microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR146B Gene

Subcategory (RNA class) for MIR146B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR146B Gene

  • MicroRNA 146b 2 3 5
  • Hsa-MiR-146b-5p 163 173
  • Hsa-MiR-146b-3p 163 173
  • Hsa-Mir-146b 2 3
  • MIR146B 2 5
  • Hsa-Mir-146-P2 178
  • MIMAT0004766 50
  • MIMAT0002809 50
  • MiRNA146B 3
  • MI0003129 50
  • MIRN146B 3
  • Mir-146b 3
  • RF00691 168

External Ids for MIR146B Gene

Previous HGNC Symbols for MIR146B Gene

  • MIRN146B

Previous GeneCards Identifiers for MIR146B Gene

  • GC10P104187
  • GC10P104196

Summaries for MIR146B Gene

Entrez Gene Summary for MIR146B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR146B Gene

MIR146B (MicroRNA 146b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146B include Glioma and Breast Cancer. Among its related pathways are Cell Differentiation - Index.

Rfam classification for MIR146B Gene

Additional gene information for MIR146B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR146B Gene

Genomics for MIR146B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR146B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102431 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 600.7 -1.9 -1876 6.3 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 ZNF512 SIX5 LEF1 SOX13 CUEDC2 MIR146B PDCD11 HPS6 PPRC1 TAF5 LDB1 SUFU GBF1 PCGF6
GH10J102438 Promoter 0.4 Ensembl 600.7 +1.8 1796 0.2 SMAD5 MIR146B RPARP-AS1 lnc-FBXL15-2-001 lnc-FBXL15-2-002 CUEDC2 C10orf95 lnc-C10orf95-2
GH10J102592 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +163.0 163024 14.1 HNRNPL GATAD2A CTCF REST TFE3 LEF1 SOX13 IKZF1 NFKBIZ RCOR2 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 MIR146B CUEDC2 ARL3
GH10J102462 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.6 +27.0 27002 1.7 LEF1 IKZF1 ZIC2 MTA1 SP1 HDAC1 SOX6 FOXK2 SCRT2 MGA MFSD13A MIR146B CUEDC2 FBXL15 PSD SUFU RNU6-43P NFKB2 ELOVL3 lnc-SUFU-1
GH10J102478 Enhancer 1.1 Ensembl ENCODE 11.6 +40.8 40844 4.7 GATAD2A CTCF PRDM10 ZNF629 ZNF692 POLR2A BACH1 JUND ZNF143 PKNOX1 NONHSAG006759.2 piR-43107-048 MFSD13A SUFU MIR146B CUEDC2 RNU6-43P NFKB2 ELOVL3 AS3MT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR146B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR146B Gene

Genomic Locations for MIR146B Gene
chr10:102,436,505-102,436,593
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr10:104,196,269-104,196,341
(GRCh37/hg19)
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR146B Gene

Genes around MIR146B on UCSC Golden Path with GeneCards custom track
MIR146B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR146B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146B Gene

Proteins for MIR146B Gene

Post-translational modifications for MIR146B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146B Gene

Domains & Families for MIR146B Gene

Gene Families for MIR146B Gene

genes like me logo Genes that share domains with MIR146B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR146B Gene

Function for MIR146B Gene

Phenotypes From GWAS Catalog for MIR146B Gene

Gene Ontology (GO) - Molecular Function for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA --
genes like me logo Genes that share ontologies with MIR146B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146B Gene

Localization for MIR146B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR146B gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA --
genes like me logo Genes that share ontologies with MIR146B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR146B Gene

Pathways & Interactions for MIR146B Gene

PathCards logo

SuperPathways for MIR146B Gene

SuperPathway Contained pathways
1 Cell Differentiation - Index
genes like me logo Genes that share pathways with MIR146B: view

Pathways by source for MIR146B Gene

1 BioSystems pathway for MIR146B Gene

Gene Ontology (GO) - Biological Process for MIR146B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IMP --
GO:0010764 negative regulation of fibroblast migration IDA --
GO:0034121 regulation of toll-like receptor signaling pathway IDA --
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0045379 negative regulation of interleukin-17 biosynthetic process IDA --
genes like me logo Genes that share ontologies with MIR146B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR146B Gene

