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Aliases for MIR137 Gene

Subcategory (RNA class) for MIR137 Gene


Quality Score for this RNA gene is


Aliases for MIR137 Gene

  • MicroRNA 137 2 3 5
  • Hsa-Mir-137 3
  • MiR-137 3
  • MIRN137 3

External Ids for MIR137 Gene

Previous HGNC Symbols for MIR137 Gene

  • MIRN137

Previous GeneCards Identifiers for MIR137 Gene

  • GC01M098284
  • GC01M098511

Summaries for MIR137 Gene

Entrez Gene Summary for MIR137 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR137 Gene

MIR137 (MicroRNA 137) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR137 include Schizophrenia. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR137 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR137

Additional gene information for MIR137 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR137 Gene

Genomics for MIR137 Gene

GeneHancer (GH) Regulatory Elements for MIR137 Gene

Promoters and enhancers for MIR137 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I098044 Promoter/Enhancer 1 Ensembl ENCODE 550.8 +0.8 799 2.6 POLR2A RAD21 CHD2 ZBTB20 EZH2 MIR2682 MIR137 MIR137HG
GH01I098047 Enhancer 0.2 FANTOM5 550.8 -1.3 -1257 0.3 MIR137 ENSG00000259946 MIR137HG
GH01I097998 Enhancer 0.4 ENCODE 10.4 +46.6 46594 2.4 JUND JUN MAFK MIR137 MIR137HG GC01P098016 ENSG00000259946
GH01I097885 Enhancer 0.3 dbSUPER 10.2 +159.8 159785 2.1 HNF4A DPYD MIR137 MIR137HG LOC100419654
GH01I098048 Promoter/Enhancer 1.3 Ensembl ENCODE 0.8 -2.4 -2392 0.5 ELF3 ARID4B SIN3A ZNF48 ZSCAN9 RAD21 RARA ZNF143 RCOR1 KLF11 MIR137HG MIR137
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR137 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR137 Gene

Genomic Locations for MIR137 Gene
102 bases
Minus strand

Genomic View for MIR137 Gene

Genes around MIR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR137 Gene

ORGUL Member Location for MIR137 Gene

ORGUL Member Location for MIR137 gene

Proteins for MIR137 Gene

Post-translational modifications for MIR137 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR137 Gene

Domains & Families for MIR137 Gene

Gene Families for MIR137 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR137: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR137 Gene

Function for MIR137 Gene

Phenotypes From GWAS Catalog for MIR137 Gene

Gene Ontology (GO) - Molecular Function for MIR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24927112
genes like me logo Genes that share ontologies with MIR137: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR137 Gene

Localization for MIR137 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR137 Gene

Pathways & Interactions for MIR137 Gene

SuperPathways for MIR137 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR137: view

Pathways by source for MIR137 Gene

1 KEGG pathway for MIR137 Gene

Interacting Proteins for MIR137 Gene

Gene Ontology (GO) - Biological Process for MIR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 26989074
GO:0016525 negative regulation of angiogenesis IDA 24927112
GO:0030336 negative regulation of cell migration IDA 26989074
GO:0035195 gene silencing by miRNA IDA 24927112
GO:0043065 positive regulation of apoptotic process IDA 26989074
genes like me logo Genes that share ontologies with MIR137: view

No data available for SIGNOR curated interactions for MIR137 Gene

Drugs & Compounds for MIR137 Gene

No Compound Related Data Available

Transcripts for MIR137 Gene

fRNAdb Secondary structures for MIR137 Gene

  • hsa-mir-137_MI0000454_Homo_sapiens_miR-137_stem-loop_hairpin

mRNA/cDNA for MIR137 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR137 Gene

No ASD Table

Relevant External Links for MIR137 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR137 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR137 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR137 Gene

Orthologs for MIR137 Gene

Evolution for MIR137 Gene

Gene Tree for MIR137 (if available)
Gene Tree for MIR137 (if available)

No data available for Orthologs for MIR137 Gene

Paralogs for MIR137 Gene

No data available for Paralogs for MIR137 Gene

Variants for MIR137 Gene

Sequence variations from dbSNP and Humsavar for MIR137 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000823142 -- 98,045,967(-) C/A downstream_transcript_variant
rs1001182415 -- 98,046,574(-) C/A upstream_transcript_variant
rs1001318285 -- 98,046,313(-) A/G upstream_transcript_variant
rs1001918108 -- 98,046,650(-) C/A upstream_transcript_variant
rs1002993497 -- 98,047,671(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR137 Gene

Variant ID Type Subtype PubMed ID
nsv830736 CNV gain 17160897
nsv546874 CNV loss 21841781
nsv470729 CNV loss 18288195

Additional Variant Information for MIR137 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR137 Gene

Disorders for MIR137 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR137 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR137

genes like me logo Genes that share disorders with MIR137: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR137 Gene

Publications for MIR137 Gene

  1. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M … Tuschl T (Current biology : CB 2002) 1 3 58
  2. miR-137 downregulates c-kit expression in acute myeloid leukemia. (PMID: 28314168) Hu Y … Zhao Y (Leukemia research 2017) 3 58
  3. The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function. (PMID: 26925706) Olde Loohuis NF … Aschrafi A (Progress in neuro-psychopharmacology & biological psychiatry 2017) 3 58
  4. The tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor. (PMID: 28757416) Peres J … Prince S (Cancer letters 2017) 3 58
  5. Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C. (PMID: 28610956) Chang TH … Shih JY (Cancer letters 2017) 3 58

Products for MIR137 Gene

Sources for MIR137 Gene

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