Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR1281 Gene

Subcategory (RNA class) for MIR1281 Gene


Quality Score for this RNA gene is


Aliases for MIR1281 Gene

  • MicroRNA 1281 2 3 5
  • Hsa-Mir-1281 3
  • MIRN1281 3

External Ids for MIR1281 Gene

ORGUL Members for MIR1281 Gene

Previous HGNC Symbols for MIR1281 Gene

  • MIRN1281

Previous GeneCards Identifiers for MIR1281 Gene

  • GC00U922887
  • GC22P039819
  • GC22P041488

Summaries for MIR1281 Gene

Entrez Gene Summary for MIR1281 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1281 Gene

MIR1281 (MicroRNA 1281) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Regulation of TP53 Activity through Acetylation and Signaling by NOTCH1.

Additional gene information for MIR1281 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1281 Gene

Genomics for MIR1281 Gene

GeneHancer (GH) Regulatory Elements for MIR1281 Gene

Promoters and enhancers for MIR1281 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I041090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 353 4.7 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 EP300 MIR1281 PHF5A ENSG00000272834 L3MBTL2 XRCC6 LOC100506544 EP300-AS1 ENSG00000232754 ENSG00000227413
GH22I041105 Enhancer 0.9 Ensembl ENCODE 0.4 +13.8 13810 1.4 TFAP4 SAP130 ARID4B CEBPG BATF ZNF644 RARA PRDM10 NR2F6 CREM LOC100506544 SMDT1 MIR1281 EP300 GC22M042622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR1281 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1281 Gene

Genomic Locations for MIR1281 Gene
54 bases
Plus strand

Genomic View for MIR1281 Gene

Genes around MIR1281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1281 Gene

Proteins for MIR1281 Gene

Post-translational modifications for MIR1281 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1281 Gene

Domains & Families for MIR1281 Gene

Gene Families for MIR1281 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1281: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1281 Gene

Function for MIR1281 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1281 Gene

Localization for MIR1281 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1281 Gene

Pathways & Interactions for MIR1281 Gene

SuperPathways for MIR1281 Gene

SuperPathway Contained pathways
1 Signaling by NOTCH1
2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
3 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
4 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5 BMAL1-CLOCK,NPAS2 activates circadian gene expression
genes like me logo Genes that share pathways with MIR1281: view

Interacting Proteins for MIR1281 Gene

Gene Ontology (GO) - Biological Process for MIR1281 Gene


No data available for SIGNOR curated interactions for MIR1281 Gene

Drugs & Compounds for MIR1281 Gene

No Compound Related Data Available

Transcripts for MIR1281 Gene

mRNA/cDNA for MIR1281 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1281 Gene

No ASD Table

Relevant External Links for MIR1281 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR1281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1281 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1281 Gene:

genes like me logo Genes that share expression patterns with MIR1281: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1281 Gene

Orthologs for MIR1281 Gene

Evolution for MIR1281 Gene

Gene Tree for MIR1281 (if available)
Gene Tree for MIR1281 (if available)

No data available for Orthologs for MIR1281 Gene

Paralogs for MIR1281 Gene

No data available for Paralogs for MIR1281 Gene

Variants for MIR1281 Gene

Sequence variations from dbSNP and Humsavar for MIR1281 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1053116813 uncertain-significance, Rubinstein-Taybi syndrome 41,092,767(+) T/A/C downstream_transcript_variant
rs116913445 likely-benign, Rubinstein-Taybi syndrome 41,092,872(+) A/G downstream_transcript_variant
rs553861147 uncertain-significance, Rubinstein-Taybi syndrome 41,092,856(+) G/A downstream_transcript_variant
rs763177046 uncertain-significance, Rubinstein-Taybi syndrome 41,092,813(+) C/T downstream_transcript_variant
rs886057550 uncertain-significance, Rubinstein-Taybi syndrome 41,092,642(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1281 Gene

Variant ID Type Subtype PubMed ID
nsv1058653 CNV gain 25217958
nsv524585 CNV loss 19592680
nsv589048 CNV loss 21841781

Additional Variant Information for MIR1281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1281 Gene

Disorders for MIR1281 Gene

Additional Disease Information for MIR1281

No disorders were found for MIR1281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1281 Gene

Publications for MIR1281 Gene

  1. Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm. (PMID: 25916817) Zhang W … Liu C (Clinical biochemistry 2015) 3 58
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  4. Circulating microRNAs found dysregulated in ex-exposed asbestos workers and pleural mesothelioma patients as potential new biomarkers. (PMID: 27716620) Bononi I … Tognon M (Oncotarget 2016) 3

Products for MIR1281 Gene

Sources for MIR1281 Gene

Loading form....