microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1307 Gene

Subcategory (RNA class) for MIR1307 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR1307 Gene

  • MIMAT0022727 50
  • MIMAT0005951 50
  • MI0006444 50
  • MIRN1307 3
  • Mir-1307 3
  • RF01038 168

External Ids for MIR1307 Gene

Previous HGNC Symbols for MIR1307 Gene

  • MIRN1307

Previous GeneCards Identifiers for MIR1307 Gene

  • GC00U923162
  • GC10M105145

Summaries for MIR1307 Gene

Entrez Gene Summary for MIR1307 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1307 Gene

MIR1307 (MicroRNA 1307) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1307 include Ovarian Cystadenocarcinoma and Oropharynx Cancer. Among its related pathways are Alzheimers Disease.

Rfam classification for MIR1307 Gene

Additional gene information for MIR1307 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1307 Gene

Genomics for MIR1307 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1307 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J103349 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.5 +43.7 43683 2.2 ZBTB33 PRDM10 ZNF629 SIX5 ZNF692 RCOR2 LARP7 ZNF143 ZIC2 RBFOX2 PCGF6 RF00017-791 lnc-ATP5MD-1 SLK MIR1307 PDCD11 ATP5MD RNU11-3P ENSG00000260461 NEURL1-AS1
GH10J103244 Enhancer 0.8 ENCODE 9.9 +149.6 149552 0.2 GATAD2A CTCF NFKBIZ ZNF143 RXRB REST RAD21 IRF2 TRIM22 CEBPB RF00017-790 RPEL1 INA RNU11-3P CNNM2 CYP17A1 MIR1307 PDCD11 ATP5MD AS3MT
GH10J103433 Enhancer 0.6 Ensembl ENCODE dbSUPER 11 -39.7 -39700 1.4 ZEB1 CALHM1 NEURL1 MIR1307 PDCD11 ATP5MD NEURL1-AS1 CALHM2 RNU11-3P AS3MT ENSG00000273485
GH10J103417 Enhancer 0.5 ENCODE 11.8 -22.6 -22618 0.2 CTCF REST RAD21 TRIM22 RUNX3 SMC3 ZNF654 ENSG00000234699 CALHM2 NEURL1 PDCD11 ATP5MD MIR1307 CALHM1 NEURL1-AS1 RF00017-793 ENSG00000273485
GH10J103416 Enhancer 0.4 ENCODE 11.8 -22.4 -22418 0.2 CTCF TRIM22 RAD21 ENSG00000234699 CALHM2 NEURL1 PDCD11 ATP5MD MIR1307 CALHM1 NEURL1-AS1 RF00017-793 ENSG00000273485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1307 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1307 Gene

Genomic Locations for MIR1307 Gene
chr10:103,394,253-103,394,401
(GRCh38/hg38)
Size:
149 bases
Orientation:
Minus strand
chr10:105,154,010-105,154,158
(GRCh37/hg19)
Size:
149 bases
Orientation:
Minus strand

Genomic View for MIR1307 Gene

Genes around MIR1307 on UCSC Golden Path with GeneCards custom track
MIR1307 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1307 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1307 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1307 Gene

Proteins for MIR1307 Gene

Post-translational modifications for MIR1307 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1307 Gene

Domains & Families for MIR1307 Gene

Gene Families for MIR1307 Gene

HGNC:
genes like me logo Genes that share domains with MIR1307: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1307 Gene

Function for MIR1307 Gene

Phenotypes From GWAS Catalog for MIR1307 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1307 Gene

Localization for MIR1307 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1307 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR1307 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR1307: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR1307 Gene

Pathways & Interactions for MIR1307 Gene

PathCards logo

SuperPathways for MIR1307 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR1307: view

Pathways by source for MIR1307 Gene

1 BioSystems pathway for MIR1307 Gene

Gene Ontology (GO) - Biological Process for MIR1307 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1307: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1307 Gene

Drugs & Compounds for MIR1307 Gene

No Compound Related Data Available

Transcripts for MIR1307 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1307 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075BD54_9606 precursor_RNA 149 5

HGNC: 35372,

RefSeq: NR_031707,

Ensembl: ENST00000408840 (view in UCSC) ,

miRBase: MI0006444,

ENA: LM610181.1:1..149:precursor_RNA,

URS00004B1671_9606 miRNA 22 5

RefSeq: NR_031707,

LncBase: hsa-miR-1307-3p,

miRBase: MIMAT0005951,

TarBase: hsa-miR-1307-3p,

ENA: LM380726.1:1..22:ncRNA, LM610181.1:80..101:ncRNA,

URS00000EEF5F_9606 miRNA 21 5

RefSeq: NR_031707,

LncBase: hsa-miR-1307-5p,

miRBase: MIMAT0022727,

TarBase: hsa-miR-1307-5p,

ENA: LM383028.1:1..21:ncRNA, LM610181.1:41..61:ncRNA,

URS000069CA1C_9606 precursor_RNA 100 1

Rfam: RF01038,

URS000070992B_9606 precursor_RNA 100 1

Rfam: RF01038,

MIR1307 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1307 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1307 Gene

No ASD Table

Relevant External Links for MIR1307 Gene

GeneLoc Exon Structure for
MIR1307

Expression for MIR1307 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1307 Gene

genes like me logo Genes that share expression patterns with MIR1307: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1307 Gene

Orthologs for MIR1307 Gene

Evolution for MIR1307 Gene

ENSEMBL:
Gene Tree for MIR1307 (if available)
TreeFam:
Gene Tree for MIR1307 (if available)

No data available for Orthologs for MIR1307 Gene

Paralogs for MIR1307 Gene

No data available for Paralogs for MIR1307 Gene

Variants for MIR1307 Gene

Additional dbSNP identifiers (rs#s) for MIR1307 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1307 Gene

Variant ID Type Subtype PubMed ID
dgv280e212 CNV gain 25503493
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
esv3624413 CNV gain 21293372
nsv7529 CNV insertion 18451855

Additional Variant Information for MIR1307 Gene

Human Gene Mutation Database (HGMD)
MIR1307
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1307

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1307 Gene

Disorders for MIR1307 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR1307 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
oropharynx cancer
  • malignant oropharyngeal tumor
ovary adenocarcinoma
  • adenocarcinoma of the ovary
ovarian serous cystadenocarcinoma
  • serous cystadenoma
usher syndrome, type ig
  • ush1g
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1307

genes like me logo Genes that share disorders with MIR1307: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1307 Gene

Publications for MIR1307 Gene

  1. The clinicopathological significance of miR-1307 in chemotherapy resistant epithelial ovarian cancer. (PMID: 25887170) Zhou Y … Shuang T (Journal of ovarian research 2015) 2 3
  2. miR-1307-3p promotes tumor growth and metastasis of hepatocellular carcinoma by repressing DAB2 interacting protein. (PMID: 31176165) Chen S … Guo C (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. miR-1307-3p overexpression inhibits cell proliferation and promotes cell apoptosis by targeting ISM1 in colon cancer. (PMID: 31513891) Zheng Y … Chen M (Molecular and cellular probes 2019) 3
  4. miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2. (PMID: 30272255) Yang Z … Tian XB (International journal of molecular medicine 2018) 3
  5. Mir-1307 regulates cisplatin resistance by targeting Mdm4 in breast cancer expressing wild type P53. (PMID: 29697201) Wang X … Zhu J (Thoracic cancer 2018) 3

Products for MIR1307 Gene

Sources for MIR1307 Gene