microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR145 Gene

Subcategory (RNA class) for MIR145 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR145 Gene

  • MicroRNA 145 2 3 5
  • Hsa-MiR-145-5p 166 177
  • Hsa-MiR-145-3p 166 177
  • MIMAT0004601 51
  • MIMAT0000437 51
  • Hsa-Mir-145 3
  • MI0000461 51
  • MiRNA145 3
  • MiR-145 3
  • MIRN145 3
  • RF00675 172
  • MIR145 2

External Ids for MIR145 Gene

Previous HGNC Symbols for MIR145 Gene

  • MIRN145

Previous GeneCards Identifiers for MIR145 Gene

  • GC05P148794
  • GC05P148810

Summaries for MIR145 Gene

Entrez Gene Summary for MIR145 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR145 Gene

MIR145 (MicroRNA 145) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR145 include Vascular Disease and Diffuse Large B-Cell Lymphoma. Among its related pathways are Heart Development and miRNAs involved in DNA damage response.

Rfam classification for MIR145 Gene

Additional gene information for MIR145 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR145 Gene

Genomics for MIR145 Gene

GeneHancer (GH) Regulatory Elements for MIR145 Gene

Promoters and enhancers for MIR145 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR145 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR145 Gene

Genomic Locations for MIR145 Gene
chr5:149,430,646-149,430,733
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand
chr5:148,809,849-148,812,397
(GRCh37/hg19)
Size:
2,549 bases
Orientation:
Plus strand

Genomic View for MIR145 Gene

Genes around MIR145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR145 Gene

Proteins for MIR145 Gene

Post-translational modifications for MIR145 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR145 Gene

Domains & Families for MIR145 Gene

Gene Families for MIR145 Gene

HGNC:
genes like me logo Genes that share domains with MIR145: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR145 Gene

Function for MIR145 Gene

Phenotypes From GWAS Catalog for MIR145 Gene

Gene Ontology (GO) - Molecular Function for MIR145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR145: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR145 Gene

Localization for MIR145 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR145 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR145 Gene

Pathways & Interactions for MIR145 Gene

genes like me logo Genes that share pathways with MIR145: view

Pathways by source for MIR145 Gene

;

Gene Ontology (GO) - Biological Process for MIR145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010668 ectodermal cell differentiation IDA 19409607
GO:0010763 positive regulation of fibroblast migration ISS --
genes like me logo Genes that share ontologies with MIR145: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR145 Gene

Drugs & Compounds for MIR145 Gene

No Compound Related Data Available

Transcripts for MIR145 Gene

mRNA/cDNA for MIR145 Gene

7 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
10 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR145 Gene

No ASD Table

Relevant External Links for MIR145 Gene

GeneLoc Exon Structure for
MIR145

Expression for MIR145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR145 Gene

mRNA differential expression in normal tissues according to GTEx for MIR145 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.0), Colon - Sigmoid (x6.8), and Esophagus - Muscularis (x5.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR145

genes like me logo Genes that share expression patterns with MIR145: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR145 Gene

Orthologs for MIR145 Gene

Evolution for MIR145 Gene

ENSEMBL:
Gene Tree for MIR145 (if available)
TreeFam:
Gene Tree for MIR145 (if available)

No data available for Orthologs for MIR145 Gene

Paralogs for MIR145 Gene

No data available for Paralogs for MIR145 Gene

Variants for MIR145 Gene

Additional dbSNP identifiers (rs#s) for MIR145 Gene

Additional Variant Information for MIR145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR145 Gene

Disorders for MIR145 Gene

MalaCards: The human disease database

(90) MalaCards diseases for MIR145 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
vascular disease
  • vascular tissue disease
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
burkitt lymphoma
  • bl
coronary heart disease 1
  • coronary heart disease, susceptibility to, 1
diabetes mellitus
  • diabetes
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR145

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR145: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR145 Gene

Publications for MIR145 Gene

  1. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. (PMID: 19578358) Cordes KR … Srivastava D (Nature 2009) 2 3 54
  2. Downregulation of miR-145-5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT. (PMID: 30365097) Hang W … Xi X (International journal of molecular medicine 2019) 3 54
  3. Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation. (PMID: 30535463) Shimonosono M … Natsugoe S (International journal of oncology 2019) 3 54
  4. Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer. (PMID: 30250297) Yu W … Yeh S (Oncogene 2019) 3 54
  5. MiR-145-targeted HBXIP modulates human breast cancer cell proliferation. (PMID: 30381907) Jiang Y … Gao Y (Thoracic cancer 2019) 3 54

Products for MIR145 Gene

Sources for MIR145 Gene