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MIR142 Gene(RNA Gene)

MicroRNA 142

GCID:
GC17M058331
GIFtS:
19
Genes Participants
UDN Logo

Aliases for MIR142 Gene

Subcategory (RNA class) for MIR142 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR142 Gene

  • MicroRNA 142 2 3 5
  • Hsa-Mir-142 3
  • Mir-142 3
  • MIRN142 3

External Ids for MIR142 Gene

ORGUL Members for MIR142 Gene

Previous HGNC Symbols for MIR142 Gene

  • MIRN142

Previous GeneCards Identifiers for MIR142 Gene

  • GC17M053766
  • GC17M056409

Summaries for MIR142 Gene

Entrez Gene Summary for MIR142 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR142 Gene

MIR142 (MicroRNA 142) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR142 include Bladder Carcinoma In Situ.

Additional gene information for MIR142 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR142 Gene

Genomics for MIR142 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR142 Gene

Promoters and enhancers for MIR142 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I058327 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -6.3 -6339 20.8 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT NEUROD1 YBX1 ZBTB7B IRF4 YY1 TSPOAP1 MIR4736 SRSF1 MKS1 SUPT4H1 VEZF1 TRIM37 DYNLL2 TEX14 MTMR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR142 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR142 Gene

Genomic Locations for MIR142 Gene
chr17:58,331,232-58,331,318
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr17:56,408,245-56,409,869
(GRCh37/hg19)

Genomic View for MIR142 Gene

Genes around MIR142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR142 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR142 Gene

Proteins for MIR142 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR142 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR142 Gene

Domains & Families for MIR142 Gene

Gene Families for MIR142 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR142: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR142 Gene

Function for MIR142 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR142 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR142 Gene

Localization for MIR142 Gene

Gene Ontology (GO) - Cellular Components for MIR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR142: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR142 Gene

Pathways & Interactions for MIR142 Gene

SuperPathways for MIR142 Gene

PathCards logo More details on SuperPathways for MIR142
No Data Available

Interacting Proteins for MIR142 Gene

Gene Ontology (GO) - Biological Process for MIR142 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR142 Gene

Drugs & Compounds for MIR142 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR142 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR142 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR142 Gene

No ASD Table

Relevant External Links for MIR142 Gene

GeneLoc Exon Structure for
MIR142
ECgene alternative splicing isoforms for
MIR142

Expression for MIR142 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR142 Gene

mRNA expression in normal human tissues for MIR142 Gene
mRNA expression by GTEx for MIR142 Gene

mRNA differential expression in normal tissues according to GTEx for MIR142 Gene

This gene is overexpressed in Whole Blood (x17.7) and Spleen (x9.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR142 Gene:

MIR142
genes like me logo Genes that share expression patterns with MIR142: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR142 Gene

Orthologs for MIR142 Gene

Evolution for MIR142 Gene

ENSEMBL:
Gene Tree for MIR142 (if available)
TreeFam:
Gene Tree for MIR142 (if available)

No data available for Orthologs for MIR142 Gene

Paralogs for MIR142 Gene

No data available for Paralogs for MIR142 Gene

Variants for MIR142 Gene

Sequence variations from dbSNP and Humsavar for MIR142 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1003748749 -- 58,332,497(-) G/A upstream_transcript_variant
rs1003931072 -- 58,332,491(-) G/C upstream_transcript_variant
rs1004081655 -- 58,332,740(-) G/A upstream_transcript_variant
rs1004631744 -- 58,332,682(-) G/A upstream_transcript_variant
rs1004913064 -- 58,332,919(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR142 Gene

Variant ID Type Subtype PubMed ID
nsv457860 CNV loss 19166990
nsv509663 CNV insertion 20534489
nsv517229 CNV gain+loss 19592680
nsv575799 CNV loss 21841781

Additional Variant Information for MIR142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR142 Gene

Disorders for MIR142 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR142 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bladder carcinoma in situ
  • bladder ca in situ
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR142

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR142: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR142 Gene

Publications for MIR142 Gene

  1. MiR-142-5p and miR-486-5p as biomarkers for early detection of chronic antibody-mediated rejection in kidney transplantation. (PMID: 27323802) Iwasaki K … Kobayashi T (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017) 3 58
  2. Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells. (PMID: 27943367) Holmstrøm K … Gad M (Scandinavian journal of immunology 2017) 3 58
  3. MicroRNA-142-5p Overexpression Inhibits Cell Growth and Induces Apoptosis by Regulating FOXO in Hepatocellular Carcinoma Cells. (PMID: 28081734) Lou K … Wang H (Oncology research 2017) 3 58
  4. MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis. (PMID: 28031239) Fernández C … Salar A (Cancer genomics & proteomics 2017) 3 58
  5. miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation. (PMID: 28100738) Mandolesi G … Centonze D (The Journal of neuroscience : the official journal of the Society for Neuroscience 2017) 3 58

Products for MIR142 Gene

Sources for MIR142 Gene

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