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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR142 (MicroRNA 142) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR142 include Brain Cancer and Endometriosis.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J058328 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | -6.2 | -6190 | 21 | ARHGAP35 CEBPG SP1 HNRNPL CREB1 CTCF PRDM10 ZNF512 RFX1 LEF1 | TSPOAP1 MN297491 MIR4736 TSPOAP1-AS1 SRSF1 MKS1 SMG8 SUPT4H1 VEZF1 TRIM37 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22870299 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 25203061 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032496 | response to lipopolysaccharide | ISS | 28100738 |
GO:0034612 | response to tumor necrosis factor | ISS | 28100738 |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0050712 | negative regulation of interleukin-1 alpha secretion | IDA | 22870299 |
GO:0050728 | negative regulation of inflammatory response | IDA | 22870299 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00002620A7_9606 | miRNA | 23 | 6 |
RefSeq: NR_029683, LncBase: hsa-miR-142-3p, miRBase: MIMAT0000434, MirGeneDB: Hsa-Mir-142-v3_3p, TarBase: hsa-miR-142-3p, ENA: AJ535836.1:1..23:ncRNA, LC194526.1:1057..1079:ncRNA, LM379052.1:1..23:ncRNA, LM608498.1:52..74:ncRNA, |
URS00001E0AEA_9606 | miRNA | 21 | 6 |
RefSeq: NR_029683, LncBase: hsa-miR-142-5p, miRBase: MIMAT0000433, MirGeneDB: Hsa-Mir-142-v1_5p, TarBase: hsa-miR-142-5p, ENA: LC194526.1:1021..1041:ncRNA, LM379051.1:1..21:ncRNA, LM608498.1:16..36:ncRNA, |
URS000075AE07_9606 | precursor_RNA | 87 | 5 |
HGNC: 31529, RefSeq: NR_029683, Ensembl: ENST00000384835 (view in UCSC) , miRBase: MI0000458, ENA: LC194526.1:1006..1092:precursor_RNA, LM608498.1:1..87:precursor_RNA, |
URS000063AE53_9606 | precursor_RNA | 106 | 1 |
Rfam: RF01896, |
URS0000EFD752_9606 | precursor_RNA | 64 | 1 |
MirGeneDB: Hsa-Mir-142-v4, |
Disorder | Aliases | PubMed IDs |
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brain cancer |
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endometriosis |
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multiple sclerosis |
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psoriasis |
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systemic lupus erythematosus |
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