microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR135B Gene

Subcategory (RNA class) for MIR135B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR135B Gene

  • MicroRNA 135b 2 3 5
  • Hsa-MiR-135b-3p 163 173
  • Hsa-MiR-135b-5p 163 173
  • Hsa-Mir-135b 2 3
  • MIR135B 2 5
  • Hsa-Mir-135-P3 178
  • MIMAT0004698 50
  • MIMAT0000758 50
  • MI0000810 50
  • MIRN135B 3
  • Mir-135b 3
  • RF00246 168

External Ids for MIR135B Gene

Previous HGNC Symbols for MIR135B Gene

  • MIRN135B

Previous GeneCards Identifiers for MIR135B Gene

  • GC01M203685
  • GC01M205417

Summaries for MIR135B Gene

Entrez Gene Summary for MIR135B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135B Gene

MIR135B (MicroRNA 135b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR135B include Osteoblastoma and Bone Benign Neoplasm. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR135B Gene

  • mir-135 microRNA precursor family

Additional gene information for MIR135B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135B Gene

Genomics for MIR135B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR135B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J205444 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.0 14 8.5 HNRNPL TEAD4 PRDM10 KDM1A RCOR2 ZNF7 LARP7 PRDM1 ZIC2 RBFOX2 MIR135B ELK4 MDM4 ENSG00000236942 BLACAT1 LEMD1 LOC105371698 KLHDC8A
GH01J205370 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 10.9 +74.6 74588 6.8 ZNF629 PRDM10 ZNF692 FOXA1 PRDM1 SCRT2 ZBTB44 ZBTB20 SP1 JUND LEMD1-AS1 KLHDC8A MIR135B CDK18 MFSD4A LOC105371698 LEMD1
GH01J205477 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.8 -31.4 -31401 6 SP1 CREB1 KDM1A ZNF692 BACH1 TARDBP FOXA1 ZNF143 RELA ZSCAN4 MDM4 ELK4 CDK18 LEMD1 LEMD1-DT MIR135B KLHDC8A LEMD1-AS1 MFSD4A NUAK2
GH01J205485 Enhancer 1.1 Ensembl ENCODE 11.4 -37.2 -37202 1.2 HNRNPL GATAD2A CTCF PRDM10 TFE3 ZNF512 KDM1A ZNF692 RCOR2 FOXA1 LEMD1 LEMD1-DT MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A TRK-TTT8-1 CDK18
GH01J205359 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +87.9 87927 1.7 ZNF341 SMARCA4 KLHDC8A MIR135B CDK18 NUAK2 MFSD4A LEMD1-AS1 LEMD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR135B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR135B Gene

Genomic Locations for MIR135B Gene
chr1:205,448,302-205,448,399
(GRCh38/hg38)
Size:
98 bases
Orientation:
Minus strand
chr1:205,417,430-205,417,526
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR135B Gene

Genes around MIR135B on UCSC Golden Path with GeneCards custom track
MIR135B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR135B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135B Gene

Proteins for MIR135B Gene

Post-translational modifications for MIR135B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135B Gene

Domains & Families for MIR135B Gene

Gene Families for MIR135B Gene

genes like me logo Genes that share domains with MIR135B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR135B Gene

Function for MIR135B Gene

Phenotypes From GWAS Catalog for MIR135B Gene

Gene Ontology (GO) - Molecular Function for MIR135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26184978
genes like me logo Genes that share ontologies with MIR135B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135B Gene

Localization for MIR135B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR135B gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR135B Gene

Pathways & Interactions for MIR135B Gene

PathCards logo

SuperPathways for MIR135B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR135B: view

Pathways by source for MIR135B Gene

1 KEGG pathway for MIR135B Gene

Gene Ontology (GO) - Biological Process for MIR135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 26184978
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 26184978
GO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA 26184978
GO:1904754 positive regulation of vascular associated smooth muscle cell migration IDA 26184978
genes like me logo Genes that share ontologies with MIR135B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR135B Gene

Drugs & Compounds for MIR135B Gene

No Compound Related Data Available

Transcripts for MIR135B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR135B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000001C659_9606 miRNA 23 6

RefSeq: NR_029893,

LncBase: hsa-miR-135b-5p,

miRBase: MIMAT0000758,

MirGeneDB: Hsa-Mir-135-P3_5p,

TarBase: hsa-miR-135b-5p,

ENA: LM379263.1:1..23:ncRNA, LM608728.1:16..38:ncRNA,

URS0000488C83_9606 miRNA 22 6

RefSeq: NR_029893,

LncBase: hsa-miR-135b-3p,

miRBase: MIMAT0004698,

MirGeneDB: Hsa-Mir-135-P3_3p,

TarBase: hsa-miR-135b-3p,

ENA: LM380358.1:1..22:ncRNA, LM608728.1:55..76:ncRNA,

URS0000759E75_9606 precursor_RNA 97 5

HGNC: 31760,

RefSeq: NR_029893,

Ensembl: ENST00000362189 (view in UCSC) ,

miRBase: MI0000810,

ENA: LM608728.1:1..97:precursor_RNA,

URS000067F106_9606 precursor_RNA 91 1

Rfam: RF00246,

URS0000EFD738_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-135-P3,

MIR135B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR135B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135B Gene

No ASD Table

Relevant External Links for MIR135B Gene

GeneLoc Exon Structure for
MIR135B

Expression for MIR135B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR135B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR135B

Evidence on tissue expression from TISSUES for MIR135B Gene

  • Intestine(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with MIR135B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135B Gene

Orthologs for MIR135B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135b 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-135b 31
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir135b 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-135b 31
  • 94 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135b 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-1 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-135a-3 31
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-135-3 31
  • 89 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-135c-1 31
  • 71 (a)
OneToOne
Species where no ortholog for MIR135B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR135B Gene

ENSEMBL:
Gene Tree for MIR135B (if available)
TreeFam:
Gene Tree for MIR135B (if available)

Paralogs for MIR135B Gene

No data available for Paralogs for MIR135B Gene

Variants for MIR135B Gene

Additional dbSNP identifiers (rs#s) for MIR135B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR135B Gene

Variant ID Type Subtype PubMed ID
nsv1068038 CNV deletion 25765185
nsv832381 CNV gain 17160897
nsv952643 CNV deletion 24416366

Additional Variant Information for MIR135B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR135B Gene

Disorders for MIR135B Gene

MalaCards: The human disease database

(17) MalaCards diseases for MIR135B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
osteoblastoma
bone benign neoplasm
melanoma
  • malignant melanoma
colorectal cancer
  • crc
myxoid liposarcoma
  • liposarcoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR135B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR135B Gene

Publications for MIR135B Gene

  1. lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through miR-135b suppression to promote CLDN11 expression. (PMID: 32119960) Zhang XZ … Liu HC (Life sciences 2020) 3
  2. miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2. (PMID: 30665445) Zhang Y … Wu Y (Journal of experimental & clinical cancer research : CR 2019) 3
  3. LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis. (PMID: 30429236) Chen N … Guo X (Bioscience reports 2019) 3
  4. miR-135b Delivered by Gastric Tumor Exosomes Inhibits FOXO1 Expression in Endothelial Cells and Promotes Angiogenesis. (PMID: 31416776) Bai M … Ba Y (Molecular therapy : the journal of the American Society of Gene Therapy 2019) 3
  5. GAS5 Regulates RECK Expression and Inhibits Invasion Potential of HCC Cells by Sponging miR-135b. (PMID: 30733959) Yang L … Jiang J (BioMed research international 2019) 3

Products for MIR135B Gene

Sources for MIR135B Gene