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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include Conventional Central Osteosarcoma and Heart Conduction Disease. Among its related pathways are TarBasePathway and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH18J021803 | Promoter | 0.8 | Ensembl | 12.2 | +22.1 | 22084 | 0.6 | GATAD2A SOX13 CEBPA CEBPB TEAD1 SAP130 CEBPG SPI1 CHD4 NFIL3 | MIB1 MIR133A1 MIR320C1 EF444995 RF00017-2637 RN7SL233P lnc-SNRPD1-6 ENSG00000199977 GATA6 | |
GH18J021852 | Enhancer | 0.7 | Ensembl ENCODE | 11.3 | -27.4 | -27416 | 1.6 | TCF12 PKNOX1 RUNX3 HDGF RFX5 HNF4A SPI1 RAD51 | RPL34P32 lnc-ABHD3-5 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 MIB1 lnc-ABHD3-4 GATA6 | |
GH18J021825 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE | 0.7 | -3.7 | -3740 | 7.9 | ZNF316 MAFF MAFK ZBTB17 MAFG HNF4A BACH1 MLLT1 EMSY | MIR133A1HG MIR1-2 RF00103-001 MIB1 MIR320C1 ABHD3 MIR133A1 RF00446-001 GATA6 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21109942 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 20159880 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | TarBasePathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008285 | negative regulation of cell proliferation | IDA | 25607810 |
GO:0010455 | positive regulation of cell fate commitment | ISS | -- |
GO:0010614 | negative regulation of cardiac muscle hypertrophy | ISS | -- |
GO:0010628 | positive regulation of gene expression | IDA | 23069713 |
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00005EB596_9606 | precursor_RNA | 88 | 5 |
HGNC: 31517, RefSeq: NR_029675, Ensembl: ENST00000385052 (view in UCSC) , miRBase: MI0000450, |
URS0000383E7F_9606 | miRNA | 22 | 5 |
LncBase: hsa-miR-133a-5p, miRBase: MIMAT0026478, MirGeneDB: Hsa-Mir-133-P1-v2_5p, Hsa-Mir-133-P2-v2_5p, ENA: LM383145.1:1..22:ncRNA, LM608490.1:16..37:ncRNA, LM608491.1:22..43:ncRNA, |
URS00004C9052_9606 | miRNA | 22 | 4 |
miRBase: MIMAT0000427, TarBase: hsa-miR-133a-3p, ENA: BK006540.1:3985..4006:ncRNA, LM379045.1:1..22:ncRNA, LM608490.1:53..74:ncRNA, LM608491.1:59..80:ncRNA, |
URS00005C04AC_9606 | precursor_RNA | 87 | 1 |
Rfam: RF00446, |
URS0000EFF1C0_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-133-P2-v1, Hsa-Mir-133-P2-v2, |
Disorder | Aliases | PubMed IDs |
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conventional central osteosarcoma |
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heart conduction disease |
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bladder carcinoma in situ |
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bone osteosarcoma |
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bone resorption disease |
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