tree for MIR146B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR146B

Paralogs for MIR146B Gene

No data available for Paralogs for MIR146B Gene

Variants for MIR146B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR146B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR146B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146B
Leiden Open Variation Database (LOVD)
MIR146B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR146B Gene

Disorders for MIR146B Gene

MalaCards: The human disease database

(56) MalaCards diseases for MIR146B Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR146B

genes like me logo Genes that share disorders with MIR146B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146B Gene

Publications for MIR146B Gene

  1. microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. (PMID: 19265686) Xia H … Lin MC (Brain research 2009) 3 72
  2. Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. (PMID: 18504431) Bhaumik D … Benz CC (Oncogene 2008) 3 72
  3. Down-regulation of the human major histocompatibility complex class I chain-related gene A (MICA) and its receptor is mediated by microRNA-146b-5p and is a potential mechanism of immunoediting in papillary thyroid carcinoma. (PMID: 31935378) Al-Abdallah A … Junaid TA (Experimental and molecular pathology 2020) 3
  4. Reciprocal Dysregulation of MiR-146b and MiR-451 Contributes in Malignant Phenotype of Follicular Thyroid Tumor. (PMID: 32824921) Knyazeva M … Malek A (International journal of molecular sciences 2020) 3
  5. MiR-146b-5p suppresses the malignancy of GSC/MSC fusion cells by targeting SMARCA5. (PMID: 32632040) Wang H … Dong J (Aging 2020) 3

Products for MIR146B Gene

Sources for MIR146B Gene