microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR135A1 Gene

Subcategory (RNA class) for MIR135A1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR135A1 Gene

  • MicroRNA 135a-1 2 3 5
  • Hsa-MiR-135a-5p 163 173
  • Hsa-MiR-135a-3p 163 173
  • MicroRNA 135-1 2 3
  • Hsa-Mir-135a-1 2 3
  • Hsa-Mir-135-1 2 3
  • MIR135A1 2 5
  • Hsa-Mir-135-P1 178
  • MIMAT0000428 50
  • MIMAT0004595 50
  • Mir-135a-1 3
  • MIRN135-1 3
  • MIRN135A1 3
  • MI0000452 50
  • RF00246 168

External Ids for MIR135A1 Gene

Previous HGNC Symbols for MIR135A1 Gene

  • MIRN135-1
  • MIRN135A1

Previous GeneCards Identifiers for MIR135A1 Gene

  • GC03M052306
  • GC03M052328

Summaries for MIR135A1 Gene

Entrez Gene Summary for MIR135A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR135A1 Gene

MIR135A1 (MicroRNA 135a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR135A1 include Ovarian Cyst and Gallbladder Disease. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR135A1 Gene

  • mir-135 microRNA precursor family

Additional gene information for MIR135A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR135A1 Gene

Genomics for MIR135A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR135A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR135A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR135A1 Gene

Genomic Locations for MIR135A1 Gene
chr3:52,294,219-52,294,308
(GRCh38/hg38)
Size:
90 bases
Orientation:
Minus strand
chr3:52,328,235-52,328,324
(GRCh37/hg19)
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR135A1 Gene

Genes around MIR135A1 on UCSC Golden Path with GeneCards custom track
MIR135A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR135A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR135A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR135A1 Gene

Proteins for MIR135A1 Gene

Post-translational modifications for MIR135A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR135A1 Gene

Domains & Families for MIR135A1 Gene

Gene Families for MIR135A1 Gene

genes like me logo Genes that share domains with MIR135A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR135A1 Gene

Function for MIR135A1 Gene

Phenotypes From GWAS Catalog for MIR135A1 Gene

Gene Ontology (GO) - Molecular Function for MIR135A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25152461
genes like me logo Genes that share ontologies with MIR135A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR135A1 Gene

Localization for MIR135A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR135A1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR135A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR135A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR135A1 Gene

Pathways & Interactions for MIR135A1 Gene

PathCards logo

SuperPathways for MIR135A1 Gene

genes like me logo Genes that share pathways with MIR135A1: view

Pathways by source for MIR135A1 Gene

1 BioSystems pathway for MIR135A1 Gene
1 KEGG pathway for MIR135A1 Gene

Gene Ontology (GO) - Biological Process for MIR135A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:1900016 negative regulation of cytokine production involved in inflammatory response IDA 29734196
GO:1903882 negative regulation of interleukin-17-mediated signaling pathway IDA 29734196
GO:1905077 negative regulation of interleukin-17 secretion IDA 29734196
genes like me logo Genes that share ontologies with MIR135A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR135A1 Gene

Drugs & Compounds for MIR135A1 Gene

No Compound Related Data Available

Transcripts for MIR135A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR135A1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00005675D3_9606 precursor_RNA 90 6

HGNC: 31520,

RefSeq: NR_029677,

Ensembl: ENST00000385191 (view in UCSC) ,

miRBase: MI0000452,

Rfam: RF00246,

ENA: LM608492.1:1..90:precursor_RNA,

URS00000DF6D0_9606 miRNA 23 6

RefSeq: NR_029677, NR_029678,

LncBase: hsa-miR-135a-5p,

miRBase: MIMAT0000428,

MirGeneDB: Hsa-Mir-135-P1_5p, Hsa-Mir-135-P2_5p,

TarBase: hsa-miR-135a-5p,

ENA: LM379046.1:1..23:ncRNA, LM608492.1:17..39:ncRNA, LM608493.1:23..45:ncRNA,

URS0000169868_9606 miRNA 22 5

RefSeq: NR_029677,

LncBase: hsa-miR-135a-3p,

miRBase: MIMAT0004595,

TarBase: hsa-miR-135a-3p,

ENA: LM380271.1:1..22:ncRNA, LM608492.1:56..77:ncRNA,

URS0000EFD51D_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-135-P1,

URS000077D324_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-135-P1_3p,

MIR135A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR135A1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR135A1 Gene

No ASD Table

Relevant External Links for MIR135A1 Gene

GeneLoc Exon Structure for
MIR135A1

Expression for MIR135A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR135A1 Gene

mRNA differential expression in normal tissues according to GTEx for MIR135A1 Gene

This gene is overexpressed in Liver (x21.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR135A1

genes like me logo Genes that share expression patterns with MIR135A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR135A1 Gene

Orthologs for MIR135A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR135A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-135a-1 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-135a-1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-135a-1 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-135b-2 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir135a-1 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-135a-1 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-135-1 31
  • 72 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-135b 31
  • 66 (a)
OneToOne
Species where no ortholog for MIR135A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR135A1 Gene

ENSEMBL:
Gene Tree for MIR135A1 (if available)
TreeFam:
Gene Tree for MIR135A1 (if available)

Paralogs for MIR135A1 Gene

No data available for Paralogs for MIR135A1 Gene

Variants for MIR135A1 Gene

Additional dbSNP identifiers (rs#s) for MIR135A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR135A1 Gene

Variant ID Type Subtype PubMed ID
esv3402579 CNV duplication 20981092
nsv470572 CNV loss 18288195
nsv519445 CNV gain+loss 19592680
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897
nsv834696 CNV loss 17160897
nsv954859 CNV deletion 24416366

Additional Variant Information for MIR135A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR135A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR135A1 Gene

Disorders for MIR135A1 Gene

MalaCards: The human disease database

(32) MalaCards diseases for MIR135A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cyst
  • ovarian cysts
gallbladder disease
  • gall bladder
ovarian disease
  • ovarian dysfunction
ovary adenocarcinoma
  • adenocarcinoma of the ovary
plasma cell neoplasm
  • multiple myeloma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR135A1

genes like me logo Genes that share disorders with MIR135A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR135A1 Gene

Publications for MIR135A1 Gene

  1. ciRS-7 targeting miR-135a-5p promotes neuropathic pain in CCI rats via inflammation and autophagy. (PMID: 31978512) Cai W … Su Z (Gene 2020) 3
  2. CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/β-catenin signaling pathway. (PMID: 30841451) Yao Y … Shen H (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. Altered miR-186 and miR-135a contribute to granulosa cell dysfunction by targeting ESR2: A possible role in polycystic ovary syndrome. (PMID: 31173821) Song Y … Tan L (Molecular and cellular endocrinology 2019) 3
  4. Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p. (PMID: 31058315) Wu Q … Ma J (Journal of cellular physiology 2019) 3
  5. Silencing of GAS5 represses the malignant progression of atherosclerosis through upregulation of miR-135a. (PMID: 31545249) Shen S … Wang Z (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3

Products for MIR135A1 Gene

Sources for MIR135A1 Gene