microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1291 Gene

Subcategory (RNA class) for MIR1291 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR1291 Gene

  • MicroRNA 1291 2 3 5
  • Hsa-MiR-1291 166 177
  • Hsa-Mir-1291 3
  • MIMAT0005881 51
  • MI0006353 51
  • Mir-1291 3
  • MIRN1291 3
  • MIR1291 2

External Ids for MIR1291 Gene

Previous HGNC Symbols for MIR1291 Gene

  • MIRN1291

Previous GeneCards Identifiers for MIR1291 Gene

  • GC00U923104
  • GC12M047341
  • GC12M049049
  • GC12M049052
  • GC12M049058
  • GC12M049066
  • GC12U901807
  • GC12M049089

Summaries for MIR1291 Gene

Entrez Gene Summary for MIR1291 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1291 Gene

MIR1291 (MicroRNA 1291) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1291 include Maxillary Sinus Cancer and Paranasal Sinus Cancer.

Additional gene information for MIR1291 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1291 Gene

Genomics for MIR1291 Gene

Genomic Locations for MIR1291 Gene

Genomic Locations for MIR1291 Gene
chr12:48,654,444-48,654,530
(GRCh38/hg38)
Size:
87 bases
Orientation:
Minus strand
chr12:49,048,227-49,048,313
(GRCh37/hg19)
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR1291 Gene

Genes around MIR1291 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1291 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1291 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1291 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR1291 Gene

Proteins for MIR1291 Gene

Post-translational modifications for MIR1291 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1291 Gene

Domains & Families for MIR1291 Gene

Gene Families for MIR1291 Gene

HGNC:
genes like me logo Genes that share domains with MIR1291: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1291 Gene

Function for MIR1291 Gene

Phenotypes From GWAS Catalog for MIR1291 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1291 Gene

Localization for MIR1291 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1291 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1291 Gene

Pathways & Interactions for MIR1291 Gene

PathCards logo

SuperPathways for MIR1291 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR1291 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1291 Gene

Drugs & Compounds for MIR1291 Gene

No Compound Related Data Available

Transcripts for MIR1291 Gene

mRNA/cDNA for MIR1291 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1291 Gene

No ASD Table

Relevant External Links for MIR1291 Gene

GeneLoc Exon Structure for
MIR1291

Expression for MIR1291 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1291 Gene

Orthologs for MIR1291 Gene

Evolution for MIR1291 Gene

ENSEMBL:
Gene Tree for MIR1291 (if available)
TreeFam:
Gene Tree for MIR1291 (if available)

No data available for Orthologs for MIR1291 Gene

Paralogs for MIR1291 Gene

No data available for Paralogs for MIR1291 Gene

Variants for MIR1291 Gene

Additional dbSNP identifiers (rs#s) for MIR1291 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1291 Gene

Variant ID Type Subtype PubMed ID
dgv1496n100 CNV gain 25217958

Additional Variant Information for MIR1291 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1291

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1291 Gene

Disorders for MIR1291 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR1291 Gene - From: DISEASES

Disorder Aliases PubMed IDs
maxillary sinus cancer
  • malignant neoplasm of antrum
paranasal sinus cancer
  • adenoid cystic carcinoma of accessory sinus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1291

genes like me logo Genes that share disorders with MIR1291: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1291 Gene

Publications for MIR1291 Gene

  1. MicroRNA-1291 promotes endometrial fibrosis by regulating the ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model. (PMID: 28849001) Xu Q … Wang S (Molecular medicine reports 2017) 3 54
  2. MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis. (PMID: 27322206) Tu MJ … Yu AM (Oncotarget 2016) 3 54
  3. miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma. (PMID: 26324125) Luo H … Wang F (Oncology reports 2015) 3 54
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 54
  5. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. (PMID: 25115443) Bi HC … Yu AM (Carcinogenesis 2014) 3 54

Products for MIR1291 Gene

Sources for MIR1291 Gene