microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1304 Gene

Data sources for MIR1304 Gene:

RNA type for MIR1304 Gene

miRNA

Aliases for MIR1304 Gene

External Ids for MIR1304 Gene

Previous HGNC Symbols for MIR1304 Gene

  • MIRN1304

Previous GeneCards Identifiers for MIR1304 Gene

  • GC00U922944
  • GC11M093196
  • GC11M093466
  • GC11M093739
  • GC11M093751
  • GC11M093947
  • GC11M094035
  • GC11M094048
  • GC11M094226
  • GC11M093761
  • GC11M093771
  • GC11M093780
  • GC11M093791
  • GC11M093802
  • GC11M093811
  • GC11M093941
  • GC11M093927
  • GC11M094418
  • GC11M094621

Summaries for MIR1304 Gene

Entrez Gene Summary for MIR1304 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1304 Gene

MIR1304 (MicroRNA 1304) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1304 include Pulmonary Valve Disease and Pulmonary Valve Stenosis. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase I Promoter Escape.

Additional gene information for MIR1304 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1304 Gene

Genomics for MIR1304 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1304 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J093731 Enhancer 0.6 Ensembl ENCODE 250.7 +1.4 1352 1.1 POLR2A RBM22 SUPT5H ZBED1 POLR2B RBFOX2 HSALNG0086486 MIR1304 NONHSAG009375.2 SNORA1 SNORA18 SNORA25 SNORA32 SNORA8 SNORD5 SNORD6
GH11J093733 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -6.2 -6191 13.2 BCLAF1 ZNF207 MYC ZNF600 SSRP1 JUND ZNF592 POLR2A CEBPA ATF3 C11orf54 TAF1D ENSG00000284057 NONHSAG009376.2 lnc-VSTM5-1 MED17 ANKRD49 MRE11 CEP295 SNORA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1304 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1304 Gene

Latest Assembly
chr11:93,733,674-93,733,764
(GRCh38/hg38)
Size:
91 bases
Orientation:
Minus strand

Previous Assembly
chr11:93,466,840-93,466,930
(GRCh37/hg19 by Entrez Gene)
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR1304 Gene

Genes around MIR1304 on UCSC Golden Path with GeneCards custom track
MIR1304 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1304 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1304 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1304 Gene

Proteins for MIR1304 Gene

Post-translational modifications for MIR1304 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1304 Gene

Domains & Families for MIR1304 Gene

Gene Families for MIR1304 Gene

HGNC:
genes like me logo Genes that share domains with MIR1304: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1304 Gene

Function for MIR1304 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1304 Gene

Localization for MIR1304 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1304 gene
Compartment Confidence
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR1304 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIR1304: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR1304 Gene

Pathways & Interactions for MIR1304 Gene

genes like me logo Genes that share pathways with MIR1304: view

Gene Ontology (GO) - Biological Process for MIR1304 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1304 Gene

Drugs & Compounds for MIR1304 Gene

No Compound Related Data Available

Transcripts for MIR1304 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1304 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000753AD_9606 miRNA 22 5

RefSeq: NR_031639,

LncBase: hsa-miR-1304-5p,

miRBase: MIMAT0005892,

TarBase: hsa-miR-1304-5p,

ENA: LM380690.1:1..22:ncRNA, LM610133.1:20..41:ncRNA,

URS000050FB05_9606 miRNA 22 5

RefSeq: NR_031639,

LncBase: hsa-miR-1304-3p,

miRBase: MIMAT0022720,

TarBase: hsa-miR-1304-3p,

ENA: LM610133.1:53..74:ncRNA,

URS000075CBE0_9606 precursor_RNA 91 4

RefSeq: NR_031639,

Ensembl: ENST00000408243 (view in UCSC) ,

miRBase: MI0006371,

ENA: LM610133.1:1..91:precursor_RNA,

MIR1304 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1304 Gene

No ASD Table

Relevant External Links for MIR1304 Gene

GeneLoc Exon Structure for
MIR1304

No data available for mRNA/cDNA for MIR1304 Gene

Expression for MIR1304 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1304 Gene

genes like me logo Genes that share expression patterns with MIR1304: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1304 Gene

Orthologs for MIR1304 Gene

Evolution for MIR1304 Gene

ENSEMBL:
Gene Tree for MIR1304 (if available)
TreeFam:
Gene Tree for MIR1304 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1304

No data available for Orthologs for MIR1304 Gene

Paralogs for MIR1304 Gene

No data available for Paralogs for MIR1304 Gene

Variants for MIR1304 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1304 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1304 Gene

Variant ID Type Subtype PubMed ID
esv3627294 CNV gain 21293372
nsv832232 CNV gain 17160897

Additional Variant Information for MIR1304 Gene

Human Gene Mutation Database (HGMD)
MIR1304
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1304
Leiden Open Variation Database (LOVD)
MIR1304

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1304 Gene

Disorders for MIR1304 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR1304 Gene - From: COP

Disorder Aliases PubMed IDs
pulmonary valve disease
  • pulmonary valve disorder
pulmonary valve stenosis
  • heart valve pulmonary stenosis
noonan syndrome with multiple lentigines
  • capute-rimoin-konigsmark-esterly-richardson syndrome
fanconi anemia, complementation group g
  • fancg
costello syndrome
  • cstlo
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1304

genes like me logo Genes that share disorders with MIR1304: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1304 Gene

Publications for MIR1304 Gene

  1. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  2. Circular RNA circ_0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression. (PMID: 31643077) Chen M … Li Y (Journal of cellular physiology 2020) 3
  3. Circular RNA circ_0067934 exhaustion expedites cell apoptosis and represses cell proliferation, migration and invasion in thyroid cancer via sponging miR-1304 and regulating CXCR1 expression. (PMID: 31858554) Zhang H … Deng FS (European review for medical and pharmacological sciences 2019) 3
  4. Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma. (PMID: 31727503) Jin Y … Liu G (Pathology, research and practice 2019) 3
  5. Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer. (PMID: 30954221) Liu G … Bi H (Biochemical and biophysical research communications 2019) 3

Products for MIR1304 Gene

Sources for MIR1304 Gene