microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR133A2 Gene

Subcategory (RNA class) for MIR133A2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR133A2 Gene

  • MicroRNA 133a-2 2 3 5
  • Hsa-Mir-133a-2 2 3
  • MIR133A2 2 5
  • Hsa-Mir-133-P1-V2 178
  • Hsa-Mir-133-P1-V1 178
  • Hsa-MiR-133a-5p 163
  • Hsa-MiR-133a-3p 173
  • MIMAT0026478 50
  • MIMAT0000427 50
  • Mir-133a-2 3
  • MIRN133A2 3
  • MI0000451 50
  • RF00446 168

External Ids for MIR133A2 Gene

Previous HGNC Symbols for MIR133A2 Gene

  • MIRN133A2

Previous GeneCards Identifiers for MIR133A2 Gene

  • GC20P060573
  • GC20P061162
  • GC20P062653
  • GC20P062659
  • GC20P062839
  • GC20P062848
  • GC20P062856
  • GC20P062877
  • GC20P062715
  • GC20P062778
  • GC20P062785
  • GC20P062790
  • GC20P062802
  • GC20P062811
  • GC20P062821
  • GC20P062829

Summaries for MIR133A2 Gene

Entrez Gene Summary for MIR133A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A2 Gene

MIR133A2 (MicroRNA 133a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TarBasePathway and MicroRNAs in cancer.

Rfam classification for MIR133A2 Gene

  • mir-133 microRNA precursor family

Additional gene information for MIR133A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR133A2 Gene

Genomics for MIR133A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR133A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR133A2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR133A2 Gene

Genomic Locations for MIR133A2 Gene
chr20:62,564,912-62,565,013
(GRCh38/hg38)
Size:
102 bases
Orientation:
Plus strand
chr20:61,162,119-61,162,220
(GRCh37/hg19)
Size:
102 bases
Orientation:
Plus strand

Genomic View for MIR133A2 Gene

Genes around MIR133A2 on UCSC Golden Path with GeneCards custom track
MIR133A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR133A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A2 Gene

Proteins for MIR133A2 Gene

Post-translational modifications for MIR133A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A2 Gene

Domains & Families for MIR133A2 Gene

Gene Families for MIR133A2 Gene

genes like me logo Genes that share domains with MIR133A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR133A2 Gene

Function for MIR133A2 Gene

Phenotypes From GWAS Catalog for MIR133A2 Gene

Gene Ontology (GO) - Molecular Function for MIR133A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21109942
genes like me logo Genes that share ontologies with MIR133A2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A2 Gene

Localization for MIR133A2 Gene

Gene Ontology (GO) - Cellular Components for MIR133A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
genes like me logo Genes that share ontologies with MIR133A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR133A2 Gene

Pathways & Interactions for MIR133A2 Gene

PathCards logo

SuperPathways for MIR133A2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR133A2: view

Pathways by source for MIR133A2 Gene

1 BioSystems pathway for MIR133A2 Gene
1 KEGG pathway for MIR133A2 Gene

Gene Ontology (GO) - Biological Process for MIR133A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 25607810
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010628 positive regulation of gene expression IDA 23069713
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
genes like me logo Genes that share ontologies with MIR133A2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR133A2 Gene

Drugs & Compounds for MIR133A2 Gene

No Compound Related Data Available

Transcripts for MIR133A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR133A2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E14C_9606 precursor_RNA 102 5

HGNC: 31518,

RefSeq: NR_029676,

Ensembl: ENST00000347538 (view in UCSC) ,

miRBase: MI0000451,

ENA: LM608491.1:1..102:precursor_RNA,

URS0000383E7F_9606 miRNA 22 5

RefSeq: NR_029675, NR_029676,

LncBase: hsa-miR-133a-5p,

miRBase: MIMAT0026478,

MirGeneDB: Hsa-Mir-133-P1-v2_5p, Hsa-Mir-133-P2-v2_5p,

ENA: LM383145.1:1..22:ncRNA, LM608490.1:16..37:ncRNA, LM608491.1:22..43:ncRNA,

URS00004C9052_9606 miRNA 22 4

RefSeq: NR_029675, NR_029676,

miRBase: MIMAT0000427,

TarBase: hsa-miR-133a-3p,

ENA: BK006540.1:3985..4006:ncRNA, LM379045.1:1..22:ncRNA, LM608490.1:53..74:ncRNA, LM608491.1:59..80:ncRNA,

URS000064BE82_9606 precursor_RNA 87 1

Rfam: RF00446,

URS0000EFCF97_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-133-P1-v1, Hsa-Mir-133-P1-v2,

MIR133A2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR133A2 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A2 Gene

No ASD Table

Relevant External Links for MIR133A2 Gene

GeneLoc Exon Structure for
MIR133A2

Expression for MIR133A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR133A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR133A2 Gene

This gene is overexpressed in Muscle - Skeletal (x51.1).
genes like me logo Genes that share expression patterns with MIR133A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133A2 Gene

Orthologs for MIR133A2 Gene

Evolution for MIR133A2 Gene

ENSEMBL:
Gene Tree for MIR133A2 (if available)
TreeFam:
Gene Tree for MIR133A2 (if available)

No data available for Orthologs for MIR133A2 Gene

Paralogs for MIR133A2 Gene

No data available for Paralogs for MIR133A2 Gene

Variants for MIR133A2 Gene

Additional dbSNP identifiers (rs#s) for MIR133A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133A2 Gene

Variant ID Type Subtype PubMed ID
dgv4343n100 CNV gain 25217958
dgv4344n100 CNV gain 25217958
esv2422398 CNV duplication 17116639
nsv459065 CNV gain 19166990
nsv459068 CNV gain 19166990
nsv470556 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv586501 CNV gain 21841781
nsv953302 CNV deletion 24416366

Additional Variant Information for MIR133A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR133A2 Gene

Disorders for MIR133A2 Gene

Additional Disease Information for MIR133A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR133A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR133A2 Gene

Publications for MIR133A2 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
  2. MicroRNA-133a inhibits gastric cancer cells growth, migration, and epithelial-mesenchymal transition process by targeting presenilin 1. (PMID: 30161272) Chen XB … Chu AX (Journal of cellular biochemistry 2019) 3
  3. Computational identification and analysis of early diagnostic biomarkers for kidney cancer. (PMID: 31350524) Tang T … Tan J (Journal of human genetics 2019) 3
  4. The long coding RNA AFAP1-AS1 promotes tumor cell growth and invasion in pancreatic cancer through upregulating the IGF1R oncogene via sequestration of miR-133a. (PMID: 30300116) Chen B … Xiong W (Cell cycle (Georgetown, Tex.) 2018) 3
  5. MicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1. (PMID: 29207145) Sui Y … Wang M (Oncology reports 2018) 3

Products for MIR133A2 Gene

Sources for MIR133A2 Gene