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Aliases for MIR134 Gene

Subcategory (RNA class) for MIR134 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR134 Gene

  • MicroRNA 134 2 3 5
  • Hsa-Mir-134 3
  • Mir-134 3
  • MIRN134 3

External Ids for MIR134 Gene

ORGUL Members for MIR134 Gene

Previous HGNC Symbols for MIR134 Gene

  • MIRN134

Previous GeneCards Identifiers for MIR134 Gene

  • GC14P100832
  • GC14P100922
  • GC14P101523
  • GC14P101552
  • GC14P101587
  • GC14P101626
  • GC14P101654
  • GC14P101688
  • GC14P101725
  • GC14P101766
  • GC14P101824
  • GC14P101964
  • GC14P102161
  • GC14P101264
  • GC14P101875
  • GC14P103601
  • GC14P102195
  • GC14P102365
  • GC14P102535
  • GC14P102714
  • GC14P102887
  • GC14P103060
  • GC14P103257
  • GC14P103417

Summaries for MIR134 Gene

Entrez Gene Summary for MIR134 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR134 Gene

MIR134 (MicroRNA 134) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR134 include Diabetes Mellitus and Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR134 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR134 Gene

Genomics for MIR134 Gene

GeneHancer (GH) Regulatory Elements for MIR134 Gene

Promoters and enhancers for MIR134 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11 +43.7 43661 3.2 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101232 Enhancer 0.7 Ensembl 9.6 +179.3 179314 3.6 ELF3 CTCF RAD21 KAT8 ZIC2 GATAD2A REST RXRB ZSCAN4 MNT MIR370 MIR655 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR1185-1 MIR300
GH14J101176 Enhancer 0.6 Ensembl ENCODE 10.7 +122.7 122679 2 ZNF680 RCOR1 ZFP3 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
GH14J101004 Enhancer 0.4 ENCODE 11 -49.6 -49602 1.9 MNT TCF7L2 MYC MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14J101091 Enhancer 0.3 Ensembl 11.1 +36.4 36414 0.2 JUN MIR377 MIR154 MIR323B MIR496 MIR134 MIR485 MIR487A MIR329-1 MIR329-2 MIR323A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR134 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR134 Gene

Genomic Locations for MIR134 Gene
chr14:101,054,687-101,054,759
(GRCh38/hg38)
Size:
73 bases
Orientation:
Plus strand
chr14:101,521,008-101,521,110
(GRCh37/hg19)
Size:
103 bases
Orientation:
Plus strand

Genomic View for MIR134 Gene

Genes around MIR134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR134 Gene

Proteins for MIR134 Gene

Post-translational modifications for MIR134 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR134 Gene

Domains & Families for MIR134 Gene

Gene Families for MIR134 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR134: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR134 Gene

Function for MIR134 Gene

Gene Ontology (GO) - Molecular Function for MIR134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26512644
genes like me logo Genes that share ontologies with MIR134: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR134 Gene

Localization for MIR134 Gene

Gene Ontology (GO) - Cellular Components for MIR134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR134: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR134 Gene

Pathways & Interactions for MIR134 Gene

genes like me logo Genes that share pathways with MIR134: view

Pathways by source for MIR134 Gene

1 BioSystems pathway for MIR134 Gene

Interacting Proteins for MIR134 Gene

Gene Ontology (GO) - Biological Process for MIR134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 26512644
GO:0045930 negative regulation of mitotic cell cycle IMP 26512644
GO:0110023 negative regulation of cardiac muscle myoblast proliferation IMP 26512644
genes like me logo Genes that share ontologies with MIR134: view

No data available for SIGNOR curated interactions for MIR134 Gene

Drugs & Compounds for MIR134 Gene

No Compound Related Data Available

Transcripts for MIR134 Gene

mRNA/cDNA for MIR134 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR134 Gene

No ASD Table

Relevant External Links for MIR134 Gene

GeneLoc Exon Structure for
MIR134
ECgene alternative splicing isoforms for
MIR134

Expression for MIR134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR134 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR134 Gene:

MIR134
genes like me logo Genes that share expression patterns with MIR134: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR134 Gene

Orthologs for MIR134 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-134 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-134 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir134 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-134 35
  • 83 (a)
OneToOne
Species where no ortholog for MIR134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR134 Gene

ENSEMBL:
Gene Tree for MIR134 (if available)
TreeFam:
Gene Tree for MIR134 (if available)

Paralogs for MIR134 Gene

No data available for Paralogs for MIR134 Gene

Variants for MIR134 Gene

Sequence variations from dbSNP and Humsavar for MIR134 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001787824 -- 101,053,450(+) A/G upstream_transcript_variant
rs1002220641 -- 101,053,138(+) G/C upstream_transcript_variant
rs1002933201 -- 101,054,171(+) G/A/C upstream_transcript_variant
rs1003488050 -- 101,054,234(+) G/A upstream_transcript_variant
rs1003864116 -- 101,054,505(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR134 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR134 Gene

Disorders for MIR134 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR134 Gene - From: miR2Disease and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR134

genes like me logo Genes that share disorders with MIR134: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR134 Gene

Publications for MIR134 Gene

  1. MiR-134, epigenetically silenced in gliomas, could mitigate the malignant phenotype by targeting KRAS. (PMID: 29432532) Wang ZL … Wang HJ (Carcinogenesis 2018) 3 58
  2. miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. (PMID: 29971778) Peng SY … Lin SC (International journal of cancer 2018) 3 58
  3. LncRNA DIGIT Accelerates Tube Formation of Vascular Endothelial Cells by Sponging miR-134. (PMID: 30158376) Miao C … Wang J (International heart journal 2018) 3 58
  4. Increased serum exosomal miR-134 expression in the acute ischemic stroke patients. (PMID: 30514242) Zhou J … Long F (BMC neurology 2018) 3 58
  5. LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1. (PMID: 30521500) Shi C … Wang M (Medical science monitor : international medical journal of experimental and clinical research 2018) 3 58

Products for MIR134 Gene

Sources for MIR134 Gene

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