microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR146A Gene

Subcategory (RNA class) for MIR146A Gene

miRNA

Aliases for MIR146A Gene

External Ids for MIR146A Gene

Previous HGNC Symbols for MIR146A Gene

  • MIRN146
  • MIRN146A

Previous GeneCards Identifiers for MIR146A Gene

  • GC05P159848
  • GC05P159912
  • GC05P159896
  • GC05P160470

Summaries for MIR146A Gene

Entrez Gene Summary for MIR146A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR146A Gene

MIR146A (MicroRNA 146a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR146A include Psoriatic Arthritis and Rheumatoid Arthritis. Among its related pathways are Melatonin metabolism and effects and MicroRNAs in cancer.

Gene Wiki entry for MIR146A Gene

Rfam classification for MIR146A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MIR146A Gene

Genomics for MIR146A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR146A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J160486 Enhancer 0.8 Ensembl ENCODE 250.7 +0.3 330 3.2 BCL11A IRF4 MAX BHLHE40 BATF ELF1 BMI1 NR2F1 JUNB ZBED1 MIR146A lnc-ATP10B-2 MIR3142HG PTTG1 ATP10B
GH05J160451 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -29.8 -29763 11.4 BCL11A POLR2A CTCF TRIM22 IRF4 SAP130 EBF1 SMARCA5 MAX ZNF146 MIR146A SLU7 MN298231 lnc-PTTG1-5 MIR3142HG PTTG1 ATP10B
GH05J160505 Enhancer 1.2 FANTOM5 Ensembl ENCODE 13.5 +21.6 21637 5 DEK CTCF BHLHE40 REST TRIM22 EBF1 SMC3 RAD21 TAF1 MBD1 MIR146A PWWP2A ZBED8 SLU7 HSALNG0046253 lnc-ATP10B-2 PTTG1 ATP10B
GH05J160433 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.3 -51.3 -51263 2 SP1 FEZF1 SMAD4 SAP130 TEAD3 KLF9 CBFB BHLHE40 ZNF2 RAD51 PTTG1 MIR146A SLU7 FABP6 PWWP2A lnc-PTTG1-4 HSALNG0046247 ATP10B
GH05J160526 Enhancer 0.6 Ensembl 11 +41.6 41573 0.8 FOXA2 ETV4 RARA JUND SOX5 ATF2 KDM1A NFIA SOX13 HLF MIR146A ENSG00000253687 ATP10B ENSG00000254391 lnc-PTTG1-9 lnc-PTTG1-10 PTTG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR146A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR146A Gene

Latest Assembly
chr5:160,485,264-160,485,646
(GRCh38/hg38)
Size:
383 bases
Orientation:
Plus strand

Previous Assembly
chr5:159,912,359-159,912,457
(GRCh37/hg19 by Entrez Gene)
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR146A Gene

Genes around MIR146A on UCSC Golden Path with GeneCards custom track
MIR146A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR146A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR146A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR146A Gene

Proteins for MIR146A Gene

Post-translational modifications for MIR146A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR146A Gene

Domains & Families for MIR146A Gene

Gene Families for MIR146A Gene

genes like me logo Genes that share domains with MIR146A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR146A Gene

Function for MIR146A Gene

Phenotypes From GWAS Catalog for MIR146A Gene

Gene Ontology (GO) - Molecular Function for MIR146A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 21329689
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 16885212
genes like me logo Genes that share ontologies with MIR146A: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR146A Gene

Localization for MIR146A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR146A gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR146A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome ISS --
genes like me logo Genes that share ontologies with MIR146A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR146A Gene

Pathways & Interactions for MIR146A Gene

PathCards logo

SuperPathways for MIR146A Gene

genes like me logo Genes that share pathways with MIR146A: view

Pathways by source for MIR146A Gene

1 BioSystems pathway for MIR146A Gene
1 KEGG pathway for MIR146A Gene

Gene Ontology (GO) - Biological Process for MIR146A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 23619365
GO:0002692 negative regulation of cellular extravasation IDA 31926946
GO:0010628 positive regulation of gene expression IDA 27121396
GO:0010629 negative regulation of gene expression IDA 29384235
GO:0010887 negative regulation of cholesterol storage IDA 21329689
genes like me logo Genes that share ontologies with MIR146A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR146A Gene

Drugs & Compounds for MIR146A Gene

No Compound Related Data Available

Transcripts for MIR146A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR146A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001EFBE3_9606 miRNA 22 5

RefSeq: NR_029701,

LncBase: hsa-miR-146a-3p,

miRBase: MIMAT0004608,

TarBase: hsa-miR-146a-3p,

ENA: LM380283.1:1..22:ncRNA, LM608517.1:57..78:ncRNA,

URS000050B527_9606 miRNA 22 5

RefSeq: NR_029701,

LncBase: hsa-miR-146a-5p,

miRBase: MIMAT0000449,

TarBase: hsa-miR-146a-5p,

ENA: View 14 records in RNAcentral

URS000075D8A0_9606 precursor_RNA 99 4

RefSeq: NR_029701,

Ensembl: ENST00000385201 (view in UCSC) ,

miRBase: MI0000477,

ENA: LM608517.1:1..99:precursor_RNA,

URS00008516C5_9606 precursor_RNA 383 1

ENA: KR606820.1:1..383:ncRNA,

URS000085B631_9606 precursor_RNA 383 1

ENA: KR606819.1:1..383:ncRNA,

MIR146A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR146A Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR146A Gene

No ASD Table

Relevant External Links for MIR146A Gene

GeneLoc Exon Structure for
MIR146A

Expression for MIR146A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR146A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR146A

Evidence on tissue expression from TISSUES for MIR146A Gene

  • Blood(2.7)
  • Heart(2.3)
  • Nervous system(2.3)
  • Lymph node(2.2)
  • Muscle(2.2)
  • Liver(2.2)
  • Spleen(2.1)
  • Skin(2.1)
  • Bone marrow(2.1)
  • Kidney(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MIR146A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR146A Gene

Orthologs for MIR146A Gene

Evolution for MIR146A Gene

ENSEMBL:
Gene Tree for MIR146A (if available)
TreeFam:
Gene Tree for MIR146A (if available)

No data available for Orthologs for MIR146A Gene

Paralogs for MIR146A Gene

No data available for Paralogs for MIR146A Gene

Variants for MIR146A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR146A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR146A Gene

Variant ID Type Subtype PubMed ID
esv3607372 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv1026980 CNV gain 25217958

Additional Variant Information for MIR146A Gene

Human Gene Mutation Database (HGMD)
MIR146A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR146A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR146A Gene

Disorders for MIR146A Gene

MalaCards: The human disease database

(94) MalaCards diseases for MIR146A Gene - From: MID, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR146A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIR146A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR146A Gene

Publications for MIR146A Gene

  1. The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility. (PMID: 20500689) Chatzikyriakidou A … Drosos AA (Scandinavian journal of immunology 2010) 3 74
  2. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. (PMID: 19902466) Xu B … Wu HF (The Prostate 2010) 3 41
  3. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M … Ni C (Journal of human genetics 2010) 3 41
  4. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I … Peterlongo P (Human mutation 2010) 3 41
  5. Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells. (PMID: 19540598) Pogue AI … Lukiw WJ (Journal of inorganic biochemistry 2009) 3 74

Products for MIR146A Gene

Sources for MIR146A Gene