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Aliases for MIR130A Gene

Subcategory (RNA class) for MIR130A Gene

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Quality Score for this RNA gene is

13

Aliases for MIR130A Gene

  • MicroRNA 130a 2 3 5
  • Hsa-Mir-130a 3
  • MiRNA130A 3
  • Mir-130a 3
  • MIRN130A 3

External Ids for MIR130A Gene

ORGUL Members for MIR130A Gene

Previous HGNC Symbols for MIR130A Gene

  • MIRN130A

Previous GeneCards Identifiers for MIR130A Gene

  • GC11P057169
  • GC11P057408

Summaries for MIR130A Gene

Entrez Gene Summary for MIR130A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR130A Gene

MIR130A (MicroRNA 130a) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR130A include Lung Cancer and Polymyositis. Among its related pathways are Hematopoietic Stem Cell Differentiation and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways.

Additional gene information for MIR130A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR130A Gene

Genomics for MIR130A Gene

GeneHancer (GH) Regulatory Elements for MIR130A Gene

Promoters and enhancers for MIR130A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057637 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 -1.7 -1684 4.5 ZNF652 SP1 ELF3 CTCF ZNF148 CEBPG YY1 SP7 SP5 PRDM1 ENSG00000254602 MIR130A CLP1 UBE2L6 RPS4XP13 SERPING1 MED19 TIMM10 PRG3 YPEL4
GH11J057529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 -110.6 -110622 2.8 ZFX SP1 ELF3 ZKSCAN8 MNT CBFA2T2 NKRF RERE POLR2A NFIB PIR39300 PIR40820 TIMM10 SSRP1 CLP1 MIR130A UBE2L6 RPS4XP13 ENSG00000254602 YPEL4
GH11J057496 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 10.8 -141.3 -141339 6.9 HDGF ZNF652 SP1 ZNF121 CEBPG RERE ZNF24 TFE3 SP7 HNF1A TIMM10 RTN4RL2 RN7SKP259 MIR130A SLC43A3 ENSG00000254979 P2RX3 SSRP1 ENSG00000254602 CLP1
GH11J057528 Enhancer 1.1 Ensembl ENCODE 10.3 -114.0 -113981 0.8 CC2D1A CTCF CEBPG PPARG RAD21 KAT8 ZNF600 RELA CEBPA GATAD2A PIR39300 PIR40820 RN7SL605P SSRP1 RTN4RL2 RN7SKP259 P2RX3 MIR130A SLC43A3 ENSG00000254602
GH11J057395 Enhancer 1.2 Ensembl dbSUPER 9.5 -243.9 -243897 5.4 ELF3 CBFA2T2 CEBPG TRIM24 PRDM1 ZNF644 ZNF639 SMARCA4 KAT8 HMG20B SSRP1 SLC43A3 P2RX3 CLP1 PRG2 ENSG00000254979 RN7SKP259 RTN4RL2 TIMM10 ENSG00000254662
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR130A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR130A Gene

Genomic Locations for MIR130A Gene
chr11:57,641,198-57,641,286
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr11:57,408,671-57,408,759
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR130A Gene

Genes around MIR130A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR130A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR130A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR130A Gene

Proteins for MIR130A Gene

Post-translational modifications for MIR130A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR130A Gene

Domains & Families for MIR130A Gene

Gene Families for MIR130A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR130A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR130A Gene

Function for MIR130A Gene

Phenotypes From GWAS Catalog for MIR130A Gene

Gene Ontology (GO) - Molecular Function for MIR130A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21067317
genes like me logo Genes that share ontologies with MIR130A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR130A Gene

Localization for MIR130A Gene

Gene Ontology (GO) - Cellular Components for MIR130A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0035068 micro-ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MIR130A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR130A Gene

Pathways & Interactions for MIR130A Gene

genes like me logo Genes that share pathways with MIR130A: view

Pathways by source for MIR130A Gene

Interacting Proteins for MIR130A Gene

Gene Ontology (GO) - Biological Process for MIR130A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032720 negative regulation of tumor necrosis factor production IDA 26435691
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0038061 NIK/NF-kappaB signaling IDA 26435691
GO:0045766 positive regulation of angiogenesis IMP 23136161
GO:0098586 cellular response to virus IMP 23418453
genes like me logo Genes that share ontologies with MIR130A: view

No data available for SIGNOR curated interactions for MIR130A Gene

Drugs & Compounds for MIR130A Gene

No Compound Related Data Available

Transcripts for MIR130A Gene

mRNA/cDNA for MIR130A Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR130A Gene

No ASD Table

Relevant External Links for MIR130A Gene

GeneLoc Exon Structure for
MIR130A
ECgene alternative splicing isoforms for
MIR130A

Expression for MIR130A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR130A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR130A Gene:

MIR130A
genes like me logo Genes that share expression patterns with MIR130A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR130A Gene

Orthologs for MIR130A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR130A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-130a 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130a 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-130a 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-130a 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir130a 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-130a 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-130c 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-130a-2 35
  • 65 (a)
OneToMany
aca-mir-130a-1 35
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130c-1 35
  • 38 (a)
ManyToMany
Species where no ortholog for MIR130A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR130A Gene

ENSEMBL:
Gene Tree for MIR130A (if available)
TreeFam:
Gene Tree for MIR130A (if available)

Paralogs for MIR130A Gene

No data available for Paralogs for MIR130A Gene

Variants for MIR130A Gene

Sequence variations from dbSNP and Humsavar for MIR130A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000153126 -- 57,640,897(+) T/C upstream_transcript_variant
rs1000232063 -- 57,640,641(+) G/A upstream_transcript_variant
rs1000890600 -- 57,640,512(+) C/T upstream_transcript_variant
rs1001388447 -- 57,639,894(+) G/A upstream_transcript_variant
rs1005742064 -- 57,639,323(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR130A Gene

Variant ID Type Subtype PubMed ID
esv992553 CNV deletion 20482838
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897

Additional Variant Information for MIR130A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR130A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR130A Gene

Disorders for MIR130A Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR130A Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
polymyositis
  • pm
dermatomyositis
  • amyopathic dermatomyositis
nonalcoholic fatty liver disease
  • non-alcoholic fatty liver disease
leukemia, acute lymphoblastic
  • all
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR130A

genes like me logo Genes that share disorders with MIR130A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR130A Gene

Publications for MIR130A Gene

  1. MicroRNA-130a-3p suppresses cell migration and invasion by inhibition of TBL1XR1-mediated EMT in human gastric carcinoma. (PMID: 29091326) Wang S … Ji J (Molecular carcinogenesis 2018) 3 58
  2. MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. (PMID: 29321333) Duan X … Chung RT (Journal of virology 2018) 3 58
  3. microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1. (PMID: 29384218) Chen X … Dai MS (Journal of cellular biochemistry 2018) 3 58
  4. MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death. (PMID: 29493383) Ding C … Dai HP (Upsala journal of medical sciences 2018) 3 58
  5. MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells. (PMID: 29746865) Kong X … Fang L (Biochemical and biophysical research communications 2018) 3 58

Products for MIR130A Gene

Sources for MIR130A Gene

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