Aliases for MIR146A Gene
Subcategory (RNA class) for MIR146A Gene
miRNA
Quality Score for this RNA gene is
13
Aliases for MIR146A Gene
External Ids for MIR146A Gene
- HGNC: 31533
- Entrez Gene: 406938
- Ensembl: ENSG00000283733
- OMIM: 610566
- miRBase: hsa-mir-146a
Previous HGNC Symbols for MIR146A Gene
- MIRN146
- MIRN146A
Previous GeneCards Identifiers for MIR146A Gene
- GC05P159848
- GC05P159912
- GC05P159896
- GC05P160470
Summaries for MIR146A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
GeneCards Summary for MIR146A Gene
MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include Rheumatoid Arthritis and Psoriatic Arthritis. Among its related pathways are MicroRNAs in cancer and Melatonin metabolism and effects.
Additional gene information for MIR146A Gene
- Monarch Initiative
- Search for MIR146A at DataMed
- Search for MIR146A at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR146A Gene
Genomics for MIR146A Gene
GeneHancer (GH) Regulatory Elements for MIR146A Gene
Promoters and enhancers for MIR146A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05J160486 | Enhancer | 0.6 | ENCODE | 650.7 | +1.2 | 1241 | 1.2 | JUNB BMI1 ELF1 DPF2 BATF IRF4 BCL11A IKZF1 IKZF2 RUNX3 | GC05P160486 GC05P160487 MIR146A GC05M160494 MIR3142HG | |
| GH05J160458 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 13.2 | -26.2 | -26200 | 1.4 | HDGF PKNOX1 SMAD1 BATF KLF5 IRF4 ATF7 IKZF2 RUNX3 CREM | MIR146A SLU7 GC05P160465 GC05M160421 MIR3142HG | |
| GH05J160505 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 13.5 | +21.4 | 21446 | 2.3 | RFX1 EBF1 MEF2B BMI1 ATF2 POLR2A IKZF1 PRDM1 RUNX3 | MIR146A SLU7 PWWP2A GC05M160494 GC05P160522 | |
| GH05J160433 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 11.3 | -51.4 | -51418 | 1 | HDGF STAT5A BMI1 FEZF1 ZNF2 KLF5 ZNF366 ZNF143 BCLAF1 IKZF2 | MIR146A PTTG1 SLU7 FABP6 PWWP2A GC05P160436 GC05M160425 GC05M160421 | |
| GH05J160460 | Enhancer | 0.4 | Ensembl | 13.3 | -24.8 | -24751 | 0.4 | CTCF RAD21 | MIR146A GC05P160465 GC05M160421 MIR3142HG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR146A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR146A Gene
Genomic Locations for MIR146A Gene
- chr5:160,485,352-160,485,450
- (GRCh38/hg38)
- Size:
- 99 bases
- Orientation:
- Plus strand
- chr5:159,895,275-159,914,433
- (GRCh37/hg19)
- Size:
- 19,159 bases
- Orientation:
- Plus strand
Genomic View for MIR146A Gene
Genes around MIR146A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.3 by Entrez Gene
- 5q33.3 by HGNC
- 5q33.3 by Ensembl
MIR146A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR146A Gene
Proteins for MIR146A Gene
Post-translational modifications for MIR146A Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR146A
Protein Products
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- Search GeneTex for Proteins for MIR146A
No data available for DME Specific Peptides for MIR146A Gene
Domains & Families for MIR146A Gene
Gene Families for MIR146A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR146A Gene
Function for MIR146A Gene
Phenotypes From GWAS Catalog for MIR146A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23619365 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR146A
-
CRISPR Products
- Browse CRISPR knockouts for MIR146A
- Applied Biological Materials CRISPR for MIR146A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR146A
- Addgene plasmids for MIR146A
- Applied Biological Materials Clones for MIR146A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146A Gene
Localization for MIR146A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 26646931 |
| GO:0070062 | extracellular exosome | IDA | 23619365 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR146A Gene
Pathways & Interactions for MIR146A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Melatonin metabolism and effects | ||
Pathways by source for MIR146A Gene
1 BioSystems pathway for MIR146A Gene
1 KEGG pathway for MIR146A Gene
Interacting Proteins for MIR146A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001937 | negative regulation of endothelial cell proliferation | IDA | 23619365 |
| GO:0010628 | positive regulation of gene expression | IDA | 27121396 |
| GO:0016525 | negative regulation of angiogenesis | IMP | 23619365 |
| GO:0035195 | gene silencing by miRNA | IDA | 23619365 |
| GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway | IDA | 27121396 |
No data available for SIGNOR curated interactions for MIR146A Gene
Transcripts for MIR146A Gene
mRNA/cDNA for MIR146A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000385201 99 bps (uc021yhe.1)
- (3) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIR146A
- Applied Biological Materials CRISPR for MIR146A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR146A
- Addgene plasmids for MIR146A
- Applied Biological Materials Clones for MIR146A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR146A Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR146A Gene:
MIR146APrimer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146A Gene
Orthologs for MIR146A Gene
No data available for Orthologs for MIR146A Gene
Paralogs for MIR146A Gene
No data available for Paralogs for MIR146A Gene
Variants for MIR146A Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000515369 | -- | 160,485,681(+) | G/A | downstream_transcript_variant | |
| rs1002867611 | -- | 160,485,572(+) | G/A | downstream_transcript_variant | |
| rs1003082502 | -- | 160,484,995(+) | G/T | upstream_transcript_variant | |
| rs1003409971 | -- | 160,483,379(+) | T/C | upstream_transcript_variant | |
| rs1003422377 | -- | 160,485,283(+) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3607372 | CNV | gain | 21293372 |
| nsv1015634 | CNV | gain | 25217958 |
| nsv1026980 | CNV | gain | 25217958 |
Additional Variant Information for MIR146A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR146A Gene
Disorders for MIR146A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rheumatoid arthritis |
|
|
| psoriatic arthritis |
|
|
| thyroid cancer, nonmedullary, 1 |
|
|
| alzheimer disease |
|
|
| hepatocellular carcinoma |
|
Search MIR146A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR146A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146A Gene
Publications for MIR146A Gene
- Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 44 58
- Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I … Peterlongo P (Human mutation 2010) 3 44 58
- A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. (PMID: 19902466) Xu B … Wu HF (The Prostate 2010) 3 44 58
- Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
- Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J … Chen Y (Human mutation 2009) 3 44 58
Products for MIR146A Gene
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Sources for MIR146A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt