microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR127 Gene

Subcategory (RNA class) for MIR127 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR127 Gene

  • MIMAT0004604 50
  • MI0000472 50
  • MiRNA127 3
  • MIRN127 3
  • Mir-127 3
  • RF00676 168

External Ids for MIR127 Gene

Previous HGNC Symbols for MIR127 Gene

  • MIRN127

Previous GeneCards Identifiers for MIR127 Gene

  • GC14P100467
  • GC14P100849
  • GC14P101349
  • GC14P101059
  • GC14P101284
  • GC14P103469
  • GC14P103659
  • GC14P103870
  • GC14P104252
  • GC14P101912
  • GC14P102221
  • GC14P102388
  • GC14P102566
  • GC14P102739
  • GC14P102913
  • GC14P103089
  • GC14P103287

Summaries for MIR127 Gene

Entrez Gene Summary for MIR127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR127 Gene

MIR127 (MicroRNA 127) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR127 include Bladder Cancer and Myelodysplastic Syndrome. Among its related pathways are Parkinsons Disease Pathway and Alzheimers Disease.

Rfam classification for MIR127 Gene

Additional gene information for MIR127 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR127 Gene

Genomics for MIR127 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR127 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100883 Enhancer 0.4 ENCODE dbSUPER 600.7 +1.9 1854 2.8 ZKSCAN1 MIR127 MIR136 MIR432 MEG3 MIR370 SNORD113-1 SNORD113-2 PPP2R5C MEG8 RTL1
GH14J100819 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -56.4 -56443 13.4 HNRNPL CREB1 GATAD2A ATF7 REST RFX5 CTCF RCOR2 ZSCAN4 RBFOX2 MEG3 ENSG00000274884 GQ183494 DLK1 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433
GH14J100381 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.5 -495.1 -495078 13.8 HNRNPL CTCF TEAD4 REST KDM1A ZNF692 GABPA ZIC2 ZSCAN4 PATZ1 WDR25 WARS1 SLC25A47 BEGAIN MIR337 MIR493 MIR431 MIR433 MIR127 MIR136
GH14J100396 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -479.1 -479126 14.9 GATAD2A ATF7 ZNF629 TFE3 RFX1 SOX13 RCOR2 JUND PRDM1 ZIC2 LOC105370664 WDR25 WARS1 SLC25A47 MIR337 MIR127 MIR431 MIR433 MIR493 MIR136
GH14J100788 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -92.2 -92242 5.5 HNRNPL LEF1 IKZF1 JUND MTA2 PHF21A POLR2A MTA1 REST BRD9 DLK1 MIR493 MIR337 MIR127 MIR136 MIR431 MIR433 RTL1 BEGAIN RF00017-1674
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR127 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR127 Gene

Genomic Locations for MIR127 Gene
chr14:100,882,979-100,883,075
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr14:101,349,316-101,349,412
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR127 Gene

Genes around MIR127 on UCSC Golden Path with GeneCards custom track
MIR127 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR127 Gene

Proteins for MIR127 Gene

Post-translational modifications for MIR127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR127 Gene

Domains & Families for MIR127 Gene

Gene Families for MIR127 Gene

HGNC:
genes like me logo Genes that share domains with MIR127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR127 Gene

Function for MIR127 Gene

Phenotypes From GWAS Catalog for MIR127 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR127 Gene

Localization for MIR127 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR127 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR127: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR127 Gene

Pathways & Interactions for MIR127 Gene

PathCards logo

SuperPathways for MIR127 Gene

genes like me logo Genes that share pathways with MIR127: view

Pathways by source for MIR127 Gene

2 BioSystems pathways for MIR127 Gene

Gene Ontology (GO) - Biological Process for MIR127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR127: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR127 Gene

Drugs & Compounds for MIR127 Gene

No Compound Related Data Available

Transcripts for MIR127 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR127 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000007340_9606 precursor_RNA 97 6

HGNC: 31509,

RefSeq: NR_029696,

Ensembl: ENST00000384876 (view in UCSC) ,

miRBase: MI0000472,

Rfam: RF00676,

ENA: LM608512.1:1..97:precursor_RNA,

URS00001E3DAA_9606 miRNA 22 6

RefSeq: NR_029696,

LncBase: hsa-miR-127-3p,

miRBase: MIMAT0000446,

MirGeneDB: Hsa-Mir-127_3p,

TarBase: hsa-miR-127-3p,

ENA: LM379064.1:1..22:ncRNA, LM608512.1:57..78:ncRNA,

URS00000A33DB_9606 miRNA 22 5

RefSeq: NR_029696,

LncBase: hsa-miR-127-5p,

miRBase: MIMAT0004604,

TarBase: hsa-miR-127-5p,

ENA: LM380279.1:1..22:ncRNA, LM608512.1:23..44:ncRNA,

URS0000EFED0D_9606 precursor_RNA 57 1

MirGeneDB: Hsa-Mir-127,

URS000054939C_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-127_5p,

MIR127 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR127 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR127 Gene

No ASD Table

Relevant External Links for MIR127 Gene

GeneLoc Exon Structure for
MIR127

Expression for MIR127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR127 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR127

Evidence on tissue expression from TISSUES for MIR127 Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with MIR127: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR127 Gene

Orthologs for MIR127 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR127 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-127 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-127 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir127 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-127 31
  • 83 (a)
OneToOne
Species where no ortholog for MIR127 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR127 Gene

ENSEMBL:
Gene Tree for MIR127 (if available)
TreeFam:
Gene Tree for MIR127 (if available)

Paralogs for MIR127 Gene

No data available for Paralogs for MIR127 Gene

Variants for MIR127 Gene

Additional dbSNP identifiers (rs#s) for MIR127 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR127 Gene

Variant ID Type Subtype PubMed ID
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Additional Variant Information for MIR127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR127 Gene

Disorders for MIR127 Gene

MalaCards: The human disease database

(54) MalaCards diseases for MIR127 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
myelodysplastic syndrome
  • mds
prostate cancer
  • prostate cancer, somatic
breast cancer
  • breast lobular carcinoma
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR127

genes like me logo Genes that share disorders with MIR127: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR127 Gene

Publications for MIR127 Gene

  1. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. (PMID: 16766263) Saito Y … Jones PA (Cancer cell 2006) 2 3
  2. SP1-mediated long noncoding RNA POU3F3 accelerates the cervical cancer through miR-127-5p/FOXD1. (PMID: 31252264) Chang S … Feng G (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. CircUSP45 inhibited osteogenesis in glucocorticoid-induced osteonecrosis of femoral head by sponging miR-127-5p through PTEN/AKT signal pathway: Experimental studies. (PMID: 30579595) Kuang MJ … Ma XL (Biochemical and biophysical research communications 2019) 3
  4. MiR-127-3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma. (PMID: 29573114) Wang D … Gu D (IUBMB life 2018) 3
  5. MALAT1/miR-127-5p Regulates Osteopontin (OPN)-Mediated Proliferation of Human Chondrocytes Through PI3K/Akt Pathway. (PMID: 28590075) Liang J … Tu M (Journal of cellular biochemistry 2018) 3

Products for MIR127 Gene

Sources for MIR127 Gene