microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1287 Gene

Subcategory (RNA class) for MIR1287 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR1287 Gene

  • MicroRNA 1287 2 3 5
  • Hsa-Mir-1287 2 3 178
  • Hsa-MiR-1287-5p 163 173
  • MIR1287 2 5
  • MIMAT0026738 50
  • MIMAT0005878 50
  • MI0006349 50
  • MIRN1287 3
  • Mir-1287 3
  • RF02015 168

External Ids for MIR1287 Gene

Previous HGNC Symbols for MIR1287 Gene

  • MIRN1287

Previous GeneCards Identifiers for MIR1287 Gene

  • GC00U923096
  • GC10M100145
  • GC10M100154

Summaries for MIR1287 Gene

Entrez Gene Summary for MIR1287 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1287 Gene

MIR1287 (MicroRNA 1287) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR1287 Gene

Additional gene information for MIR1287 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1287 Gene

Genomics for MIR1287 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1287 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J098394 Enhancer 0.7 Ensembl ENCODE 600.7 +0.9 902 1.6 RAD21 ZNF341 CTCF SMC3 NR2F2 POLR2A SMARCA4 MAX MIR1287 PYROXD2 LOXL4 lnc-HPS1-2
GH10J098373 Enhancer 0.7 Ensembl ENCODE 13.1 +20.9 20914 2.4 ZIC2 ESR1 ZNF316 MAFF FOS MAFK PKNOX1 MAFG GATA2 EMSY PYROXD2 LOXL4 MIR1287 HE856182 piR-52773-001
GH10J098390 Enhancer 0.7 Ensembl ENCODE 0.7 +4.0 4007 2.6 REST EED RUNX3 GABPA USF2 IKZF1 SPI1 STAT5A MYC MAX PYROXD2 LOXL4 MIR1287 lnc-HPS1-2
GH10J098403 Enhancer 0.9 Ensembl ENCODE 0.4 -9.1 -9061 3.1 RELA PKNOX1 IKZF2 EED ARID3A DPF2 RELB EGR1 RUNX3 GATAD2B lnc-R3HCC1L-4 PYROXD2 LOXL4 HPS1 MIR1287
GH10J098388 Enhancer 0.2 Ensembl 0.4 +6.4 6406 0.2 lnc-HPS1-2 PYROXD2 LOXL4 MIR1287
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1287 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1287 Gene

Genomic Locations for MIR1287 Gene
chr10:98,395,218-98,395,307
(GRCh38/hg38)
Size:
90 bases
Orientation:
Minus strand
chr10:100,154,975-100,155,064
(GRCh37/hg19)
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR1287 Gene

Genes around MIR1287 on UCSC Golden Path with GeneCards custom track
MIR1287 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1287 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1287 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1287 Gene

Proteins for MIR1287 Gene

Post-translational modifications for MIR1287 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1287 Gene

Domains & Families for MIR1287 Gene

Gene Families for MIR1287 Gene

HGNC:
genes like me logo Genes that share domains with MIR1287: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1287 Gene

Function for MIR1287 Gene

Phenotypes From GWAS Catalog for MIR1287 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1287 Gene

Localization for MIR1287 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1287 gene
Compartment Confidence
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1287 Gene

Pathways & Interactions for MIR1287 Gene

PathCards logo

SuperPathways for MIR1287 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1287: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1287 Gene

Drugs & Compounds for MIR1287 Gene

No Compound Related Data Available

Transcripts for MIR1287 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1287 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000072632B_9606 precursor_RNA 90 6

HGNC: 35280,

RefSeq: NR_031619,

Ensembl: ENST00000408492 (view in UCSC) ,

miRBase: MI0006349,

Rfam: RF02015,

ENA: LM610114.1:1..90:precursor_RNA,

URS00004C5774_9606 miRNA 22 6

RefSeq: NR_031619,

LncBase: hsa-miR-1287-5p,

miRBase: MIMAT0005878,

MirGeneDB: Hsa-Mir-1287_5p,

TarBase: hsa-miR-1287-5p,

ENA: LM380678.1:1..22:ncRNA, LM610114.1:16..37:ncRNA,

URS0000759A79_9606 miRNA 22 4

RefSeq: NR_031619,

miRBase: MIMAT0026738,

MirGeneDB: Hsa-Mir-1287_3p,

ENA: LM383205.1:1..22:ncRNA, LM610114.1:55..76:ncRNA,

URS0000EFCA69_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-1287,

MIR1287 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1287 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1287 Gene

No ASD Table

Relevant External Links for MIR1287 Gene

GeneLoc Exon Structure for
MIR1287

Expression for MIR1287 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1287 Gene

genes like me logo Genes that share expression patterns with MIR1287: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1287 Gene

Orthologs for MIR1287 Gene

Evolution for MIR1287 Gene

ENSEMBL:
Gene Tree for MIR1287 (if available)
TreeFam:
Gene Tree for MIR1287 (if available)

No data available for Orthologs for MIR1287 Gene

Paralogs for MIR1287 Gene

No data available for Paralogs for MIR1287 Gene

Variants for MIR1287 Gene

Additional dbSNP identifiers (rs#s) for MIR1287 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1287 Gene

Variant ID Type Subtype PubMed ID
nsv515723 CNV loss 19592680

Additional Variant Information for MIR1287 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1287

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1287 Gene

Disorders for MIR1287 Gene

Additional Disease Information for MIR1287

No disorders were found for MIR1287 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1287 Gene

Publications for MIR1287 Gene

  1. MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors. (PMID: 30709367) Schwarzenbacher D … Pichler M (Breast cancer research : BCR 2019) 3
  2. Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis. (PMID: 30103946) Li Y … Dong X (Biochemical and biophysical research communications 2018) 3
  3. Diagnostic and Prognostic Value of miR-1287 in Colorectal Cancer. (PMID: 27251300) Fateh A … Ravanbakhsh R (Journal of gastrointestinal cancer 2016) 3
  4. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3
  5. Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. (PMID: 24238754) Wang Y … Xiao B (Cancer genetics 2013) 3

Products for MIR1287 Gene

Sources for MIR1287 Gene