microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR129-2 Gene

Subcategory (RNA class) for MIR129-2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR129-2 Gene

  • MicroRNA 129-2 2 3 5
  • Hsa-MiR-129-2-3p 163 173
  • Hsa-MiR-129-5p 163 173
  • Hsa-Mir-129-2 2 3
  • MIR129-2 2 5
  • Hsa-Mir-129-P2 178
  • MIMAT0000242 50
  • MIMAT0004605 50
  • MIRN129-2 3
  • Mir-129-2 3
  • MI0000473 50
  • MIR-129b 3
  • RF00486 168

External Ids for MIR129-2 Gene

Previous HGNC Symbols for MIR129-2 Gene

  • MIRN129-2

Previous GeneCards Identifiers for MIR129-2 Gene

  • GC11P043562
  • GC11P043602
  • GC11P043592
  • GC11P043593
  • GC11P043621
  • GC11P043626
  • GC11P043627
  • GC11P043633
  • GC11P043594
  • GC11P043596
  • GC11P043604
  • GC11P043609
  • GC11P043613
  • GC11P043618

Summaries for MIR129-2 Gene

Entrez Gene Summary for MIR129-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR129-2 Gene

MIR129-2 (MicroRNA 129-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR129-2 include Retinoblastoma and Univentricular Heart. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR129-2 Gene

  • mir-129 microRNA precursor family

Additional gene information for MIR129-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR129-2 Gene

Genomics for MIR129-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR129-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J043578 Promoter/Enhancer 1.1 Ensembl ENCODE 600.7 -1.1 -1093 3 PRDM10 ZNF629 KDM1A CTCF PRDM1 ZSCAN4 POLR2A PATZ1 ZNF501 EZH2 ENSG00000283341 MIR129-2 HSD17B12 ENSG00000283217 ALKBH3
GH11J043643 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 11 +63.1 63107 2.2 SP1 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 SIX5 SOX13 POLR2A JUND HSD17B12 MIR129-2 ALKBH3 ENSG00000246250 piR-32461-033 ENSG00000283341 ENSG00000283217
GH11J043546 Promoter/Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas 10.9 -33.8 -33790 1.9 ZNF512 ZIC2 MGA CBX3 EGR1 USF1 NR2C2 MNT MYC ZFHX2 lnc-ALX4-13 lnc-TTC17-5 HSD17B12 MIR129-2 C11orf96 CTBP2P6 TTC17
GH11J043868 Enhancer 1.1 Ensembl ENCODE 9.3 +287.8 287807 2 SP1 REST LEF1 IKZF1 BACH1 JUND STAT3 GABPA PRDM1 MTA2 ALKBH3-AS1 C11orf96 ALKBH3 MIR129-2 HSD17B12 MN297041 lnc-ALX4-11 ENSG00000246250
GH11J043694 Enhancer 1 Ensembl ENCODE 10.4 +112.1 112107 1.4 LEF1 IKZF1 JUND PKNOX1 MTA1 ZNF24 DPF2 HDAC1 SOX6 FOXJ2 HSD17B12 MIR129-2 RF00017-900 RPL23AP63 ENSG00000283341 ALKBH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR129-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR129-2 Gene

Genomic Locations for MIR129-2 Gene
chr11:43,581,394-43,581,483
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr11:43,602,944-43,603,033
(GRCh37/hg19)
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR129-2 Gene

Genes around MIR129-2 on UCSC Golden Path with GeneCards custom track
MIR129-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR129-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR129-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR129-2 Gene

Proteins for MIR129-2 Gene

Post-translational modifications for MIR129-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR129-2 Gene

Domains & Families for MIR129-2 Gene

Gene Families for MIR129-2 Gene

genes like me logo Genes that share domains with MIR129-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR129-2 Gene

Function for MIR129-2 Gene

Phenotypes From GWAS Catalog for MIR129-2 Gene

Gene Ontology (GO) - Molecular Function for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23390134
genes like me logo Genes that share ontologies with MIR129-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR129-2 Gene

Localization for MIR129-2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR129-2 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR129-2 Gene

