microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR133A1 Gene

Subcategory (RNA class) for MIR133A1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR133A1 Gene

  • MicroRNA 133a-1 2 3 5
  • Hsa-Mir-133a-1 2 3
  • MIR133A1 2 5
  • Hsa-Mir-133-P2-V2 178
  • Hsa-Mir-133-P2-V1 178
  • Hsa-MiR-133a-5p 163
  • Hsa-MiR-133a-3p 173
  • MIMAT0026478 50
  • MIMAT0000427 50
  • Mir-133a-1 3
  • MIRN133A1 3
  • MI0000450 50
  • RF00446 168

External Ids for MIR133A1 Gene

Previous HGNC Symbols for MIR133A1 Gene

  • MIRN133A1

Previous GeneCards Identifiers for MIR133A1 Gene

  • GC18M017666
  • GC18M019405

Summaries for MIR133A1 Gene

Entrez Gene Summary for MIR133A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR133A1 Gene

MIR133A1 (MicroRNA 133a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR133A1 include Conventional Central Osteosarcoma and Heart Conduction Disease. Among its related pathways are TarBasePathway and MicroRNAs in cancer.

Rfam classification for MIR133A1 Gene

  • mir-133 microRNA precursor family

Additional gene information for MIR133A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR133A1 Gene

Genomics for MIR133A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR133A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J021803 Promoter 0.8 Ensembl 12.2 +22.1 22084 0.6 GATAD2A SOX13 CEBPA CEBPB TEAD1 SAP130 CEBPG SPI1 CHD4 NFIL3 MIB1 MIR133A1 MIR320C1 EF444995 RF00017-2637 RN7SL233P lnc-SNRPD1-6 ENSG00000199977 GATA6
GH18J021852 Enhancer 0.7 Ensembl ENCODE 11.3 -27.4 -27416 1.6 TCF12 PKNOX1 RUNX3 HDGF RFX5 HNF4A SPI1 RAD51 RPL34P32 lnc-ABHD3-5 ENSG00000199977 MIR1-2 MIR133A1 MIR320C1 MIB1 lnc-ABHD3-4 GATA6
GH18J021825 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 0.7 -3.7 -3740 7.9 ZNF316 MAFF MAFK ZBTB17 MAFG HNF4A BACH1 MLLT1 EMSY MIR133A1HG MIR1-2 RF00103-001 MIB1 MIR320C1 ABHD3 MIR133A1 RF00446-001 GATA6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR133A1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR133A1 Gene

Genomic Locations for MIR133A1 Gene
chr18:21,825,697-21,825,785
(GRCh38/hg38)
Size:
89 bases
Orientation:
Minus strand
chr18:19,405,448-19,411,371
(GRCh37/hg19)
Size:
5,924 bases
Orientation:
Minus strand

Genomic View for MIR133A1 Gene

Genes around MIR133A1 on UCSC Golden Path with GeneCards custom track
MIR133A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR133A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR133A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR133A1 Gene

Proteins for MIR133A1 Gene

Post-translational modifications for MIR133A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR133A1 Gene

Domains & Families for MIR133A1 Gene

Gene Families for MIR133A1 Gene

genes like me logo Genes that share domains with MIR133A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR133A1 Gene

Function for MIR133A1 Gene

Gene Ontology (GO) - Molecular Function for MIR133A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21109942
genes like me logo Genes that share ontologies with MIR133A1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR133A1 Gene

Localization for MIR133A1 Gene

Gene Ontology (GO) - Cellular Components for MIR133A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
genes like me logo Genes that share ontologies with MIR133A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR133A1 Gene

Pathways & Interactions for MIR133A1 Gene

PathCards logo

SuperPathways for MIR133A1 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
2 TarBasePathway
genes like me logo Genes that share pathways with MIR133A1: view

