microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR1261 Gene

Subcategory (RNA class) for MIR1261 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR1261 Gene

  • MicroRNA 1261 2 3 5
  • Hsa-Mir-1261 2 3
  • MIR1261 2 5
  • MIMAT0005913 50
  • MI0006396 50
  • MIRN1261 3

External Ids for MIR1261 Gene

Previous HGNC Symbols for MIR1261 Gene

  • MIRN1261

Previous GeneCards Identifiers for MIR1261 Gene

  • GC00U922981
  • GC11M090242
  • GC11M090602

Summaries for MIR1261 Gene

Entrez Gene Summary for MIR1261 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1261 Gene

MIR1261 (MicroRNA 1261) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR1261 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR1261 Gene

Genomics for MIR1261 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR1261 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J090874 Enhancer 0.4 Ensembl 0.4 -5.3 -5299 0.2 CEBPB CEBPG ATF4 MIR1261 HSALNG0086384 CHORDC1 DISC1FP1
GH11J090891 Enhancer 0.4 Ensembl 0.4 -22.2 -22199 0.4 FOXA1 GATA3 JUND MIR1261 HSALNG0086384 DISC1FP1 CHORDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR1261 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR1261 Gene

Genomic Locations for MIR1261 Gene
chr11:90,869,121-90,869,202
(GRCh38/hg38)
Size:
82 bases
Orientation:
Minus strand
chr11:90,602,289-90,602,370
(GRCh37/hg19)
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR1261 Gene

Genes around MIR1261 on UCSC Golden Path with GeneCards custom track
MIR1261 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR1261 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1261 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1261 Gene

Proteins for MIR1261 Gene

Post-translational modifications for MIR1261 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1261 Gene

Domains & Families for MIR1261 Gene

Gene Families for MIR1261 Gene

HGNC:
genes like me logo Genes that share domains with MIR1261: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR1261 Gene

Function for MIR1261 Gene

Phenotypes From GWAS Catalog for MIR1261 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1261 Gene

Localization for MIR1261 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR1261 Gene

Pathways & Interactions for MIR1261 Gene

PathCards logo

SuperPathways for MIR1261 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1261 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR1261 Gene

Drugs & Compounds for MIR1261 Gene

No Compound Related Data Available

Transcripts for MIR1261 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR1261 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075992E_9606 precursor_RNA 82 4

HGNC: 35327,

RefSeq: NR_031663,

Ensembl: ENST00000408659 (view in UCSC) ,

miRBase: MI0006396,

URS00003975B5_9606 miRNA 19 2

RefSeq: NR_031663,

miRBase: MIMAT0005913,

MIR1261 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1261 Gene

No ASD Table

Relevant External Links for MIR1261 Gene

GeneLoc Exon Structure for
MIR1261

No data available for mRNA/cDNA for MIR1261 Gene

Expression for MIR1261 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1261 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR1261

genes like me logo Genes that share expression patterns with MIR1261: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1261 Gene

Orthologs for MIR1261 Gene

Evolution for MIR1261 Gene

ENSEMBL:
Gene Tree for MIR1261 (if available)
TreeFam:
Gene Tree for MIR1261 (if available)

No data available for Orthologs for MIR1261 Gene

Paralogs for MIR1261 Gene

No data available for Paralogs for MIR1261 Gene

Variants for MIR1261 Gene

Additional dbSNP identifiers (rs#s) for MIR1261 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1261 Gene

Variant ID Type Subtype PubMed ID
nsv1048624 CNV loss 25217958
nsv1129324 OTHER inversion 24896259
nsv555884 CNV loss 21841781
nsv826029 CNV loss 20364138

Additional Variant Information for MIR1261 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1261

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR1261 Gene

Disorders for MIR1261 Gene

Additional Disease Information for MIR1261

No disorders were found for MIR1261 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1261 Gene

Publications for MIR1261 Gene

  1. MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion. (PMID: 31364003) Zhang F … Zhang L (Human cell 2019) 3
  2. Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. (PMID: 29842886) Wei H … Li R (Biochemical and biophysical research communications 2018) 3
  3. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PMID: 22566498) Turner ST … Boerwinkle E (Hypertension (Dallas, Tex. : 1979) 2012) 3
  4. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR1261 Gene

Sources for MIR1261 Gene