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MIR128-2 Gene(RNA Gene)

MicroRNA 128-2

GCID:
GC03P035753
GIFtS:
19
Genes Participants
UDN Logo

Aliases for MIR128-2 Gene

Subcategory (RNA class) for MIR128-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR128-2 Gene

  • MicroRNA 128-2 2 3 5
  • MicroRNA 128b 2 3
  • Hsa-Mir-128-2 3
  • Hsa-Mir-128b 3
  • Mir-128-2 3
  • MIRN128-2 3
  • Mir-128b 3
  • MIRN128B 3
  • MIR128B 3

External Ids for MIR128-2 Gene

ORGUL Members for MIR128-2 Gene

Previous HGNC Symbols for MIR128-2 Gene

  • MIRN128B
  • MIRN128-2

Previous GeneCards Identifiers for MIR128-2 Gene

  • GC03P035764
  • GC03P035787
  • GC03P035790
  • GC03P035746
  • GC03P035747
  • GC03P035748
  • GC03P035749
  • GC03P035750
  • GC03P035751
  • GC03P035752

Summaries for MIR128-2 Gene

Entrez Gene Summary for MIR128-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR128-2 Gene

MIR128-2 (MicroRNA 128-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

Additional gene information for MIR128-2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR128-2 Gene

Genomics for MIR128-2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR128-2 Gene

Promoters and enhancers for MIR128-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I035676 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 10.3 -65.6 -65617 3.8 POLR2A ARPP21 ARPP21-AS1 MIR128-2 GC03P035745
GH03I035680 Promoter/Enhancer 0.7 EPDnew dbSUPER 10.3 -63.6 -63555 0.1 ARPP21 ARPP21-AS1 MIR128-2 GC03P035745
GH03I035707 Enhancer 0.5 dbSUPER 11.4 -35.8 -35813 1.6 JUND JUN FOS EP300 SPI1 MIR128-2 GC03P035745 ARPP21-AS1 ARPP21
GH03I035687 Enhancer 0.4 dbSUPER 10.7 -56.4 -56440 1.1 FOXA2 FOXA1 MIR128-2 ARPP21-AS1 ARPP21 GC03P035745
GH03I035492 Enhancer 0.3 ENCODE 10.7 -251.5 -251500 1.1 CREB1 MIR128-2 GC03P035521 LOC101928135
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR128-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR128-2 Gene

Genomic Locations for MIR128-2 Gene
chr3:35,744,476-35,744,559
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr3:35,785,968-35,786,051
(GRCh37/hg19)

Genomic View for MIR128-2 Gene

Genes around MIR128-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR128-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR128-2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR128-2 Gene

Proteins for MIR128-2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR128-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR128-2 Gene

Domains & Families for MIR128-2 Gene

Gene Families for MIR128-2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR128-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR128-2 Gene

Function for MIR128-2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR128-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26501192
genes like me logo Genes that share ontologies with MIR128-2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR128-2 Gene

Localization for MIR128-2 Gene

Gene Ontology (GO) - Cellular Components for MIR128-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR128-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR128-2 Gene

Pathways & Interactions for MIR128-2 Gene

genes like me logo Genes that share pathways with MIR128-2: view

Pathways by source for MIR128-2 Gene

1 BioSystems pathway for MIR128-2 Gene
1 KEGG pathway for MIR128-2 Gene

Interacting Proteins for MIR128-2 Gene

Gene Ontology (GO) - Biological Process for MIR128-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010985 negative regulation of lipoprotein particle clearance ISS --
GO:0035195 gene silencing by miRNA IDA 26501192
GO:0042632 cholesterol homeostasis ISS --
GO:0055088 lipid homeostasis ISS --
GO:0090370 negative regulation of cholesterol efflux IDA 26501192
genes like me logo Genes that share ontologies with MIR128-2: view

No data available for SIGNOR curated interactions for MIR128-2 Gene

Drugs & Compounds for MIR128-2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR128-2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR128-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR128-2 Gene

No ASD Table

Relevant External Links for MIR128-2 Gene

GeneLoc Exon Structure for
MIR128-2
ECgene alternative splicing isoforms for
MIR128-2

Expression for MIR128-2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR128-2 Gene

mRNA expression in normal human tissues for MIR128-2 Gene
mRNA expression by GTEx for MIR128-2 Gene
genes like me logo Genes that share expression patterns with MIR128-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR128-2 Gene

Orthologs for MIR128-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR128-2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia cfa-mir-128-2 34
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-128-2 34
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir128-2 34
  • 98 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-128-2 34
  • 96 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-128a 34
  • 92 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-128-2 34
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-128-2 34
  • 92 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-128-1 34
  • 84 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-128-2 34
  • 48 (a)
 OneToOne
Species where no ortholog for MIR128-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR128-2 Gene

ENSEMBL:
Gene Tree for MIR128-2 (if available)
TreeFam:
Gene Tree for MIR128-2 (if available)

Paralogs for MIR128-2 Gene

No data available for Paralogs for MIR128-2 Gene

Variants for MIR128-2 Gene

Sequence variations from dbSNP and Humsavar for MIR128-2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000198891 -- 35,744,312(+) G/C upstream_transcript_variant
rs1000626637 -- 35,742,501(+) C/T upstream_transcript_variant
rs1001684519 -- 35,744,725(+) G/A downstream_transcript_variant
rs1006891589 -- 35,744,188(+) C/G upstream_transcript_variant
rs1007006065 -- 35,743,580(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR128-2 Gene

Variant ID Type Subtype PubMed ID
nsv590055 CNV gain 21841781
nsv526191 CNV loss 19592680

Additional Variant Information for MIR128-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR128-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR128-2 Gene

Disorders for MIR128-2 Gene

Additional Disease Information for MIR128-2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR128-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR128-2 Gene

Publications for MIR128-2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  2. MiR-128 regulation of glucose metabolism and cell proliferation in triple-negative breast cancer. (PMID: 29116653) Xiao M … Huang Y (The British journal of surgery 2018) 3 58
  3. VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells. (PMID: 28179359) Jang K … Slingerland JM (EMBO molecular medicine 2017) 3 58
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  5. AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128. (PMID: 27341528) Eterno V … Amato A (Scientific reports 2016) 3 58

Products for MIR128-2 Gene

Sources for MIR128-2 Gene

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