microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1281 Gene

Subcategory (RNA class) for MIR1281 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR1281 Gene

  • MicroRNA 1281 2 3 5
  • Hsa-Mir-1281 2 3
  • Hsa-MiR-1281 163 173
  • MIR1281 2 5
  • MIMAT0005939 50
  • MI0006428 50
  • MIRN1281 3

External Ids for MIR1281 Gene

Previous HGNC Symbols for MIR1281 Gene

  • MIRN1281

Previous GeneCards Identifiers for MIR1281 Gene

  • GC00U922887
  • GC22P039819
  • GC22P041488

Summaries for MIR1281 Gene

Entrez Gene Summary for MIR1281 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1281 Gene

MIR1281 (MicroRNA 1281) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Regulation of TP53 Activity through Acetylation and Chromatin organization.

Additional gene information for MIR1281 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1281 Gene

Genomics for MIR1281 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1281 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041090 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.0 988 6.2 SP1 PRDM10 REST ZNF629 TFE3 ZNF692 NFRKB POLR2A BACH1 LARP7 EP300 MIR1281 PHF5A ENSG00000272834 XRCC6 EP300-AS1 ENSG00000232754 L3MBTL2 ENSG00000227413 RPL4P6
GH22J041088 Enhancer 0.2 Ensembl 0.7 -3.6 -3612 0.6 L3MBTL2-AS1 XPNPEP3 EP300 MIR1281 ENSG00000213857 RBX1 L13304-025
GH22J041087 Enhancer 0.2 Ensembl 0.7 -4.4 -4412 0.6 EP300 MIR1281 ENSG00000213857 RBX1 L13304-025
GH22J041077 Enhancer 0.3 Ensembl 0.4 -13.3 -13312 1.6 ZNF777 ADSL ENSG00000213857 EP300 MIR1281 RBX1 L13304-025
GH22J041081 Enhancer 0.2 Ensembl 0.4 -11.1 -11113 0.8 ENSG00000213857 EP300 MIR1281 RBX1 L13304-025
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1281 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1281 Gene

Genomic Locations for MIR1281 Gene
chr22:41,092,513-41,092,566
(GRCh38/hg38)
Size:
54 bases
Orientation:
Plus strand
chr22:41,488,517-41,488,570
(GRCh37/hg19)
Size:
54 bases
Orientation:
Plus strand

Genomic View for MIR1281 Gene

Genes around MIR1281 on UCSC Golden Path with GeneCards custom track
MIR1281 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1281 Gene

Proteins for MIR1281 Gene

Post-translational modifications for MIR1281 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1281 Gene

Domains & Families for MIR1281 Gene

Gene Families for MIR1281 Gene

HGNC:
genes like me logo Genes that share domains with MIR1281: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1281 Gene

Function for MIR1281 Gene

Phenotypes From GWAS Catalog for MIR1281 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1281 Gene

Localization for MIR1281 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1281 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1281 Gene

Pathways & Interactions for MIR1281 Gene

PathCards logo

SuperPathways for MIR1281 Gene

SuperPathway Contained pathways
1 Signaling by NOTCH1
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5 BMAL1-CLOCK,NPAS2 activates circadian gene expression
genes like me logo Genes that share pathways with MIR1281: view

Gene Ontology (GO) - Biological Process for MIR1281 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR1281 Gene

Drugs & Compounds for MIR1281 Gene

No Compound Related Data Available

Transcripts for MIR1281 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1281 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DF7B_9606 precursor_RNA 54 4

HGNC: 35359,

RefSeq: NR_031694,

Ensembl: ENST00000408233 (view in UCSC) ,

miRBase: MI0006428,

URS000075E7A3_9606 miRNA 17 4

RefSeq: NR_031694,

LncBase: hsa-miR-1281,

miRBase: MIMAT0005939,

TarBase: hsa-miR-1281,

MIR1281 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1281 Gene

No ASD Table

Relevant External Links for MIR1281 Gene

GeneLoc Exon Structure for
MIR1281

No data available for mRNA/cDNA for MIR1281 Gene

Expression for MIR1281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1281 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1281

genes like me logo Genes that share expression patterns with MIR1281: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1281 Gene

Orthologs for MIR1281 Gene

Evolution for MIR1281 Gene

ENSEMBL:
Gene Tree for MIR1281 (if available)
TreeFam:
Gene Tree for MIR1281 (if available)

No data available for Orthologs for MIR1281 Gene

Paralogs for MIR1281 Gene

No data available for Paralogs for MIR1281 Gene

Variants for MIR1281 Gene

Additional dbSNP identifiers (rs#s) for MIR1281 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1281 Gene

Variant ID Type Subtype PubMed ID
nsv1058653 CNV gain 25217958
nsv524585 CNV loss 19592680
nsv589048 CNV loss 21841781

Additional Variant Information for MIR1281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1281 Gene

Disorders for MIR1281 Gene

No disorders were found for MIR1281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1281 Gene

Publications for MIR1281 Gene

  1. LncRNA LINC01857 promotes growth, migration, and invasion of glioma by modulating miR-1281/TRIM65 axis. (PMID: 31049960) Hu G … Guo Z (Journal of cellular physiology 2019) 3
  2. HPV16 increases the number of migratory cancer stem cells and modulates their miRNA expression profile in oropharyngeal cancer. (PMID: 29663357) Hufbauer M … Akgül B (International journal of cancer 2018) 3
  3. Circulating microRNAs found dysregulated in ex-exposed asbestos workers and pleural mesothelioma patients as potential new biomarkers. (PMID: 27716620) Bononi I … Tognon M (Oncotarget 2016) 3
  4. Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm. (PMID: 25916817) Zhang W … Liu C (Clinical biochemistry 2015) 3
  5. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3

Products for MIR1281 Gene

Sources for MIR1281 Gene