microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR129-2 Gene

Subcategory (RNA class) for MIR129-2 Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR129-2 Gene

  • MicroRNA 129-2 2 3 5
  • Hsa-MiR-129-2-3p 168 179
  • Hsa-MiR-129-5p 168 179
  • Hsa-Mir-129-2 3
  • MIMAT0004605 53
  • MIMAT0000242 53
  • Mir-129-2 3
  • MIRN129-2 3
  • MI0000473 53
  • MIR-129b 3
  • MIR129-2 2
  • RF00486 174

External Ids for MIR129-2 Gene

Previous HGNC Symbols for MIR129-2 Gene

  • MIRN129-2

Previous GeneCards Identifiers for MIR129-2 Gene

  • GC11P043562
  • GC11P043602
  • GC11P043592
  • GC11P043593
  • GC11P043621
  • GC11P043626
  • GC11P043594
  • GC11P043596
  • GC11P043604
  • GC11P043609
  • GC11P043613
  • GC11P043618

Summaries for MIR129-2 Gene

Entrez Gene Summary for MIR129-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR129-2 Gene

MIR129-2 (MicroRNA 129-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR129-2 include Retinoblastoma and Univentricular Heart. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR129-2 Gene

  • mir-129 microRNA precursor family

Additional gene information for MIR129-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR129-2 Gene

Genomics for MIR129-2 Gene

GeneHancer (GH) Regulatory Elements for MIR129-2 Gene

Promoters and enhancers for MIR129-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J043578 Promoter/Enhancer 1.1 Ensembl ENCODE 750.6 -1.1 -1093 3 CTCF ZNF362 ZNF652 SP7 PRDM1 ZNF547 GLIS2 ZBTB8A PRDM10 ZSCAN4 ENSG00000283341 MIR129-2 HSD17B12 ENSG00000283217
GH11J043643 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 11 +63.1 63107 2.2 SIN3A ZNF24 SP1 ZBTB40 SIX5 MLX SMARCE1 RBPJ POLR2A HDAC2 lnc-HSD17B12-1 ALKBH3 TTC17 ENSG00000246250 SEC14L1P1 HSD17B12 EXT2 ENSG00000254907 HNRNPKP3 ACCS
GH11J043546 Promoter/Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 10.9 -33.8 -33790 1.9 USF2 L3MBTL2 GMEB1 ZIC2 ZNF512 MGA EGR1 USF1 NR2C2 MNT lnc-ALX4-13 lnc-TTC17-5 MIR129-2 HSD17B12 C11orf96 CTBP2P6
GH11J043868 Enhancer 1.1 Ensembl ENCODE 9.3 +287.8 287807 2 ZNF24 ZBTB40 SP1 SMARCE1 JUND CC2D1A ETV6 RELA L3MBTL2 CEBPB ALKBH3-AS1 ALKBH3 API5 TTC17 C11orf96 SEC14L1P1 HSD17B12 MIR129-2 lnc-ALX4-11 ENSG00000246250
GH11J043694 Enhancer 1 Ensembl ENCODE 10.4 +112.1 112107 1.4 SMARCE1 CC2D1A TEAD4 CBFA2T2 SMARCA4 ZNF639 TRIM24 MTA1 IKZF1 DPF2 HSD17B12 MIR129-2 RPL23AP63 ENSG00000283341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR129-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR129-2 Gene

Genomic Locations for MIR129-2 Gene
chr11:43,581,394-43,581,483
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr11:43,602,944-43,603,033
(GRCh37/hg19)
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR129-2 Gene

Genes around MIR129-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR129-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR129-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR129-2 Gene

Proteins for MIR129-2 Gene

Post-translational modifications for MIR129-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR129-2 Gene

Domains & Families for MIR129-2 Gene

Gene Families for MIR129-2 Gene

genes like me logo Genes that share domains with MIR129-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR129-2 Gene

Function for MIR129-2 Gene

Phenotypes From GWAS Catalog for MIR129-2 Gene

Gene Ontology (GO) - Molecular Function for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23390134
genes like me logo Genes that share ontologies with MIR129-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR129-2 Gene

Localization for MIR129-2 Gene

Gene Ontology (GO) - Cellular Components for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR129-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR129-2 Gene

Pathways & Interactions for MIR129-2 Gene

genes like me logo Genes that share pathways with MIR129-2: view

Pathways by source for MIR129-2 Gene

1 BioSystems pathway for MIR129-2 Gene
1 KEGG pathway for MIR129-2 Gene

Gene Ontology (GO) - Biological Process for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 26790441
GO:1905563 negative regulation of vascular endothelial cell proliferation IDA 26790441
genes like me logo Genes that share ontologies with MIR129-2: view

No data available for SIGNOR curated interactions for MIR129-2 Gene

Drugs & Compounds for MIR129-2 Gene

No Compound Related Data Available

Transcripts for MIR129-2 Gene

mRNA/cDNA for MIR129-2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(2) LncBase transcripts :
(9) ENA transcripts :
(2) TarBase transcripts :
(3) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR129-2 Gene

No ASD Table

Relevant External Links for MIR129-2 Gene

GeneLoc Exon Structure for
MIR129-2
ECgene alternative splicing isoforms for
MIR129-2

Expression for MIR129-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR129-2 Gene

genes like me logo Genes that share expression patterns with MIR129-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR129-2 Gene

Orthologs for MIR129-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR129-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-129-2 33
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-129-2 33
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir129-2 33
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-129-2 33
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-129a 33
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR376745.1 33
  • 89 (a)
ManyToMany
dre-mir-129-2 33
  • 87 (a)
ManyToMany
dre-mir-129-1 33
  • 79 (a)
ManyToMany
Species where no ortholog for MIR129-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR129-2 Gene

ENSEMBL:
Gene Tree for MIR129-2 (if available)
TreeFam:
Gene Tree for MIR129-2 (if available)

Paralogs for MIR129-2 Gene

No data available for Paralogs for MIR129-2 Gene

Variants for MIR129-2 Gene

Sequence variations from dbSNP and Humsavar for MIR129-2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000362805 -- 43,580,592(+) TTT/TT upstream_transcript_variant
rs1002682720 -- 43,579,664(+) T/A upstream_transcript_variant
rs1003123822 -- 43,579,454(+) G/A upstream_transcript_variant
rs1005120272 -- 43,579,467(+) T/A/C upstream_transcript_variant
rs1006196411 -- 43,579,394(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR129-2 Gene

Variant ID Type Subtype PubMed ID
nsv951606 CNV deletion 24416366

Additional Variant Information for MIR129-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR129-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR129-2 Gene

Disorders for MIR129-2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR129-2 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
univentricular heart
  • double inlet left ventricle
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR129-2

genes like me logo Genes that share disorders with MIR129-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR129-2 Gene

Publications for MIR129-2 Gene

  1. UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis. (PMID: 29777711) Wang J … Hu Y (Biochemical and biophysical research communications 2018) 3 56
  2. MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9. (PMID: 29879625) Liu Q … Zhang X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  3. miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10. (PMID: 29864913) Wang X … Li Q (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  4. The effect of microRNA-129 on the migration and invasion in NSCLC cells and its mechanism. (PMID: 30475081) Bin C … Wanzi X (Experimental lung research 2018) 3 56
  5. miR-129-5p inhibits gemcitabine resistance and promotes cell apoptosis of bladder cancer cells by targeting Wnt5a. (PMID: 30117016) Cao J … Wang Q (International urology and nephrology 2018) 3 56

Products for MIR129-2 Gene

Sources for MIR129-2 Gene