Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR145 Gene

Subcategory (RNA class) for MIR145 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR145 Gene

  • MicroRNA 145 2 3 5
  • Hsa-Mir-145 3
  • MiRNA145 3
  • MiR-145 3
  • MIRN145 3

External Ids for MIR145 Gene

ORGUL Members for MIR145 Gene

Previous HGNC Symbols for MIR145 Gene

  • MIRN145

Previous GeneCards Identifiers for MIR145 Gene

  • GC05P148794
  • GC05P148810

Summaries for MIR145 Gene

Entrez Gene Summary for MIR145 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR145 Gene

MIR145 (MicroRNA 145) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Heart Development and miRNAs involved in DNA damage response.

Additional gene information for MIR145 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR145 Gene

Genomics for MIR145 Gene

GeneHancer (GH) Regulatory Elements for MIR145 Gene

Promoters and enhancers for MIR145 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I149429 Enhancer 1.4 Ensembl ENCODE dbSUPER 550.8 +1.6 1557 5.2 HDGF PKNOX1 ATF1 SMAD1 ARNT ARID4B DMAP1 POLR2B ZNF766 GLIS2 GC05P149433 MIR145 CARMN ENSG00000230551
GH05I149356 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 11.1 -72.6 -72615 2.6 HDGF PKNOX1 ATF1 SIN3A GLIS2 ELK1 ZNF207 ZNF143 FOS ATF7 PCYOX1L GC05P149356 GRPEL2-AS1 TCOF1 MIR145 MIR143 RNU6-588P IL17B CARMN FBXO38
GH05I149343 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 -83.9 -83949 6.4 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 PPARGC1A MEF2D ZNF610 GRPEL2 HMGXB3 ENSG00000251330 FBXO38 PCYOX1L RPL7P1 ENSG00000253865 RPS20P4 MIR143 MIR145
GH05I149319 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -108.0 -108048 6.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 HMGXB3 PCYOX1L RPL7P1 GRPEL2 ENSG00000251330 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143
GH05I149481 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +56.0 55954 9.6 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 POLR2B ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN IL17B MIR143 RNU6-588P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR145 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR145 Gene

Genomic Locations for MIR145 Gene
chr5:149,430,646-149,430,733
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand
chr5:148,809,849-148,812,397
(GRCh37/hg19)

Genomic View for MIR145 Gene

Genes around MIR145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR145 Gene

Proteins for MIR145 Gene

Post-translational modifications for MIR145 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR145 Gene

Domains & Families for MIR145 Gene

Gene Families for MIR145 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR145: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR145 Gene

Function for MIR145 Gene

Gene Ontology (GO) - Molecular Function for MIR145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR145: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR145 Gene

Localization for MIR145 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR145 Gene

Pathways & Interactions for MIR145 Gene

genes like me logo Genes that share pathways with MIR145: view

Pathways by source for MIR145 Gene

Interacting Proteins for MIR145 Gene

Gene Ontology (GO) - Biological Process for MIR145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0010668 ectodermal cell differentiation IDA 19409607
GO:0010763 positive regulation of fibroblast migration ISS --
genes like me logo Genes that share ontologies with MIR145: view

No data available for SIGNOR curated interactions for MIR145 Gene

Drugs & Compounds for MIR145 Gene

No Compound Related Data Available

Transcripts for MIR145 Gene

mRNA/cDNA for MIR145 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR145 Gene

No ASD Table

Relevant External Links for MIR145 Gene

GeneLoc Exon Structure for
MIR145
ECgene alternative splicing isoforms for
MIR145

Expression for MIR145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR145 Gene

mRNA differential expression in normal tissues according to GTEx for MIR145 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.0), Colon - Sigmoid (x6.8), and Esophagus - Muscularis (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of MIR145 Gene:

MIR145
genes like me logo Genes that share expression patterns with MIR145: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR145 Gene

Orthologs for MIR145 Gene

Evolution for MIR145 Gene

ENSEMBL:
Gene Tree for MIR145 (if available)
TreeFam:
Gene Tree for MIR145 (if available)

No data available for Orthologs for MIR145 Gene

Paralogs for MIR145 Gene

No data available for Paralogs for MIR145 Gene

Variants for MIR145 Gene

Sequence variations from dbSNP and Humsavar for MIR145 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1002578845 -- 149,430,369(+) T/A upstream_transcript_variant
rs1003723006 -- 149,431,037(+) A/G downstream_transcript_variant
rs1007810229 -- 149,429,654(+) T/C upstream_transcript_variant
rs1007842653 -- 149,428,742(+) A/G upstream_transcript_variant
rs1007923471 -- 149,429,477(+) G/A upstream_transcript_variant

Additional Variant Information for MIR145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR145 Gene

Disorders for MIR145 Gene

Additional Disease Information for MIR145

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR145 Gene

Publications for MIR145 Gene

  1. Tumor-suppressive miR-145 co-repressed by TCF4-β-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer. (PMID: 28921929) Wang W … Wang T (International journal of cancer 2018) 3 58
  2. MiR-145 detection in urinary extracellular vesicles increase diagnostic efficiency of prostate cancer based on hydrostatic filtration dialysis method. (PMID: 28617988) Xu Y … Zheng L (The Prostate 2017) 3 58
  3. Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer. (PMID: 29073169) Johannessen C … Busund LT (PloS one 2017) 3 58
  4. Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3. (PMID: 28902846) Ye Y … Wang B (PloS one 2017) 3 58
  5. The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases. (PMID: 28704499) Goto A … Maeda D (PloS one 2017) 3 58

Products for MIR145 Gene

Sources for MIR145 Gene

Content
Loading form....