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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR141 (MicroRNA 141) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR141 include Cholangiocarcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Mesodermal Commitment Pathway and miRNA targets in ECM and membrane receptors.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J006923 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 11.8 | -36.7 | -36730 | 7.3 | SP1 GATAD2A CTCF PRDM10 ZNF629 RFX1 IKZF1 ZNF692 POLR2A BACH1 | ATN1 HSALNG0088942 ZNF384 LRRC23 CHD4 ENSG00000219410 SPSB2 ENSG00000247853 SCARNA12 EMG1 | |
GH12J007004 | Enhancer | 0.5 | Ensembl | 11.6 | +43.2 | 43207 | 6.6 | ZNF600 SPI1 HNF4A RXRA PRDM10 MAFK HLF SP1 | RF00998-028 lnc-PHB2-5 EMG1 C1R C1RL PHB2 SCARNA12 MIR141 MIR200C MIR200CHG | |
GH12J006940 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.4 | -10.4 | -10439 | 25.9 | ZNF221 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 | EMG1 PTPN6 MN309532 MIR200CHG C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 15131085 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mesodermal Commitment Pathway | ||
2 | MicroRNAs in cancer | ||
3 | miRNA targets in ECM and membrane receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008284 | positive regulation of cell proliferation | IMP | 16762633 |
GO:0035195 | gene silencing by miRNA | IGI,IMP | 16762633 |
GO:0050728 | negative regulation of inflammatory response | ISS | -- |
GO:1904995 | negative regulation of leukocyte adhesion to vascular endothelial cell | IGI | 26371161 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000055E199_9606 | miRNA | 22 | 6 |
RefSeq: NR_029682, LncBase: hsa-miR-141-5p, miRBase: MIMAT0004598, MirGeneDB: Hsa-Mir-8-P1b_5p, TarBase: hsa-miR-141-5p, |
URS000075ECD7_9606 | precursor_RNA | 95 | 5 |
HGNC: 31528, RefSeq: NR_029682, Ensembl: ENST00000384975 (view in UCSC) , miRBase: MI0000457, |
URS000003E1A9_9606 | miRNA | 22 | 5 |
RefSeq: NR_029682, LncBase: hsa-miR-141-3p, miRBase: MIMAT0000432, TarBase: hsa-miR-141-3p, |
URS0000667F3B_9606 | precursor_RNA | 81 | 1 |
Rfam: RF00241, |
URS0000EFBEA5_9606 | precursor_RNA | 66 | 1 |
MirGeneDB: Hsa-Mir-8-P1b, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-141-1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-141 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir141 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-141 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-141 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-200a 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-200a 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-200a 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-200a 31 |
|
OneToMany | |
dre-mir-141 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | csa-mir-141 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1035811 | CNV | gain | 25217958 |
nsv1047373 | CNV | gain | 25217958 |
nsv509453 | CNV | insertion | 20534489 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cholangiocarcinoma |
|
|
renal cell carcinoma, nonpapillary |
|
|
lung cancer |
|
|
gastric cancer |
|
|
colorectal cancer |
|