microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR143 Gene

Subcategory (RNA class) for MIR143 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR143 Gene

  • MicroRNA 143 2 3 5
  • Hsa-MiR-143-5p 166 177
  • Hsa-MiR-143-3p 166 177
  • MIMAT0004599 51
  • MIMAT0000435 51
  • Hsa-Mir-143 3
  • MI0000459 51
  • Mir-143 3
  • MIRN143 3
  • RF00683 172
  • MIR143 2

External Ids for MIR143 Gene

Previous HGNC Symbols for MIR143 Gene

  • MIRN143

Previous GeneCards Identifiers for MIR143 Gene

  • GC05P148793
  • GC05P148808
  • GC05P149429

Summaries for MIR143 Gene

Entrez Gene Summary for MIR143 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR143 Gene

MIR143 (MicroRNA 143) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR143 include Diffuse Large B-Cell Lymphoma and Niemann-Pick Disease, Type C1. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR143 Gene

Additional gene information for MIR143 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR143 Gene

Genomics for MIR143 Gene

GeneHancer (GH) Regulatory Elements for MIR143 Gene

Promoters and enhancers for MIR143 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR143 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR143 Gene

Genomic Locations for MIR143 Gene
chr5:149,406,845-149,432,834
(GRCh38/hg38)
Size:
25,990 bases
Orientation:
Plus strand
chr5:148,808,481-148,808,586
(GRCh37/hg19)
Size:
106 bases
Orientation:
Plus strand

Genomic View for MIR143 Gene

Genes around MIR143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR143 Gene

Proteins for MIR143 Gene

Post-translational modifications for MIR143 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR143 Gene

Domains & Families for MIR143 Gene

Gene Families for MIR143 Gene

HGNC:
genes like me logo Genes that share domains with MIR143: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR143 Gene

Function for MIR143 Gene

Phenotypes From GWAS Catalog for MIR143 Gene

Gene Ontology (GO) - Molecular Function for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25801897
genes like me logo Genes that share ontologies with MIR143: view

Animal Model Products

CRISPR Products

miRNA for MIR143 Gene

miRTarBase miRNAs that target MIR143

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR143 Gene

Localization for MIR143 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR143 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0070062 extracellular exosome IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR143 Gene

Pathways & Interactions for MIR143 Gene

PathCards logo

SuperPathways for MIR143 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR143: view

Pathways by source for MIR143 Gene

1 KEGG pathway for MIR143 Gene
;

Gene Ontology (GO) - Biological Process for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0016525 negative regulation of angiogenesis IDA 25801897
GO:0030036 actin cytoskeleton organization ISS --
GO:0032148 activation of protein kinase B activity ISS --
GO:0035195 gene silencing by miRNA IDA 25801897
genes like me logo Genes that share ontologies with MIR143: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR143 Gene

Drugs & Compounds for MIR143 Gene

No Compound Related Data Available

Transcripts for MIR143 Gene

mRNA/cDNA for MIR143 Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
8 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR143 Gene

No ASD Table

Relevant External Links for MIR143 Gene

GeneLoc Exon Structure for
MIR143

Expression for MIR143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR143 Gene

mRNA differential expression in normal tissues according to GTEx for MIR143 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x11.0), Esophagus - Muscularis (x8.3), and Artery - Coronary (x5.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR143

genes like me logo Genes that share expression patterns with MIR143: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR143 Gene

Orthologs for MIR143 Gene

Evolution for MIR143 Gene

ENSEMBL:
Gene Tree for MIR143 (if available)
TreeFam:
Gene Tree for MIR143 (if available)

No data available for Orthologs for MIR143 Gene

Paralogs for MIR143 Gene

No data available for Paralogs for MIR143 Gene

Variants for MIR143 Gene

Additional dbSNP identifiers (rs#s) for MIR143 Gene

Additional Variant Information for MIR143 Gene

Human Gene Mutation Database (HGMD)
MIR143
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR143 Gene

Disorders for MIR143 Gene

MalaCards: The human disease database

(85) MalaCards diseases for MIR143 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
niemann-pick disease, type c1
  • npc1
burkitt lymphoma
  • bl
t-cell leukemia
  • leukemia, t-cell, chronic
bladder cancer
  • bladder cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR143

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR143: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR143 Gene

Publications for MIR143 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41 54
  2. MicroRNA-143 regulates adipocyte differentiation. (PMID: 15504739) Esau C … Griffey R (The Journal of biological chemistry 2004) 2 3 54
  3. Angiopoietin-like 8 (ANGPTL8) expression is regulated by miR-143-3p in human hepatocytes. (PMID: 30261196) DiStefano JK (Gene 2019) 3 54
  4. MicroRNA-143-3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3. (PMID: 30536996) Guo L … Wang S (Cancer science 2019) 3 54
  5. MicroRNA‑143‑3p suppresses cell growth and invasion in laryngeal squamous cell carcinoma via targeting the k‑Ras/Raf/MEK/ERK signaling pathway. (PMID: 30535502) Zhang F … Cao H (International journal of oncology 2019) 3 54

Products for MIR143 Gene

Sources for MIR143 Gene