microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR140 Gene

Subcategory (RNA class) for MIR140 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR140 Gene

  • MicroRNA 140 2 3 5
  • Hsa-MiR-140-5p 166 177
  • Hsa-MiR-140-3p 166 177
  • MIMAT0000431 51
  • MIMAT0004597 51
  • Hsa-Mir-140 3
  • MI0000456 51
  • MiRNA140 3
  • Mir-140 3
  • MIRN140 3
  • RF00678 172
  • MIR140 2
  • SEDN 3

External Ids for MIR140 Gene

Previous HGNC Symbols for MIR140 Gene

  • MIRN140

Previous GeneCards Identifiers for MIR140 Gene

  • GC16P068527
  • GC16P069966

Summaries for MIR140 Gene

Entrez Gene Summary for MIR140 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR140 Gene

MIR140 (MicroRNA 140) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR140 include Spondyloepiphyseal Dysplasia, Nishimura Type and Coronary Heart Disease 1. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

Rfam classification for MIR140 Gene

Additional gene information for MIR140 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR140 Gene

Genomics for MIR140 Gene

GeneHancer (GH) Regulatory Elements for MIR140 Gene

Promoters and enhancers for MIR140 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J069931 Enhancer 0.2 dbSUPER 500.7 -1.5 -1478 1.1 MIR140 CLEC18A PDXDC2P RF00994-386 WWP2
GH16J069820 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 12.3 -111.3 -111259 2.3 EP300 FOXK2 POLR2G NCOR1 KDM6A ZBTB25 TGIF2 SKI TEAD1 ZBTB26 NPIPB14P MIR140 CLEC18A ENSG00000252443 WWP2 PDXDC2P PDXDC2P-NPIPB14P NQO1 ENSG00000261777 lnc-CLEC18A-2
GH16J069813 Enhancer 1 ENCODE dbSUPER 12.3 -118.5 -118468 1.9 NCOR1 KDM6A ZBTB25 TEAD1 FOXA2 KAT7 SAP130 MIER3 HDAC1 FOXP1 NPIPB14P NQO1 MIR140 CLEC18A ENSG00000252443 WWP2 PDXDC2P ENSG00000261777 lnc-CLEC18A-2 L13304-014
GH16J069818 Enhancer 0.7 Ensembl ENCODE dbSUPER 12.3 -114.0 -113981 1 POLR2A SMARCA4 MIR140 CLEC18A ENSG00000252443 WWP2 PDXDC2P-NPIPB14P PDXDC2P lnc-CLEC18A-2 L13304-014
GH16J069904 Enhancer 0.6 Ensembl ENCODE 13 -28.1 -28087 0.8 PRDM10 SRF ZNF549 KDM1A ELF1 MIR140 CLEC18A ENSG00000252443 WWP2 NQO1 NPIPB14P AARS1 RF00994-386
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR140 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR140 Gene

Genomic Locations for MIR140 Gene
chr16:69,933,081-69,933,180
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr16:69,966,984-69,967,083
(GRCh37/hg19)
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR140 Gene

Genes around MIR140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR140 Gene

Proteins for MIR140 Gene

Post-translational modifications for MIR140 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR140 Gene

Domains & Families for MIR140 Gene

Gene Families for MIR140 Gene

HGNC:
genes like me logo Genes that share domains with MIR140: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR140 Gene

Function for MIR140 Gene

Phenotypes From GWAS Catalog for MIR140 Gene

Gene Ontology (GO) - Molecular Function for MIR140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27021683
genes like me logo Genes that share ontologies with MIR140: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR140 Gene

Localization for MIR140 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR140 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR140: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR140 Gene

Pathways & Interactions for MIR140 Gene

PathCards logo

SuperPathways for MIR140 Gene

genes like me logo Genes that share pathways with MIR140: view

Pathways by source for MIR140 Gene

1 BioSystems pathway for MIR140 Gene
;

Gene Ontology (GO) - Biological Process for MIR140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 27021683
GO:0030513 positive regulation of BMP signaling pathway IDA 27214554
GO:0032715 negative regulation of interleukin-6 production IDA 30321456
GO:0032720 negative regulation of tumor necrosis factor production IDA 30321456
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway IGI 30321456
genes like me logo Genes that share ontologies with MIR140: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR140 Gene

Drugs & Compounds for MIR140 Gene

No Compound Related Data Available

Transcripts for MIR140 Gene

mRNA/cDNA for MIR140 Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR140 Gene

No ASD Table

Relevant External Links for MIR140 Gene

GeneLoc Exon Structure for
MIR140

Expression for MIR140 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR140 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR140

genes like me logo Genes that share expression patterns with MIR140: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR140 Gene

Orthologs for MIR140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR140 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-140 31
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir140 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-140 31
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-140 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-140 31
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-140 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-140 31
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-140 31
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir140 31
  • 82 (a)
OneToOne
Species where no ortholog for MIR140 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR140 Gene

ENSEMBL:
Gene Tree for MIR140 (if available)
TreeFam:
Gene Tree for MIR140 (if available)

Paralogs for MIR140 Gene

No data available for Paralogs for MIR140 Gene

Variants for MIR140 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR140 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1567443039 Pathogenic: Spondyloepiphyseal dysplasia MIR140 type Nishimura 69,933,104(+) A/G NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR140 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR140 Gene

Variant ID Type Subtype PubMed ID
esv2758652 CNV gain+loss 17122850
nsv1853 CNV deletion 18451855
nsv509630 CNV insertion 20534489

Additional Variant Information for MIR140 Gene

Human Gene Mutation Database (HGMD)
MIR140
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR140 Gene

Disorders for MIR140 Gene

MalaCards: The human disease database

(96) MalaCards diseases for MIR140 Gene - From: miR2Disease, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spondyloepiphyseal dysplasia, nishimura type
  • sedn
coronary heart disease 1
  • coronary heart disease, susceptibility to, 1
osteogenic sarcoma
  • osteosarcoma; osrc
diabetes mellitus
  • diabetes
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR140

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR140: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR140 Gene

Publications for MIR140 Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41 54
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41 54
  3. Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140. (PMID: 20358594) Li L … Shi B (American journal of medical genetics. Part A 2010) 3 41 54
  4. Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140. (PMID: 18945805) Nicolas FE … Dalmay T (RNA (New York, N.Y.) 2008) 2 3 54
  5. LncRNA SNHG1 promoted HGC-27 cell growth and migration via the miR-140/ADAM10 axis. (PMID: 30391432) Guo W … Li X (International journal of biological macromolecules 2019) 3 54

Products for MIR140 Gene

Sources for MIR140 Gene