microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1275 Gene

Data sources for MIR1275 Gene:

RNA type for MIR1275 Gene

miRNA

Aliases for MIR1275 Gene

External Ids for MIR1275 Gene

Previous HGNC Symbols for MIR1275 Gene

  • MIRN1275

Previous GeneCards Identifiers for MIR1275 Gene

  • GC00U922833
  • GC06M034076
  • GC06M033967
  • GC06M034527
  • GC06M035546
  • GC06M038923
  • GC06M039614
  • GC06M039935
  • GC06M041264
  • GC06M036225
  • GC06M036634
  • GC06M036988
  • GC06M037339
  • GC06M037691
  • GC06M038041
  • GC06M038431
  • GC06M038771
  • GC06M042203
  • GC06M043456

Summaries for MIR1275 Gene

Entrez Gene Summary for MIR1275 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1275 Gene

MIR1275 (MicroRNA 1275) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1275 include Multiple Sclerosis.

Rfam classification for MIR1275 Gene

Additional gene information for MIR1275 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1275 Gene

Genomics for MIR1275 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1275 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033896 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 11 +103.9 103850 3.6 NFIC ZNF217 ZNF316 TCF7L2 FOXA1 JUND EGR1 NCOA3 PRDM4 ZNF687 LINC01016 piR-31687 piR-31848 piR-31934 piR-34603 piR-34737 piR-41256 piR-34779 piR-41267 piR-32198
GH06J033843 Enhancer 0.8 Ensembl dbSUPER 10.4 +156.6 156608 1.7 MYC ZIC2 ZNF341 MNT ZNF189 EGR1 RLF KLF1 L3MBTL2 MEIS2 MLN LEMD2 GRM4 MIR1275 IP6K3 HMGA1 HSALNG0049580 lnc-ITPR3-9
GH06J033926 Enhancer 0.7 Ensembl dbSUPER 11.1 +73.1 73138 1 ELF1 ZFP91 PKNOX1 FOXM1 SP1 DDX20 CHD2 PBX2 piR-38707 piR-48833 LEMD2 MIR1275 MLN IP6K3 GRM4 ENSG00000233183 lnc-GRM4-2
GH06J033929 Enhancer 0.6 Ensembl dbSUPER 11.1 +70.1 70050 0.4 EBF1 BHLHE40 ZNF140 IKZF2 SCRT2 RF00017-4951 LEMD2 RING1 HCG25 VPS52 BRD2 TAF11 RXRB MIR1275 MLN
GH06J033861 Enhancer 0.6 ENCODE 11.4 +138.8 138772 0.2 MAFF IRF4 ZNF316 NFE2 MAFK BATF MAFG ATF2 JUNB BACH1 piR-46103 MLN MIR1275 LOC105375027 lnc-ITPR3-9 piR-49539 GRM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1275 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1275 Gene

Latest Assembly
chr6:33,999,972-34,000,051
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand

Previous Assembly
chr6:33,967,749-33,967,828
(GRCh37/hg19 by Entrez Gene)
Size:
80 bases
Orientation:
Minus strand

chr6:33,967,749-33,967,828
(GRCh37/hg19 by Ensembl)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR1275 Gene

Genes around MIR1275 on UCSC Golden Path with GeneCards custom track
MIR1275 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1275 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1275 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1275 Gene

Proteins for MIR1275 Gene

Post-translational modifications for MIR1275 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1275 Gene

Domains & Families for MIR1275 Gene

Gene Families for MIR1275 Gene

HGNC:
genes like me logo Genes that share domains with MIR1275: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1275 Gene

Function for MIR1275 Gene

Phenotypes From GWAS Catalog for MIR1275 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1275 Gene

Localization for MIR1275 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1275 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1275 Gene

Pathways & Interactions for MIR1275 Gene

PathCards logo

SuperPathways for MIR1275 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1275 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1275: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1275 Gene

Drugs & Compounds for MIR1275 Gene

No Compound Related Data Available

Transcripts for MIR1275 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1275 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006C1415_9606 pre_miRNA 80 5

RefSeq: NR_031681,

Ensembl: ENST00000408770 (view in UCSC) ,

miRBase: MI0006415,

Rfam: RF02022,

ENA: LM610165.1:1..80:precursor_RNA,

URS000009EA8F_9606 miRNA 17 5

RefSeq: NR_031681,

LncBase: hsa-miR-1275,

miRBase: MIMAT0005929,

TarBase: hsa-miR-1275,

ENA: LM380714.1:1..17:ncRNA, LM610165.1:18..34:ncRNA,

URS0001BBFDE1_9606 pre_miRNA 80 1

Rfam: RF02022,

MIR1275 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR1275 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1275 Gene

No ASD Table

Relevant External Links for MIR1275 Gene

GeneLoc Exon Structure for
MIR1275

Expression for MIR1275 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1275 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1275

genes like me logo Genes that share expression patterns with MIR1275: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1275 Gene

Orthologs for MIR1275 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1275 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1275 30
  • 100 (a)
OneToOne
Species where no ortholog for MIR1275 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR1275 Gene

ENSEMBL:
Gene Tree for MIR1275 (if available)
TreeFam:
Gene Tree for MIR1275 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1275

Paralogs for MIR1275 Gene

No data available for Paralogs for MIR1275 Gene

Variants for MIR1275 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1275 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1275 Gene

Variant ID Type Subtype PubMed ID
esv23448 CNV loss 19812545
esv2661199 CNV deletion 23128226
esv3608630 CNV gain 21293372
esv3608649 CNV loss 21293372
esv3608650 CNV gain 21293372
nsv602843 CNV gain 21841781
nsv602861 CNV loss 21841781

Additional Variant Information for MIR1275 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1275
Leiden Open Variation Database (LOVD)
MIR1275

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1275 Gene

Disorders for MIR1275 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1275 Gene - From: MID and COP

Disorder Aliases PubMed IDs
multiple sclerosis
  • multiple sclerosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1275

genes like me logo Genes that share disorders with MIR1275: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1275 Gene

Publications for MIR1275 Gene

  1. Blood miR-1275 is associated with risk of ischemic stroke and inhibits macrophage foam cell formation by targeting ApoC2 gene. (PMID: 31935511) Li L … Lv Z (Gene 2020) 3
  2. Long noncoding RNA HAND2-AS1 restrains proliferation and metastasis of breast cancer cells through sponging miR-1275 and promoting SOX7. (PMID: 31683462) Wang Y … Cai X (Cancer biomarkers : section A of Disease markers 2020) 3
  3. Long non-coding RNA DANCR induces chondrogenesis by regulating the miR-1275/MMP-13 axis in synovial fluid-derived mesenchymal stem cells. (PMID: 31841200) Fang P … Zhou LW (European review for medical and pharmacological sciences 2019) 3
  4. LncRNA HAND2-AS1 inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells by sponging with micRNA-1275. (PMID: 30915755) Yang JR … Zeng Y (European review for medical and pharmacological sciences 2019) 3
  5. MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1. (PMID: 31357957) Mei JW … Shu YJ (BMC cancer 2019) 3

Products for MIR1275 Gene

Sources for MIR1275 Gene