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Aliases for MIR140 Gene

Subcategory (RNA class) for MIR140 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR140 Gene

  • MicroRNA 140 2 3 5
  • Hsa-Mir-140 3
  • MiRNA140 3
  • Mir-140 3
  • MIRN140 3

External Ids for MIR140 Gene

ORGUL Members for MIR140 Gene

Previous HGNC Symbols for MIR140 Gene

  • MIRN140

Previous GeneCards Identifiers for MIR140 Gene

  • GC16P068527
  • GC16P069966

Summaries for MIR140 Gene

Entrez Gene Summary for MIR140 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR140 Gene

MIR140 (MicroRNA 140) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR140 include Spinal Chordoma. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

Additional gene information for MIR140 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR140 Gene

Genomics for MIR140 Gene

GeneHancer (GH) Regulatory Elements for MIR140 Gene

Promoters and enhancers for MIR140 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I069931 Enhancer 0.2 dbSUPER 550.8 -1.5 -1478 1.1 MIR140 GC16P069933 CLEC18A PDXDC2P GC16P069921 WWP2
GH16I069820 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.3 -111.3 -111259 2.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 ATF7 RXRA SP5 MIER2 NPIPB14P MIR140 CLEC18A ENSG00000252443 WWP2 PDXDC2P PDXDC2P-NPIPB14P NQO1 LOC100506083 GC16P069921
GH16I069813 Enhancer 1 ENCODE dbSUPER 12.3 -118.5 -118468 1.9 FOXA2 ARID4B RAD21 ZNF48 RARA MIXL1 PPARG NFIL3 MIER3 RCOR2 NPIPB14P NQO1 MIR140 CLEC18A ENSG00000252443 WWP2 PDXDC2P LOC100506083 GC16P069921
GH16I069906 Enhancer 0.4 ENCODE 13 -26.0 -26011 1.5 CEBPB CEBPG NPIPB14P MIR140 CLEC18A ENSG00000252443 WWP2 NQO1 AARS PDXDC2P PDXDC2P-NPIPB14P LOC100506083
GH16I069818 Enhancer 0.4 ENCODE dbSUPER 12.3 -114.2 -114248 0.2 MIR140 CLEC18A ENSG00000252443 WWP2 GC16P069921
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR140 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR140 Gene

Genomic Locations for MIR140 Gene
chr16:69,933,081-69,933,180
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr16:69,966,984-69,967,083
(GRCh37/hg19)

Genomic View for MIR140 Gene

Genes around MIR140 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR140 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR140 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR140 Gene

Proteins for MIR140 Gene

Post-translational modifications for MIR140 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR140 Gene

Domains & Families for MIR140 Gene

Gene Families for MIR140 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR140: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR140 Gene

Function for MIR140 Gene

Gene Ontology (GO) - Molecular Function for MIR140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27214554
genes like me logo Genes that share ontologies with MIR140: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR140 Gene

Localization for MIR140 Gene

Gene Ontology (GO) - Cellular Components for MIR140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR140: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR140 Gene

Pathways & Interactions for MIR140 Gene

genes like me logo Genes that share pathways with MIR140: view

Pathways by source for MIR140 Gene

1 BioSystems pathway for MIR140 Gene

Interacting Proteins for MIR140 Gene

Gene Ontology (GO) - Biological Process for MIR140 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030513 positive regulation of BMP signaling pathway IDA 27214554
GO:0035195 gene silencing by miRNA IMP 27214554
GO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP 27214554
GO:1904753 negative regulation of vascular associated smooth muscle cell migration IMP 27214554
genes like me logo Genes that share ontologies with MIR140: view

No data available for SIGNOR curated interactions for MIR140 Gene

Drugs & Compounds for MIR140 Gene

No Compound Related Data Available

Transcripts for MIR140 Gene

mRNA/cDNA for MIR140 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR140 Gene

No ASD Table

Relevant External Links for MIR140 Gene

GeneLoc Exon Structure for
MIR140
ECgene alternative splicing isoforms for
MIR140

Expression for MIR140 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR140 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR140 Gene:

MIR140
genes like me logo Genes that share expression patterns with MIR140: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR140 Gene

Orthologs for MIR140 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR140 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-140 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-140 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-140 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir140 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-140 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-140 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-140 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-140 34
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir140 34
  • 82 (a)
OneToOne
Species where no ortholog for MIR140 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR140 Gene

ENSEMBL:
Gene Tree for MIR140 (if available)
TreeFam:
Gene Tree for MIR140 (if available)

Paralogs for MIR140 Gene

No data available for Paralogs for MIR140 Gene

Variants for MIR140 Gene

Sequence variations from dbSNP and Humsavar for MIR140 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000146646 -- 69,931,119(+) G/A upstream_transcript_variant
rs1001208057 -- 69,931,408(+) C/T upstream_transcript_variant
rs1001325808 -- 69,931,646(+) C/A upstream_transcript_variant
rs1001568489 -- 69,932,511(+) A/G upstream_transcript_variant
rs1001934331 -- 69,932,742(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR140 Gene

Variant ID Type Subtype PubMed ID
esv2758652 CNV gain+loss 17122850
nsv1853 CNV deletion 18451855
nsv509630 CNV insertion 20534489

Additional Variant Information for MIR140 Gene

Human Gene Mutation Database (HGMD)
MIR140
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR140

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR140 Gene

Disorders for MIR140 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR140 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
spinal chordoma
  • chordoma of spine
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR140

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR140: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR140 Gene

Publications for MIR140 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 44 58
  3. Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140. (PMID: 20358594) Li L … Shi B (American journal of medical genetics. Part A 2010) 3 44 58
  4. Elevated plasma miRNA-122, -140-3p, -720, -2861, and -3149 during early period of acute coronary syndrome are derived from peripheral blood mononuclear cells. (PMID: 28961259) Li XD … Gu DF (PloS one 2017) 3 58
  5. Long Noncoding RNA HOXA11-AS Functions as miRNA Sponge to Promote the Glioma Tumorigenesis Through Targeting miR-140-5p. (PMID: 28832185) Cui Y … Jiang YG (DNA and cell biology 2017) 3 58

Products for MIR140 Gene

Sources for MIR140 Gene

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