microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1271 Gene

Subcategory (RNA class) for MIR1271 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR1271 Gene

  • MicroRNA 1271 2 3 5
  • Hsa-MiR-1271-3p 168 179
  • Hsa-MiR-1271-5p 168 179
  • Hsa-Mir-1271 3
  • MIMAT0005796 53
  • MIMAT0022712 53
  • MI0003814 53
  • MIRN1271 3
  • MIR1271 2

External Ids for MIR1271 Gene

Previous HGNC Symbols for MIR1271 Gene

  • MIRN1271

Previous GeneCards Identifiers for MIR1271 Gene

  • GC00U922886
  • GC05P175729
  • GC05P175794

Summaries for MIR1271 Gene

Entrez Gene Summary for MIR1271 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1271 Gene

MIR1271 (MicroRNA 1271) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1271 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1271 Gene

Genomics for MIR1271 Gene

GeneHancer (GH) Regulatory Elements for MIR1271 Gene

Promoters and enhancers for MIR1271 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176367 Promoter 0.3 Ensembl 750.6 -0.7 -746 0.4 ARL10 MIR1271 RF00017-5132 RF00017-5131
GH05J176410 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +47.0 46970 8.8 ZNF24 SP1 CTCF SREBF1 POLR2A MIXL1 MYC NFYC ZNF701 L3MBTL2 CLTB ARL10 UIMC1 ENSG00000251414 FAF2 NSD1 HIGD2A UNC5A GPRIN1 NOP16
GH05J176552 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 +185.9 185862 3.5 POLR2A ZNF362 MNT MAFK FOSL2 GLIS2 CREB1 ZIC2 RFX1 ZBTB33 FAF2 ARL10 MIR1271 KIAA1191 UNC5A CDHR2 ENSG00000207420 RN7SL684P lnc-RNF44-1
GH05J176340 Enhancer 0.8 ENCODE 11.6 -26.0 -25984 2.6 HLF ZNF121 NFIB SP1 CBFA2T2 SP7 ZNF644 PKNOX1 CREB1 CEBPA ARL10 MIR1271 KIAA1191 SIMC1 FAM153B ENSG00000250909 RF00017-5132 RF00017-5131
GH05J176423 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.8 +58.1 58094 5.6 ELF1 PKNOX1 ZSCAN29 ZFP91 VEZF1 GLIS1 FAF2 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 GPRIN1 ENSG00000251414 HIGD2A CLTB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1271 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1271 Gene

Genomic Locations for MIR1271 Gene
chr5:176,367,946-176,368,031
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr5:175,794,949-175,795,034
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR1271 Gene

Genes around MIR1271 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1271 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1271 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1271 Gene

Proteins for MIR1271 Gene

Post-translational modifications for MIR1271 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1271 Gene

Domains & Families for MIR1271 Gene

Gene Families for MIR1271 Gene

HGNC:
genes like me logo Genes that share domains with MIR1271: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1271 Gene

Function for MIR1271 Gene

Phenotypes From GWAS Catalog for MIR1271 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1271 Gene

Localization for MIR1271 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1271 Gene

Pathways & Interactions for MIR1271 Gene

PathCards logo

SuperPathways for MIR1271 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1271 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1271 Gene

Drugs & Compounds for MIR1271 Gene

No Compound Related Data Available

Transcripts for MIR1271 Gene

mRNA/cDNA for MIR1271 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(3) RNACentral transcripts :
(5) ENA transcripts :
(2) TarBase transcripts :
(2) LncBase transcripts :
(3) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1271 Gene

No ASD Table

Relevant External Links for MIR1271 Gene

GeneLoc Exon Structure for
MIR1271
ECgene alternative splicing isoforms for
MIR1271

Expression for MIR1271 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1271 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1271 Gene:

MIR1271
genes like me logo Genes that share expression patterns with MIR1271: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1271 Gene

Orthologs for MIR1271 Gene

Evolution for MIR1271 Gene

ENSEMBL:
Gene Tree for MIR1271 (if available)
TreeFam:
Gene Tree for MIR1271 (if available)

No data available for Orthologs for MIR1271 Gene

Paralogs for MIR1271 Gene

No data available for Paralogs for MIR1271 Gene

Variants for MIR1271 Gene

Sequence variations from dbSNP and Humsavar for MIR1271 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1003354377 -- 176,366,108(+) T/G upstream_transcript_variant
rs1003813163 -- 176,368,136(+) G/A downstream_transcript_variant
rs1004401373 -- 176,366,458(+) G/A upstream_transcript_variant
rs1004805819 -- 176,365,983(+) C/T upstream_transcript_variant
rs1004836896 -- 176,366,208(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1271 Gene

Variant ID Type Subtype PubMed ID
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Additional Variant Information for MIR1271 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1271

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1271 Gene

Disorders for MIR1271 Gene

Additional Disease Information for MIR1271

No disorders were found for MIR1271 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1271 Gene

Publications for MIR1271 Gene

  1. Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression. (PMID: 30823890) Liu BW … Cao XC (Journal of experimental & clinical cancer research : CR 2019) 3 56
  2. miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2. (PMID: 30483794) Chen X … Chen M (Molecular medicine reports 2019) 3 56
  3. Chemo-resistance of A172 glioblastoma cells is controlled by miR-1271-regulated Bcl-2. (PMID: 30248541) Yang L … Zeng CC (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  4. Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells. (PMID: 29331762) Li J … Zhang R (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  5. MiR-1271 Inhibits Cell Growth in Prostate Cancer by Targeting ERG. (PMID: 28551819) Wang M … Teng L (Pathology oncology research : POR 2018) 3 56

Products for MIR1271 Gene

Sources for MIR1271 Gene