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Aliases for MIR127 Gene

Subcategory (RNA class) for MIR127 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR127 Gene

  • MicroRNA 127 2 3 5
  • Hsa-Mir-127 3
  • MiRNA127 3
  • Mir-127 3
  • MIRN127 3

External Ids for MIR127 Gene

Previous HGNC Symbols for MIR127 Gene

  • MIRN127

Previous GeneCards Identifiers for MIR127 Gene

  • GC14P100467
  • GC14P100849
  • GC14P101349
  • GC14P101059
  • GC14P101284
  • GC14P101912
  • GC14P102221
  • GC14P102388
  • GC14P102566
  • GC14P102739
  • GC14P102913

Summaries for MIR127 Gene

Entrez Gene Summary for MIR127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR127 Gene

MIR127 (MicroRNA 127) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR127 include Bladder Cancer and Myelodysplastic Syndrome. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR127 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR127 Gene

Genomics for MIR127 Gene

GeneHancer (GH) Regulatory Elements for MIR127 Gene

Promoters and enhancers for MIR127 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100883 Enhancer 0.5 ENCODE dbSUPER 650.7 +1.9 1854 2.8 ZKSCAN1 GC14P103289 MIR127 MIR432 RTL1 MIR136 MEG3 MIR370 SNORD113-1 SNORD113-2 PPP2R5C
GH14J100819 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -56.4 -56443 13.4 ELF3 PKNOX1 FOXA2 ZSCAN4 NFXL1 ZNF48 RAD21 RFX5 ZNF280A SLC30A9 ENSG00000274884 DLK1 MEG3 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433 RTL1
GH14J100691 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -189.6 -189562 4.1 FOXA2 MLX SIN3A ZNF48 ETS1 YY1 GLIS2 ZNF143 FOS SP5 DLK1 MIR493 MIR337 MIR433 MIR431 MIR127 MIR136 RTL1 LINC00523 LOC105370668
GH14J100486 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -396.5 -396540 0.6 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF143 ATF7 RUNX3 JUNB MXD4 RN7SKP92 MIR337 MIR127 MIR136 MIR433 RTL1 MIR431 MIR493 GC14P103466 GC14M100431
GH14J100657 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 -218.5 -218468 13.4 ATF1 FOXA2 ARID4B DMAP1 ZNF2 ZNF48 ZNF143 ATF7 FOS RXRA LOC105370667 DLK1 WARS WDR25 BEGAIN MEG9 MIR493 MIR337 MIR127 MIR431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR127 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR127 Gene

Genomic Locations for MIR127 Gene
chr14:100,882,979-100,883,075
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr14:101,349,316-101,349,412
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR127 Gene

Genes around MIR127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR127 Gene

Proteins for MIR127 Gene

Post-translational modifications for MIR127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR127 Gene

Domains & Families for MIR127 Gene

Gene Families for MIR127 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR127 Gene

Function for MIR127 Gene

Phenotypes From GWAS Catalog for MIR127 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR127 Gene

Localization for MIR127 Gene

Gene Ontology (GO) - Cellular Components for MIR127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR127: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR127 Gene

Pathways & Interactions for MIR127 Gene

genes like me logo Genes that share pathways with MIR127: view

Pathways by source for MIR127 Gene

2 BioSystems pathways for MIR127 Gene

Interacting Proteins for MIR127 Gene

Gene Ontology (GO) - Biological Process for MIR127 Gene

None

No data available for SIGNOR curated interactions for MIR127 Gene

Drugs & Compounds for MIR127 Gene

No Compound Related Data Available

Transcripts for MIR127 Gene

mRNA/cDNA for MIR127 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR127 Gene

No ASD Table

Relevant External Links for MIR127 Gene

GeneLoc Exon Structure for
MIR127
ECgene alternative splicing isoforms for
MIR127

Expression for MIR127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR127 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR127 Gene:

MIR127
genes like me logo Genes that share expression patterns with MIR127: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR127 Gene

Orthologs for MIR127 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR127 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-127 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-127 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir127 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-127 34
  • 83 (a)
OneToOne
Species where no ortholog for MIR127 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR127 Gene

ENSEMBL:
Gene Tree for MIR127 (if available)
TreeFam:
Gene Tree for MIR127 (if available)

Paralogs for MIR127 Gene

No data available for Paralogs for MIR127 Gene

Variants for MIR127 Gene

Sequence variations from dbSNP and Humsavar for MIR127 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000317571 -- 100,881,905(+) G/A upstream_transcript_variant
rs1002034807 -- 100,883,388(+) A/C/G downstream_transcript_variant
rs1003148534 -- 100,882,423(+) A/T upstream_transcript_variant
rs1006137561 -- 100,881,424(+) C/T upstream_transcript_variant
rs1006170180 -- 100,881,621(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR127 Gene

Variant ID Type Subtype PubMed ID
nsv509549 CNV insertion 20534489
esv3635518 CNV gain 21293372

Additional Variant Information for MIR127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR127 Gene

Disorders for MIR127 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR127 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
myelodysplastic syndrome
  • mds
breast cancer
  • breast cancer, familial
prostate cancer
  • prostate cancer, susceptibility to
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR127

genes like me logo Genes that share disorders with MIR127: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR127 Gene

Publications for MIR127 Gene

  1. DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. (PMID: 27998789) Pronina IV … Braga EA (Gene 2017) 3 58
  2. MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. (PMID: 28866093) Herr I … Fellenberg J (Cancer letters 2017) 3 58
  3. Dysregulated miR-127-5p contributes to type II collagen degradation by targeting matrix metalloproteinase-13 in human intervertebral disc degeneration. (PMID: 28559201) Hua WB … Yang C (Biochimie 2017) 3 58
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  5. MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3. (PMID: 27645894) Gao X … Wu H (European journal of pharmacology 2016) 3 58

Products for MIR127 Gene

Sources for MIR127 Gene

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