microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1271 Gene

Subcategory (RNA class) for MIR1271 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR1271 Gene

  • MicroRNA 1271 2 3 5
  • Hsa-Mir-1271 2 3 178
  • Hsa-MiR-1271-5p 163 173
  • Hsa-MiR-1271-3p 163 173
  • MIR1271 2 5
  • MIMAT0022712 50
  • MIMAT0005796 50
  • MI0003814 50
  • MIRN1271 3

External Ids for MIR1271 Gene

Previous HGNC Symbols for MIR1271 Gene

  • MIRN1271

Previous GeneCards Identifiers for MIR1271 Gene

  • GC00U922886
  • GC05P175729
  • GC05P175794

Summaries for MIR1271 Gene

Entrez Gene Summary for MIR1271 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1271 Gene

MIR1271 (MicroRNA 1271) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1271 include Branchiooculofacial Syndrome and Opitz-Gbbb Syndrome.

Additional gene information for MIR1271 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1271 Gene

Genomics for MIR1271 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1271 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176367 Promoter 0.3 Ensembl 600.7 -0.7 -746 0.4 ARL10 MIR1271 HIGD2A RF00017-5134 RF00017-5133
GH05J176410 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +47.0 46970 8.8 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 TFE3 KDM1A CTCF ZNF692 CLTB ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 UIMC1 ENSG00000250909 MIR1271 KIAA1191
GH05J176552 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 +185.9 185862 3.5 CREB1 ZBTB33 RFX1 KDM1A ZIC2 ZNF341 ZBTB20 BMI1 ZKSCAN1 ZBTB17 FAF2 ENSG00000250909 NSD1 ENSG00000251414 ARL10 MIR1271 KIAA1191 UNC5A CDHR2 ENSG00000207420
GH05J176340 Enhancer 0.8 ENCODE 11.6 -26.0 -25984 2.6 CREB1 ATF7 PRDM10 PKNOX1 RXRB IRF2 SP1 CEBPA CTBP1 ZKSCAN8 ARL10 MIR1271 KIAA1191 SIMC1 FAM153B ENSG00000250909 RF00017-5134 RF00017-5133
GH05J176423 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.8 +58.1 58094 5.6 PKNOX1 ZSCAN29 ZFP91 VEZF1 GLIS1 ELF1 FAF2 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 GPRIN1 ENSG00000251414 HIGD2A CLTB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1271 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1271 Gene

Genomic Locations for MIR1271 Gene
chr5:176,367,946-176,368,031
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr5:175,794,949-175,795,034
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR1271 Gene

Genes around MIR1271 on UCSC Golden Path with GeneCards custom track
MIR1271 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1271 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1271 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1271 Gene

Proteins for MIR1271 Gene

Post-translational modifications for MIR1271 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1271 Gene

Domains & Families for MIR1271 Gene

Gene Families for MIR1271 Gene

HGNC:
genes like me logo Genes that share domains with MIR1271: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1271 Gene

Function for MIR1271 Gene

Phenotypes From GWAS Catalog for MIR1271 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1271 Gene

Localization for MIR1271 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1271 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1271 Gene

Pathways & Interactions for MIR1271 Gene

PathCards logo

SuperPathways for MIR1271 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1271 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1271 Gene

Drugs & Compounds for MIR1271 Gene

No Compound Related Data Available

Transcripts for MIR1271 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1271 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00001D4A78_9606 miRNA 22 6

RefSeq: NR_031569,

LncBase: hsa-miR-1271-3p,

miRBase: MIMAT0022712,

MirGeneDB: Hsa-Mir-1271_3p,

TarBase: hsa-miR-1271-3p,

ENA: LM383018.1:1..22:ncRNA, LM609629.1:51..72:ncRNA,

URS00001F61BA_9606 miRNA 22 6

RefSeq: NR_031569,

LncBase: hsa-miR-1271-5p,

miRBase: MIMAT0005796,

MirGeneDB: Hsa-Mir-1271_5p,

TarBase: hsa-miR-1271-5p,

ENA: LM380643.1:1..22:ncRNA, LM609629.1:15..36:ncRNA,

URS000075C9F1_9606 precursor_RNA 86 5

HGNC: 35252,

RefSeq: NR_031569,

Ensembl: ENST00000408537 (view in UCSC) ,

miRBase: MI0003814,

ENA: LM609629.1:1..86:precursor_RNA,

URS0000EFF557_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-1271,

MIR1271 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1271 Gene

No ASD Table

Relevant External Links for MIR1271 Gene

GeneLoc Exon Structure for
MIR1271

No data available for mRNA/cDNA for MIR1271 Gene

Expression for MIR1271 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1271 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1271

genes like me logo Genes that share expression patterns with MIR1271: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1271 Gene

Orthologs for MIR1271 Gene

Evolution for MIR1271 Gene

ENSEMBL:
Gene Tree for MIR1271 (if available)
TreeFam:
Gene Tree for MIR1271 (if available)

No data available for Orthologs for MIR1271 Gene

Paralogs for MIR1271 Gene

No data available for Paralogs for MIR1271 Gene

Variants for MIR1271 Gene

Additional dbSNP identifiers (rs#s) for MIR1271 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1271 Gene

Variant ID Type Subtype PubMed ID
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Additional Variant Information for MIR1271 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1271

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1271 Gene

Disorders for MIR1271 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR1271 Gene - From: DISEASES

Disorder Aliases PubMed IDs
branchiooculofacial syndrome
  • bofs
opitz-gbbb syndrome
  • hypertelorism with esophageal abnormality and hypospadias
upper respiratory tract disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1271

genes like me logo Genes that share disorders with MIR1271: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1271 Gene

Publications for MIR1271 Gene

  1. Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression. (PMID: 30823890) Liu BW … Cao XC (Journal of experimental & clinical cancer research : CR 2019) 3
  2. miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2. (PMID: 30483794) Chen X … Chen M (Molecular medicine reports 2019) 3
  3. MicroRNA-1271 functions as a potential tumor suppressor in hepatitis B virus-associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1. (PMID: 30565670) Chen Y … Tang D (Journal of cellular physiology 2019) 3
  4. Chemo-resistance of A172 glioblastoma cells is controlled by miR-1271-regulated Bcl-2. (PMID: 30248541) Yang L … Zeng CC (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  5. Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells. (PMID: 29331762) Li J … Zhang R (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3

Products for MIR1271 Gene

Sources for MIR1271 Gene