microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR138-2 Gene

Subcategory (RNA class) for MIR138-2 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR138-2 Gene

  • MicroRNA 138-2 2 3 5
  • Hsa-MiR-138-2-3p 166 177
  • Hsa-MiR-138-5p 166 177
  • Hsa-Mir-138-2 3
  • MIMAT0000430 51
  • MIMAT0004596 51
  • Mir-138-2 3
  • MIRN138-2 3
  • MI0000455 51
  • MIR138-2 2
  • RF00671 172

External Ids for MIR138-2 Gene

Previous HGNC Symbols for MIR138-2 Gene

  • MIRN138-2

Previous GeneCards Identifiers for MIR138-2 Gene

  • GC16P055452
  • GC16P056892

Summaries for MIR138-2 Gene

Entrez Gene Summary for MIR138-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-2 Gene

MIR138-2 (MicroRNA 138-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR138-2 include Pituitary Adenoma and Oral Squamous Cell Carcinoma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR138-2 Gene

Additional gene information for MIR138-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR138-2 Gene

Genomics for MIR138-2 Gene

GeneHancer (GH) Regulatory Elements for MIR138-2 Gene

Promoters and enhancers for MIR138-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056858 Promoter/Enhancer 0.8 Ensembl ENCODE 500.7 +0.2 237 1.1 CEBPG ATF4 ZFP64 E4F1 MYC ATF3 CEBPB MIR138-2 SLC12A3
GH16J056857 Enhancer 0.8 ENCODE 500.7 -1.4 -1434 0.2 ZBTB25 ZKSCAN8 ZSCAN9 KMT2B TFDP1 SAP130 MIER3 CREM DRAP1 SMAD4 MIR138-2 lnc-SLC12A3-2
GH16J056604 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -248.4 -248362 10.8 FOXK2 SIN3A NRF1 TCF12 POLR2G NCOR1 JUND FOS ZNF10 REST MT2A ENSG00000260823 NONHSAG019534.2 RSPRY1 BBS2 MT1A MT1F NUDT21 MT1G MT1H
GH16J056914 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.4 +58.8 58778 5.6 EP300 SP1 NCOR1 ZIC2 KDM6A TCF7 RELA MEF2C ZBTB25 TGIF2 HERPUD1 MIR138-2 ENSG00000261270 MT1X NLRC5 piR-33614-099 RPS24P17 SLC12A3
GH16J056908 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.5 +52.9 52852 5.5 SP1 EP300 TCF7 RELA MEF2C RCOR1 TRIM22 TEAD1 BCL11A TCF12 HERPUD1 MIR138-2 MT1G MT1H ENSG00000261270 NLRC5 RPS24P17 piR-33614-099 SLC12A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR138-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR138-2 Gene

Genomic Locations for MIR138-2 Gene
chr16:56,858,518-56,858,601
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr16:56,892,430-56,892,513
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR138-2 Gene

Genes around MIR138-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR138-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR138-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-2 Gene

Proteins for MIR138-2 Gene

Post-translational modifications for MIR138-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-2 Gene

Domains & Families for MIR138-2 Gene

Gene Families for MIR138-2 Gene

genes like me logo Genes that share domains with MIR138-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR138-2 Gene

Function for MIR138-2 Gene

Phenotypes From GWAS Catalog for MIR138-2 Gene

Gene Ontology (GO) - Molecular Function for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20232393
genes like me logo Genes that share ontologies with MIR138-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR138-2 Gene

Localization for MIR138-2 Gene

Gene Ontology (GO) - Cellular Components for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIR138-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR138-2 Gene

Pathways & Interactions for MIR138-2 Gene

genes like me logo Genes that share pathways with MIR138-2: view

Pathways by source for MIR138-2 Gene

1 BioSystems pathway for MIR138-2 Gene
;

Gene Ontology (GO) - Biological Process for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion ISS --
GO:0008285 negative regulation of cell proliferation IDA 21079996
GO:0010629 negative regulation of gene expression IDA 28450935
GO:0030336 negative regulation of cell migration IDA 20232393
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 23319823
genes like me logo Genes that share ontologies with MIR138-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR138-2 Gene

Drugs & Compounds for MIR138-2 Gene

No Compound Related Data Available

Transcripts for MIR138-2 Gene

mRNA/cDNA for MIR138-2 Gene

4 RNACentral transcripts :
2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-2 Gene

No ASD Table

Relevant External Links for MIR138-2 Gene

GeneLoc Exon Structure for
MIR138-2

Expression for MIR138-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR138-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR138-2

genes like me logo Genes that share expression patterns with MIR138-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR138-2 Gene

Orthologs for MIR138-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-138 31
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-138-2 31
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir138-2 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-138b 31
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-138 31
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-2 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-138-2 31
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-138-1 31
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-138 31
  • 75 (a)
OneToOne
Species where no ortholog for MIR138-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-2 Gene

ENSEMBL:
Gene Tree for MIR138-2 (if available)
TreeFam:
Gene Tree for MIR138-2 (if available)

Paralogs for MIR138-2 Gene

No data available for Paralogs for MIR138-2 Gene

Variants for MIR138-2 Gene

Additional dbSNP identifiers (rs#s) for MIR138-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR138-2 Gene

Variant ID Type Subtype PubMed ID
esv33108 CNV loss 17666407
nsv1059098 CNV gain 25217958

Additional Variant Information for MIR138-2 Gene

Human Gene Mutation Database (HGMD)
MIR138-2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR138-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR138-2 Gene

Disorders for MIR138-2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR138-2 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR138-2

genes like me logo Genes that share disorders with MIR138-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR138-2 Gene

Publications for MIR138-2 Gene

  1. [Expression and Clinical Significance of PD-L1 and MicroRNA-138-5p in Patients with Acute Myeloid Leukemia]. (PMID: 30998140) Huang CY … Wen WR (Zhongguo shi yan xue ye xue za zhi 2019) 3 54
  2. miR‑138‑5p modulates the expression of excision repair cross‑complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin. (PMID: 30535472) Ning J … Gu K (Oncology reports 2019) 3 54
  3. MiR-138-5p suppresses lung adenocarcinoma cell epithelial-mesenchymal transition, proliferation and metastasis by targeting ZEB2. (PMID: 30712885) Zhu D … Ren T (Pathology, research and practice 2019) 3 54
  4. Effects of miR‑138‑5p and miR‑204‑5p on the migration and proliferation of gastric cancer cells by targeting EGFR. (PMID: 29693184) Wang Y … Ba Y (Oncology reports 2018) 3 54
  5. Decreased Expression of miR-138-5p by lncRNA H19 in Cervical Cancer Promotes Tumor Proliferation. (PMID: 28797320) Ou L … Hua F (Oncology research 2018) 3 54

Products for MIR138-2 Gene

Sources for MIR138-2 Gene