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Aliases for MIR143 Gene

Subcategory (RNA class) for MIR143 Gene


Quality Score for this RNA gene is


Aliases for MIR143 Gene

  • MicroRNA 143 2 3 5
  • Hsa-Mir-143 3
  • Mir-143 3
  • MIRN143 3

External Ids for MIR143 Gene

ORGUL Members for MIR143 Gene

Previous HGNC Symbols for MIR143 Gene

  • MIRN143

Previous GeneCards Identifiers for MIR143 Gene

  • GC05P148793
  • GC05P148808
  • GC05P149429

Summaries for MIR143 Gene

Entrez Gene Summary for MIR143 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR143 Gene

MIR143 (MicroRNA 143) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR143 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR143 Gene

Genomics for MIR143 Gene

GeneHancer (GH) Regulatory Elements for MIR143 Gene

Promoters and enhancers for MIR143 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I149343 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -82.2 -82221 6.4 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 PPARGC1A MEF2D ZNF610 GRPEL2 HMGXB3 ENSG00000251330 FBXO38 PCYOX1L RPL7P1 ENSG00000253865 RPS20P4 MIR143 MIR145
GH05I149356 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 10.2 -70.9 -70887 2.6 HDGF PKNOX1 ATF1 SIN3A GLIS2 ELK1 ZNF207 ZNF143 FOS ATF7 PCYOX1L GRPEL2-AS1 GC05P149356 TCOF1 MIR145 MIR143 RNU6-588P CARMN IL17B FBXO38
GH05I149319 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -106.3 -106320 6.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 HMGXB3 PCYOX1L RPL7P1 GRPEL2 ENSG00000251330 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143
GH05I149466 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 +37.7 37698 1.2 HDGF PKNOX1 ATF1 ARNT ZNF2 TCF12 ZNF121 ZNF766 GLIS2 FOS CSNK1A1 MIR145 MIR143 RNU6-588P RPL29P14 ARHGEF37 CARMN IL17B ENSG00000253865 ENSG00000248647
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR143 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR143 Gene

Genomic Locations for MIR143 Gene
106 bases
Plus strand

Genomic View for MIR143 Gene

Genes around MIR143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR143 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR143 Gene

Proteins for MIR143 Gene

Post-translational modifications for MIR143 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR143 Gene

Domains & Families for MIR143 Gene

Gene Families for MIR143 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR143: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR143 Gene

Function for MIR143 Gene

Phenotypes From GWAS Catalog for MIR143 Gene

Animal Model Products

miRNA for MIR143 Gene

miRTarBase miRNAs that target MIR143

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR143 Gene

Localization for MIR143 Gene

Gene Ontology (GO) - Cellular Components for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0070062 extracellular exosome IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR143 Gene

Pathways & Interactions for MIR143 Gene

SuperPathways for MIR143 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR143: view

Pathways by source for MIR143 Gene

1 KEGG pathway for MIR143 Gene

Interacting Proteins for MIR143 Gene

Gene Ontology (GO) - Biological Process for MIR143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006940 regulation of smooth muscle contraction ISS --
GO:0030036 actin cytoskeleton organization ISS --
GO:0032148 activation of protein kinase B activity ISS --
GO:0038166 angiotensin-activated signaling pathway ISS --
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26311719
genes like me logo Genes that share ontologies with MIR143: view

No data available for SIGNOR curated interactions for MIR143 Gene

Drugs & Compounds for MIR143 Gene

No Compound Related Data Available

Transcripts for MIR143 Gene

mRNA/cDNA for MIR143 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR143 Gene

No ASD Table

Relevant External Links for MIR143 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR143 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR143 Gene

mRNA differential expression in normal tissues according to GTEx for MIR143 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x11.0), Esophagus - Muscularis (x8.3), and Artery - Coronary (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR143 Gene:

genes like me logo Genes that share expression patterns with MIR143: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR143 Gene

Orthologs for MIR143 Gene

Evolution for MIR143 Gene

Gene Tree for MIR143 (if available)
Gene Tree for MIR143 (if available)

No data available for Orthologs for MIR143 Gene

Paralogs for MIR143 Gene

No data available for Paralogs for MIR143 Gene

Variants for MIR143 Gene

Sequence variations from dbSNP and Humsavar for MIR143 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001897687 -- 149,428,154(+) A/G upstream_transcript_variant
rs1002245280 -- 149,427,813(+) G/A upstream_transcript_variant
rs1004803422 -- 149,427,129(+) T/C upstream_transcript_variant
rs1005457089 -- 149,427,769(+) A/G upstream_transcript_variant
rs1007842653 -- 149,428,742(+) A/G upstream_transcript_variant

Additional Variant Information for MIR143 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR143 Gene

Disorders for MIR143 Gene

Additional Disease Information for MIR143

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR143 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR143 Gene

Publications for MIR143 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke. (PMID: 28724745) Tiedt S … Dichgans M (Circulation research 2017) 3 58
  3. Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143. (PMID: 28933584) Tang YY … Wang XL (DNA and cell biology 2017) 3 58
  4. MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer. (PMID: 28803245) He M … Wang J (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. MicroRNA-143 inhibits cell growth by targeting ERK5 and MAP3K7 in breast cancer. (PMID: 28746466) Zhou LL … Wu J (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2017) 3 58

Products for MIR143 Gene

Sources for MIR143 Gene

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