microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR144 Gene

Subcategory (RNA class) for MIR144 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR144 Gene

  • MicroRNA 144 2 3 5
  • Hsa-MiR-144-5p 168 179
  • Hsa-MiR-144-3p 168 179
  • MIMAT0004600 53
  • MIMAT0000436 53
  • Hsa-Mir-144 3
  • MI0000460 53
  • Mir-144 3
  • MIRN144 3
  • RF00682 174
  • MIR144 2

External Ids for MIR144 Gene

Previous HGNC Symbols for MIR144 Gene

  • MIRN144

Previous GeneCards Identifiers for MIR144 Gene

  • GC17M024217
  • GC17M027189
  • GC17M027193
  • GC17M027267
  • GC17M028862
  • GC17M028864
  • GC17M029286
  • GC17M029385
  • GC17M028920
  • GC17M029013
  • GC17M029017
  • GC17M029115
  • GC17M029196

Summaries for MIR144 Gene

Entrez Gene Summary for MIR144 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR144 Gene

MIR144 (MicroRNA 144) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR144 include Sickle Cell Disease and Thalassemia.

Rfam classification for MIR144 Gene

Additional gene information for MIR144 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR144 Gene

Genomics for MIR144 Gene

GeneHancer (GH) Regulatory Elements for MIR144 Gene

Promoters and enhancers for MIR144 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028861 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 750.6 -0.7 -734 1.9 ZBTB40 SMARCE1 RUNX1 ELF1 ZNF652 MLLT1 SMARCA4 TRIM24 MTA1 GMEB1 ENSG00000264066 MIR144 MIR451A MIR451B MIR4732 lnc-ERAL1-1 FLOT2 DHRS13 ENSG00000265908 PHF12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR144 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR144 Gene

Genomic Locations for MIR144 Gene
chr17:28,861,533-28,861,618
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr17:27,188,090-27,188,984
(GRCh37/hg19)
Size:
895 bases
Orientation:
Minus strand

Genomic View for MIR144 Gene

Genes around MIR144 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR144 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR144 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR144 Gene

Proteins for MIR144 Gene

Post-translational modifications for MIR144 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR144 Gene

Domains & Families for MIR144 Gene

Gene Families for MIR144 Gene

HGNC:
genes like me logo Genes that share domains with MIR144: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR144 Gene

Function for MIR144 Gene

Phenotypes From GWAS Catalog for MIR144 Gene

Gene Ontology (GO) - Molecular Function for MIR144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23519695
genes like me logo Genes that share ontologies with MIR144: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR144 Gene

Localization for MIR144 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR144 gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR144: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR144 Gene

Pathways & Interactions for MIR144 Gene

PathCards logo

SuperPathways for MIR144 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR144 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010886 positive regulation of cholesterol storage IGI 24733347
GO:0010983 positive regulation of high-density lipoprotein particle clearance ISS 23519695
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0042632 cholesterol homeostasis IDA,IGI 24733347
GO:0050718 positive regulation of interleukin-1 beta secretion IDA 24733347
genes like me logo Genes that share ontologies with MIR144: view

No data available for Pathways by source and SIGNOR curated interactions for MIR144 Gene

Drugs & Compounds for MIR144 Gene

No Compound Related Data Available

Transcripts for MIR144 Gene

mRNA/cDNA for MIR144 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(5) ENA transcripts :
(3) miRBase transcripts :
(2) LncBase transcripts :
(1) Rfam transcripts :
(2) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR144 Gene

No ASD Table

Relevant External Links for MIR144 Gene

GeneLoc Exon Structure for
MIR144
ECgene alternative splicing isoforms for
MIR144

Expression for MIR144 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR144 Gene:

MIR144
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR144 Gene

Orthologs for MIR144 Gene

Evolution for MIR144 Gene

ENSEMBL:
Gene Tree for MIR144 (if available)
TreeFam:
Gene Tree for MIR144 (if available)

No data available for Orthologs for MIR144 Gene

Paralogs for MIR144 Gene

No data available for Paralogs for MIR144 Gene

Variants for MIR144 Gene

Sequence variations from dbSNP and Humsavar for MIR144 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000736932 -- 28,862,534(-) A/G upstream_transcript_variant
rs1000983181 -- 28,861,821(-) A/G upstream_transcript_variant
rs1001446212 -- 28,863,599(-) G/A upstream_transcript_variant
rs1001880847 -- 28,863,066(-) C/T upstream_transcript_variant
rs1002142648 -- 28,863,379(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR144 Gene

Variant ID Type Subtype PubMed ID
esv3640315 CNV loss 21293372

Additional Variant Information for MIR144 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR144

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR144 Gene

Disorders for MIR144 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR144 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sickle cell disease
  • scd
thalassemia
  • sickle-cell thalassemia with crisis
spinocerebellar ataxia 1
  • sca1
leiomyoma, uterine
  • ul
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR144

genes like me logo Genes that share disorders with MIR144: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR144 Gene

Publications for MIR144 Gene

  1. Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis. (PMID: 18941117) Fu YF … Liu TX (Blood 2009) 2 3 56
  2. MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer. (PMID: 30816505) Jiang Y … Feng S (Oncology reports 2019) 3 56
  3. Knockdown of lncRNA DLX6-AS1 inhibits cell proliferation, migration and invasion while promotes apoptosis by downregulating PRR11 expression and upregulating miR-144 in non-small cell lung cancer. (PMID: 30551440) Huang Y … Liu Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 56
  4. Screening of differentially expressed microRNAs of essential hypertension in Uyghur population. (PMID: 30975221) Ye Y … Tang B (Lipids in health and disease 2019) 3 56
  5. Down-regulation of microRNA-144-3p and its clinical value in non-small cell lung cancer: a comprehensive analysis based on microarray, miRNA-sequencing, and quantitative real-time PCR data. (PMID: 30832674) Chen YJ … Chen G (Respiratory research 2019) 3 56

Products for MIR144 Gene

Sources for MIR144 Gene