microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR132 Gene

Subcategory (RNA class) for MIR132 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR132 Gene

  • MicroRNA 132 2 3 5
  • Hsa-MiR-132-5p 168 179
  • Hsa-MiR-132-3p 168 179
  • MIMAT0000426 53
  • MIMAT0004594 53
  • Hsa-Mir-132 3
  • MI0000449 53
  • MiRNA132 3
  • Mir-132 3
  • MIRN132 3
  • RF00662 174
  • MIR132 2

External Ids for MIR132 Gene

Previous HGNC Symbols for MIR132 Gene

  • MIRN132

Previous GeneCards Identifiers for MIR132 Gene

  • GC17M001927
  • GC17M001930
  • GC17M001953

Summaries for MIR132 Gene

Entrez Gene Summary for MIR132 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR132 Gene

MIR132 (MicroRNA 132) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR132 include Huntington Disease and Rheumatoid Arthritis. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR132 Gene

Additional gene information for MIR132 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR132 Gene

Genomics for MIR132 Gene

GeneHancer (GH) Regulatory Elements for MIR132 Gene

Promoters and enhancers for MIR132 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J002049 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -0.5 -548 3.1 ZBTB40 L3MBTL2 MNT ZKSCAN8 ZNF148 NKRF AHR ZNF687 CREM ZNF639 MIR132 MIR212 lnc-HIC1-3 RTN4RL1 TSR1 PITPNA SGSM2 SLC43A2 SMG6 RF00017-2214
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR132 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR132 Gene

Genomic Locations for MIR132 Gene
chr17:2,049,908-2,050,008
(GRCh38/hg38)
Size:
101 bases
Orientation:
Minus strand
chr17:1,953,202-1,953,302
(GRCh37/hg19)
Size:
101 bases
Orientation:
Minus strand

Genomic View for MIR132 Gene

Genes around MIR132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR132 Gene

Proteins for MIR132 Gene

Post-translational modifications for MIR132 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR132 Gene

Domains & Families for MIR132 Gene

Gene Families for MIR132 Gene

genes like me logo Genes that share domains with MIR132: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR132 Gene

Function for MIR132 Gene

Gene Ontology (GO) - Molecular Function for MIR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR132: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR132 Gene

Localization for MIR132 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR132 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 21868695
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR132: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR132 Gene

Pathways & Interactions for MIR132 Gene

genes like me logo Genes that share pathways with MIR132: view

Pathways by source for MIR132 Gene

2 BioSystems pathways for MIR132 Gene

Gene Ontology (GO) - Biological Process for MIR132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 21868695
GO:0010575 positive regulation of vascular endothelial growth factor production ISS --
GO:0010628 positive regulation of gene expression IDA 24924687
GO:0010629 negative regulation of gene expression IDA 24924687
GO:0031393 negative regulation of prostaglandin biosynthetic process ISS --
genes like me logo Genes that share ontologies with MIR132: view

No data available for SIGNOR curated interactions for MIR132 Gene

Drugs & Compounds for MIR132 Gene

No Compound Related Data Available

Transcripts for MIR132 Gene

mRNA/cDNA for MIR132 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(2) LncBase transcripts :
(3) miRBase transcripts :
(2) TarBase transcripts :
(1) Rfam transcripts :
(5) ENA transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR132 Gene

No ASD Table

Relevant External Links for MIR132 Gene

GeneLoc Exon Structure for
MIR132
ECgene alternative splicing isoforms for
MIR132

Expression for MIR132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR132 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR132 Gene:

MIR132

Evidence on tissue expression from TISSUES for MIR132 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with MIR132: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR132 Gene

Orthologs for MIR132 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR132 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-132 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-132 33
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir132 33
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-132 33
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-132-3 33
  • 54 (a)
ManyToMany
Species where no ortholog for MIR132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR132 Gene

ENSEMBL:
Gene Tree for MIR132 (if available)
TreeFam:
Gene Tree for MIR132 (if available)

Paralogs for MIR132 Gene

No data available for Paralogs for MIR132 Gene

Variants for MIR132 Gene

Sequence variations from dbSNP and Humsavar for MIR132 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000289205 -- 2,051,474(-) G/C upstream_transcript_variant
rs1000719068 -- 2,050,231(-) T/C/G upstream_transcript_variant
rs1000894579 -- 2,050,551(-) G/C upstream_transcript_variant
rs1001166349 -- 2,051,308(-) C/T upstream_transcript_variant
rs1001263117 -- 2,050,708(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR132 Gene

Variant ID Type Subtype PubMed ID
dgv1403n106 CNV deletion 24896259
esv33884 CNV gain 17666407
nsv1070376 CNV deletion 25765185
nsv574216 CNV gain 21841781
nsv827857 CNV gain 20364138
nsv952103 CNV deletion 24416366

Additional Variant Information for MIR132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR132 Gene

Disorders for MIR132 Gene

MalaCards: The human disease database

(20) MalaCards diseases for MIR132 Gene - From: miR2Disease, LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR132

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR132: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR132 Gene

Publications for MIR132 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 43 56
  2. Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway. (PMID: 30983072) Liu P … Zu X (Cell proliferation 2019) 3 56
  3. miR-132 Targets FOXA1 and Exerts Tumor-Suppressing Functions in Thyroid Cancer. (PMID: 29523221) Chen X … Zhang L (Oncology research 2019) 3 56
  4. Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF-β-driven progression of pancreatic cancer. (PMID: 30387838) Abukiwan A … Herr I (International journal of oncology 2019) 3 56
  5. miR-132-3p boosts caveolae-mediated transcellular transport in glioma endothelial cells by targeting PTEN/PI3K/PKB/Src/Cav-1 signaling pathway. (PMID: 30024792) Gu Y … Zhang Z (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 56

Products for MIR132 Gene

Sources for MIR132 Gene