Free for academic non-profit institutions. Other users need a Commercial license

MIR141 Gene(RNA Gene)

MicroRNA 141

GCID:
GC12P007502
GIFtS:
21
Genes Participants
UDN Logo

Aliases for MIR141 Gene

Subcategory (RNA class) for MIR141 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR141 Gene

  • MicroRNA 141 2 3 5
  • Hsa-Mir-141 3
  • Mir-141 3
  • MIRN141 3

External Ids for MIR141 Gene

ORGUL Members for MIR141 Gene

Previous HGNC Symbols for MIR141 Gene

  • MIRN141

Previous GeneCards Identifiers for MIR141 Gene

  • GC12P006972
  • GC12P006976
  • GC12P007073
  • GC12P007035
  • GC12P007178
  • GC12P007225
  • GC12P007278
  • GC12P007320
  • GC12P007375
  • GC12P007421
  • GC12P007464

Summaries for MIR141 Gene

Entrez Gene Summary for MIR141 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR141 Gene

MIR141 (MicroRNA 141) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR141 include Cholangiocarcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors.

Additional gene information for MIR141 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR141 Gene

Genomics for MIR141 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR141 Gene

Promoters and enhancers for MIR141 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J006923 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -36.9 -36946 6.8 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF143 FOS ATN1 ZNF384 LRRC23 CHD4 ENSG00000219410 ENSG00000247853 SCARNA12 ENSG00000126749 PHB2 RPL13P5
GH12J006930 Enhancer 0.2 dbSUPER 11.8 -33.0 -33039 0.4 MIR200CHG MIR200C MIR141 SCARNA12 ENSG00000126749 PHB2 EMG1 SPSB2 LRRC23 RPL13P5
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -10.4 -10439 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 EMG1 ZNF384 ENSG00000219410 ENSG00000247853 SPSB2 SCARNA12 NCAPD2 ENSG00000256967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR141 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR141 Gene

Genomic Locations for MIR141 Gene
chr12:6,964,097-6,964,191
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand
chr12:7,073,260-7,073,354
(GRCh37/hg19)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR141 Gene

Genes around MIR141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR141 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR141 Gene

Proteins for MIR141 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR141 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR141 Gene

Domains & Families for MIR141 Gene

Gene Families for MIR141 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR141: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR141 Gene

Function for MIR141 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR141 Gene

Gene Ontology (GO) - Molecular Function for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR141: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR141 Gene

Localization for MIR141 Gene

Gene Ontology (GO) - Cellular Components for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR141: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR141 Gene

Pathways & Interactions for MIR141 Gene

genes like me logo Genes that share pathways with MIR141: view

Pathways by source for MIR141 Gene

1 KEGG pathway for MIR141 Gene

Interacting Proteins for MIR141 Gene

Gene Ontology (GO) - Biological Process for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 16762633
GO:0035195 gene silencing by miRNA IMP 16762633
GO:0050728 negative regulation of inflammatory response ISS --
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell IGI 26371161
genes like me logo Genes that share ontologies with MIR141: view

No data available for SIGNOR curated interactions for MIR141 Gene

Drugs & Compounds for MIR141 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR141 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR141 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR141 Gene

No ASD Table

Relevant External Links for MIR141 Gene

GeneLoc Exon Structure for
MIR141
ECgene alternative splicing isoforms for
MIR141

Expression for MIR141 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR141 Gene

mRNA expression in normal human tissues for MIR141 Gene
mRNA expression by GTEx for MIR141 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR141 Gene:

MIR141
genes like me logo Genes that share expression patterns with MIR141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR141 Gene

Orthologs for MIR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-141-1 34
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir141 34
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-141 34
  • 92 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-141 34
  • 89 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-141 34
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-200a 34
  • 41 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-200a 34
  • 60 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-200a 34
  • 63 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-200a 34
  • 63 (a)
 OneToMany
dre-mir-141 34
  • 60 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea csa-mir-141 34
  • 49 (a)
 OneToMany
Species where no ortholog for MIR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR141 Gene

ENSEMBL:
Gene Tree for MIR141 (if available)
TreeFam:
Gene Tree for MIR141 (if available)

Paralogs for MIR141 Gene

No data available for Paralogs for MIR141 Gene

Variants for MIR141 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR141 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001110105 -- 6,963,829(+) C/A upstream_transcript_variant
rs1001273984 -- 6,964,080(+) G/A upstream_transcript_variant
rs1001417130 -- 6,963,487(+) C/A/T upstream_transcript_variant
rs1005625574 -- 6,963,031(+) C/T upstream_transcript_variant
rs1005677858 -- 6,963,176(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR141 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Additional Variant Information for MIR141 Gene

Human Gene Mutation Database (HGMD)
MIR141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR141 Gene

Disorders for MIR141 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MIR141 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cholangiocarcinoma, susceptibility to
renal cell carcinoma, nonpapillary
  • rcc
gastric cancer
  • gastric cancer, somatic
lung cancer
  • lung cancer, susceptibility to
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR141

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR141: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR141 Gene

Publications for MIR141 Gene

  1. Circulating microRNAs and treatment response in the Phase II SWOG S0925 study for patients with new metastatic hormone-sensitive prostate cancer. (PMID: 29105802) Cheng HH … Yu EY (The Prostate 2018) 3 58
  2. TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141. (PMID: 27974706) Xue L … Lu SH (Oncotarget 2017) 3 58
  3. Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation. (PMID: 28453628) Svetoni F … Paronetto MP (Human molecular genetics 2017) 3 58
  4. MicroRNA-141 Is Involved in Ulcerative Colitis Pathogenesis via Aiming at CXCL5. (PMID: 28854064) Cai M … Hu W (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2017) 3 58
  5. MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. (PMID: 28637482) Zhang G … Wang L (Breast cancer research : BCR 2017) 3 58

Products for MIR141 Gene

Sources for MIR141 Gene

Content
Loading form....