Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR138-1 Gene

Subcategory (RNA class) for MIR138-1 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR138-1 Gene

  • MicroRNA 138-1 2 3 5
  • Hsa-Mir-138-1 3
  • Mir-138-1 3
  • MIRN138-1 3

External Ids for MIR138-1 Gene

ORGUL Members for MIR138-1 Gene

Previous HGNC Symbols for MIR138-1 Gene

  • MIRN138-1

Previous GeneCards Identifiers for MIR138-1 Gene

  • GC03P044133

Summaries for MIR138-1 Gene

Entrez Gene Summary for MIR138-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR138-1 Gene

MIR138-1 (MicroRNA 138-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR138-1 include Oral Squamous Cell Carcinoma and Thyroid Cancer, Nonmedullary, 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR138-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR138-1 Gene

Genomics for MIR138-1 Gene

GeneHancer (GH) Regulatory Elements for MIR138-1 Gene

Promoters and enhancers for MIR138-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J043997 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -115.3 -115344 2.3 SIN3A ZNF2 KLF5 ZNF335 GLIS2 ZNF207 EGR2 SMARCA5 SP3 USF2 ENSG00000272121 ENSG00000271192 MIR138-1 RNU6-367P ENSG00000261786
GH03J043994 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -118.2 -118178 2.7 HDGF SIN3A ZNF2 GLIS2 ZNF143 KLF7 SP3 GLIS1 NBN CTCF ENSG00000271192 ENSG00000261786 MIR138-1 GC03M043165
GH03J043869 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -242.4 -242415 5 JUN MAFG SP1 JUND ZNF316 POLR2A ZFP91 CREB1 RCOR1 ZNF548 ENSG00000261786 ZNF852 ZNF662 ZNF502 RNU6-367P SNRK MIR138-1 TOPAZ1 ANO10 GC03P043926
GH03J044233 Enhancer 1.2 Ensembl ENCODE 9.5 +121.7 121690 5.6 ATF1 PKNOX1 ARNT BRCA1 TCF12 GATA2 E2F8 ARID2 ZNF143 ATF7 ZNF660 ZNF502 ZNF197 ZKSCAN7 ZNF445 ZNF852 RNU6-367P ZNF35 SNRK-AS1 MIR138-1
GH03J044045 Enhancer 1 Ensembl ENCODE 10.3 -68.2 -68171 1.3 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 RNU6-367P MIR138-1 ENSG00000261786 GC03M044031
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR138-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR138-1 Gene

Genomic Locations for MIR138-1 Gene
chr3:44,114,212-44,114,310
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr3:44,155,704-44,155,802
(GRCh37/hg19)
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR138-1 Gene

Genes around MIR138-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR138-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR138-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR138-1 Gene

Proteins for MIR138-1 Gene

Post-translational modifications for MIR138-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR138-1 Gene

Domains & Families for MIR138-1 Gene

Gene Families for MIR138-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR138-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR138-1 Gene

Function for MIR138-1 Gene

Phenotypes From GWAS Catalog for MIR138-1 Gene

Gene Ontology (GO) - Molecular Function for MIR138-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24244340
genes like me logo Genes that share ontologies with MIR138-1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR138-1 Gene

Localization for MIR138-1 Gene

Gene Ontology (GO) - Cellular Components for MIR138-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25336585
GO:0005737 cytoplasm IDA 25336585
genes like me logo Genes that share ontologies with MIR138-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR138-1 Gene

Pathways & Interactions for MIR138-1 Gene

genes like me logo Genes that share pathways with MIR138-1: view

Pathways by source for MIR138-1 Gene

1 BioSystems pathway for MIR138-1 Gene

Interacting Proteins for MIR138-1 Gene

Gene Ontology (GO) - Biological Process for MIR138-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 28450935
GO:0035195 gene silencing by miRNA IDA 24244340
GO:0035278 miRNA mediated inhibition of translation IDA 28450935
GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity IDA 28450935
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 25336585
genes like me logo Genes that share ontologies with MIR138-1: view

No data available for SIGNOR curated interactions for MIR138-1 Gene

Drugs & Compounds for MIR138-1 Gene

No Compound Related Data Available

Transcripts for MIR138-1 Gene

mRNA/cDNA for MIR138-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR138-1 Gene

No ASD Table

Relevant External Links for MIR138-1 Gene

GeneLoc Exon Structure for
MIR138-1
ECgene alternative splicing isoforms for
MIR138-1

Expression for MIR138-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR138-1 Gene

genes like me logo Genes that share expression patterns with MIR138-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR138-1 Gene

Orthologs for MIR138-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR138-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-138a 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-138-1 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir138-1 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-138-1 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-138-1 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-138-2 34
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01061343.1 34
  • 74 (a)
OneToOne
Species where no ortholog for MIR138-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR138-1 Gene

ENSEMBL:
Gene Tree for MIR138-1 (if available)
TreeFam:
Gene Tree for MIR138-1 (if available)

Paralogs for MIR138-1 Gene

No data available for Paralogs for MIR138-1 Gene

Variants for MIR138-1 Gene

Sequence variations from dbSNP and Humsavar for MIR138-1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1002544885 -- 44,114,011(+) A/G upstream_transcript_variant
rs1003517655 -- 44,112,627(+) T/G upstream_transcript_variant
rs1003822294 -- 44,113,932(+) G/C upstream_transcript_variant
rs1005301961 -- 44,113,912(+) T/A upstream_transcript_variant
rs1005695996 -- 44,113,486(+) G/C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR138-1 Gene

Variant ID Type Subtype PubMed ID
nsv834674 CNV gain 17160897

Additional Variant Information for MIR138-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR138-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR138-1 Gene

Disorders for MIR138-1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR138-1 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
thyroid cancer, nonmedullary, 1
  • nmtc1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR138-1

genes like me logo Genes that share disorders with MIR138-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR138-1 Gene

Publications for MIR138-1 Gene

  1. A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population. (PMID: 29298094) Gao X … Lu C (DNA and cell biology 2018) 3 58
  2. TGFβ1-induced down-regulation of microRNA-138 contributes to epithelial-mesenchymal transition in primary lung cancer cells. (PMID: 29407170) Zhang F … Song Y (Biochemical and biophysical research communications 2018) 3 58
  3. MiR-138 indirectly regulates the MDR1 promoter by NF-κB/p65 silencing. (PMID: 28153721) Requenez-Contreras JL … Aquino-Jarquin G (Biochemical and biophysical research communications 2017) 3 58
  4. MiR-138: A promising therapeutic target for cancer. (PMID: 28378633) Sha HH … Feng JF (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. Knockdown of Long Noncoding RNA Small Nucleolar RNA Host Gene 12 Inhibits Cell Growth and Induces Apoptosis by Upregulating miR-138 in Nonsmall Cell Lung Cancer. (PMID: 28872894) Wang X … Ma J (DNA and cell biology 2017) 3 58

Products for MIR138-1 Gene

Sources for MIR138-1 Gene

Content
Loading form....