Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR133A1 Gene
Subcategory (RNA class) for MIR133A1 Gene
miRNA
Number of RNA Genes sources:
6 / 17
Aliases for MIR133A1 Gene
External Ids for MIR133A1 Gene
- HGNC: 31517
- Entrez Gene: 406922
- Ensembl: ENSG00000283927
- OMIM: 610254
- miRBase: hsa-mir-133a-1
Previous HGNC Symbols for MIR133A1 Gene
- MIRN133A1
Previous GeneCards Identifiers for MIR133A1 Gene
- GC18M017666
- GC18M019405
Summaries for MIR133A1 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR133A1 Gene
MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include Conventional Central Osteosarcoma and Heart Conduction Disease. Among its related pathways are TarBasePathway and MicroRNAs in cancer.
Rfam classification for MIR133A1 Gene
-
mir-133 microRNA precursor family
Additional gene information for MIR133A1 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR133A1 Gene
Genomics for MIR133A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR133A1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J021803 | Promoter | 0.8 | Ensembl | 12.2 | +22.1 | 22084 | 0.6 | GATAD2A SOX13 CEBPA CEBPB TEAD1 SAP130 CEBPG SPI1 CHD4 NFIL3 | MIB1 MIR133A1 MIR320C1 EF444995 RF00017-2637 RN7SL233P lnc-SNRPD1-6 ENSG00000199977 GATA6 | |
| GH18J021852 | Enhancer | 0.7 | Ensembl ENCODE | 11.3 | -27.4 | -27416 | 1.6 | TCF12 PKNOX1 RUNX3 HDGF RFX5 HNF4A SPI1 RAD51 | RPL34P32 lnc-ABHD3-5 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 MIB1 lnc-ABHD3-4 GATA6 | |
| GH18J021825 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE | 0.7 | -3.7 | -3740 | 7.9 | ZNF316 MAFF MAFK ZBTB17 MAFG HNF4A BACH1 MLLT1 EMSY | MIR133A1HG MIR1-2 RF00103-001 MIB1 MIR320C1 ABHD3 MIR133A1 RF00446-001 GATA6 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR133A1 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR133A1 Gene
Genomic Locations for MIR133A1 Gene
- chr18:21,825,697-21,825,785
- (GRCh38/hg38)
- Size:
- 89 bases
- Orientation:
- Minus strand
- chr18:19,405,448-19,411,371
- (GRCh37/hg19)
- Size:
- 5,924 bases
- Orientation:
- Minus strand
Genomic View for MIR133A1 Gene
Genes around MIR133A1 on UCSC Golden Path with GeneCards custom track
MIR133A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 18q11.2 by HGNC
- 18q11.2 by Entrez Gene
- 18q11.2 by Ensembl
MIR133A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR133A1 Gene
Proteins for MIR133A1 Gene
Post-translational modifications for MIR133A1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR133A1
- Origene Custom Protein Services for MIR133A1
No data available for DME Specific Peptides for MIR133A1 Gene
Domains & Families for MIR133A1 Gene
Gene Families for MIR133A1 Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR133A1 Gene
Function for MIR133A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 21109942 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR133A1 - Select products 50% OFF >
- * MIR133A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR133A1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR133A1 - Select products 50% OFF >
- * MIR133A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR133A1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A1 Gene
Localization for MIR133A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 20159880 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR133A1 Gene
Pathways & Interactions for MIR133A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | TarBasePathway | ||
Pathways by source for MIR133A1 Gene
1 BioSystems pathway for MIR133A1 Gene
1 KEGG pathway for MIR133A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008285 | negative regulation of cell proliferation | IDA | 25607810 |
| GO:0010455 | positive regulation of cell fate commitment | ISS | -- |
| GO:0010614 | negative regulation of cardiac muscle hypertrophy | ISS | -- |
| GO:0010628 | positive regulation of gene expression | IDA | 23069713 |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | ISS | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR133A1 Gene
Transcripts for MIR133A1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR133A1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00005EB596_9606 | precursor_RNA | 88 | 5 |
HGNC: 31517, RefSeq: NR_029675, Ensembl: ENST00000385052 (view in UCSC) , miRBase: MI0000450, |
| URS0000383E7F_9606 | miRNA | 22 | 5 |
LncBase: hsa-miR-133a-5p, miRBase: MIMAT0026478, MirGeneDB: Hsa-Mir-133-P1-v2_5p, Hsa-Mir-133-P2-v2_5p, ENA: LM383145.1:1..22:ncRNA, LM608490.1:16..37:ncRNA, LM608491.1:22..43:ncRNA, |
| URS00004C9052_9606 | miRNA | 22 | 4 |
miRBase: MIMAT0000427, TarBase: hsa-miR-133a-3p, ENA: BK006540.1:3985..4006:ncRNA, LM379045.1:1..22:ncRNA, LM608490.1:53..74:ncRNA, LM608491.1:59..80:ncRNA, |
| URS00005C04AC_9606 | precursor_RNA | 87 | 1 |
Rfam: RF00446, |
| URS0000EFF1C0_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-133-P2-v1, Hsa-Mir-133-P2-v2, |
MIR133A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR133A1 Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIR133A1 - Select products 50% OFF >
- * MIR133A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for MIR133A1
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for MIR133A1 - Select products 50% OFF >
- * MIR133A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for MIR133A1
Relevant External Links for MIR133A1 Gene
- GeneLoc Exon Structure for
- MIR133A1
Expression for MIR133A1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR133A1
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for MIR133A1
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133A1 Gene
Orthologs for MIR133A1 Gene
No data available for Orthologs for MIR133A1 Gene
Paralogs for MIR133A1 Gene
No data available for Paralogs for MIR133A1 Gene
Variants for MIR133A1 Gene
Additional Variant Information for MIR133A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR133A1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR133A1 Gene
Disorders for MIR133A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| conventional central osteosarcoma |
|
|
| heart conduction disease |
|
|
| bladder carcinoma in situ |
|
|
| bone osteosarcoma |
|
|
| bone resorption disease |
|
|
Search MIR133A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR133A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR133A1 Gene
Publications for MIR133A1 Gene
- Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
- Knockdown of TUG 1 suppresses hypoxia-induced apoptosis of cardiomyocytes by up-regulating miR-133a. (PMID: 31926162) Yang H … Wang K (Archives of biochemistry and biophysics 2020) 3
- CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p. (PMID: 30678736) Yu X … Qu X (Journal of experimental & clinical cancer research : CR 2019) 3
- Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18. (PMID: 31781298) Hromádka M … Moťovská Z (Disease markers 2019) 3
- Serum miR-483-5p and miR-133a as Biomarkers for Diagnosis of Hepatocellular Carcinoma Post-Hepatitis C Infection in Egyptian Patients. (PMID: 31926493) Hassan AS … Elnasser AM (The Egyptian journal of immunology 2019) 3
ExternalLinks
Products for MIR133A1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR133A1
- Origene Custom Protein Services for MIR133A1
- Browse OriGene Inhibitory RNA Products For MIR133A1
- OriGene qPCR primer pairs for MIR133A1
- Browse CRISPR knockouts for MIR133A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR133A1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Addgene plasmids for MIR133A1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR133A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR133A1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR133A1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR133A1
Sources for MIR133A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB