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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include Psoriatic Arthritis and Rheumatoid Arthritis. Among its related pathways are Melatonin metabolism and effects and MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003730 | mRNA 3'-UTR binding | IDA | 21329689 |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 16885212 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
GO:0070062 | extracellular exosome | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Melatonin metabolism and effects |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001937 | negative regulation of endothelial cell proliferation | IDA | 23619365 |
GO:0002692 | negative regulation of cellular extravasation | IDA | 31926946 |
GO:0010628 | positive regulation of gene expression | IDA | 27121396 |
GO:0010629 | negative regulation of gene expression | IDA | 29384235 |
GO:0010887 | negative regulation of cholesterol storage | IDA | 21329689 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00001EFBE3_9606 | miRNA | 22 | 5 |
RefSeq: NR_029701, LncBase: hsa-miR-146a-3p, miRBase: MIMAT0004608, TarBase: hsa-miR-146a-3p, |
URS000050B527_9606 | miRNA | 22 | 5 |
RefSeq: NR_029701, LncBase: hsa-miR-146a-5p, miRBase: MIMAT0000449, TarBase: hsa-miR-146a-5p, ENA: View 14 records in RNAcentral |
URS000075D8A0_9606 | precursor_RNA | 99 | 4 |
RefSeq: NR_029701, Ensembl: ENST00000385201 (view in UCSC) , miRBase: MI0000477, |
URS00008516C5_9606 | precursor_RNA | 383 | 1 |
ENA: KR606820.1:1..383:ncRNA, |
URS000085B631_9606 | precursor_RNA | 383 | 1 |
ENA: KR606819.1:1..383:ncRNA, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3607372 | CNV | gain | 21293372 |
nsv1015634 | CNV | gain | 25217958 |
nsv1026980 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
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psoriatic arthritis |
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rheumatoid arthritis |
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thyroid cancer, nonmedullary, 1 |
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alzheimer disease |
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hepatocellular carcinoma |
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