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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR128-2 (MicroRNA 128-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR128-2 include Lung Cancer and Pancreatitis, Hereditary. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03J035744 | Enhancer | 0.5 | Ensembl | 600.7 | +1.1 | 1125 | 2 | POLR2A RAD21 USF1 SIN3A SMARCA4 SP1 | MIR128-2 NONHSAG034747.2 Hsa-Mir-574_5p-046 ARPP21 STAC | |
GH03J035743 | Enhancer | 0.2 | Ensembl | 600.7 | -0.5 | -475 | 0.4 | MIR128-2 ARPP21 NONHSAG034747.2 STAC | ||
GH03J035676 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE dbSUPER | 10.4 | -64.9 | -64888 | 5.2 | POLR2A SMARCA4 SPI1 | ARPP21 ARPP21-AS1 MIR128-2 HSALNG0025117 HSALNG0025119 STAC | |
GH03J035778 | Enhancer | 0.5 | Ensembl | 12.2 | +33.8 | 33825 | 0.2 | NR2F2 POLR2A HNF4A RXRA SMARCA4 SP1 | MIR128-2 Hsa-Mir-574_5p-046 NONHSAG034747.2 ARPP21 STAC | |
GH03J035707 | Enhancer | 0.5 | dbSUPER | 11.4 | -35.8 | -35813 | 1.6 | JUN JUND EP300 SPI1 FOS | MIR128-2 HSALNG0025119 HSALNG0025117 ARPP21 STAC |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | ISS | 19228967 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | ISS | 19228967 |
GO:0010985 | negative regulation of lipoprotein particle clearance | ISS | -- |
GO:0035195 | gene silencing by miRNA | ISS | 19228967 |
GO:0042632 | cholesterol homeostasis | ISS | -- |
GO:0055088 | lipid homeostasis | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000046FA49_9606 | precursor_RNA | 84 | 6 |
HGNC: 31511, RefSeq: NR_029824, Ensembl: ENST00000384893 (view in UCSC) , miRBase: MI0000727, Rfam: RF00649, |
URS000024A59E_9606 | miRNA | 21 | 6 |
LncBase: hsa-miR-128-3p, miRBase: MIMAT0000424, MirGeneDB: Hsa-Mir-128-P1_3p, Hsa-Mir-128-P2_3p, TarBase: hsa-miR-128-3p, ENA: AJ550404.1:1..21:ncRNA, LM379042.1:1..21:ncRNA, LM608487.1:50..70:ncRNA, LM608654.1:52..72:ncRNA, |
URS000075ECF1_9606 | miRNA | 23 | 4 |
RefSeq: NR_029824, miRBase: MIMAT0031095, MirGeneDB: Hsa-Mir-128-P2_5p, ENA: LM608654.1:15..37:ncRNA, |
URS0000637802_9606 | precursor_RNA | 83 | 1 |
Rfam: RF00649, |
URS0000EFE84B_9606 | precursor_RNA | 59 | 1 |
MirGeneDB: Hsa-Mir-128-P2, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-128-2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-128-2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir128-2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-128-2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-128a 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-128-2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-128-2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-128-1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-128-2 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
lung cancer |
|
|
pancreatitis, hereditary |
|
|
acute promyelocytic leukemia |
|
|
leukemia, acute lymphoblastic |
|
|
leukemia, acute myeloid |
|