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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR146A Gene
Subcategory (RNA class) for MIR146A Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR146A Gene
External Ids for MIR146A Gene
- HGNC: 31533
- Entrez Gene: 406938
- Ensembl: ENSG00000283733
- OMIM: 610566
- miRBase: hsa-mir-146a
Previous HGNC Symbols for MIR146A Gene
- MIRN146
- MIRN146A
Previous GeneCards Identifiers for MIR146A Gene
- GC05P159848
- GC05P159912
- GC05P159896
- GC05P160470
Summaries for MIR146A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
GeneCards Summary for MIR146A Gene
MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include Psoriatic Arthritis and Rheumatoid Arthritis. Among its related pathways are Melatonin metabolism and effects and MicroRNAs in cancer.
Rfam classification for MIR146A Gene
-
microRNA mir-146
Additional gene information for MIR146A Gene
- HGNC(31533)
- Entrez Gene(406938)
- Ensembl(ENSG00000283733)
- OMIM(610566)
- Open Targets Platform(ENSG00000283733)
- Monarch Initiative
- Search for MIR146A at DataMed
- Search for MIR146A at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MIR146A Gene
Genomics for MIR146A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR146A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR146A on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR146A Gene
Genomic Locations for MIR146A Gene
- chr5:160,485,264-160,485,646
- (GRCh38/hg38)
- Size:
- 383 bases
- Orientation:
- Plus strand
- chr5:159,895,275-159,914,433
- (GRCh37/hg19)
- Size:
- 19,159 bases
- Orientation:
- Plus strand
Genomic View for MIR146A Gene
Genes around MIR146A on UCSC Golden Path with GeneCards custom track
MIR146A in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 5q33.3 by HGNC
- 5q33.3 by Entrez Gene
- 5q33.3 by Ensembl
MIR146A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR146A Gene
Proteins for MIR146A Gene
Post-translational modifications for MIR146A Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR146A
- Origene Custom Protein Services for MIR146A
No data available for DME Specific Peptides for MIR146A Gene
Domains & Families for MIR146A Gene
Gene Families for MIR146A Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR146A Gene
Function for MIR146A Gene
Phenotypes From GWAS Catalog for MIR146A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | 21329689 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 16885212 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR146A - Select products 50% OFF >
- * MIR146A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR146A
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR146A - Select products 50% OFF >
- * MIR146A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR146A
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146A Gene
Localization for MIR146A Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0005623 | cell | IEA | -- |
| GO:0070062 | extracellular exosome | ISS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR146A Gene
Pathways & Interactions for MIR146A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Melatonin metabolism and effects | ||
Pathways by source for MIR146A Gene
1 BioSystems pathway for MIR146A Gene
1 KEGG pathway for MIR146A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001937 | negative regulation of endothelial cell proliferation | IDA | 23619365 |
| GO:0010628 | positive regulation of gene expression | IDA | 27121396 |
| GO:0010629 | negative regulation of gene expression | IDA | 29384235 |
| GO:0010887 | negative regulation of cholesterol storage | IDA | 21329689 |
| GO:0016525 | negative regulation of angiogenesis | IMP | 23619365 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR146A Gene
Transcripts for MIR146A Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR146A Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075D8A0_9606 | precursor_RNA | 99 | 5 |
HGNC: 31533, RefSeq: NR_029701, Ensembl: ENST00000385201 (view in UCSC) , miRBase: MI0000477, |
| URS00001EFBE3_9606 | miRNA | 22 | 5 |
RefSeq: NR_029701, LncBase: hsa-miR-146a-3p, miRBase: MIMAT0004608, TarBase: hsa-miR-146a-3p, |
| URS000050B527_9606 | miRNA | 22 | 5 |
RefSeq: NR_029701, LncBase: hsa-miR-146a-5p, miRBase: MIMAT0000449, TarBase: hsa-miR-146a-5p, ENA: View 14 records in RNAcentral |
| URS00008516C5_9606 | precursor_RNA | 383 | 1 |
ENA: KR606820.1:1..383:ncRNA, |
| URS000085B631_9606 | precursor_RNA | 383 | 1 |
ENA: KR606819.1:1..383:ncRNA, |
MIR146A in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR146A Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR146A - Select products 50% OFF >
- * MIR146A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR146A
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR146A - Select products 50% OFF >
- * MIR146A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR146A
Relevant External Links for MIR146A Gene
- GeneLoc Exon Structure for
- MIR146A
Expression for MIR146A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR146A
Evidence on tissue expression from TISSUES for MIR146A Gene
- Blood(3)
- Heart(2.6)
- Nervous system(2.5)
- Lymph node(2.5)
- Muscle(2.5)
- Liver(2.4)
- Spleen(2.4)
- Skin(2.4)
- Bone marrow(2.3)
- Kidney(2.3)
- Intestine(2.3)
- Lung(2.2)
- Urine(2.2)
- Saliva(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for MIR146A
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146A Gene
Orthologs for MIR146A Gene
No data available for Orthologs for MIR146A Gene
Paralogs for MIR146A Gene
No data available for Paralogs for MIR146A Gene
Variants for MIR146A Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3607372 | CNV | gain | 21293372 |
| nsv1015634 | CNV | gain | 25217958 |
| nsv1026980 | CNV | gain | 25217958 |
Additional Variant Information for MIR146A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR146A Gene
Disorders for MIR146A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| psoriatic arthritis |
|
|
| rheumatoid arthritis |
|
|
| thyroid cancer, nonmedullary, 1 |
|
|
| alzheimer disease |
|
|
| prostate cancer |
|
Search MIR146A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR146A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146A Gene
Publications for MIR146A Gene
- A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. (PMID: 19902466) Xu B … Wu HF (The Prostate 2010) 3 41
- Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 41
- Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I … Peterlongo P (Human mutation 2010) 3 41
- Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
- Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J … Chen Y (Human mutation 2009) 3 41
ExternalLinks
Products for MIR146A Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR146A
- Origene Custom Protein Services for MIR146A
- Browse OriGene Inhibitory RNA Products For MIR146A
- OriGene qPCR primer pairs for MIR146A
- Browse CRISPR knockouts for MIR146A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR146A
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR146A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR146A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR146A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR146A
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR146A
Sources for MIR146A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB