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Aliases for MIR138-2 Gene

Subcategory (RNA class) for MIR138-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR138-2 Gene

  • MicroRNA 138-2 2 3 5
  • Hsa-Mir-138-2 3
  • Mir-138-2 3
  • MIRN138-2 3

External Ids for MIR138-2 Gene

ORGUL Members for MIR138-2 Gene

Previous HGNC Symbols for MIR138-2 Gene

  • MIRN138-2

Previous GeneCards Identifiers for MIR138-2 Gene

  • GC16P055452
  • GC16P056892

Summaries for MIR138-2 Gene

Entrez Gene Summary for MIR138-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-2 Gene

MIR138-2 (MicroRNA 138-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR138-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR138-2 Gene

Genomics for MIR138-2 Gene

GeneHancer (GH) Regulatory Elements for MIR138-2 Gene

Promoters and enhancers for MIR138-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I056857 Enhancer 0.7 ENCODE 550.8 -1.4 -1434 0.2 DRAP1 ELF3 SOX13 SAP130 MLX RAD21 ZSCAN9 RARA HNF4G CREM GC16P056858 MIR138-2 NUP93
GH16I056858 Enhancer 0.5 ENCODE 550.8 +0.3 266 1.1 ATF4 ZFP64 CEBPG MYC E4F1 GC16P056858 MIR138-2 GC16P056865
GH16I056604 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -248.4 -248362 10.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MT2A ENSG00000260823 GC16P056608 GC16P056609 RSPRY1 POLR2C BBS2 MT1A MT1F MT1G
GH16I056914 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +58.8 58778 5.6 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YBX1 IRF4 ZNF48 SLC30A9 HERPUD1 MIR138-2 ENSG00000261270 MT1X NLRC5 RPS24P17 SLC12A3
GH16I056908 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +52.9 52852 5.5 HDGF FOXA2 RB1 BMI1 BATF KLF5 IRF4 EGR1 SCRT2 ATF7 HERPUD1 MIR138-2 MT1G MT1H ENSG00000261270 NLRC5 RPS24P17 SLC12A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR138-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR138-2 Gene

Genomic Locations for MIR138-2 Gene
chr16:56,858,518-56,858,601
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr16:56,892,430-56,892,513
(GRCh37/hg19)

Genomic View for MIR138-2 Gene

Genes around MIR138-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR138-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR138-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-2 Gene

Proteins for MIR138-2 Gene

Post-translational modifications for MIR138-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-2 Gene

Domains & Families for MIR138-2 Gene

Gene Families for MIR138-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR138-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR138-2 Gene

Function for MIR138-2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR138-2 Gene

Localization for MIR138-2 Gene

Gene Ontology (GO) - Cellular Components for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIR138-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR138-2 Gene

Pathways & Interactions for MIR138-2 Gene

genes like me logo Genes that share pathways with MIR138-2: view

Pathways by source for MIR138-2 Gene

1 BioSystems pathway for MIR138-2 Gene

Interacting Proteins for MIR138-2 Gene

Gene Ontology (GO) - Biological Process for MIR138-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
genes like me logo Genes that share ontologies with MIR138-2: view

No data available for SIGNOR curated interactions for MIR138-2 Gene

Drugs & Compounds for MIR138-2 Gene

No Compound Related Data Available

Transcripts for MIR138-2 Gene

mRNA/cDNA for MIR138-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-2 Gene

No ASD Table

Relevant External Links for MIR138-2 Gene

GeneLoc Exon Structure for
MIR138-2
ECgene alternative splicing isoforms for
MIR138-2

Expression for MIR138-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR138-2 Gene

genes like me logo Genes that share expression patterns with MIR138-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR138-2 Gene

Orthologs for MIR138-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-138-2 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-138 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-138b 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir138-2 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-138 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-138-2 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-138-1 34
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-138 34
  • 75 (a)
OneToOne
Species where no ortholog for MIR138-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-2 Gene

ENSEMBL:
Gene Tree for MIR138-2 (if available)
TreeFam:
Gene Tree for MIR138-2 (if available)

Paralogs for MIR138-2 Gene

No data available for Paralogs for MIR138-2 Gene

Variants for MIR138-2 Gene

Sequence variations from dbSNP and Humsavar for MIR138-2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000433296 -- 56,856,974(+) A/T upstream_transcript_variant
rs1001706062 -- 56,858,431(+) G/T upstream_transcript_variant
rs1002115703 -- 56,858,148(+) G/T upstream_transcript_variant
rs1004178618 -- 56,856,557(+) G/C upstream_transcript_variant
rs1005903419 -- 56,857,722(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR138-2 Gene

Variant ID Type Subtype PubMed ID
esv33108 CNV loss 17666407
nsv1059098 CNV gain 25217958

Additional Variant Information for MIR138-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR138-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR138-2 Gene

Disorders for MIR138-2 Gene

Additional Disease Information for MIR138-2

No disorders were found for MIR138-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR138-2 Gene

Publications for MIR138-2 Gene

  1. miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. (PMID: 28052003) Tian S … Jiang J (Oncotarget 2017) 3 58
  2. MiR-138: A promising therapeutic target for cancer. (PMID: 28378633) Sha HH … Feng JF (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  3. Induction of alpha-methylacyl-CoA racemase by miR-138 via up-regulation of β-catenin in prostate cancer cells. (PMID: 28741117) Erdmann K … Fuessel S (Journal of cancer research and clinical oncology 2017) 3 58
  4. Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138. (PMID: 28077595) Cai Q … Quan Z (Open biology 2017) 3 58
  5. Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype. (PMID: 26359943) Seidl CI … Murphy CL (Arthritis & rheumatology (Hoboken, N.J.) 2016) 3 58

Products for MIR138-2 Gene

Sources for MIR138-2 Gene

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