microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR135A2 Gene

Subcategory (RNA class) for MIR135A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR135A2 Gene

  • MicroRNA 135a-2 2 3 5
  • Hsa-MiR-135a-5p 163 173
  • MicroRNA 135-2 2 3
  • Hsa-Mir-135a-2 2 3
  • Hsa-Mir-135-2 2 3
  • MIR135A2 2 5
  • Hsa-Mir-135-P2 178
  • MIMAT0037309 50
  • MIMAT0000428 50
  • Mir-135a-2 3
  • MIRN135-2 3
  • MIRN135A2 3
  • MI0000453 50
  • RF00246 168

External Ids for MIR135A2 Gene

Previous HGNC Symbols for MIR135A2 Gene

  • MIRN135-2
  • MIRN135A2

Previous GeneCards Identifiers for MIR135A2 Gene

  • GC12P096481
  • GC12P097957

Summaries for MIR135A2 Gene

Entrez Gene Summary for MIR135A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A2 Gene

MIR135A2 (MicroRNA 135a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR135A2 Gene

  • mir-135 microRNA precursor family

Additional gene information for MIR135A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135A2 Gene

Genomics for MIR135A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR135A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J097595 Enhancer 0.8 Ensembl 10.6 +32.5 32489 2.6 GATAD2A RBFOX2 POLR2A RXRB GABPA CEBPA SOX13 TCF7 FOXA2 TEAD1 MIR135A2 MIR1251 RMST piR-38562-020 ENSG00000277081 NEDD1 TMPO
GH12J097536 Enhancer 0.7 Ensembl dbSUPER 10.8 -26.2 -26211 2.4 CEBPG FOXA1 CTBP1 PKNOX1 ZNF217 MBD2 GATA3 DPF2 JUND SMARCA4 MIR135A2 MIR1251 RMST ENSG00000274819 ENSG00000251844 NEDD1 TMPO
GH12J097534 Enhancer 0.5 Ensembl dbSUPER 10.8 -29.7 -29711 2.2 ZNF316 MAFK ENSG00000274819 RMST MIR135A2 MIR1251 ENSG00000251844 NEDD1 TMPO
GH12J097639 Enhancer 0.5 Ensembl 10.4 +76.4 76389 1.2 CREB1 ATF7 FOXA2 JUN ZNF24 ATF2 JUND MIR135A2 MIR1251 RMST HSALNG0093349 piR-38562-020 NEDD1 TMPO
GH12J097503 Enhancer 0.3 ENCODE 10.2 -60.6 -60554 0.2 HNF4A SP1 ENSG00000251844 MIR135A2 ENSG00000273570 piR-36573-023 RMST NEDD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR135A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR135A2 Gene

Genomic Locations for MIR135A2 Gene
chr12:97,563,812-97,563,911
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr12:97,957,590-97,957,689
(GRCh37/hg19)
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR135A2 Gene

Genes around MIR135A2 on UCSC Golden Path with GeneCards custom track
MIR135A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR135A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A2 Gene

Proteins for MIR135A2 Gene

Post-translational modifications for MIR135A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A2 Gene

Domains & Families for MIR135A2 Gene

Gene Families for MIR135A2 Gene

genes like me logo Genes that share domains with MIR135A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR135A2 Gene

Function for MIR135A2 Gene

Phenotypes From GWAS Catalog for MIR135A2 Gene

Gene Ontology (GO) - Molecular Function for MIR135A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25152461
genes like me logo Genes that share ontologies with MIR135A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A2 Gene

Localization for MIR135A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR135A2 Gene

Pathways & Interactions for MIR135A2 Gene

PathCards logo

SuperPathways for MIR135A2 Gene

genes like me logo Genes that share pathways with MIR135A2: view

Pathways by source for MIR135A2 Gene

1 BioSystems pathway for MIR135A2 Gene
1 KEGG pathway for MIR135A2 Gene

Gene Ontology (GO) - Biological Process for MIR135A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR135A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR135A2 Gene

Drugs & Compounds for MIR135A2 Gene

No Compound Related Data Available

Transcripts for MIR135A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR135A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000DF6D0_9606 miRNA 23 6

RefSeq: NR_029677, NR_029678,

LncBase: hsa-miR-135a-5p,

miRBase: MIMAT0000428,

MirGeneDB: Hsa-Mir-135-P1_5p, Hsa-Mir-135-P2_5p,

TarBase: hsa-miR-135a-5p,

ENA: LM379046.1:1..23:ncRNA, LM608492.1:17..39:ncRNA, LM608493.1:23..45:ncRNA,

URS00000A7BEB_9606 precursor_RNA 100 5

HGNC: 31521,

RefSeq: NR_029678,

Ensembl: ENST00000384854 (view in UCSC) ,

miRBase: MI0000453,

ENA: LM608493.1:1..100:precursor_RNA,

URS000075AB6F_9606 miRNA 22 3

RefSeq: NR_029678,

miRBase: MIMAT0037309,

MirGeneDB: Hsa-Mir-135-P2_3p,

URS00000E86D5_9606 precursor_RNA 88 1

Rfam: RF00246,

URS0000EFC5B7_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-135-P2,

MIR135A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR135A2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A2 Gene

No ASD Table

Relevant External Links for MIR135A2 Gene

GeneLoc Exon Structure for
MIR135A2

Expression for MIR135A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR135A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR135A2

genes like me logo Genes that share expression patterns with MIR135A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135A2 Gene

Orthologs for MIR135A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-135a-2 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-135a-2 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-2 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir135a-2 31
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-135a 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135a 31
  • 91 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-135a-2 31
  • 91 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-135-2 31
  • 91 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-135a 31
  • 70 (a)
OneToOne
Species where no ortholog for MIR135A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR135A2 Gene

ENSEMBL:
Gene Tree for MIR135A2 (if available)
TreeFam:
Gene Tree for MIR135A2 (if available)

Paralogs for MIR135A2 Gene

No data available for Paralogs for MIR135A2 Gene

Variants for MIR135A2 Gene

Additional dbSNP identifiers (rs#s) for MIR135A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR135A2 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855
nsv9001 CNV loss 18304495

Additional Variant Information for MIR135A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR135A2 Gene

Disorders for MIR135A2 Gene

Additional Disease Information for MIR135A2

No disorders were found for MIR135A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR135A2 Gene

Publications for MIR135A2 Gene

  1. Altered miR-186 and miR-135a contribute to granulosa cell dysfunction by targeting ESR2: A possible role in polycystic ovary syndrome. (PMID: 31173821) Song Y … Tan L (Molecular and cellular endocrinology 2019) 3
  2. Silencing of GAS5 represses the malignant progression of atherosclerosis through upregulation of miR-135a. (PMID: 31545249) Shen S … Wang Z (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA-135a binding site affects bladder cancer risk. (PMID: 30006972) Wang W … Ying M (International journal of cancer 2019) 3
  4. Downregulation of lysyl oxidase-like 4 LOXL4 by miR-135a-5p promotes lung cancer progression in vitro and in vivo. (PMID: 30993701) Zhang Y … Xie S (Journal of cellular physiology 2019) 3
  5. Downregulated microRNA-135a ameliorates rheumatoid arthritis by inactivation of the phosphatidylinositol 3-kinase/AKT signaling pathway via phosphatidylinositol 3-kinase regulatory subunit 2. (PMID: 30912120) Qu Y … Yu QH (Journal of cellular physiology 2019) 3

Products for MIR135A2 Gene

Sources for MIR135A2 Gene