microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR126 Gene

RNA type for MIR126 Gene

miRNA

Aliases for MIR126 Gene

External Ids for MIR126 Gene

Previous HGNC Symbols for MIR126 Gene

  • MIRN126

Previous GeneCards Identifiers for MIR126 Gene

  • GC09P138685
  • GC09P139566
  • GC09P139569
  • GC09P139572

Summaries for MIR126 Gene

Entrez Gene Summary for MIR126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR126 Gene

MIR126 (MicroRNA 126) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR126 include Lipoprotein Quantitative Trait Locus and Esophageal Cancer. Among its related pathways are Melatonin metabolism and effects and EV release from cardiac cells and their functional effects.

Rfam classification for MIR126 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR126 Gene

Genomics for MIR126 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR126 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J136671 Enhancer 0.9 ENCODE dbSUPER 250.7 +1.4 1419 1.3 ZIC2 ZBTB10 CTCF REST SMAD5 ZNF513 HCFC1 SMC3 RAD21 POLR2A HSALNG0075284 NONHSAG053803.2-002 MIR126 SNHG7 SEC16A DPH7 EHMT1 ANAPC2 DIPK1B AGPAT2
GH09J136653 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -8.1 -8071 17.3 ZNF600 MYC NCOR1 IKZF1 ZNF592 ZNF10 NFIC ZIC2 ZBTB10 NONO EGFL7 EHMT1 DPH7 ANAPC2 AGPAT2 SNHG7 EXD3 MAN1B1 INPP5E SNAPC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR126 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR126 Gene

Latest Assembly
chr9:136,670,602-136,670,686
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand

Previous Assembly
chr9:139,565,054-139,565,138
(GRCh37/hg19 by Entrez Gene)
Size:
85 bases
Orientation:
Plus strand

chr9:139,565,054-139,565,138
(GRCh37/hg19 by Ensembl)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR126 Gene

Genes around MIR126 on UCSC Golden Path with GeneCards custom track
MIR126 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR126 Gene

Proteins for MIR126 Gene

Post-translational modifications for MIR126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR126 Gene

Domains & Families for MIR126 Gene

Gene Families for MIR126 Gene

HGNC:
genes like me logo Genes that share domains with MIR126: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR126 Gene

Function for MIR126 Gene

Phenotypes From GWAS Catalog for MIR126 Gene

Gene Ontology (GO) - Molecular Function for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
GO:0003730 mRNA 3'-UTR binding IMP 23437250
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23437250
genes like me logo Genes that share ontologies with MIR126: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR126 Gene

Localization for MIR126 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR126 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR126: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR126 Gene

Pathways & Interactions for MIR126 Gene

genes like me logo Genes that share pathways with MIR126: view

Pathways by source for MIR126 Gene

1 KEGG pathway for MIR126 Gene

Gene Ontology (GO) - Biological Process for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS --
GO:0030336 negative regulation of cell migration IDA 23437250
GO:0035195 gene silencing by miRNA IMP 23437250
GO:0043410 positive regulation of MAPK cascade IMP,ISS --
GO:0043536 positive regulation of blood vessel endothelial cell migration IMP 18694566
genes like me logo Genes that share ontologies with MIR126: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR126 Gene

Drugs & Compounds for MIR126 Gene

No Compound Related Data Available

Transcripts for MIR126 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR126 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00001F1DA8_9606 miRNA 22 6

RefSeq: NR_029695,

LncBase: hsa-miR-126-3p,

miRBase: MIMAT0000445,

MirGeneDB: Hsa-Mir-126-v2_3p,

TarBase: hsa-miR-126-3p,

ENA: LM379063.1:1..22:ncRNA, LM608511.1:52..73:ncRNA,

URS00001D69F6_9606 miRNA 21 6

RefSeq: NR_029695,

LncBase: hsa-miR-126-5p,

miRBase: MIMAT0000444,

MirGeneDB: Hsa-Mir-126-v1_5p,

TarBase: hsa-miR-126-5p,

ENA: LM379062.1:1..21:ncRNA, LM608511.1:15..35:ncRNA,

URS0000759B6D_9606 pre_miRNA 85 4

RefSeq: NR_029695,

Ensembl: ENST00000362291 (view in UCSC) ,

miRBase: MI0000471,

ENA: LM608511.1:1..85:precursor_RNA,

URS0000718DAA_9606 pre_miRNA 73 1

Rfam: RF00701,

URS0000EFBB94_9606 pre_miRNA 60 1

MirGeneDB: Hsa-Mir-126-v1, Hsa-Mir-126-v2, Hsa-Mir-126-v3,

MIR126 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR126 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR126 Gene

No ASD Table

Relevant External Links for MIR126 Gene

GeneLoc Exon Structure for
MIR126

Expression for MIR126 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR126 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR126

Evidence on tissue expression from TISSUES for MIR126 Gene

  • Heart(2.5)
  • Blood(2.5)
  • Muscle(2.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with MIR126: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR126 Gene

Orthologs for MIR126 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR126 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-126 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-126 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-126 30
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir126 30
  • 93 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-126 30
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-126 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-126 30
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-126 30
  • 79 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-126b 30
  • 60 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-126 30
  • 49 (a)
OneToOne
Species where no ortholog for MIR126 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR126 Gene

ENSEMBL:
Gene Tree for MIR126 (if available)
TreeFam:
Gene Tree for MIR126 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR126

Paralogs for MIR126 Gene

No data available for Paralogs for MIR126 Gene

Variants for MIR126 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR126 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR126 Gene

Variant ID Type Subtype PubMed ID
dgv13005n54 CNV loss 21841781
dgv13006n54 CNV loss 21841781
dgv955n27 CNV loss 19166990
dgv957n27 CNV loss 19166990
esv2422220 CNV deletion 17116639
esv2759720 CNV loss 17122850
esv32979 CNV gain 17666407
nsv1053781 CNV gain 25217958
nsv469918 CNV loss 18288195
nsv509334 CNV insertion 20534489
nsv8579 CNV gain 18304495
nsv951203 CNV deletion 24416366

Additional Variant Information for MIR126 Gene

Human Gene Mutation Database (HGMD)
MIR126
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR126
Leiden Open Variation Database (LOVD)
MIR126

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR126 Gene

Disorders for MIR126 Gene

MalaCards: The human disease database

(139) MalaCards diseases for MIR126 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
lipoprotein quantitative trait locus
  • lpaqtl
esophageal cancer
  • esophageal cancer, somatic
asthma
  • asthma, susceptibility to
lung cancer
  • lung cancer, susceptibility to
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR126

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MIR126: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR126 Gene

Publications for MIR126 Gene

  1. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. (PMID: 20651284) Zampetaki A … Mayr M (Circulation research 2010) 3 72
  2. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. (PMID: 18602365) Crawford M … Nana-Sinkam SP (Biochemical and biophysical research communications 2008) 3 72
  3. MicroRNA-126 regulates HOXA9 by binding to the homeobox. (PMID: 18474618) Shen WF … Largman C (Molecular and cellular biology 2008) 3 72
  4. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. (PMID: 18663744) Guo C … Guda K (Genes, chromosomes & cancer 2008) 3 72
  5. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. (PMID: 18694565) Wang S … Olson EN (Developmental cell 2008) 2 3

Products for MIR126 Gene

Sources for MIR126 Gene