microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1275 Gene

Subcategory (RNA class) for MIR1275 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR1275 Gene

  • MicroRNA 1275 2 3 5
  • Hsa-MiR-1275 166 177
  • Hsa-Mir-1275 3
  • MIMAT0005929 51
  • MI0006415 51
  • Mir-1275 3
  • MIRN1275 3
  • MIR1275 2
  • RF02022 172

External Ids for MIR1275 Gene

Previous HGNC Symbols for MIR1275 Gene

  • MIRN1275

Previous GeneCards Identifiers for MIR1275 Gene

  • GC00U922833
  • GC06M034076
  • GC06M033967
  • GC06M034527
  • GC06M035546
  • GC06M038923
  • GC06M039614
  • GC06M039935
  • GC06M036225
  • GC06M036634
  • GC06M036988
  • GC06M037339
  • GC06M037691
  • GC06M038041
  • GC06M038431
  • GC06M038771

Summaries for MIR1275 Gene

Entrez Gene Summary for MIR1275 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1275 Gene

MIR1275 (MicroRNA 1275) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1275 include Multiple Sclerosis.

Rfam classification for MIR1275 Gene

Additional gene information for MIR1275 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1275 Gene

Genomics for MIR1275 Gene

GeneHancer (GH) Regulatory Elements for MIR1275 Gene

Promoters and enhancers for MIR1275 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033895 Enhancer 0.8 Ensembl ENCODE 11 +103.5 103451 3.2 ZNF217 MYC ZNF316 NFIC ZNF592 ESR1 ZFHX2 FOXA1 EGR1 PRDM4 LINC01016 piR-36836 piR-37036 piR-33550 piR-39897 piR-39970 piR-37368 piR-37422 piR-37515 piR-37549
GH06J033966 Enhancer 0.6 dbSUPER 12 +32.4 32387 2.7 CTCF TEAD4 REST RAD21 YY1 ZFHX2 MIER2 TEAD3 GTF2F1 ZNF184 MIR1275 LEMD2 MLN hsa-miR-5095-424 lnc-GRM4-2 piR-35302 RF00017-5440
GH06J033929 Enhancer 0.7 Ensembl dbSUPER 11.1 +70.1 70050 0.4 EBF1 TBX21 SMARCA4 BHLHE40 IKZF2 ZNF140 SCRT2 RF00017-5440 LEMD2 MIR1275 MLN IP6K3 GRM4 piR-58548 lnc-GRM4-2
GH06J033861 Enhancer 0.6 ENCODE 11.4 +138.8 138772 0.2 TCF12 ZNF316 MAFF MAFK NFE2 BATF IRF4 MAFG ATF2 JUNB piR-46103 MLN MIR1275 lnc-ITPR3-9 LOC105375027 piR-49539
GH06J033962 Enhancer 0.6 Ensembl dbSUPER 11.9 +37.7 37650 1.6 FOS GATA1 MYC MIR1275 LEMD2 MLN piR-35302 hsa-miR-5095-424 lnc-GRM4-2 RF00017-5440
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1275 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1275 Gene

Genomic Locations for MIR1275 Gene
chr6:33,999,972-34,000,051
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand
chr6:33,967,749-33,967,828
(GRCh37/hg19)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR1275 Gene

Genes around MIR1275 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1275 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1275 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1275 Gene

Proteins for MIR1275 Gene

Post-translational modifications for MIR1275 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1275 Gene

Domains & Families for MIR1275 Gene

Gene Families for MIR1275 Gene

HGNC:
genes like me logo Genes that share domains with MIR1275: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1275 Gene

Function for MIR1275 Gene

Phenotypes From GWAS Catalog for MIR1275 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1275 Gene

Localization for MIR1275 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1275 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1275 Gene

Pathways & Interactions for MIR1275 Gene

PathCards logo

SuperPathways for MIR1275 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR1275 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1275 Gene

Drugs & Compounds for MIR1275 Gene

No Compound Related Data Available

Transcripts for MIR1275 Gene

mRNA/cDNA for MIR1275 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1275 Gene

No ASD Table

Relevant External Links for MIR1275 Gene

GeneLoc Exon Structure for
MIR1275

Expression for MIR1275 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1275 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1275

genes like me logo Genes that share expression patterns with MIR1275: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1275 Gene

Orthologs for MIR1275 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1275 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1275 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR1275 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1275 Gene

ENSEMBL:
Gene Tree for MIR1275 (if available)
TreeFam:
Gene Tree for MIR1275 (if available)

Paralogs for MIR1275 Gene

No data available for Paralogs for MIR1275 Gene

Variants for MIR1275 Gene

Additional dbSNP identifiers (rs#s) for MIR1275 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1275 Gene

Variant ID Type Subtype PubMed ID
esv23448 CNV loss 19812545
esv2661199 CNV deletion 23128226
esv3608630 CNV gain 21293372
esv3608649 CNV loss 21293372
esv3608650 CNV gain 21293372
nsv602843 CNV gain 21841781
nsv602861 CNV loss 21841781

Additional Variant Information for MIR1275 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1275

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1275 Gene

Disorders for MIR1275 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1275 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
multiple sclerosis
  • multiple sclerosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1275

genes like me logo Genes that share disorders with MIR1275: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1275 Gene

Publications for MIR1275 Gene

  1. MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7. (PMID: 29278769) Liu MD … Liu FY (Gene 2018) 3 54
  2. Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis. (PMID: 29550475) Ma X … Zhao C (Biochemical and biophysical research communications 2018) 3 54
  3. LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14. (PMID: 30078677) Zhou J … Xie R (Biochemical and biophysical research communications 2018) 3 54
  4. MiR-1275 promotes non-small cell lung cancer cell proliferation and metastasis by regulating LZTS3 expression. (PMID: 29771419) He J … Zhou XF (European review for medical and pharmacological sciences 2018) 3 54
  5. MircoRNA-1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1. (PMID: 30024092) Wu DM … Zheng YL (Journal of cellular and molecular medicine 2018) 3 54

Products for MIR1275 Gene

Sources for MIR1275 Gene