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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR128-1 (MicroRNA 128-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR128-1 include Breast Cancer and Pituitary Adenoma. Among its related pathways are Hematopoietic Stem Cell Differentiation and Parkinsons Disease Pathway.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J135664 | Enhancer | 0.7 | Ensembl | 600.7 | +0.3 | 303 | 4.2 | SP1 REST RELA IKZF2 PKNOX1 EED ARID3A DPF2 RELB RUNX3 | MIR128-1 R3HDM1 ZRANB3 RAB3GAP1 MAP3K19 DARS1 UBXN4 MCM6 NONHSAG029367.2 piR-61029-084 | |
GH02J135657 | Enhancer | 0.6 | ENCODE | 0.4 | -7.2 | -7233 | 0.9 | EED RUNX3 CBFB ARNT ELF1 NBN HDGF JUNB TBX21 ATF7 | RF00026-581 RNU6-512P MIR128-1 NONHSAG029367.2 UBXN4 R3HDM1 | |
GH02J135687 | Enhancer | 0.6 | Ensembl | 0.4 | +22.7 | 22704 | 0.6 | IKZF2 TRIM22 EED RELB RUNX3 ARNT NBN IKZF1 BHLHE40 TBX21 | R3HDM1 ZRANB3 UBXN4 piR-61029-084 MIR128-1 | |
GH02J135662 | Enhancer | 0.3 | Ensembl | 0.7 | -3.1 | -3096 | 0.2 | FOSL1 | UBXN4 MIR128-1 RNU6-512P RF00026-581 NONHSAG029367.2 R3HDM1 | |
GH02J135686 | Enhancer | 0.4 | Ensembl | 0.4 | +20.1 | 20104 | 0.6 | CEBPB JUND FOS | LCT piR-61029-084 MIR128-1 UBXN4 R3HDM1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | ISS | 19228967 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | ISS | 19228967 |
GO:0010985 | negative regulation of lipoprotein particle clearance | ISS | -- |
GO:0035195 | gene silencing by miRNA | ISS | 19228967 |
GO:0042632 | cholesterol homeostasis | ISS | -- |
GO:0055088 | lipid homeostasis | ISS | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00002D9CBA_9606 | precursor_RNA | 82 | 6 |
HGNC: 31510, RefSeq: NR_029672, Ensembl: ENST00000384921 (view in UCSC) , miRBase: MI0000447, Rfam: RF00649, ENA: HI454488.1:1..82:misc_RNA, LM608487.1:1..82:precursor_RNA, |
URS000024A59E_9606 | miRNA | 21 | 6 |
LncBase: hsa-miR-128-3p, miRBase: MIMAT0000424, MirGeneDB: Hsa-Mir-128-P1_3p, Hsa-Mir-128-P2_3p, TarBase: hsa-miR-128-3p, ENA: AJ550404.1:1..21:ncRNA, LM379042.1:1..21:ncRNA, LM608487.1:50..70:ncRNA, LM608654.1:52..72:ncRNA, |
URS0000537082_9606 | miRNA | 23 | 4 |
RefSeq: NR_029672, miRBase: MIMAT0026477, MirGeneDB: Hsa-Mir-128-P1_5p, |
URS000047DC24_9606 | precursor_RNA | 82 | 1 | |
URS0000EFCBF4_9606 | precursor_RNA | 57 | 1 |
MirGeneDB: Hsa-Mir-128-P1, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-128b 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir128-1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-128-1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-128-1 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-128-1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-128-1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-128-1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-128-2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01102274.1 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv34026 | CNV | loss | 18971310 |
nsv1000750 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|
pituitary adenoma |
|
|
glioblastoma multiforme |
|
|
autism spectrum disorder |
|
|
leukemia, acute lymphoblastic |
|