microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR133B Gene

Subcategory (RNA class) for MIR133B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR133B Gene

  • MicroRNA 133b 2 3 5
  • Hsa-Mir-133b 2 3
  • Hsa-MiR-133b 163 173
  • MIR133B 2 5
  • Hsa-Mir-133-P3-V2 178
  • Hsa-Mir-133-P3-V1 178
  • MIMAT0000770 50
  • MiRNA133B 3
  • MI0000822 50
  • MIRN133B 3
  • Mir-133b 3
  • RF00446 168

External Ids for MIR133B Gene

Previous HGNC Symbols for MIR133B Gene

  • MIRN133B

Previous GeneCards Identifiers for MIR133B Gene

  • GC06P052123
  • GC06P052013

Summaries for MIR133B Gene

Entrez Gene Summary for MIR133B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is considered a canonical myomiR and is important for normal cardiac and skeletal muscle development. It is additionally important for normal development in non-muscle tissues, and is abnormally expressed in a variety of cancers. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]

GeneCards Summary for MIR133B Gene

MIR133B (MicroRNA 133b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133B include Tongue Squamous Cell Carcinoma and Parkinson Disease, Late-Onset. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and TFs Regulate miRNAs related to cardiac hypertrophy.

Rfam classification for MIR133B Gene

  • mir-133 microRNA precursor family

Additional gene information for MIR133B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR133B Gene

Genomics for MIR133B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR133B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J052317 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.1 +169.5 169464 3.6 ZNF629 JUND PRDM1 ZNF143 IKZF2 CEBPA EED CEBPB ARID3A HMBOX1 PAQR8 MCM3 LINCMD1 MIR133B MN298306 piR-48759-264 lnc-MCM3-3
GH06J052263 Enhancer 0.9 Ensembl ENCODE 10.4 +115.1 115119 0.7 CTCF ZNF143 RXRB REST RAD21 TRIM22 ZNF561 POLR2A BCLAF1 SMC3 LINCMD1 MIR133B PKHD1 IL17A MIR206 lnc-MCM3-1 IL17F piR-43046 MCM3
GH06J052063 Enhancer 0.9 Ensembl ENCODE 10.1 -84.8 -84751 2.1 CEBPG CTCF GABPA ZNF143 RAD21 TRIM22 CEBPA CEBPB ELK1 CBX3 PKHD1 MIR133B LINCMD1 IL17F SLC25A20P1 RF01061-144 HSALNG0050595
GH06J052261 Enhancer 0.9 Ensembl ENCODE 10.2 +112.7 112678 1.2 PRDM10 ZNF629 PRDM1 SMAD5 POLR2A ZNF600 ZNF639 ZNF10 TSHZ1 ZSCAN5C EFHC1 MCM3 PKHD1 IL17A LINCMD1 MIR133B lnc-MCM3-1 IL17F piR-43046
GH06J052116 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.7 -32.4 -32405 0.9 FEZF1 GLIS1 MIR133B LINCMD1 PKHD1 MIR206 piR-46002-484 IL17A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR133B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR133B Gene

Genomic Locations for MIR133B Gene
chr6:52,148,923-52,149,041
(GRCh38/hg38)
Size:
119 bases
Orientation:
Plus strand
chr6:52,013,721-52,013,839
(GRCh37/hg19)
Size:
119 bases
Orientation:
Plus strand

Genomic View for MIR133B Gene

Genes around MIR133B on UCSC Golden Path with GeneCards custom track
MIR133B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR133B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133B Gene

Proteins for MIR133B Gene

Post-translational modifications for MIR133B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133B Gene

Domains & Families for MIR133B Gene

Gene Families for MIR133B Gene

genes like me logo Genes that share domains with MIR133B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR133B Gene

Function for MIR133B Gene

Phenotypes From GWAS Catalog for MIR133B Gene

Gene Ontology (GO) - Molecular Function for MIR133B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 24443799
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21351259
genes like me logo Genes that share ontologies with MIR133B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133B Gene