Drugs & Compounds for MIR146B Gene

No Compound Related Data Available

Transcripts for MIR146B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR146B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C2A0_9606 precursor_RNA 73 5

HGNC: 32079,

RefSeq: NR_030169,

Ensembl: ENST00000365699 (view in UCSC) ,

miRBase: MI0003129,

ENA: LM609460.1:1..73:precursor_RNA,

URS0000D52743_9606 miRNA 22 3

RefSeq: NR_030169,

miRBase: MIMAT0004766,

MirGeneDB: Hsa-Mir-146-P2_3p,

URS000075DF95_9606 miRNA 23 2

RefSeq: NR_030169,

miRBase: MIMAT0002809,

URS000050CCE0_9606 miRNA 22 3

LncBase: hsa-miR-146b-3p,

TarBase: hsa-miR-146b-3p,

ENA: LM380383.1:1..22:ncRNA, LM609460.1:45..66:ncRNA,

URS000061B694_9606 miRNA 22 3

LncBase: hsa-miR-146b-5p,

TarBase: hsa-miR-146b-5p,

ENA: AY882276.1:1..22:ncRNA, LM379768.1:1..22:ncRNA, LM609460.1:9..30:ncRNA,

MIR146B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR146B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146B Gene

No ASD Table

Relevant External Links for MIR146B Gene

GeneLoc Exon Structure for
MIR146B

Expression for MIR146B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR146B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR146B

Evidence on tissue expression from TISSUES for MIR146B Gene

  • Blood(2.4)
  • Thyroid gland(2.1)
  • Lymph node(2)
  • Muscle(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with MIR146B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146B Gene

Orthologs for MIR146B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR146B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-146b 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-146b 31
  • 84 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-146b 31
  • 80 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-146b 31
  • 66 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir146b 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-146b 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-146b 31
  • 50 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-146a 31
  • 55 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-146a 31
  • 39 (a)
OneToOne
Species where no ortholog for MIR146B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR146B Gene

ENSEMBL:
Gene Tree for MIR146B (if available)
TreeFam:
Gene Tree for MIR146B (if available)

Paralogs for MIR146B Gene

No data available for Paralogs for MIR146B Gene

Variants for MIR146B Gene

Additional dbSNP identifiers (rs#s) for MIR146B Gene

Additional Variant Information for MIR146B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR146B Gene

Disorders for MIR146B Gene

MalaCards: The human disease database

(56) MalaCards diseases for MIR146B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glioma
breast cancer
  • breast lobular carcinoma
muscular dystrophy, becker type
  • bmd
inclusion body myositis
  • ibm
dermatomyositis
  • amyopathic dermatomyositis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR146B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146B Gene

Publications for MIR146B Gene

  1. Correlation of microRNA-146a/b with disease risk, biochemical indices, inflammatory cytokines, overall disease severity, and prognosis of sepsis. (PMID: 32481361) Chen L … Shen W (Medicine 2020) 3
  2. MiR-146b protects against the inflammation injury in pediatric pneumonia through MyD88/NF-κB signaling pathway. (PMID: 31583932) Zhang L … Zhang M (Infectious diseases (London, England) 2020) 3
  3. MicroRNA-146b-5p as an oncomiR promotes papillary thyroid carcinoma development by targeting CCDC6. (PMID: 30503553) Jia M … Wang J (Cancer letters 2019) 3
  4. Investigations on the mechanism of progesterone in inhibiting endometrial cancer cell cycle and viability via regulation of long noncoding RNA NEAT1/microRNA-146b-5p mediated Wnt/β-catenin signaling. (PMID: 30452118) Huang X … Luo X (IUBMB life 2019) 3
  5. p16INK4a inhibits the proliferation of osteosarcoma cells through regulating the miR-146b-5p/TRAF6 pathway. (PMID: 30643010) Jiang M … Wu X (Bioscience reports 2019) 3

Products for MIR146B Gene

Sources for MIR146B Gene