microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1268B Gene

Subcategory (RNA class) for MIR1268B Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR1268B Gene

  • MicroRNA 1268b 2 3 5
  • Hsa-MiR-1268b 168 179
  • Hsa-Mir-1268b 3
  • MIMAT0018925 53
  • MI0016748 53
  • MIR1268B 2

External Ids for MIR1268B Gene

Previous GeneCards Identifiers for MIR1268B Gene

  • GC17U901632
  • GC17P078073

Summaries for MIR1268B Gene

Entrez Gene Summary for MIR1268B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1268B Gene

MIR1268B (MicroRNA 1268b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR1268B include Ciliary Dyskinesia, Primary, 15.

Additional gene information for MIR1268B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1268B Gene

Genomics for MIR1268B Gene

GeneHancer (GH) Regulatory Elements for MIR1268B Gene

Promoters and enhancers for MIR1268B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J080096 Enhancer 0.6 Ensembl CraniofacialAtlas 750.6 -1.7 -1660 1.1 TFE3 GATAD2A RNF2 POLR2A MIR1268B GAA RF00017-2581 CCDC40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1268B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1268B Gene

Genomic Locations for MIR1268B Gene
chr17:80,098,828-80,098,877
(GRCh38/hg38)
Size:
50 bases
Orientation:
Plus strand
chr17:78,072,627-78,072,676
(GRCh37/hg19)
Size:
50 bases
Orientation:
Plus strand

Genomic View for MIR1268B Gene

Genes around MIR1268B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1268B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1268B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1268B Gene

Proteins for MIR1268B Gene

Post-translational modifications for MIR1268B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1268B Gene

Domains & Families for MIR1268B Gene

Gene Families for MIR1268B Gene

HGNC:
genes like me logo Genes that share domains with MIR1268B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1268B Gene

Function for MIR1268B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1268B Gene

Localization for MIR1268B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR1268B gene
Compartment Confidence
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1268B Gene

Pathways & Interactions for MIR1268B Gene

PathCards logo

SuperPathways for MIR1268B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1268B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1268B Gene

Drugs & Compounds for MIR1268B Gene

No Compound Related Data Available

Transcripts for MIR1268B Gene

mRNA/cDNA for MIR1268B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(1) LncBase transcripts :
(3) ENA transcripts :
(1) TarBase transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1268B Gene

No ASD Table

Relevant External Links for MIR1268B Gene

GeneLoc Exon Structure for
MIR1268B
ECgene alternative splicing isoforms for
MIR1268B

Expression for MIR1268B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1268B Gene:

MIR1268B
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1268B Gene

Orthologs for MIR1268B Gene

Evolution for MIR1268B Gene

ENSEMBL:
Gene Tree for MIR1268B (if available)
TreeFam:
Gene Tree for MIR1268B (if available)

No data available for Orthologs for MIR1268B Gene

Paralogs for MIR1268B Gene

No data available for Paralogs for MIR1268B Gene

Variants for MIR1268B Gene

Sequence variations from dbSNP and Humsavar for MIR1268B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1028095921 likely-benign, Ciliary dyskinesia 80,097,370(+) C/T upstream_transcript_variant
rs117307093 likely-benign, uncertain-significance, not specified, Ciliary dyskinesia 80,097,269(+) G/A upstream_transcript_variant
rs1257141883 uncertain-significance, Ciliary dyskinesia 80,097,261(+) C/G/T upstream_transcript_variant
rs12952612 benign, not specified, Glycogen storage disease, type II, Ciliary dyskinesia, Ciliary dyskinesia, primary, 15 80,097,253(+) T/A/C upstream_transcript_variant
rs1418585908 pathogenic, Ciliary dyskinesia 80,097,352(+) C/ upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1268B Gene

Variant ID Type Subtype PubMed ID
esv3641362 CNV loss 21293372
esv3641363 CNV gain 21293372
nsv1066606 CNV gain 25217958
nsv469591 CNV loss 16826518
nsv833561 CNV loss 17160897

Additional Variant Information for MIR1268B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1268B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1268B Gene

Disorders for MIR1268B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR1268B Gene - From: GeneCards

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 15
  • cild15
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR1268B

genes like me logo Genes that share disorders with MIR1268B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR1268B Gene

Publications for MIR1268B Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR1268B Gene

Sources for MIR1268B Gene