microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1301 Gene

Subcategory (RNA class) for MIR1301 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR1301 Gene

  • MicroRNA 1301 2 3 5
  • Hsa-MiR-1301-3p 168 179
  • Hsa-Mir-1301 3
  • MIMAT0005797 53
  • MIMAT0026639 53
  • MI0003815 53
  • Mir-1301 3
  • MIRN1301 3
  • MIR1301 2

External Ids for MIR1301 Gene

Previous HGNC Symbols for MIR1301 Gene

  • MIRN1301

Previous GeneCards Identifiers for MIR1301 Gene

  • GC00U923084
  • GC02M025406
  • GC02M025551

Summaries for MIR1301 Gene

Entrez Gene Summary for MIR1301 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1301 Gene

MIR1301 (MicroRNA 1301) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1301 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1301 Gene

Genomics for MIR1301 Gene

GeneHancer (GH) Regulatory Elements for MIR1301 Gene

Promoters and enhancers for MIR1301 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J025327 Enhancer 0.5 dbSUPER 750.6 -1.9 -1937 5.7 ZSCAN4 ZKSCAN1 BCOR ZFHX2 ADNP ZMYM3 KDM1A MIR1301 DTNB lnc-EFR3B-7 DNMT3A
GH02J025272 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.1 +51.8 51793 8.7 ZNF24 SP1 CTCF NR2F6 ZNF362 MYC ETV6 RELA HLF L3MBTL2 MIR1301 POMC DNAJC27 piR-43105-342 DNMT3A
GH02J025292 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.1 +33.7 33677 4.3 ZBTB40 POLR2A MYC MAX NKRF MLLT1 ZNF687 ZBED1 IKZF1 ZIC2 DNMT3A MIR1301 DNAJC27 piR-43105-342
GH02J025284 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 11.7 +42.6 42635 2.3 NR2F1 NR2F6 MYC MAX POLR2A ZNF687 IKZF1 PKNOX1 DPF2 ELF1 DNMT3A MIR1301 LINC01381 DNAJC27 piR-43105-342
GH02J025288 Enhancer 0.7 ENCODE dbSUPER 12.1 +38.3 38299 3.2 HLF NFIB POLR2A RCOR1 NFIC ZFHX2 ZNF48 MIR1301 LINC01381 POMC piR-43105-342 DNMT3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1301 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1301 Gene

Genomic Locations for MIR1301 Gene
chr2:25,328,640-25,328,721
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand
chr2:25,551,509-25,551,590
(GRCh37/hg19)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR1301 Gene

Genes around MIR1301 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1301 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1301 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1301 Gene

Proteins for MIR1301 Gene

Post-translational modifications for MIR1301 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1301 Gene

Domains & Families for MIR1301 Gene

Gene Families for MIR1301 Gene

HGNC:
genes like me logo Genes that share domains with MIR1301: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1301 Gene

Function for MIR1301 Gene

Phenotypes From GWAS Catalog for MIR1301 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1301 Gene

Localization for MIR1301 Gene

Gene Ontology (GO) - Cellular Components for MIR1301 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR1301: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR1301 Gene

Pathways & Interactions for MIR1301 Gene

PathCards logo

SuperPathways for MIR1301 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1301 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1301 Gene

Drugs & Compounds for MIR1301 Gene

No Compound Related Data Available

Transcripts for MIR1301 Gene

mRNA/cDNA for MIR1301 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(1) LncBase transcripts :
(4) ENA transcripts :
(1) TarBase transcripts :
(3) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1301 Gene

No ASD Table

Relevant External Links for MIR1301 Gene

GeneLoc Exon Structure for
MIR1301
ECgene alternative splicing isoforms for
MIR1301

Expression for MIR1301 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1301 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1301 Gene:

MIR1301
genes like me logo Genes that share expression patterns with MIR1301: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1301 Gene

Orthologs for MIR1301 Gene

Evolution for MIR1301 Gene

ENSEMBL:
Gene Tree for MIR1301 (if available)
TreeFam:
Gene Tree for MIR1301 (if available)

No data available for Orthologs for MIR1301 Gene

Paralogs for MIR1301 Gene

No data available for Paralogs for MIR1301 Gene

Variants for MIR1301 Gene

Sequence variations from dbSNP and Humsavar for MIR1301 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001374401 -- 25,329,659(-) C/G upstream_transcript_variant
rs1001447948 -- 25,329,446(-) G/C upstream_transcript_variant
rs1001722627 -- 25,329,226(-) G/C upstream_transcript_variant
rs1003303491 -- 25,328,909(-) T/C upstream_transcript_variant
rs1003789953 -- 25,328,232(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1301 Gene

Variant ID Type Subtype PubMed ID
esv33372 CNV loss 17666407
nsv1008732 CNV loss 25217958
nsv581216 CNV loss 21841781
nsv581217 CNV loss 21841781
nsv581218 CNV loss 21841781
nsv828653 CNV loss 20364138

Additional Variant Information for MIR1301 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1301

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1301 Gene

Disorders for MIR1301 Gene

Additional Disease Information for MIR1301

No disorders were found for MIR1301 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1301 Gene

Publications for MIR1301 Gene

  1. STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway. (PMID: 30657221) Wen J … Zhu Q (Cell proliferation 2019) 3 56
  2. MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9. (PMID: 30172867) Wang L … Chao Y (Gene 2018) 3 56
  3. EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer. (PMID: 29790898) Wu Q … Feng J (Acta biochimica et biophysica Sinica 2018) 3 56
  4. miR-1301-3p promotes prostate cancer stem cell expansion by targeting SFRP1 and GSK3β. (PMID: 29358129) Song XL … Zhao SC (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  5. MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1. (PMID: 29951881) Peng X … Shen Y (Breast cancer (Tokyo, Japan) 2018) 3 56

Products for MIR1301 Gene

Sources for MIR1301 Gene