microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR142 Gene

Subcategory (RNA class) for MIR142 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR142 Gene

  • MicroRNA 142 2 3 5
  • Hsa-MiR-142-3p 166 177
  • Hsa-MiR-142-5p 166 177
  • MIMAT0000433 51
  • MIMAT0000434 51
  • Hsa-Mir-142 3
  • MI0000458 51
  • Mir-142 3
  • MIRN142 3
  • RF01896 172
  • MIR142 2

External Ids for MIR142 Gene

Previous HGNC Symbols for MIR142 Gene

  • MIRN142

Previous GeneCards Identifiers for MIR142 Gene

  • GC17M053766
  • GC17M056409

Summaries for MIR142 Gene

Entrez Gene Summary for MIR142 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR142 Gene

MIR142 (MicroRNA 142) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR142 include Brain Cancer and Multiple Sclerosis.

Rfam classification for MIR142 Gene

Additional gene information for MIR142 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR142 Gene

Genomics for MIR142 Gene

GeneHancer (GH) Regulatory Elements for MIR142 Gene

Promoters and enhancers for MIR142 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058328 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -6.2 -6190 21 RXRA FOXK2 HNRNPK ZBTB40 CTCF ZSCAN5C SIN3A NRF1 POLR2G SP1 TSPOAP1 MIR4736 SRSF1 MKS1 SUPT4H1 SMG8 VEZF1 TRIM37 DYNLL2 TEX14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR142 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR142 Gene

Genomic Locations for MIR142 Gene
chr17:58,331,222-58,331,327
(GRCh38/hg38)
Size:
106 bases
Orientation:
Minus strand
chr17:56,408,245-56,409,869
(GRCh37/hg19)
Size:
1,625 bases
Orientation:
Minus strand

Genomic View for MIR142 Gene

Genes around MIR142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR142 Gene

Proteins for MIR142 Gene

Post-translational modifications for MIR142 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR142 Gene

Domains & Families for MIR142 Gene

Gene Families for MIR142 Gene

HGNC:
genes like me logo Genes that share domains with MIR142: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR142 Gene

Function for MIR142 Gene

Phenotypes From GWAS Catalog for MIR142 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR142 Gene

Localization for MIR142 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR142 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endosome 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR142: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR142 Gene

Pathways & Interactions for MIR142 Gene

PathCards logo

SuperPathways for MIR142 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR142 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032496 response to lipopolysaccharide ISS 28100738
GO:0034612 response to tumor necrosis factor ISS 28100738
GO:0051966 regulation of synaptic transmission, glutamatergic ISS 28100738
GO:0061890 positive regulation of astrocyte activation ISS --
GO:0070555 response to interleukin-1 ISS 28100738
genes like me logo Genes that share ontologies with MIR142: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR142 Gene

Drugs & Compounds for MIR142 Gene

No Compound Related Data Available

Transcripts for MIR142 Gene

mRNA/cDNA for MIR142 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
9 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR142 Gene

No ASD Table

Relevant External Links for MIR142 Gene

GeneLoc Exon Structure for
MIR142

Expression for MIR142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR142 Gene

mRNA differential expression in normal tissues according to GTEx for MIR142 Gene

This gene is overexpressed in Whole Blood (x17.7) and Spleen (x9.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR142

genes like me logo Genes that share expression patterns with MIR142: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR142 Gene

Orthologs for MIR142 Gene

Evolution for MIR142 Gene

ENSEMBL:
Gene Tree for MIR142 (if available)
TreeFam:
Gene Tree for MIR142 (if available)

No data available for Orthologs for MIR142 Gene

Paralogs for MIR142 Gene

No data available for Paralogs for MIR142 Gene

Variants for MIR142 Gene

Additional dbSNP identifiers (rs#s) for MIR142 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR142 Gene

Variant ID Type Subtype PubMed ID
nsv457860 CNV loss 19166990
nsv509663 CNV insertion 20534489
nsv517229 CNV gain+loss 19592680
nsv575799 CNV loss 21841781

Additional Variant Information for MIR142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR142 Gene

Disorders for MIR142 Gene

MalaCards: The human disease database

(146) MalaCards diseases for MIR142 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
multiple sclerosis
  • multiple sclerosis, susceptibility to
endometriosis
psoriasis
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR142

genes like me logo Genes that share disorders with MIR142: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR142 Gene

Publications for MIR142 Gene

  1. Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p. (PMID: 24401604) Zhai Z … Kwon JH (Autophagy 2014) 2 3 54
  2. Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer. (PMID: 30178386) Yan J … Lu Y (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2019) 3 54
  3. miR-142 Suppresses Endometrial Cancer Proliferation In Vitro and In Vivo by Targeting Cyclin D1. (PMID: 30585737) Su Y … Yu L (DNA and cell biology 2019) 3 54
  4. MicroRNA-142-3p/MALAT1 inhibits lung cancer progression through repressing β-catenin expression. (PMID: 30970294) Liu J … Zhang J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 54
  5. Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p/SOCS6/NF-κB pathway. (PMID: 31144533) Chen H … Li Y (Artificial cells, nanomedicine, and biotechnology 2019) 3 54

Products for MIR142 Gene

Sources for MIR142 Gene