Pathways by source for MIR133A1 Gene

1 BioSystems pathway for MIR133A1 Gene
1 KEGG pathway for MIR133A1 Gene

Gene Ontology (GO) - Biological Process for MIR133A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 25607810
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0010628 positive regulation of gene expression IDA 23069713
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
genes like me logo Genes that share ontologies with MIR133A1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR133A1 Gene

Drugs & Compounds for MIR133A1 Gene

No Compound Related Data Available

Transcripts for MIR133A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR133A1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00005EB596_9606 precursor_RNA 88 5

HGNC: 31517,

RefSeq: NR_029675,

Ensembl: ENST00000385052 (view in UCSC) ,

miRBase: MI0000450,

ENA: LM608490.1:1..88:precursor_RNA,

URS0000383E7F_9606 miRNA 22 5

RefSeq: NR_029675, NR_029676,

LncBase: hsa-miR-133a-5p,

miRBase: MIMAT0026478,

MirGeneDB: Hsa-Mir-133-P1-v2_5p, Hsa-Mir-133-P2-v2_5p,

ENA: LM383145.1:1..22:ncRNA, LM608490.1:16..37:ncRNA, LM608491.1:22..43:ncRNA,

URS00004C9052_9606 miRNA 22 4

RefSeq: NR_029675, NR_029676,

miRBase: MIMAT0000427,

TarBase: hsa-miR-133a-3p,

ENA: BK006540.1:3985..4006:ncRNA, LM379045.1:1..22:ncRNA, LM608490.1:53..74:ncRNA, LM608491.1:59..80:ncRNA,

URS00005C04AC_9606 precursor_RNA 87 1

Rfam: RF00446,

URS0000EFF1C0_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-133-P2-v1, Hsa-Mir-133-P2-v2,

MIR133A1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR133A1 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR133A1 Gene

No ASD Table

Relevant External Links for MIR133A1 Gene

GeneLoc Exon Structure for
MIR133A1

Expression for MIR133A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR133A1

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR133A1 Gene

Orthologs for MIR133A1 Gene

Evolution for MIR133A1 Gene

ENSEMBL:
Gene Tree for MIR133A1 (if available)
TreeFam:
Gene Tree for MIR133A1 (if available)

No data available for Orthologs for MIR133A1 Gene

Paralogs for MIR133A1 Gene

No data available for Paralogs for MIR133A1 Gene

Variants for MIR133A1 Gene

Additional dbSNP identifiers (rs#s) for MIR133A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR133A1 Gene

Variant ID Type Subtype PubMed ID
nsv2222 CNV insertion 18451855

Additional Variant Information for MIR133A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR133A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR133A1 Gene

Disorders for MIR133A1 Gene

MalaCards: The human disease database

(29) MalaCards diseases for MIR133A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conventional central osteosarcoma
  • conventional osteosarcoma
heart conduction disease
  • heart rhythm disease
bladder carcinoma in situ
  • bladder ca in situ
bone osteosarcoma
  • osteosarcoma of bone
bone resorption disease
  • bone resorption
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR133A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR133A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR133A1 Gene

Publications for MIR133A1 Gene

  1. Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease. (PMID: 20468068) de Mena L … Alvarez V (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
  2. Knockdown of TUG 1 suppresses hypoxia-induced apoptosis of cardiomyocytes by up-regulating miR-133a. (PMID: 31926162) Yang H … Wang K (Archives of biochemistry and biophysics 2020) 3
  3. CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p. (PMID: 30678736) Yu X … Qu X (Journal of experimental & clinical cancer research : CR 2019) 3
  4. Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18. (PMID: 31781298) Hromádka M … Moťovská Z (Disease markers 2019) 3
  5. Serum miR-483-5p and miR-133a as Biomarkers for Diagnosis of Hepatocellular Carcinoma Post-Hepatitis C Infection in Egyptian Patients. (PMID: 31926493) Hassan AS … Elnasser AM (The Egyptian journal of immunology 2019) 3

Products for MIR133A1 Gene

Sources for MIR133A1 Gene