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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR129-2 (MicroRNA 129-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR129-2 include Retinoblastoma and Univentricular Heart. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 23390134 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Alzheimers Disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
GO:0043537 | negative regulation of blood vessel endothelial cell migration | IDA | 26790441 |
GO:0045415 | negative regulation of interleukin-8 biosynthetic process | IDA | 27468870 |
GO:1900016 | negative regulation of cytokine production involved in inflammatory response | IC | 27468870 |
GO:1905563 | negative regulation of vascular endothelial cell proliferation | IDA | 26790441 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00006515A6_9606 | precursor_RNA | 90 | 6 |
HGNC: 31513, RefSeq: NR_029697, Ensembl: ENST00000362207 (view in UCSC) , miRBase: MI0000473, Rfam: RF00486, |
URS000048F59D_9606 | miRNA | 22 | 6 |
RefSeq: NR_029697, LncBase: hsa-miR-129-2-3p, miRBase: MIMAT0004605, MirGeneDB: Hsa-Mir-129-P2_3p, TarBase: hsa-miR-129-2-3p, ENA: AY940855.1:1..22:ncRNA, LM380280.1:1..22:ncRNA, LM608513.1:57..78:ncRNA, |
URS00004E1410_9606 | miRNA | 21 | 6 |
LncBase: hsa-miR-129-5p, miRBase: MIMAT0000242, MirGeneDB: Hsa-Mir-129-P1_5p, Hsa-Mir-129-P2_5p, TarBase: hsa-miR-129-5p, ENA: AJ550405.1:1..21:ncRNA, LM378884.1:1..21:ncRNA, LM608329.1:5..25:ncRNA, LM608513.1:15..35:ncRNA, |
URS0000EFCE5A_9606 | precursor_RNA | 65 | 1 |
MirGeneDB: Hsa-Mir-129-P2, |
URS00000E0403_9606 | miRNA | 22 | 1 |
ENA: AJ560751.1:1..22:ncRNA, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-129-2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir129-2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-129-2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-129-2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-129a 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | CR376745.1 31 |
|
ManyToMany | |
dre-mir-129-2 31 |
|
ManyToMany | |||
dre-mir-129-1 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinoblastoma |
|
|
univentricular heart |
|
|
colorectal cancer |
|