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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR135A2 Gene
Subcategory (RNA class) for MIR135A2 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR135A2 Gene
External Ids for MIR135A2 Gene
- HGNC: 31521
- Entrez Gene: 406926
- Ensembl: ENSG00000207586
- miRBase: hsa-mir-135a-2
Previous HGNC Symbols for MIR135A2 Gene
- MIRN135-2
- MIRN135A2
Previous GeneCards Identifiers for MIR135A2 Gene
- GC12P096481
- GC12P097957
Summaries for MIR135A2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR135A2 Gene
MIR135A2 (MicroRNA 135a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
Rfam classification for MIR135A2 Gene
-
mir-135 microRNA precursor family
Additional gene information for MIR135A2 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135A2 Gene
Genomics for MIR135A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR135A2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J097595 | Enhancer | 0.8 | Ensembl | 10.6 | +32.5 | 32489 | 2.6 | GATAD2A RBFOX2 POLR2A RXRB GABPA CEBPA SOX13 TCF7 FOXA2 TEAD1 | MIR135A2 MIR1251 RMST piR-38562-020 ENSG00000277081 NEDD1 TMPO | |
| GH12J097536 | Enhancer | 0.7 | Ensembl dbSUPER | 10.8 | -26.2 | -26211 | 2.4 | CEBPG FOXA1 CTBP1 PKNOX1 ZNF217 MBD2 GATA3 DPF2 JUND SMARCA4 | MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844 NEDD1 TMPO | |
| GH12J097534 | Enhancer | 0.5 | Ensembl dbSUPER | 10.8 | -29.7 | -29711 | 2.2 | ZNF316 MAFK | ENSG00000274819 RMST MIR135A2 MIR1251 ENSG00000251844 NEDD1 TMPO | |
| GH12J097639 | Enhancer | 0.5 | Ensembl | 10.4 | +76.4 | 76389 | 1.2 | CREB1 ATF7 FOXA2 JUN ZNF24 ATF2 JUND | MIR135A2 MIR1251 RMST HSALNG0093349 piR-38562-020 NEDD1 TMPO | |
| GH12J097503 | Enhancer | 0.3 | ENCODE | 10.2 | -60.6 | -60554 | 0.2 | HNF4A SP1 | ENSG00000251844 MIR135A2 ENSG00000273570 piR-36573-023 RMST NEDD1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR135A2 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR135A2 Gene
Genomic Locations for MIR135A2 Gene
- chr12:97,563,812-97,563,911
- (GRCh38/hg38)
- Size:
- 100 bases
- Orientation:
- Plus strand
- chr12:97,957,590-97,957,689
- (GRCh37/hg19)
- Size:
- 100 bases
- Orientation:
- Plus strand
Genomic View for MIR135A2 Gene
Genes around MIR135A2 on UCSC Golden Path with GeneCards custom track
MIR135A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 12q23.1 by HGNC
- 12q23.1 by Entrez Gene
- 12q23.1 by Ensembl
MIR135A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR135A2 Gene
Proteins for MIR135A2 Gene
Post-translational modifications for MIR135A2 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR135A2
- Origene Custom Protein Services for MIR135A2
No data available for DME Specific Peptides for MIR135A2 Gene
Domains & Families for MIR135A2 Gene
Gene Families for MIR135A2 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR135A2 Gene
Function for MIR135A2 Gene
Phenotypes From GWAS Catalog for MIR135A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 25152461 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR135A2 - Select products 50% OFF >
- * MIR135A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR135A2
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR135A2 - Select products 50% OFF >
- * MIR135A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A2 Gene
Localization for MIR135A2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR135A2 Gene
Pathways & Interactions for MIR135A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Alzheimers Disease | ||
Pathways by source for MIR135A2 Gene
1 BioSystems pathway for MIR135A2 Gene
1 KEGG pathway for MIR135A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR135A2 Gene
Transcripts for MIR135A2 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR135A2 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00000DF6D0_9606 | miRNA | 23 | 6 |
LncBase: hsa-miR-135a-5p, miRBase: MIMAT0000428, MirGeneDB: Hsa-Mir-135-P1_5p, Hsa-Mir-135-P2_5p, TarBase: hsa-miR-135a-5p, ENA: LM379046.1:1..23:ncRNA, LM608492.1:17..39:ncRNA, LM608493.1:23..45:ncRNA, |
| URS00000A7BEB_9606 | precursor_RNA | 100 | 5 |
HGNC: 31521, RefSeq: NR_029678, Ensembl: ENST00000384854 (view in UCSC) , miRBase: MI0000453, |
| URS000075AB6F_9606 | miRNA | 22 | 3 |
RefSeq: NR_029678, miRBase: MIMAT0037309, MirGeneDB: Hsa-Mir-135-P2_3p, |
| URS00000E86D5_9606 | precursor_RNA | 88 | 1 |
Rfam: RF00246, |
| URS0000EFC5B7_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-135-P2, |
MIR135A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR135A2 Gene
- 2 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR135A2 - Select products 50% OFF >
- * MIR135A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR135A2
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR135A2 - Select products 50% OFF >
- * MIR135A2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for MIR135A2 Gene
- GeneLoc Exon Structure for
- MIR135A2
Expression for MIR135A2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR135A2
Primer Products
-
OriGene qPCR primer pairs for MIR135A2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135A2 Gene
Orthologs for MIR135A2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | bta-mir-135a-2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-135a-2 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-135a-2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir135a-2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-135a 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-135a 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-135a-2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-135-2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-135a 31 |
|
OneToOne |
- Species where no ortholog for MIR135A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for MIR135A2 Gene
No data available for Paralogs for MIR135A2 Gene
Variants for MIR135A2 Gene
Additional Variant Information for MIR135A2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR135A2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR135A2 Gene
Disorders for MIR135A2 Gene
Additional Disease Information for MIR135A2
No disorders were found for MIR135A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135A2 Gene
Publications for MIR135A2 Gene
- Altered miR-186 and miR-135a contribute to granulosa cell dysfunction by targeting ESR2: A possible role in polycystic ovary syndrome. (PMID: 31173821) Song Y … Tan L (Molecular and cellular endocrinology 2019) 3
- Silencing of GAS5 represses the malignant progression of atherosclerosis through upregulation of miR-135a. (PMID: 31545249) Shen S … Wang Z (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
- LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA-135a binding site affects bladder cancer risk. (PMID: 30006972) Wang W … Ying M (International journal of cancer 2019) 3
- Downregulation of lysyl oxidase-like 4 LOXL4 by miR-135a-5p promotes lung cancer progression in vitro and in vivo. (PMID: 30993701) Zhang Y … Xie S (Journal of cellular physiology 2019) 3
- Downregulated microRNA-135a ameliorates rheumatoid arthritis by inactivation of the phosphatidylinositol 3-kinase/AKT signaling pathway via phosphatidylinositol 3-kinase regulatory subunit 2. (PMID: 30912120) Qu Y … Yu QH (Journal of cellular physiology 2019) 3
ExternalLinks
Products for MIR135A2 Gene
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR135A2
- Origene Custom Protein Services for MIR135A2
- Browse OriGene Inhibitory RNA Products For MIR135A2
- OriGene qPCR primer pairs for MIR135A2
- Browse CRISPR knockouts for MIR135A2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR135A2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR135A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR135A2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR135A2
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR135A2
Sources for MIR135A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB