microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR128-2 Gene

Subcategory (RNA class) for MIR128-2 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR128-2 Gene

  • MicroRNA 128-2 2 3 5
  • Hsa-MiR-128-3p 163 173
  • MicroRNA 128b 2 3
  • Hsa-Mir-128-2 2 3
  • Hsa-Mir-128b 2 3
  • MIR128-2 2 5
  • Hsa-Mir-128-P2 178
  • MIMAT0031095 50
  • MIMAT0000424 50
  • MIRN128-2 3
  • Mir-128-2 3
  • MI0000727 50
  • MIRN128B 3
  • Mir-128b 3
  • MIR128B 3
  • RF00649 168

External Ids for MIR128-2 Gene

Previous HGNC Symbols for MIR128-2 Gene

  • MIRN128B
  • MIRN128-2

Previous GeneCards Identifiers for MIR128-2 Gene

  • GC03P035764
  • GC03P035787
  • GC03P035790
  • GC03P035746
  • GC03P035747
  • GC03P035754
  • GC03P035753
  • GC03P035752
  • GC03P035751
  • GC03P035748
  • GC03P035749

Summaries for MIR128-2 Gene

Entrez Gene Summary for MIR128-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR128-2 Gene

MIR128-2 (MicroRNA 128-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR128-2 include Lung Cancer and Pancreatitis, Hereditary. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR128-2 Gene

Additional gene information for MIR128-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR128-2 Gene

Genomics for MIR128-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR128-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J035744 Enhancer 0.5 Ensembl 600.7 +1.1 1125 2 POLR2A RAD21 USF1 SIN3A SMARCA4 SP1 MIR128-2 NONHSAG034747.2 Hsa-Mir-574_5p-046 ARPP21 STAC
GH03J035743 Enhancer 0.2 Ensembl 600.7 -0.5 -475 0.4 MIR128-2 ARPP21 NONHSAG034747.2 STAC
GH03J035676 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 10.4 -64.9 -64888 5.2 POLR2A SMARCA4 SPI1 ARPP21 ARPP21-AS1 MIR128-2 HSALNG0025117 HSALNG0025119 STAC
GH03J035778 Enhancer 0.5 Ensembl 12.2 +33.8 33825 0.2 NR2F2 POLR2A HNF4A RXRA SMARCA4 SP1 MIR128-2 Hsa-Mir-574_5p-046 NONHSAG034747.2 ARPP21 STAC
GH03J035707 Enhancer 0.5 dbSUPER 11.4 -35.8 -35813 1.6 JUN JUND EP300 SPI1 FOS MIR128-2 HSALNG0025119 HSALNG0025117 ARPP21 STAC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR128-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR128-2 Gene

Genomic Locations for MIR128-2 Gene
chr3:35,744,476-35,744,559
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr3:35,785,968-35,786,051
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR128-2 Gene

Genes around MIR128-2 on UCSC Golden Path with GeneCards custom track
MIR128-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR128-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR128-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR128-2 Gene

Proteins for MIR128-2 Gene

Post-translational modifications for MIR128-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR128-2 Gene

Domains & Families for MIR128-2 Gene

Gene Families for MIR128-2 Gene

genes like me logo Genes that share domains with MIR128-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR128-2 Gene

Function for MIR128-2 Gene

Phenotypes From GWAS Catalog for MIR128-2 Gene

Gene Ontology (GO) - Molecular Function for MIR128-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing ISS 19228967
genes like me logo Genes that share ontologies with MIR128-2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR128-2 Gene

Localization for MIR128-2 Gene

Gene Ontology (GO) - Cellular Components for MIR128-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR128-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR128-2 Gene

Pathways & Interactions for MIR128-2 Gene

PathCards logo

SuperPathways for MIR128-2 Gene

genes like me logo Genes that share pathways with MIR128-2: view

Pathways by source for MIR128-2 Gene

1 BioSystems pathway for MIR128-2 Gene
1 KEGG pathway for MIR128-2 Gene

Gene Ontology (GO) - Biological Process for MIR128-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS 19228967
GO:0010985 negative regulation of lipoprotein particle clearance ISS --
GO:0035195 gene silencing by miRNA ISS 19228967
GO:0042632 cholesterol homeostasis ISS --
GO:0055088 lipid homeostasis ISS --
genes like me logo Genes that share ontologies with MIR128-2: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR128-2 Gene

Drugs & Compounds for MIR128-2 Gene

No Compound Related Data Available

Transcripts for MIR128-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR128-2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000046FA49_9606 precursor_RNA 84 6

HGNC: 31511,

RefSeq: NR_029824,

Ensembl: ENST00000384893 (view in UCSC) ,

miRBase: MI0000727,

Rfam: RF00649,

ENA: LM608654.1:1..84:precursor_RNA,

URS000024A59E_9606 miRNA 21 6

RefSeq: NR_029672, NR_029824,

LncBase: hsa-miR-128-3p,

miRBase: MIMAT0000424,

MirGeneDB: Hsa-Mir-128-P1_3p, Hsa-Mir-128-P2_3p,

TarBase: hsa-miR-128-3p,

ENA: AJ550404.1:1..21:ncRNA, LM379042.1:1..21:ncRNA, LM608487.1:50..70:ncRNA, LM608654.1:52..72:ncRNA,

URS000075ECF1_9606 miRNA 23 4

RefSeq: NR_029824,

miRBase: MIMAT0031095,

MirGeneDB: Hsa-Mir-128-P2_5p,

ENA: LM608654.1:15..37:ncRNA,

URS0000637802_9606 precursor_RNA 83 1

Rfam: RF00649,

URS0000EFE84B_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-128-P2,

MIR128-2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR128-2 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR128-2 Gene

No ASD Table

Relevant External Links for MIR128-2 Gene

GeneLoc Exon Structure for
MIR128-2

Expression for MIR128-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR128-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR128-2

genes like me logo Genes that share expression patterns with MIR128-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR128-2 Gene

Orthologs for MIR128-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR128-2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-128-2 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-128-2 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir128-2 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-128-2 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-128a 31
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-128-2 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-128-2 31
  • 92 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-128-1 31
  • 84 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-128-2 31
  • 48 (a)
OneToOne
Species where no ortholog for MIR128-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR128-2 Gene

ENSEMBL:
Gene Tree for MIR128-2 (if available)
TreeFam:
Gene Tree for MIR128-2 (if available)

Paralogs for MIR128-2 Gene

No data available for Paralogs for MIR128-2 Gene

Variants for MIR128-2 Gene

Additional dbSNP identifiers (rs#s) for MIR128-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR128-2 Gene

Variant ID Type Subtype PubMed ID
nsv526191 CNV loss 19592680
nsv590055 CNV gain 21841781

Additional Variant Information for MIR128-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR128-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR128-2 Gene

Disorders for MIR128-2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR128-2 Gene - From: miR2Disease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR128-2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR128-2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR128-2 Gene

Publications for MIR128-2 Gene

  1. Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells. (PMID: 23019226) Qian P … Zhu T (Cancer research 2012) 2 3
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 41
  3. MicroRNA‑128‑b regulates epidermal growth factor receptor expression in non‑small cell lung cancer. (PMID: 31638205) Li L … Wang D (Molecular medicine reports 2019) 3
  4. Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128. (PMID: 30076414) He F … Cao J (Oncogene 2019) 3
  5. Knockdown of HCP5 exerts tumor-suppressive functions by up-regulating tumor suppressor miR-128-3p in anaplastic thyroid cancer. (PMID: 31102936) Chen J … Meng Q (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3

Products for MIR128-2 Gene

Sources for MIR128-2 Gene