Localization for MIR133B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR133B gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR133B Gene

Pathways & Interactions for MIR133B Gene

genes like me logo Genes that share pathways with MIR133B: view

Pathways by source for MIR133B Gene

Gene Ontology (GO) - Biological Process for MIR133B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 24714873
GO:0010831 positive regulation of myotube differentiation ISS --
GO:0010976 positive regulation of neuron projection development IDA 27412702
GO:0030336 negative regulation of cell migration IDA 24714873
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR133B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR133B Gene

Drugs & Compounds for MIR133B Gene

No Compound Related Data Available

Transcripts for MIR133B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR133B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000032BD73_9606 miRNA 22 6

RefSeq: NR_029903,

LncBase: hsa-miR-133b,

miRBase: MIMAT0000770,

MirGeneDB: Hsa-Mir-133-P3-v1_3p,

TarBase: hsa-miR-133b,

ENA: LM379274.1:1..22:ncRNA, LM608739.1:66..87:ncRNA,

URS000075DAC1_9606 precursor_RNA 119 5

HGNC: 31759,

RefSeq: NR_029903,

Ensembl: ENST00000362210 (view in UCSC) ,

miRBase: MI0000822,

ENA: LM608739.1:1..119:precursor_RNA,

URS00003EDD3D_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-133-P3-v2_3p,

ENA: AJ550407.1:1..21:ncRNA,

URS00006C176C_9606 precursor_RNA 88 1

Rfam: RF00446,

URS0000EFCBE8_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-133-P3-v1, Hsa-Mir-133-P3-v2,

MIR133B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR133B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133B Gene

No ASD Table

Relevant External Links for MIR133B Gene

GeneLoc Exon Structure for
MIR133B

Expression for MIR133B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR133B Gene

mRNA differential expression in normal tissues according to GTEx for MIR133B Gene

This gene is overexpressed in Muscle - Skeletal (x53.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR133B

Evidence on tissue expression from TISSUES for MIR133B Gene

  • Muscle(2.5)
  • Heart(2.2)
  • Nervous system(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MIR133B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133B Gene

Orthologs for MIR133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR133B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-133b 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-133b 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-133b 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir133b 31
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-133b 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-133b 31
  • 88 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 77 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-133a-1 31
  • 61 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-133 31
  • 47 (a)
OneToMany
Species where no ortholog for MIR133B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR133B Gene

ENSEMBL:
Gene Tree for MIR133B (if available)
TreeFam:
Gene Tree for MIR133B (if available)

Paralogs for MIR133B Gene

No data available for Paralogs for MIR133B Gene

Variants for MIR133B Gene

Additional dbSNP identifiers (rs#s) for MIR133B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133B Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Additional Variant Information for MIR133B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR133B Gene

Disorders for MIR133B Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR133B Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tongue squamous cell carcinoma
  • squamous cell carcinoma of tongue
parkinson disease, late-onset
  • pd
lung cancer
  • adenocarcinoma of lung
testicular germ cell tumor
  • tgct
primary biliary cirrhosis
  • pbc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR133B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR133B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR133B Gene

Publications for MIR133B Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
  2. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. (PMID: 19654003) Crawford M … Nana-Sinkam SP (Biochemical and biophysical research communications 2009) 3 23
  3. miR-133b suppresses colorectal cancer cell stemness and chemoresistance by targeting methyltransferase DOT1L. (PMID: 31525340) Lv L … He L (Experimental cell research 2019) 3
  4. The lncRNA EGFR-AS1 is linked to migration, invasion and apoptosis in glioma cells by targeting miR-133b/RACK1. (PMID: 31545240) Dong ZQ … Xie J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of Breast Cancer Cells. (PMID: 31344855) Li X … Pan Y (International journal of molecular sciences 2019) 3

Products for MIR133B Gene

Sources for MIR133B Gene