Aliases for MIR133A1 Gene
Subcategory (RNA class) for MIR133A1 Gene
miRNA
Quality Score for this RNA gene is
18
External Ids for MIR133A1 Gene
- HGNC: 31517
- Entrez Gene: 406922
- Ensembl: ENSG00000283927
- OMIM: 610254
- miRBase: hsa-mir-133a-1
ORGUL Members for MIR133A1 Gene
Previous HGNC Symbols for MIR133A1 Gene
- MIRN133A1
Previous GeneCards Identifiers for MIR133A1 Gene
- GC18M017666
- GC18M019405
Summaries for MIR133A1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR133A1 Gene
MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include Bladder Carcinoma In Situ. Among its related pathways are MicroRNAs in cancer and TarBasePathway.
Additional gene information for MIR133A1 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR133A1 Gene
Genomics for MIR133A1 Gene
GeneHancer (GH) Regulatory Elements for MIR133A1 Gene
Promoters and enhancers for MIR133A1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J021852 | Enhancer | 0.7 | Ensembl ENCODE | 11.3 | -27.3 | -27301 | 1.1 | HDGF PKNOX1 RUNX3 SPI1 | RPL34P32 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 MIR133A1HG MIB1 | |
| GH18J021803 | Enhancer | 0.6 | Ensembl | 12.2 | +22.3 | 22284 | 0.2 | ELF3 SOX5 GATAD2A SOX13 SAP130 TEAD1 HLF CEBPB CEBPG HMG20A | MIB1 MIR133A1 MIR320C1 RN7SL233P GC18P021818 | |
| GH18J021804 | Enhancer | 0.6 | Ensembl | 12.2 | +21.7 | 21684 | 0.6 | ELF3 SOX5 GATAD2A SOX13 SAP130 TEAD1 HMG20A NFIL3 CEBPA KDM1A | MIR133A1 MIR320C1 MIB1 RN7SL233P GC18P021818 | |
| GH18J021825 | Enhancer | 0.6 | ENCODE | 0.7 | -3.7 | -3740 | 7.9 | BACH1 MAFG MAFF ZNF316 MLLT1 HNF4A MAFK EMSY ZBTB17 | MIR133A1HG MIR1-2 MIB1 MIR320C1 ABHD3 GC18P021825 MIR133A1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR133A1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR133A1 Gene
Genomic Locations for MIR133A1 Gene
- chr18:21,825,698-21,825,785
- (GRCh38/hg38)
- Size:
- 88 bases
- Orientation:
- Minus strand
- chr18:19,405,448-19,411,371
- (GRCh37/hg19)
- Size:
- 5,924 bases
- Orientation:
- Minus strand
Genomic View for MIR133A1 Gene
Genes around MIR133A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q11.2 by Entrez Gene
- 18q11.2 by HGNC
- 18q11.2 by Ensembl
MIR133A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR133A1 Gene
ORGUL Member Location for MIR133A1 Gene
Proteins for MIR133A1 Gene
Post-translational modifications for MIR133A1 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR133A1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR133A1
- Origene Custom Protein Services for MIR133A1
- Search GeneTex for Proteins for MIR133A1
No data available for DME Specific Peptides for MIR133A1 Gene
Domains & Families for MIR133A1 Gene
Gene Families for MIR133A1 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR133A1 Gene
Function for MIR133A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 22163007 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR133A1
-
CRISPR Products
- Browse CRISPR knockouts for MIR133A1
- Applied Biological Materials CRISPR for MIR133A1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR133A1
- Addgene plasmids for MIR133A1
- Applied Biological Materials Clones for MIR133A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A1 Gene
Localization for MIR133A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 20159880 |
| GO:0005622 | intracellular | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR133A1 Gene
Pathways & Interactions for MIR133A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | TarBasePathway | ||
Pathways by source for MIR133A1 Gene
1 BioSystems pathway for MIR133A1 Gene
1 KEGG pathway for MIR133A1 Gene
Interacting Proteins for MIR133A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007194 | negative regulation of adenylate cyclase activity | ISS | -- |
| GO:0010455 | positive regulation of cell fate commitment | ISS | -- |
| GO:0010614 | negative regulation of cardiac muscle hypertrophy | ISS | -- |
| GO:0010628 | positive regulation of gene expression | IDA | 23069713 |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
No data available for SIGNOR curated interactions for MIR133A1 Gene
Transcripts for MIR133A1 Gene
mRNA/cDNA for MIR133A1 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000385052 88 bps (uc021uib.1)
- (3) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for MIR133A1
- Applied Biological Materials CRISPR for MIR133A1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for MIR133A1
- Addgene plasmids for MIR133A1
- Applied Biological Materials Clones for MIR133A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR133A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR133A1 Gene:
MIR133A1
No Expression Related Data Available
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133A1 Gene
Orthologs for MIR133A1 Gene
No data available for Orthologs for MIR133A1 Gene
Paralogs for MIR133A1 Gene
No data available for Paralogs for MIR133A1 Gene
Variants for MIR133A1 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000882824 | -- | 21,826,465(-) | T/C | upstream_transcript_variant | |
| rs1002195393 | -- | 21,825,632(-) | A/G | downstream_transcript_variant | |
| rs1002256781 | -- | 21,825,357(-) | A/AA | downstream_transcript_variant | |
| rs1004501796 | -- | 21,825,521(-) | C/G | downstream_transcript_variant | |
| rs1008107368 | -- | 21,826,842(-) | G/A | upstream_transcript_variant |
Additional Variant Information for MIR133A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR133A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR133A1 Gene
Disorders for MIR133A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bladder carcinoma in situ |
|
|
Search MIR133A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR133A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR133A1 Gene
Publications for MIR133A1 Gene
- Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
- miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1. (PMID: 28466778) Li W … Xu Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
- Analysis of miR-96 and miR-133a Expression in Gastrointestinal Neuroendocrine Neoplasms. (PMID: 29032398) Mandal R … Lloyd RV (Endocrine pathology 2017) 3 58
- LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p. (PMID: 28320084) Wang Q … Zhang Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
- USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway. (PMID: 28286270) Cai J … Liu A (Biochemical and biophysical research communications 2017) 3 58
Products for MIR133A1 Gene
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Sources for MIR133A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (114) diseasecard
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt