microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1304 Gene

Subcategory (RNA class) for MIR1304 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR1304 Gene

  • MicroRNA 1304 2 3 5
  • Hsa-MiR-1304-3p 163 173
  • Hsa-MiR-1304-5p 163 173
  • Hsa-Mir-1304 2 3
  • MIR1304 2 5
  • MIMAT0022720 50
  • MIMAT0005892 50
  • MI0006371 50
  • MIRN1304 3

External Ids for MIR1304 Gene

Previous HGNC Symbols for MIR1304 Gene

  • MIRN1304

Previous GeneCards Identifiers for MIR1304 Gene

  • GC00U922944
  • GC11M093196
  • GC11M093466
  • GC11M093739
  • GC11M093751
  • GC11M093947
  • GC11M094035
  • GC11M094048
  • GC11M094226
  • GC11M093761
  • GC11M093771
  • GC11M093780
  • GC11M093791
  • GC11M093802
  • GC11M093811
  • GC11M093941
  • GC11M093927

Summaries for MIR1304 Gene

Entrez Gene Summary for MIR1304 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1304 Gene

MIR1304 (MicroRNA 1304) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1304 include Pulmonary Valve Disease and Pulmonary Valve Stenosis. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

Additional gene information for MIR1304 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1304 Gene

Genomics for MIR1304 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1304 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J093731 Enhancer 0.6 Ensembl ENCODE 600.7 +1.4 1371 1.2 POLR2A RBFOX2 RBM22 SUPT5H POLR2B ZBED1 MIR1304 NONHSAG009375.2 SNORA1 SNORA18 SNORA25 SNORA32 SNORA8 SNORD5 SNORD6 piR-31447
GH11J093733 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -6.2 -6191 13.2 BRCA1 ARHGAP35 HNRNPL GATAD2A PRDM10 REST TFE3 LEF1 SOX13 NFKBIZ C11orf54 TAF1D ENSG00000284057 NONHSAG009376.2 lnc-VSTM5-1 MED17 ANKRD49 MRE11 CEP295 SNORA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1304 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1304 Gene

Genomic Locations for MIR1304 Gene
chr11:93,733,674-93,733,764
(GRCh38/hg38)
Size:
91 bases
Orientation:
Minus strand
chr11:93,466,840-93,466,930
(GRCh37/hg19)
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR1304 Gene

Genes around MIR1304 on UCSC Golden Path with GeneCards custom track
MIR1304 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1304 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1304 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1304 Gene

Proteins for MIR1304 Gene

Post-translational modifications for MIR1304 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1304 Gene

Domains & Families for MIR1304 Gene

Gene Families for MIR1304 Gene

HGNC:
genes like me logo Genes that share domains with MIR1304: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1304 Gene

Function for MIR1304 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1304 Gene

Localization for MIR1304 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1304 gene
Compartment Confidence
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1304 Gene

Pathways & Interactions for MIR1304 Gene

genes like me logo Genes that share pathways with MIR1304: view

Gene Ontology (GO) - Biological Process for MIR1304 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1304 Gene

Drugs & Compounds for MIR1304 Gene

No Compound Related Data Available

Transcripts for MIR1304 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1304 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075CBE0_9606 precursor_RNA 91 5

HGNC: 35302,

RefSeq: NR_031639,

Ensembl: ENST00000408243 (view in UCSC) ,

miRBase: MI0006371,

ENA: LM610133.1:1..91:precursor_RNA,

URS00000753AD_9606 miRNA 22 5

RefSeq: NR_031639,

LncBase: hsa-miR-1304-5p,

miRBase: MIMAT0005892,

TarBase: hsa-miR-1304-5p,

ENA: LM380690.1:1..22:ncRNA, LM610133.1:20..41:ncRNA,

URS000050FB05_9606 miRNA 22 5

RefSeq: NR_031639,

LncBase: hsa-miR-1304-3p,

miRBase: MIMAT0022720,

TarBase: hsa-miR-1304-3p,

ENA: LM610133.1:53..74:ncRNA,

MIR1304 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1304 Gene

No ASD Table

Relevant External Links for MIR1304 Gene

GeneLoc Exon Structure for
MIR1304

No data available for mRNA/cDNA for MIR1304 Gene

Expression for MIR1304 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1304 Gene

genes like me logo Genes that share expression patterns with MIR1304: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1304 Gene

Orthologs for MIR1304 Gene

Evolution for MIR1304 Gene

ENSEMBL:
Gene Tree for MIR1304 (if available)
TreeFam:
Gene Tree for MIR1304 (if available)

No data available for Orthologs for MIR1304 Gene

Paralogs for MIR1304 Gene

No data available for Paralogs for MIR1304 Gene

Variants for MIR1304 Gene

Additional dbSNP identifiers (rs#s) for MIR1304 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1304 Gene

Variant ID Type Subtype PubMed ID
esv3627294 CNV gain 21293372
nsv832232 CNV gain 17160897

Additional Variant Information for MIR1304 Gene

Human Gene Mutation Database (HGMD)
MIR1304
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1304

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1304 Gene

Disorders for MIR1304 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR1304 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pulmonary valve disease
  • pulmonary valve disorder
pulmonary valve stenosis
  • heart valve pulmonary stenosis
noonan syndrome with multiple lentigines
  • lentiginosis profusa
fanconi anemia, complementation group g
  • fancg
costello syndrome
  • cstlo
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1304

genes like me logo Genes that share disorders with MIR1304: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1304 Gene

Publications for MIR1304 Gene

  1. Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer. (PMID: 30954221) Liu G … Bi H (Biochemical and biophysical research communications 2019) 3
  2. Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma. (PMID: 31727503) Jin Y … Liu G (Pathology, research and practice 2019) 3
  3. Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304. (PMID: 30709584) Pan Y … Zhang W (Biochemical and biophysical research communications 2019) 3
  4. Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC. (PMID: 31701767) Du W … Liang D (Artificial cells, nanomedicine, and biotechnology 2019) 3
  5. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3

Products for MIR1304 Gene

Sources for MIR1304 Gene