Pathways & Interactions for MIR129-2 Gene

PathCards logo

SuperPathways for MIR129-2 Gene

genes like me logo Genes that share pathways with MIR129-2: view

Pathways by source for MIR129-2 Gene

1 BioSystems pathway for MIR129-2 Gene
1 KEGG pathway for MIR129-2 Gene

Gene Ontology (GO) - Biological Process for MIR129-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 26790441
GO:0045415 negative regulation of interleukin-8 biosynthetic process IDA 27468870
GO:1900016 negative regulation of cytokine production involved in inflammatory response IC 27468870
GO:1905563 negative regulation of vascular endothelial cell proliferation IDA 26790441
genes like me logo Genes that share ontologies with MIR129-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR129-2 Gene

Drugs & Compounds for MIR129-2 Gene

No Compound Related Data Available

Transcripts for MIR129-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR129-2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006515A6_9606 precursor_RNA 90 6

HGNC: 31513,

RefSeq: NR_029697,

Ensembl: ENST00000362207 (view in UCSC) ,

miRBase: MI0000473,

Rfam: RF00486,

ENA: LM608513.1:1..90:precursor_RNA,

URS000048F59D_9606 miRNA 22 6

RefSeq: NR_029697,

LncBase: hsa-miR-129-2-3p,

miRBase: MIMAT0004605,

MirGeneDB: Hsa-Mir-129-P2_3p,

TarBase: hsa-miR-129-2-3p,

ENA: AY940855.1:1..22:ncRNA, LM380280.1:1..22:ncRNA, LM608513.1:57..78:ncRNA,

URS00004E1410_9606 miRNA 21 6

RefSeq: NR_029596, NR_029697,

LncBase: hsa-miR-129-5p,

miRBase: MIMAT0000242,

MirGeneDB: Hsa-Mir-129-P1_5p, Hsa-Mir-129-P2_5p,

TarBase: hsa-miR-129-5p,

ENA: AJ550405.1:1..21:ncRNA, LM378884.1:1..21:ncRNA, LM608329.1:5..25:ncRNA, LM608513.1:15..35:ncRNA,

URS0000EFCE5A_9606 precursor_RNA 65 1

MirGeneDB: Hsa-Mir-129-P2,

URS00000E0403_9606 miRNA 22 1

ENA: AJ560751.1:1..22:ncRNA,

MIR129-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR129-2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR129-2 Gene

No ASD Table

Relevant External Links for MIR129-2 Gene

GeneLoc Exon Structure for
MIR129-2

Expression for MIR129-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR129-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR129-2

genes like me logo Genes that share expression patterns with MIR129-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR129-2 Gene

Orthologs for MIR129-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR129-2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-129-2 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir129-2 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-129-2 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-129-2 31
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-129a 31
  • 65 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CR376745.1 31
  • 89 (a)
ManyToMany
dre-mir-129-2 31
  • 87 (a)
ManyToMany
dre-mir-129-1 31
  • 79 (a)
ManyToMany
Species where no ortholog for MIR129-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR129-2 Gene

ENSEMBL:
Gene Tree for MIR129-2 (if available)
TreeFam:
Gene Tree for MIR129-2 (if available)

Paralogs for MIR129-2 Gene

No data available for Paralogs for MIR129-2 Gene

Variants for MIR129-2 Gene

Additional dbSNP identifiers (rs#s) for MIR129-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR129-2 Gene

Variant ID Type Subtype PubMed ID
nsv951606 CNV deletion 24416366

Additional Variant Information for MIR129-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR129-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR129-2 Gene

Disorders for MIR129-2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR129-2 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
univentricular heart
  • double inlet left ventricle
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR129-2

genes like me logo Genes that share disorders with MIR129-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR129-2 Gene

Publications for MIR129-2 Gene

  1. miR-129-2-3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population. (PMID: 30499219) Huang S … Cheng J (Journal of cellular and molecular medicine 2019) 3
  2. MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9. (PMID: 29879625) Liu Q … Zhang X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  3. UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis. (PMID: 29777711) Wang J … Hu Y (Biochemical and biophysical research communications 2018) 3
  4. LncRNA MALAT1 induces colon cancer development by regulating miR-129-5p/HMGB1 axis. (PMID: 29226325) Wu Q … Zhao H (Journal of cellular physiology 2018) 3
  5. MiR-129 is involved in the occurrence of uterine fibroid through inhibiting TET1. (PMID: 30058675) Lu JL … Lin L (European review for medical and pharmacological sciences 2018) 3

Products for MIR129-2 Gene

Sources for MIR129-2 Gene