microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR135B Gene

Subcategory (RNA class) for MIR135B Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR135B Gene

  • MicroRNA 135b 2 3 5
  • Hsa-MiR-135b-5p 168 179
  • Hsa-MiR-135b-3p 168 179
  • Hsa-Mir-135b 3
  • MIMAT0000758 53
  • MIMAT0004698 53
  • MI0000810 53
  • Mir-135b 3
  • MIRN135B 3
  • MIR135B 2
  • RF00246 174

External Ids for MIR135B Gene

Previous HGNC Symbols for MIR135B Gene

  • MIRN135B

Previous GeneCards Identifiers for MIR135B Gene

  • GC01M203685
  • GC01M205417

Summaries for MIR135B Gene

Entrez Gene Summary for MIR135B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135B Gene

MIR135B (MicroRNA 135b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR135B include Melanoma and Colorectal Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR135B Gene

  • mir-135 microRNA precursor family

Additional gene information for MIR135B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135B Gene

Genomics for MIR135B Gene

GeneHancer (GH) Regulatory Elements for MIR135B Gene

Promoters and enhancers for MIR135B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J205444 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.0 14 8.5 RBPJ SMARCE1 POLR2A NR2F6 POU5F1 NFIB ZNF652 SP1 ZKSCAN8 ZNF148 MIR135B NFASC NUCKS1 DSTYK BLACAT1 LEMD1 LOC105371698
GH01J205477 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.8 -31.4 -31401 6 ZNF785 SP1 HCFC1 ZNF133 RELA HLF ZNF121 MNT NFIB NKRF MDM4 ELK4 RBBP5 CDK18 LEMD1 LEMD1-DT MIR135B KLHDC8A LEMD1-AS1 MFSD4A
GH01J205485 Enhancer 1.1 Ensembl ENCODE 11.4 -37.2 -37202 1.2 CTCF MLX RBPJ NR2F1 NR2F6 MIXL1 CC2D1A RAD21 ZNF121 SP1 LEMD1 LEMD1-DT MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A TRK-TTT8-1 CDK18
GH01J205370 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +74.6 74588 6.8 ZNF362 MNT ZNF652 SP7 PRDM1 PRDM10 ZEB2 ZNF629 ZNF692 JUND LEMD1-AS1 KLHDC8A MIR135B CDK18 MFSD4A LOC105371698
GH01J205359 Enhancer 0.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +87.9 87927 1.7 KLHDC8A MIR135B CDK18 NUAK2 MFSD4A LEMD1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR135B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR135B Gene

Genomic Locations for MIR135B Gene
chr1:205,448,302-205,448,399
(GRCh38/hg38)
Size:
98 bases
Orientation:
Minus strand
chr1:205,417,430-205,417,526
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR135B Gene

Genes around MIR135B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR135B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135B Gene

Proteins for MIR135B Gene

Post-translational modifications for MIR135B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135B Gene

Domains & Families for MIR135B Gene

Gene Families for MIR135B Gene

genes like me logo Genes that share domains with MIR135B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR135B Gene

Function for MIR135B Gene

Phenotypes From GWAS Catalog for MIR135B Gene

Gene Ontology (GO) - Molecular Function for MIR135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26184978
genes like me logo Genes that share ontologies with MIR135B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135B Gene

Localization for MIR135B Gene

Gene Ontology (GO) - Cellular Components for MIR135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR135B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR135B Gene

Pathways & Interactions for MIR135B Gene

PathCards logo

SuperPathways for MIR135B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135B: view

Pathways by source for MIR135B Gene

1 KEGG pathway for MIR135B Gene

Gene Ontology (GO) - Biological Process for MIR135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 26184978
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26184978
GO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA 26184978
GO:1904754 positive regulation of vascular associated smooth muscle cell migration IDA 26184978
genes like me logo Genes that share ontologies with MIR135B: view

No data available for SIGNOR curated interactions for MIR135B Gene

Drugs & Compounds for MIR135B Gene

No Compound Related Data Available

Transcripts for MIR135B Gene

mRNA/cDNA for MIR135B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(3) miRBase transcripts :
(2) TarBase transcripts :
(2) LncBase transcripts :
(5) ENA transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135B Gene

No ASD Table

Relevant External Links for MIR135B Gene

GeneLoc Exon Structure for
MIR135B
ECgene alternative splicing isoforms for
MIR135B

Expression for MIR135B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR135B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR135B Gene:

MIR135B
genes like me logo Genes that share expression patterns with MIR135B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135B Gene

Orthologs for MIR135B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135b 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-135b 33
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir135b 33
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-135b 33
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135b 33
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-1 33
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-135a-3 33
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-135-3 33
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-135c-1 33
  • 71 (a)
OneToOne
Species where no ortholog for MIR135B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR135B Gene

ENSEMBL:
Gene Tree for MIR135B (if available)
TreeFam:
Gene Tree for MIR135B (if available)

Paralogs for MIR135B Gene

No data available for Paralogs for MIR135B Gene

Variants for MIR135B Gene

Sequence variations from dbSNP and Humsavar for MIR135B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000371276 -- 205,449,244(-) AAAA/AAA upstream_transcript_variant
rs1000911825 -- 205,450,008(-) C/T upstream_transcript_variant
rs1000983437 -- 205,449,830(-) T/C upstream_transcript_variant
rs1001993270 -- 205,448,132(-) G/A downstream_transcript_variant
rs1002847553 -- 205,450,242(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR135B Gene

Variant ID Type Subtype PubMed ID
nsv1068038 CNV deletion 25765185
nsv832381 CNV gain 17160897
nsv952643 CNV deletion 24416366

Additional Variant Information for MIR135B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR135B Gene

Disorders for MIR135B Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR135B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
colorectal cancer
  • crc
myxoid liposarcoma
  • liposarcoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR135B

genes like me logo Genes that share disorders with MIR135B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR135B Gene

Publications for MIR135B Gene

  1. miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2. (PMID: 30665445) Zhang Y … Wu Y (Journal of experimental & clinical cancer research : CR 2019) 3 56
  2. LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis. (PMID: 30429236) Chen N … Guo X (Bioscience reports 2019) 3 56
  3. GAS5 Regulates RECK Expression and Inhibits Invasion Potential of HCC Cells by Sponging miR-135b. (PMID: 30733959) Yang L … Jiang J (BioMed research international 2019) 3 56
  4. Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice. (PMID: 30508510) Han TS … Oshima M (Gastroenterology 2019) 3 56
  5. Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer. (PMID: 29985646) Shao L … El-Rifai W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 56

Products for MIR135B Gene

Sources for MIR135B Gene