microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1265 Gene

Subcategory (RNA class) for MIR1265 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR1265 Gene

  • MicroRNA 1265 2 3 5
  • Hsa-Mir-1265 3
  • MIMAT0005918 53
  • MI0006401 53
  • MIRN1265 3
  • MIR1265 2
  • RF02019 174

External Ids for MIR1265 Gene

Previous HGNC Symbols for MIR1265 Gene

  • MIRN1265

Previous GeneCards Identifiers for MIR1265 Gene

  • GC00U922838
  • GC10P014519

Summaries for MIR1265 Gene

Entrez Gene Summary for MIR1265 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1265 Gene

MIR1265 (MicroRNA 1265) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR1265 Gene

Additional gene information for MIR1265 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR1265 Gene

Genomics for MIR1265 Gene

GeneHancer (GH) Regulatory Elements for MIR1265 Gene

Promoters and enhancers for MIR1265 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J014435 Promoter 0.3 EPDnew 750.6 -1.4 -1372 0.1 MIR1265 FRMD4A ENSG00000278100
GH10J014403 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -31.0 -31016 4.5 GATA3 TCF7L2 ZNF217 NCOA3 POLR2A RFX1 CTBP1 FOS DPF2 RCOR1 FRMD4A MIR1265 ENSG00000278100
GH10J014381 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 -52.4 -52417 6.2 ZNF24 CTCF RELA BCL6B MAFK ZNF687 IKZF1 ZIC2 IKZF2 ZSCAN4 MIR4293 MIR1265 ENSG00000278100 FRMD4A
GH10J014395 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -39.5 -39538 2.7 CTCF ZNF362 ZNF384 POLR2A ELF4 FOS YY1 NFIC HIC1 JUND MIR1265 ENSG00000229751 ENSG00000278100 FRMD4A
GH10J014409 Enhancer 0.6 Ensembl 11.2 -26.4 -26375 1.2 ETV6 HLF PRDM1 ZNF512 TRIM22 PKNOX1 RUNX3 IKZF1 NBN ZNF366 MIR1265 FRMD4A ENSG00000278100
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1265 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR1265 Gene

Genomic Locations for MIR1265 Gene
chr10:14,436,576-14,436,661
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr10:14,478,575-14,478,660
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR1265 Gene

Genes around MIR1265 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1265 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1265 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1265 Gene

Proteins for MIR1265 Gene

Post-translational modifications for MIR1265 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1265 Gene

Domains & Families for MIR1265 Gene

Gene Families for MIR1265 Gene

HGNC:
genes like me logo Genes that share domains with MIR1265: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1265 Gene

Function for MIR1265 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1265 Gene

Localization for MIR1265 Gene

Gene Ontology (GO) - Cellular Components for MIR1265 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR1265: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR1265 Gene

Pathways & Interactions for MIR1265 Gene

PathCards logo

SuperPathways for MIR1265 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1265 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR1265: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1265 Gene

Drugs & Compounds for MIR1265 Gene

No Compound Related Data Available

Transcripts for MIR1265 Gene

mRNA/cDNA for MIR1265 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1265 Gene

No ASD Table

Relevant External Links for MIR1265 Gene

GeneLoc Exon Structure for
MIR1265
ECgene alternative splicing isoforms for
MIR1265

Expression for MIR1265 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1265 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1265 Gene:

MIR1265
genes like me logo Genes that share expression patterns with MIR1265: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1265 Gene

Orthologs for MIR1265 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR1265 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1265 33
  • 97 (a)
OneToOne
Species where no ortholog for MIR1265 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR1265 Gene

ENSEMBL:
Gene Tree for MIR1265 (if available)
TreeFam:
Gene Tree for MIR1265 (if available)

Paralogs for MIR1265 Gene

No data available for Paralogs for MIR1265 Gene

Variants for MIR1265 Gene

Sequence variations from dbSNP and Humsavar for MIR1265 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001146711 -- 14,436,850(+) T/A downstream_transcript_variant
rs1002148885 -- 14,435,850(+) G/T upstream_transcript_variant
rs1003178160 -- 14,436,471(+) G/A upstream_transcript_variant
rs1003701906 -- 14,436,335(+) A/T upstream_transcript_variant
rs1005197701 -- 14,436,028(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR1265 Gene

Variant ID Type Subtype PubMed ID
esv34151 CNV loss 18971310
nsv528028 CNV gain 19592680

Additional Variant Information for MIR1265 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1265

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1265 Gene

Disorders for MIR1265 Gene

Additional Disease Information for MIR1265

No disorders were found for MIR1265 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1265 Gene

Publications for MIR1265 Gene

  1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR1265 Gene

Sources for MIR1265 Gene