microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR139 Gene

Subcategory (RNA class) for MIR139 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR139 Gene

  • MIMAT0000250 50
  • MIR139-3p 3
  • MI0000261 50
  • MIRN139 3
  • Mir-139 3
  • RF00703 168

External Ids for MIR139 Gene

Previous HGNC Symbols for MIR139 Gene

  • MIRN139

Previous GeneCards Identifiers for MIR139 Gene

  • GC11M072006
  • GC11M072326

Summaries for MIR139 Gene

Entrez Gene Summary for MIR139 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR139 Gene

MIR139 (MicroRNA 139) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR139 include Leiomyoma, Uterine and Follicular Lymphoma. Among its related pathways are Alzheimers Disease.

Rfam classification for MIR139 Gene

Additional gene information for MIR139 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR139 Gene

Genomics for MIR139 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR139 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J072615 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 600.7 +0.8 781 0.5 PRDM10 ZNF692 REST IKZF2 EGR1 CTBP1 RUNX3 TCF12 EHMT2 IKZF1 LOC105369377 MIR139 PDE2A lnc-PDE2A-2 CLPB
GH11J072617 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 -0.2 -170 0.2 ZFHX2 ZNF398 EGR2 MIR139 ENSG00000256148 LOC105369377 RNU7-105P RF00066-037 PDE2A lnc-PDE2A-2 CLPB
GH11J072614 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 +0.2 229 0.2 PRDM10 ZNF692 MIR139 LOC105369377 PDE2A lnc-PDE2A-2 CLPB
GH11J072652 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 -38.4 -38367 1.4 RFX1 IKZF1 RFX5 MTA2 PKNOX1 MTA1 NR2C1 DPF2 HDAC1 SOX6 PDE2A ARAP1 MIR139 ARAP1-AS1 RNU7-105P PDE2A-AS1 lnc-PDE2A-2 CLPB
GH11J072550 Enhancer 0.8 Ensembl ENCODE 11.6 +62.7 62683 3.3 CTCF PKNOX1 REST RAD21 ZNF316 MAFF SMC3 MAFK YY1 MAFG ENSG00000276109 LOC100421204 PDE2A-AS2 MIR139 PDE2A ARAP1-AS1 ARAP1 ENSG00000256403 STARD10 ENSG00000274664
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR139 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR139 Gene

Genomic Locations for MIR139 Gene
chr11:72,615,063-72,615,130
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand
chr11:72,326,107-72,326,174
(GRCh37/hg19)
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR139 Gene

Genes around MIR139 on UCSC Golden Path with GeneCards custom track
MIR139 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR139 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR139 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR139 Gene

Proteins for MIR139 Gene

Post-translational modifications for MIR139 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR139 Gene

Domains & Families for MIR139 Gene

Gene Families for MIR139 Gene

HGNC:
genes like me logo Genes that share domains with MIR139: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR139 Gene

Function for MIR139 Gene

Phenotypes From GWAS Catalog for MIR139 Gene

Gene Ontology (GO) - Molecular Function for MIR139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
genes like me logo Genes that share ontologies with MIR139: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR139 Gene

Localization for MIR139 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR139 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for MIR139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR139: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR139 Gene

Pathways & Interactions for MIR139 Gene

PathCards logo

SuperPathways for MIR139 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR139: view

Pathways by source for MIR139 Gene

1 BioSystems pathway for MIR139 Gene

Gene Ontology (GO) - Biological Process for MIR139 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR139: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR139 Gene

Drugs & Compounds for MIR139 Gene

No Compound Related Data Available

Transcripts for MIR139 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR139 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000306C33_9606 precursor_RNA 68 6

HGNC: 31526,

RefSeq: NR_029603,

Ensembl: ENST00000606837 (view in UCSC) ,

miRBase: MI0000261,

Rfam: RF00703,

ENA: LM608336.1:1..68:precursor_RNA,

URS000023BE29_9606 miRNA 23 6

RefSeq: NR_029603,

LncBase: hsa-miR-139-3p,

miRBase: MIMAT0004552,

MirGeneDB: Hsa-Mir-139_3p,

TarBase: hsa-miR-139-3p,

ENA: LM380231.1:1..23:ncRNA, LM608336.1:43..65:ncRNA,

URS000025D232_9606 miRNA 23 6

RefSeq: NR_029603,

LncBase: hsa-miR-139-5p,

miRBase: MIMAT0000250,

MirGeneDB: Hsa-Mir-139_5p,

TarBase: hsa-miR-139-5p,

ENA: LM378892.1:1..23:ncRNA, LM608336.1:7..29:ncRNA,

URS0000EFE6B7_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-139,

MIR139 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR139 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR139 Gene

No ASD Table

Relevant External Links for MIR139 Gene

GeneLoc Exon Structure for
MIR139

Expression for MIR139 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR139 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR139

genes like me logo Genes that share expression patterns with MIR139: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR139 Gene

Orthologs for MIR139 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR139 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-139 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir139 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-139 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-139 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-139 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-139 31
  • 60 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-139 31
  • 66 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-139 31
  • 81 (a)
OneToOne
Species where no ortholog for MIR139 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR139 Gene

ENSEMBL:
Gene Tree for MIR139 (if available)
TreeFam:
Gene Tree for MIR139 (if available)

Paralogs for MIR139 Gene

No data available for Paralogs for MIR139 Gene

Variants for MIR139 Gene

Additional dbSNP identifiers (rs#s) for MIR139 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR139 Gene

Variant ID Type Subtype PubMed ID
dgv2005n54 CNV loss 21841781
nsv1042182 CNV gain 25217958
nsv468633 CNV loss 19166990
nsv523601 CNV loss 19592680
nsv825991 CNV gain 20364138
nsv832207 CNV loss 17160897

Additional Variant Information for MIR139 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR139

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR139 Gene

Disorders for MIR139 Gene

MalaCards: The human disease database

(84) MalaCards diseases for MIR139 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leiomyoma, uterine
  • ul
follicular lymphoma
  • lymphoma, follicular
bladder carcinoma in situ
  • bladder ca in situ
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR139

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR139: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR139 Gene

Publications for MIR139 Gene

  1. ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation. (PMID: 25778535) Alemdehy MF … Erkeland SJ (Blood 2015) 2 3
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  3. Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing. (PMID: 31403184) Montero-Conde C … Robledo M (International journal of cancer 2020) 3
  4. miR-139-mediated NOTCH1 regulation is crucial for the inhibition of osteosarcoma progression caused by resveratrol. (PMID: 31881225) Xiao X … Chen F (Life sciences 2020) 3
  5. Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis. (PMID: 31598673) Pei FL … Li YF (Journal of biochemistry 2020) 3

Products for MIR139 Gene

Sources for MIR139 Gene