microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR129-1 Gene

Subcategory (RNA class) for MIR129-1 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR129-1 Gene

  • MicroRNA 129-1 2 3 5
  • Hsa-MiR-129-1-3p 163 173
  • Hsa-MiR-129-5p 163 173
  • Hsa-Mir-129-1 2 3
  • MIR129-1 2 5
  • Hsa-Mir-129-P1 178
  • MIMAT0004548 50
  • MIMAT0000242 50
  • MIRN129-1 3
  • Mir-129-1 3
  • MI0000252 50
  • MIR-129b 3
  • RF00486 168

External Ids for MIR129-1 Gene

Previous HGNC Symbols for MIR129-1 Gene

  • MIRN129-1

Previous GeneCards Identifiers for MIR129-1 Gene

  • GC07P127637
  • GC07P127847

Summaries for MIR129-1 Gene

Entrez Gene Summary for MIR129-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR129-1 Gene

MIR129-1 (MicroRNA 129-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR129-1 include Retinoblastoma and Stomach Disease. Among its related pathways are MicroRNAs in cancer and Alzheimers Disease.

Rfam classification for MIR129-1 Gene

  • mir-129 microRNA precursor family

Additional gene information for MIR129-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR129-1 Gene

Genomics for MIR129-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR129-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR129-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR129-1 Gene

Genomic Locations for MIR129-1 Gene
chr7:128,207,864-128,207,953
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand
chr7:127,847,924-127,847,996
(GRCh37/hg19)
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR129-1 Gene

Genes around MIR129-1 on UCSC Golden Path with GeneCards custom track
MIR129-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR129-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR129-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR129-1 Gene

Proteins for MIR129-1 Gene

Post-translational modifications for MIR129-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR129-1 Gene

Domains & Families for MIR129-1 Gene

Gene Families for MIR129-1 Gene

genes like me logo Genes that share domains with MIR129-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR129-1 Gene

Function for MIR129-1 Gene

Phenotypes From GWAS Catalog for MIR129-1 Gene

Gene Ontology (GO) - Molecular Function for MIR129-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23390134
genes like me logo Genes that share ontologies with MIR129-1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR129-1 Gene

Localization for MIR129-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR129-1 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR129-1 Gene

Pathways & Interactions for MIR129-1 Gene

PathCards logo

SuperPathways for MIR129-1 Gene

genes like me logo Genes that share pathways with MIR129-1: view

Pathways by source for MIR129-1 Gene

1 BioSystems pathway for MIR129-1 Gene
1 KEGG pathway for MIR129-1 Gene

Gene Ontology (GO) - Biological Process for MIR129-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA 26790441
GO:0045415 negative regulation of interleukin-8 biosynthetic process IDA 27468870
GO:1900016 negative regulation of cytokine production involved in inflammatory response IC 27468870
GO:1905563 negative regulation of vascular endothelial cell proliferation IDA 26790441
genes like me logo Genes that share ontologies with MIR129-1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR129-1 Gene

Drugs & Compounds for MIR129-1 Gene

No Compound Related Data Available

Transcripts for MIR129-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR129-1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004CCDA3_9606 miRNA 22 6

RefSeq: NR_029596,

LncBase: hsa-miR-129-1-3p,

miRBase: MIMAT0004548,

MirGeneDB: Hsa-Mir-129-P1_3p,

TarBase: hsa-miR-129-1-3p,

ENA: LM380227.1:1..22:ncRNA, LM608329.1:49..70:ncRNA,

URS00004E1410_9606 miRNA 21 6

RefSeq: NR_029596, NR_029697,

LncBase: hsa-miR-129-5p,

miRBase: MIMAT0000242,

MirGeneDB: Hsa-Mir-129-P1_5p, Hsa-Mir-129-P2_5p,

TarBase: hsa-miR-129-5p,

ENA: AJ550405.1:1..21:ncRNA, LM378884.1:1..21:ncRNA, LM608329.1:5..25:ncRNA, LM608513.1:15..35:ncRNA,

URS000075A41E_9606 precursor_RNA 72 5

HGNC: 31512,

RefSeq: NR_029596,

Ensembl: ENST00000384972 (view in UCSC) ,

miRBase: MI0000252,

ENA: LM608329.1:1..72:precursor_RNA,

URS00002B39E8_9606 precursor_RNA 90 1

Rfam: RF00486,

URS0000EFEABE_9606 precursor_RNA 67 1

MirGeneDB: Hsa-Mir-129-P1,

MIR129-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR129-1 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR129-1 Gene

No ASD Table

Relevant External Links for MIR129-1 Gene

GeneLoc Exon Structure for
MIR129-1

Expression for MIR129-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR129-1

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR129-1 Gene

Orthologs for MIR129-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR129-1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-129-1 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-129-1 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir129-1 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-129 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-129-1 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-129 31
  • 55 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-129b 31
  • 68 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BX927136.1 31
  • 55 (a)
OneToOne
Species where no ortholog for MIR129-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR129-1 Gene

ENSEMBL:
Gene Tree for MIR129-1 (if available)
TreeFam:
Gene Tree for MIR129-1 (if available)

Paralogs for MIR129-1 Gene

No data available for Paralogs for MIR129-1 Gene

Variants for MIR129-1 Gene

Additional dbSNP identifiers (rs#s) for MIR129-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR129-1 Gene

Variant ID Type Subtype PubMed ID
esv33413 CNV gain 17666407

Additional Variant Information for MIR129-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR129-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR129-1 Gene

Disorders for MIR129-1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for MIR129-1 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
stomach disease
  • gastric disease
gastrointestinal system cancer
  • digestive system cancer
gastrointestinal system disease
  • alimentary system disease
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR129-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR129-1 Gene

Publications for MIR129-1 Gene

  1. c-Src promotes tumor progression through downregulation of microRNA-129-1-3p. (PMID: 31799727) Okuzaki D … Oneyama C (Cancer science 2020) 3
  2. Nrf2-miR-129-3p-mTOR Axis Controls an miRNA Regulatory Network Involved in HDACi-Induced Autophagy. (PMID: 30852137) Sun W … Shen X (Molecular therapy : the journal of the American Society of Gene Therapy 2019) 3
  3. miR-129-5p attenuates cell proliferation and epithelial mesenchymal transition via HMGB1 in gastric cancer. (PMID: 30635217) Wang S … Teng L (Pathology, research and practice 2019) 3
  4. miR-129-5p suppresses proliferation, migration, and induces apoptosis in pancreatic cancer cells by targeting PBX3. (PMID: 31518383) Qiu Z … Da M (Acta biochimica et biophysica Sinica 2019) 3
  5. [miR-129-1-3p reverses cisplatin resistance of HNE1/CDDP human nasopharyngeal carcinoma cells by targeting inhibition of WEE1 kinase]. (PMID: 31878998) Zhang H … Lu W (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2019) 3

Products for MIR129-1 Gene

Sources for MIR129-1 Gene