microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR141 Gene

RNA type for MIR141 Gene

miRNA

Aliases for MIR141 Gene

External Ids for MIR141 Gene

Previous HGNC Symbols for MIR141 Gene

  • MIRN141

Previous GeneCards Identifiers for MIR141 Gene

  • GC12P006972
  • GC12P006976
  • GC12P007073
  • GC12P007035
  • GC12P007178
  • GC12P007586
  • GC12P007639
  • GC12P007692
  • GC12P007879
  • GC12P007225
  • GC12P007278
  • GC12P007320
  • GC12P007375
  • GC12P007421
  • GC12P007464
  • GC12P007502
  • GC12P007546
  • GC12P008231
  • GC12P009005

Summaries for MIR141 Gene

Entrez Gene Summary for MIR141 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR141 Gene

MIR141 (MicroRNA 141) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR141 include Cholangiocarcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Mesodermal Commitment Pathway and MicroRNAs in cancer.

Rfam classification for MIR141 Gene

  • mir-8/mir-141/mir-200 microRNA precursor family

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR141 Gene

Genomics for MIR141 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR141 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006923 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -36.7 -36730 7.3 BCLAF1 SP1 ZNF600 IKZF1 ZNF654 NCOR1 JUND CEBPA ZNF223 POLR2A ATN1 HSALNG0088942 MK280091 ZNF384 CHD4 ENSG00000219410 LRRC23 SPSB2 ENSG00000247853 SCARNA12
GH12J007004 Enhancer 0.5 Ensembl 11.6 +43.2 43207 6.6 ZNF600 RXRA PRDM10 SPI1 HNF4A MAFK HLF SP1 RF00998-028 lnc-PHB2-5 EMG1 C1R C1RL PHB2 SCARNA12 MIR141 MIR200C MIR200CHG
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -10.4 -10439 25.9 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC ZNF600 IKZF1 SSRP1 ZNF580 EMG1 PTPN6 MN309532 MIR200CHG C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR141 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR141 Gene

Latest Assembly
chr12:6,964,097-6,964,191
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand

Previous Assembly
chr12:7,073,260-7,073,354
(GRCh37/hg19 by Entrez Gene)
Size:
95 bases
Orientation:
Plus strand

chr12:7,073,260-7,073,354
(GRCh37/hg19 by Ensembl)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR141 Gene

Genes around MIR141 on UCSC Golden Path with GeneCards custom track
MIR141 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR141 Gene

Proteins for MIR141 Gene

Post-translational modifications for MIR141 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR141 Gene

Domains & Families for MIR141 Gene

Gene Families for MIR141 Gene

genes like me logo Genes that share domains with MIR141: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR141 Gene

Function for MIR141 Gene

Phenotypes From GWAS Catalog for MIR141 Gene

Gene Ontology (GO) - Molecular Function for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 22479552
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR141: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR141 Gene

Localization for MIR141 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR141 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR141: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR141 Gene

Pathways & Interactions for MIR141 Gene

genes like me logo Genes that share pathways with MIR141: view

Pathways by source for MIR141 Gene

Gene Ontology (GO) - Biological Process for MIR141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 16762633
GO:0035195 gene silencing by miRNA IGI,IMP 16762633
GO:0045071 negative regulation of viral genome replication IDA 22479552
GO:0050728 negative regulation of inflammatory response ISS --
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell IGI 26371161
genes like me logo Genes that share ontologies with MIR141: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR141 Gene

Drugs & Compounds for MIR141 Gene

No Compound Related Data Available

Transcripts for MIR141 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR141 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000055E199_9606 miRNA 22 6

RefSeq: NR_029682,

LncBase: hsa-miR-141-5p,

miRBase: MIMAT0004598,

MirGeneDB: Hsa-Mir-8-P1b_5p,

TarBase: hsa-miR-141-5p,

ENA: LM380273.1:1..22:ncRNA, LM608497.1:17..38:ncRNA,

URS000003E1A9_9606 miRNA 22 5

RefSeq: NR_029682,

LncBase: hsa-miR-141-3p,

miRBase: MIMAT0000432,

TarBase: hsa-miR-141-3p,

ENA: LM379050.1:1..22:ncRNA, LM608497.1:59..80:ncRNA,

URS000075ECD7_9606 pre_miRNA 95 4

RefSeq: NR_029682,

Ensembl: ENST00000384975 (view in UCSC) ,

miRBase: MI0000457,

ENA: LM608497.1:1..95:precursor_RNA,

URS0000667F3B_9606 pre_miRNA 81 1

Rfam: RF00241,

URS0001BC32A8_9606 pre_miRNA 81 1

Rfam: RF00241,

MIR141 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR141 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR141 Gene

No ASD Table

Relevant External Links for MIR141 Gene

GeneLoc Exon Structure for
MIR141

Expression for MIR141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR141 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR141

Evidence on tissue expression from TISSUES for MIR141 Gene

  • Blood(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with MIR141: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR141 Gene

Orthologs for MIR141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR141 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-141-1 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-141 30
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir141 30
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-141 30
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-141 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200a 30
  • 41 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-200a 30
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-200a 30
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-200a 30
  • 63 (a)
OneToMany
dre-mir-141 30
  • 60 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 30
  • 49 (a)
OneToMany
Species where no ortholog for MIR141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR141 Gene

ENSEMBL:
Gene Tree for MIR141 (if available)
TreeFam:
Gene Tree for MIR141 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR141

Paralogs for MIR141 Gene

No data available for Paralogs for MIR141 Gene

Variants for MIR141 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR141 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR141 Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Additional Variant Information for MIR141 Gene

Human Gene Mutation Database (HGMD)
MIR141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR141
Leiden Open Variation Database (LOVD)
MIR141

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR141 Gene

Disorders for MIR141 Gene

MalaCards: The human disease database

(59) MalaCards diseases for MIR141 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cholangiocarcinoma, susceptibility to
renal cell carcinoma, nonpapillary
  • rcc
gastric cancer
  • gastric cancer, somatic
lung cancer
  • lung cancer, susceptibility to
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR141

genes like me logo Genes that share disorders with MIR141: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR141 Gene

Publications for MIR141 Gene

  1. MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells. (PMID: 19830559) Hu M … Su L (Digestive diseases and sciences 2010) 3 72
  2. Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. (PMID: 19363643) Du Y … Si J (Journal of gastroenterology 2009) 3 72
  3. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. (PMID: 16762633) Meng F … Patel T (Gastroenterology 2006) 3 72
  4. MicroRNA-141-3p regulates cellular proliferation, migration, and invasion in esophageal cancer by targeting tuberous sclerosis complex 1. (PMID: 33382472) Phatak P … Donahue JM (Molecular carcinogenesis 2021) 3
  5. Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression. (PMID: 32247266) Zhang X … Zheng X (International immunopharmacology 2020) 3

Products for MIR141 Gene

Sources for MIR141 Gene