microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1306 Gene

Data sources for MIR1306 Gene:

RNA type for MIR1306 Gene

miRNA

Aliases for MIR1306 Gene

External Ids for MIR1306 Gene

Previous HGNC Symbols for MIR1306 Gene

  • MIRN1306

Previous GeneCards Identifiers for MIR1306 Gene

  • GC00U922843
  • GC22P018454
  • GC22P020073

Summaries for MIR1306 Gene

Entrez Gene Summary for MIR1306 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1306 Gene

MIR1306 (MicroRNA 1306) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1306 include Cerebral Atherosclerosis and Mild Pre-Eclampsia. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and DDX1 as a regulatory component of the Drosha microprocessor.

Rfam classification for MIR1306 Gene

Additional gene information for MIR1306 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1306 Gene

Genomics for MIR1306 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1306 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J020084 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 250.7 -1.1 -1135 1.4 NCOR1 IKZF1 MYC MXD4 REST HES1 BHLHE40 ZNF341 MNT CTCF MIR1306 MIR3618 DGCR8 TRMT2A LZTR1 LINC01311 MED15 ENSG00000215493 RPL7AP70 ESS2
GH22J020085 Promoter/Enhancer 0.7 EPDnew dbSUPER 250.7 -0.3 -256 0.1 MLLT1 ZBTB33 NFXL1 MIR1306 MIR3618 DGCR8 RANBP1
GH22J020087 Enhancer 0.5 Ensembl 0.7 +2.4 2443 2.2 POLR2A SUPT5H TSC22D4 USF2 HDGF ABHD17AP4 ZDHHC8 HSALNG0134092 MIR1306 DGCR8 RANBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1306 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1306 Gene

Latest Assembly
chr22:20,086,058-20,086,142
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand

Previous Assembly
chr22:20,073,581-20,073,665
(GRCh37/hg19 by Entrez Gene)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR1306 Gene

Genes around MIR1306 on UCSC Golden Path with GeneCards custom track
MIR1306 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1306 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1306 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1306 Gene

Proteins for MIR1306 Gene

Post-translational modifications for MIR1306 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1306 Gene

Domains & Families for MIR1306 Gene

Gene Families for MIR1306 Gene

HGNC:
genes like me logo Genes that share domains with MIR1306: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1306 Gene

Function for MIR1306 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1306 Gene

Localization for MIR1306 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1306 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR1306 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR1306: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR1306 Gene

Pathways & Interactions for MIR1306 Gene

genes like me logo Genes that share pathways with MIR1306: view

Pathways by source for MIR1306 Gene

Gene Ontology (GO) - Biological Process for MIR1306 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1306: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1306 Gene

Drugs & Compounds for MIR1306 Gene

No Compound Related Data Available

Transcripts for MIR1306 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1306 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000500449_9606 miRNA 22 5

RefSeq: NR_031706,

LncBase: hsa-miR-1306-5p,

miRBase: MIMAT0022726,

TarBase: hsa-miR-1306-5p,

ENA: LM383027.1:1..22:ncRNA, LM610180.1:15..36:ncRNA,

URS000041E780_9606 miRNA 18 5

RefSeq: NR_031706,

LncBase: hsa-miR-1306-3p,

miRBase: MIMAT0005950,

TarBase: hsa-miR-1306-3p,

ENA: LM380725.1:1..18:ncRNA, LM610180.1:55..72:ncRNA,

URS000075B769_9606 pre_miRNA 85 4

RefSeq: NR_031706,

Ensembl: ENST00000408439 (view in UCSC) ,

miRBase: MI0006443,

ENA: LM610180.1:1..85:precursor_RNA,

URS0000690711_9606 pre_miRNA 74 1

Rfam: RF01014,

URS0001BC74CF_9606 pre_miRNA 74 1

Rfam: RF01014,

MIR1306 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1306 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1306 Gene

No ASD Table

Relevant External Links for MIR1306 Gene

GeneLoc Exon Structure for
MIR1306

Expression for MIR1306 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1306 Gene

genes like me logo Genes that share expression patterns with MIR1306: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1306 Gene

Orthologs for MIR1306 Gene

Evolution for MIR1306 Gene

ENSEMBL:
Gene Tree for MIR1306 (if available)
TreeFam:
Gene Tree for MIR1306 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1306

No data available for Orthologs for MIR1306 Gene

Paralogs for MIR1306 Gene

No data available for Paralogs for MIR1306 Gene

Variants for MIR1306 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1306 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1306 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2758825 CNV loss 17122850
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953027 CNV deletion 24416366

Additional Variant Information for MIR1306 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1306
Leiden Open Variation Database (LOVD)
MIR1306

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1306 Gene

Disorders for MIR1306 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR1306 Gene - From: COP

Disorder Aliases PubMed IDs
cerebral atherosclerosis
  • intracranial arteriosclerosis
mild pre-eclampsia
  • mild toxemia
chromosomal deletion syndrome
mitral valve stenosis
  • mitral stenosis
chromosomal disease
  • chromosomal anomaly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1306

genes like me logo Genes that share disorders with MIR1306: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1306 Gene

Publications for MIR1306 Gene

  1. Upregulation of miR-1306-5p decreases cerebral ischemia/reperfusion injury in vitro by targeting BIK. (PMID: 31460837) Chen X … Liu X (Bioscience, biotechnology, and biochemistry 2019) 3
  2. miR-1306-3p targets FBXL5 to promote metastasis of hepatocellular carcinoma through suppressing snail degradation. (PMID: 30219228) He ZJ … Liu YJ (Biochemical and biophysical research communications 2018) 3
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3

Products for MIR1306 Gene

Sources for MIR1306 Gene