MIR141 Gene (RNA Gene)

MicroRNA 141

GC12P007692
GIFtS:
21
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR141 Gene

Subcategory (RNA class) for MIR141 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR141 Gene

  • MicroRNA 141 2 3 5
  • Hsa-MiR-141-3p 168 179
  • Hsa-MiR-141-5p 168 179
  • MIMAT0004598 53
  • MIMAT0000432 53
  • Hsa-Mir-141 3
  • MI0000457 53
  • Mir-141 3
  • MIRN141 3
  • RF00241 174
  • MIR141 2

External Ids for MIR141 Gene

Previous HGNC Symbols for MIR141 Gene

  • MIRN141

Previous GeneCards Identifiers for MIR141 Gene

  • GC12P006972
  • GC12P006976
  • GC12P007073
  • GC12P007035
  • GC12P007178
  • GC12P007586
  • GC12P007639
  • GC12P007225
  • GC12P007278
  • GC12P007320
  • GC12P007375
  • GC12P007421
  • GC12P007464
  • GC12P007502
  • GC12P007546

Summaries for MIR141 Gene

Entrez Gene Summary for MIR141 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR141 Gene

MIR141 (MicroRNA 141) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR141 include Cholangiocarcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Mesodermal Commitment Pathway and MicroRNAs in cancer.

Rfam classification for MIR141 Gene

  • mir-8/mir-141/mir-200 microRNA precursor family

Additional gene information for MIR141 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR141 Gene

Genomics for MIR141 Gene

GeneHancer (GH) Regulatory Elements for MIR141 Gene

Promoters and enhancers for MIR141 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J006923 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -36.7 -36730 7.3 SP1 ZBTB40 CTCF ZBTB6 LCORL SMARCE1 POLR2A MYC MAX RAD21 ATN1 HSALNG0088942 LRRC23 SPSB2 ZNF384 RPL13P5 CHD4 EMG1 ENSG00000219410 ENSG00000247853
GH12J007004 Enhancer 0.5 Ensembl 11.6 +43.2 43207 6.6 HLF SP1 MAFK HNF4A RXRA PRDM10 RF00998-028 lnc-PHB2-5 EMG1 C1R C1RL PHB2 SCARNA12 MIR141 MIR200C MIR200CHG
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -10.4 -10439 25.9 PPP1R10 GTF3C2 FOXK2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF LCORL EMG1 PTPN6 C12orf57 ZNF384 ENSG00000219410 ENSG00000247853 SPSB2 ENSG00000256967 SCARNA12 C1RL-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR141 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR141 Gene

Genomic Locations for MIR141 Gene
chr12:6,964,097-6,964,191
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand
chr12:7,073,260-7,073,354
(GRCh37/hg19)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR141 Gene

Genes around MIR141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR141 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR141 Gene

Proteins for MIR141 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR141 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR141 Gene

Domains & Families for MIR141 Gene

Gene Families for MIR141 Gene

HGNC:
genes like me logo Genes that share domains with MIR141: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR141 Gene

Function for MIR141 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR141 Gene

Gene Ontology (GO) - Molecular Function for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR141: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR141 Gene

Localization for MIR141 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR141 gene
Compartment Confidence
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR141: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR141 Gene

Pathways & Interactions for MIR141 Gene

genes like me logo Genes that share pathways with MIR141: view

Pathways by source for MIR141 Gene

1 KEGG pathway for MIR141 Gene

Gene Ontology (GO) - Biological Process for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 16762633
GO:0035195 gene silencing by miRNA IMP,IGI 16762633
GO:0050728 negative regulation of inflammatory response ISS --
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell IGI 26371161
genes like me logo Genes that share ontologies with MIR141: view

No data available for SIGNOR curated interactions for MIR141 Gene

Drugs & Compounds for MIR141 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR141 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR141 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(6) ENA transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :
(2) TarBase transcripts :
(2) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR141 Gene

No ASD Table

Relevant External Links for MIR141 Gene

GeneLoc Exon Structure for
MIR141
ECgene alternative splicing isoforms for
MIR141

Expression for MIR141 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR141 Gene

mRNA expression in normal human tissues for MIR141 Gene
mRNA expression by GTEx for MIR141 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR141 Gene:

MIR141
genes like me logo Genes that share expression patterns with MIR141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR141 Gene

Orthologs for MIR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-141-1 33
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir141 33
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-141 33
  • 92 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-141 33
  • 89 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-141 33
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-200a 33
  • 41 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-200a 33
  • 60 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-200a 33
  • 63 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-200a 33
  • 63 (a)
 OneToMany
dre-mir-141 33
  • 60 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea csa-mir-141 33
  • 49 (a)
 OneToMany
Species where no ortholog for MIR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR141 Gene

ENSEMBL:
Gene Tree for MIR141 (if available)
TreeFam:
Gene Tree for MIR141 (if available)

Paralogs for MIR141 Gene

No data available for Paralogs for MIR141 Gene

Variants for MIR141 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR141 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001110105 -- 6,963,829(+) C/A upstream_transcript_variant
rs1001273984 -- 6,964,080(+) G/A upstream_transcript_variant
rs1001417130 -- 6,963,487(+) C/A/T upstream_transcript_variant
rs1005625574 -- 6,963,031(+) C/T upstream_transcript_variant
rs1005677858 -- 6,963,176(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR141 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Additional Variant Information for MIR141 Gene

Human Gene Mutation Database (HGMD)
MIR141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR141 Gene

Disorders for MIR141 Gene

MalaCards: The human disease database

(23) MalaCards diseases for MIR141 Gene - From: miR2Disease, HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cca
renal cell carcinoma, nonpapillary
  • rcc
gastric cancer
  • gastric cancer, somatic
lung cancer
  • adenocarcinoma of lung
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR141

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR141: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR141 Gene

Publications for MIR141 Gene

  1. Down-regulation of lncRNA-ATB inhibits epithelial-mesenchymal transition of breast cancer cells by increasing miR-141-3p expression. (PMID: 30352165) Zhang Y … Zhang W (Biochemistry and cell biology = Biochimie et biologie cellulaire 2019) 3 56
  2. miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer. (PMID: 30194772) Ghorbanmehr N … Mowla SJ (The Prostate 2019) 3 56
  3. MiR-141-3p suppresses gastric cancer induced transition of normal fibroblast and BMSC to cancer-associated fibroblasts via targeting STAT4. (PMID: 30502321) Zhou Y … Xiao J (Experimental and molecular pathology 2019) 3 56
  4. miR-141 alleviates LPS-induced inflammation injury in WI-38 fibroblasts by up-regulation of NOX2. (PMID: 30500550) Quan B … Xue R (Life sciences 2019) 3 56
  5. BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141. (PMID: 29559001) Liu Y … Zhou M (Journal of experimental & clinical cancer research : CR 2018) 3 56

ExternalLinks

View latest publications for MIR141 gene in Mastermind

Products for MIR141 Gene

Sources for MIR141 Gene