microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1268B Gene

Data sources for MIR1268B Gene:

RNA type for MIR1268B Gene

miRNA

Aliases for MIR1268B Gene

External Ids for MIR1268B Gene

Previous GeneCards Identifiers for MIR1268B Gene

  • GC17U901632
  • GC17P078073

Summaries for MIR1268B Gene

Entrez Gene Summary for MIR1268B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1268B Gene

MIR1268B (MicroRNA 1268b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1268B include Congenital Disorder Of Glycosylation, Type Iic.

Additional gene information for MIR1268B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1268B Gene

Genomics for MIR1268B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1268B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J080096 Enhancer 0.6 Ensembl CraniofacialAtlas 250.7 -1.7 -1660 1.1 MXD3 GATAD2A CHD2 RNF2 TFE3 MIR1268B GAA RF00017-2326 CCDC40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1268B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1268B Gene

Latest Assembly
chr17:80,098,828-80,098,877
(GRCh38/hg38)
Size:
50 bases
Orientation:
Plus strand

Previous Assembly
chr17:78,072,627-78,072,676
(GRCh37/hg19 by Entrez Gene)
Size:
50 bases
Orientation:
Plus strand

chr5:31,880,141-31,880,190
(GRCh37/hg19 by Ensembl)
Size:
50 bases
Orientation:
Minus strand

Genomic View for MIR1268B Gene

Genes around MIR1268B on UCSC Golden Path with GeneCards custom track
MIR1268B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR1268B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1268B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1268B Gene

Proteins for MIR1268B Gene

Post-translational modifications for MIR1268B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1268B Gene

Domains & Families for MIR1268B Gene

Gene Families for MIR1268B Gene

HGNC:
genes like me logo Genes that share domains with MIR1268B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1268B Gene

Function for MIR1268B Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1268B Gene

Localization for MIR1268B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1268B gene
Compartment Confidence
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR1268B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIR1268B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR1268B Gene

Pathways & Interactions for MIR1268B Gene

PathCards logo

SuperPathways for MIR1268B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1268B Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1268B Gene

Drugs & Compounds for MIR1268B Gene

No Compound Related Data Available

Transcripts for MIR1268B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1268B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000033B91D_9606 miRNA 20 5

RefSeq: NR_039607,

LncBase: hsa-miR-1268b,

miRBase: MIMAT0018925,

TarBase: hsa-miR-1268b,

ENA: LM382371.1:1..20:ncRNA, LM611274.1:4..23:ncRNA,

URS000075CD61_9606 precursor_RNA 50 4

RefSeq: NR_039607,

Ensembl: ENST00000579691 (view in UCSC) ,

miRBase: MI0016748,

ENA: LM611274.1:1..50:precursor_RNA,

MIR1268B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1268B Gene

No ASD Table

Relevant External Links for MIR1268B Gene

GeneLoc Exon Structure for
MIR1268B

No data available for mRNA/cDNA for MIR1268B Gene

Expression for MIR1268B Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1268B Gene

Orthologs for MIR1268B Gene

Evolution for MIR1268B Gene

ENSEMBL:
Gene Tree for MIR1268B (if available)
TreeFam:
Gene Tree for MIR1268B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR1268B

No data available for Orthologs for MIR1268B Gene

Paralogs for MIR1268B Gene

No data available for Paralogs for MIR1268B Gene

Variants for MIR1268B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR1268B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR1268B Gene

Variant ID Type Subtype PubMed ID
esv3641362 CNV loss 21293372
esv3641363 CNV gain 21293372
nsv1066606 CNV gain 25217958
nsv469591 CNV loss 16826518
nsv833561 CNV loss 17160897

Additional Variant Information for MIR1268B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1268B
Leiden Open Variation Database (LOVD)
MIR1268B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1268B Gene

Disorders for MIR1268B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1268B Gene - From: COP

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type iic
  • cdg2c
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1268B

genes like me logo Genes that share disorders with MIR1268B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1268B Gene

Publications for MIR1268B Gene

  1. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR1268B Gene

Sources for MIR1268B Gene