microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR137 Gene

Subcategory (RNA class) for MIR137 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR137 Gene

  • MicroRNA 137 2 3 5
  • Hsa-MiR-137 166 177
  • MIMAT0037310 51
  • MIMAT0000429 51
  • Hsa-Mir-137 3
  • MI0000454 51
  • MiR-137 3
  • MIRN137 3
  • RF00694 172
  • MIR137 2

External Ids for MIR137 Gene

Previous HGNC Symbols for MIR137 Gene

  • MIRN137

Previous GeneCards Identifiers for MIR137 Gene

  • GC01M098284
  • GC01M098511

Summaries for MIR137 Gene

Entrez Gene Summary for MIR137 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR137 Gene

MIR137 (MicroRNA 137) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR137 include Oral Squamous Cell Carcinoma and Glioblastoma Multiforme. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR137 Gene

Additional gene information for MIR137 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR137 Gene

Genomics for MIR137 Gene

GeneHancer (GH) Regulatory Elements for MIR137 Gene

Promoters and enhancers for MIR137 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J098044 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 500.7 -0.1 -130 7.4 ZBTB40 SIN3A PHF8 REST SAP30 ZBTB25 RCOR1 TGIF2 ZBTB26 HDAC2 MIR2682 MK631887 MIR137 ENSG00000259946 MIR137HG MK631885 lnc-SNX7-10
GH01J097998 Enhancer 0.6 Ensembl ENCODE 10.7 +47.1 47070 3.4 FOS JUN JUND MAFK STAT3 MIR137 MIR137HG DPYD MK631885 lnc-SNX7-9 lnc-SNX7-10 MK631887
GH01J098005 Enhancer 0.5 Ensembl 10.5 +40.6 40570 1.2 EP300 BRCA1 FOSL2 CEBPB JUN JUND FOS RFX5 GATA2 POLR2A MIR137 MIR137HG lnc-SNX7-9 DPYD MK631885 lnc-SNX7-10 MK631887
GH01J098001 Enhancer 0.4 Ensembl 10.4 +43.7 43671 1 CTCF RAD21 HNF4A SMC3 CEBPB MIR137 MIR137HG DPYD lnc-SNX7-9 MK631885 lnc-SNX7-10 MK631887
GH01J098019 Enhancer 0.4 Ensembl 11.9 +26.3 26270 0.6 EP300 GATA2 EZH2 MIR137 MIR137HG lnc-SNX7-7 MIR2682 MK631887 MK631885 lnc-SNX7-10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR137 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR137 Gene

Genomic Locations for MIR137 Gene
chr1:98,046,070-98,046,171
(GRCh38/hg38)
Size:
102 bases
Orientation:
Minus strand
chr1:98,453,556-98,515,419
(GRCh37/hg19)
Size:
61,864 bases
Orientation:
Minus strand

Genomic View for MIR137 Gene

Genes around MIR137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR137 Gene

Proteins for MIR137 Gene

Post-translational modifications for MIR137 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR137 Gene

Domains & Families for MIR137 Gene

Gene Families for MIR137 Gene

HGNC:
genes like me logo Genes that share domains with MIR137: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR137 Gene

Function for MIR137 Gene

Phenotypes From GWAS Catalog for MIR137 Gene

Gene Ontology (GO) - Molecular Function for MIR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21067317
genes like me logo Genes that share ontologies with MIR137: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR137 Gene

Localization for MIR137 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR137 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR137 Gene

Pathways & Interactions for MIR137 Gene

PathCards logo

SuperPathways for MIR137 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR137: view

Pathways by source for MIR137 Gene

1 KEGG pathway for MIR137 Gene
;

Gene Ontology (GO) - Biological Process for MIR137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IDA 30102687
GO:0007406 negative regulation of neuroblast proliferation IDA 23400681
GO:0008285 negative regulation of cell proliferation IDA 26989074
GO:0016525 negative regulation of angiogenesis IDA 24927112
GO:0030336 negative regulation of cell migration IDA 26989074
genes like me logo Genes that share ontologies with MIR137: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR137 Gene

Drugs & Compounds for MIR137 Gene

No Compound Related Data Available

Transcripts for MIR137 Gene

mRNA/cDNA for MIR137 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR137 Gene

No ASD Table

Relevant External Links for MIR137 Gene

GeneLoc Exon Structure for
MIR137

Expression for MIR137 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR137

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR137 Gene

Orthologs for MIR137 Gene

Evolution for MIR137 Gene

ENSEMBL:
Gene Tree for MIR137 (if available)
TreeFam:
Gene Tree for MIR137 (if available)

No data available for Orthologs for MIR137 Gene

Paralogs for MIR137 Gene

No data available for Paralogs for MIR137 Gene

Variants for MIR137 Gene

Additional dbSNP identifiers (rs#s) for MIR137 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR137 Gene

Variant ID Type Subtype PubMed ID
nsv470729 CNV loss 18288195
nsv546874 CNV loss 21841781
nsv830736 CNV gain 17160897

Additional Variant Information for MIR137 Gene

Human Gene Mutation Database (HGMD)
MIR137
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR137 Gene

Disorders for MIR137 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR137 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
glioblastoma multiforme
  • adult glioblastoma multiforme
glioma susceptibility 1
  • glm1
lung cancer
  • adenocarcinoma of lung
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR137

genes like me logo Genes that share disorders with MIR137: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR137 Gene

Publications for MIR137 Gene

  1. [Effect of miR-137 on the proliferation and apoptosis of endothelial cells regulated by AKT2 gene]. (PMID: 31598939) Xu Z … Tian F (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2019) 3 54
  2. miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer. (PMID: 30166592) Sun J … Zhu W (Oncogene 2019) 3 54
  3. MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12. (PMID: 30866999) He Z … Sun C (Journal of experimental & clinical cancer research : CR 2019) 3 54
  4. Genetic variant in the promoter region of microRNA‑137 reduces the warfarin maintenance dose in patients with atrial fibrillation. (PMID: 31059093) Tian Z … Liu D (Molecular medicine reports 2019) 3 54
  5. Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development. (PMID: 31004009) Velasco MX … Penalva LOF (RNA (New York, N.Y.) 2019) 3 54

Products for MIR137 Gene

Sources for MIR137 Gene