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Aliases for MIR126 Gene

Subcategory (RNA class) for MIR126 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR126 Gene

  • MicroRNA 126 2 3 5
  • Hsa-Mir-126 3
  • MiRNA126 3
  • Mir-126 3
  • MIRN126 3

External Ids for MIR126 Gene

ORGUL Members for MIR126 Gene

Previous HGNC Symbols for MIR126 Gene

  • MIRN126

Previous GeneCards Identifiers for MIR126 Gene

  • GC09P138685
  • GC09P139566
  • GC09P139569
  • GC09P139572

Summaries for MIR126 Gene

Entrez Gene Summary for MIR126 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR126 Gene

MIR126 (MicroRNA 126) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Melatonin metabolism and effects and EV release from cardiac cells and their functional effects.

Additional gene information for MIR126 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR126 Gene

Genomics for MIR126 Gene

GeneHancer (GH) Regulatory Elements for MIR126 Gene

Promoters and enhancers for MIR126 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I136671 Enhancer 1 ENCODE dbSUPER 550.8 +1.4 1419 1.3 HNRNPUL1 RB1 ZNF2 RAD21 POLR2B GLIS2 EGR1 ZNF143 EGR2 SMAD5 MIR126 GC09P136671 SNHG7 SEC16A DPH7 EHMT1 ANAPC2 FAM69B AGPAT2 EXD3
GH09I136653 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.2 -8181 17.1 HDGF HNRNPUL1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GLIS2 GATA2 EGFL7 GC09M136660 HSPC324 AGPAT2 SNHG7 DPH7 EHMT1 ANAPC2 EXD3 MAN1B1
GH09I136673 Enhancer 1.1 ENCODE dbSUPER 0.8 +4.9 4899 3.7 HNRNPUL1 ATF1 ARID4B YY1 GLIS2 ZNF213 RXRA SP5 PPARG NFIL3 SNHG7 EHMT1 AGPAT2 FAM69B SEC16A DNLZ MIR126
GH09I136684 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.4 +16.6 16552 4.7 SIN3A IRF4 YY1 POLR2B ZNF207 ZNF143 JUNB REST SMARCB1 ZNF592 AGPAT2 DPH7 INPP5E EXD3 ARRDC1-AS1 ANAPC2 QSOX2 NPDC1 AJM1 SNAPC4
GH09I136674 Enhancer 0.9 ENCODE dbSUPER 0.8 +2.6 2632 0.2 HNRNPUL1 SMAD1 CCNT2 POLR2B E2F8 NCOR1 POLR2A GATAD2A ZNF282 MTA2 SNHG7 EHMT1 FAM69B SEC16A AGPAT2 MIR126
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR126 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR126 Gene

Genomic Locations for MIR126 Gene
chr9:136,670,602-136,670,686
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr9:139,565,054-139,565,138
(GRCh37/hg19)

Genomic View for MIR126 Gene

Genes around MIR126 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR126 Gene

Proteins for MIR126 Gene

Post-translational modifications for MIR126 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR126 Gene

Domains & Families for MIR126 Gene

Gene Families for MIR126 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR126: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR126 Gene

Function for MIR126 Gene

Gene Ontology (GO) - Molecular Function for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26934179
genes like me logo Genes that share ontologies with MIR126: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR126 Gene

Localization for MIR126 Gene

Gene Ontology (GO) - Cellular Components for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR126: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR126 Gene

Pathways & Interactions for MIR126 Gene

genes like me logo Genes that share pathways with MIR126: view

Pathways by source for MIR126 Gene

1 KEGG pathway for MIR126 Gene

Interacting Proteins for MIR126 Gene

Gene Ontology (GO) - Biological Process for MIR126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 28578351
GO:0035195 gene silencing by miRNA IDA 26646931
GO:0045747 positive regulation of Notch signaling pathway ISS --
GO:0045766 positive regulation of angiogenesis IMP 23136161
GO:0050728 negative regulation of inflammatory response IDA 28578351
genes like me logo Genes that share ontologies with MIR126: view

No data available for SIGNOR curated interactions for MIR126 Gene

Drugs & Compounds for MIR126 Gene

No Compound Related Data Available

Transcripts for MIR126 Gene

mRNA/cDNA for MIR126 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR126 Gene

No ASD Table

Relevant External Links for MIR126 Gene

GeneLoc Exon Structure for
MIR126
ECgene alternative splicing isoforms for
MIR126

Expression for MIR126 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR126 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR126 Gene:

MIR126
genes like me logo Genes that share expression patterns with MIR126: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR126 Gene

Orthologs for MIR126 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR126 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-126 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-126 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-126 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-126 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir126 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-126 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-126 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-126 34
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-126b 34
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-126 34
  • 49 (a)
OneToOne
Species where no ortholog for MIR126 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR126 Gene

ENSEMBL:
Gene Tree for MIR126 (if available)
TreeFam:
Gene Tree for MIR126 (if available)

Paralogs for MIR126 Gene

No data available for Paralogs for MIR126 Gene

Variants for MIR126 Gene

Sequence variations from dbSNP and Humsavar for MIR126 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000037301 -- 136,669,195(+) T/C upstream_transcript_variant
rs1002822631 -- 136,669,886(+) G/A upstream_transcript_variant
rs1002950372 -- 136,670,112(+) C/G/T upstream_transcript_variant
rs1005206809 -- 136,669,111(+) AAA/AA upstream_transcript_variant
rs1005905531 -- 136,669,205(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR126 Gene

Variant ID Type Subtype PubMed ID
nsv951203 CNV deletion 24416366
nsv8579 CNV gain 18304495
nsv509334 CNV insertion 20534489
nsv469918 CNV loss 18288195
nsv1053781 CNV gain 25217958
esv32979 CNV gain 17666407
esv2759720 CNV loss 17122850
esv2422220 CNV deletion 17116639
dgv957n27 CNV loss 19166990
dgv955n27 CNV loss 19166990
dgv13006n54 CNV loss 21841781
dgv13005n54 CNV loss 21841781

Additional Variant Information for MIR126 Gene

Human Gene Mutation Database (HGMD)
MIR126
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR126

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR126 Gene

Disorders for MIR126 Gene

Additional Disease Information for MIR126

No disorders were found for MIR126 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR126 Gene

Publications for MIR126 Gene

  1. MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway. (PMID: 29203244) Tang F … Yang TL (Biochemical and biophysical research communications 2018) 3 58
  2. Calmodulin Regulated Spectrin Associated Protein 1 mRNA is Directly Regulated by miR-126 in Primary Human Osteoblasts. (PMID: 27958650) Strassburg S … Simunovic F (Journal of cellular biochemistry 2017) 3 58
  3. Regulator of G-protein signaling 3 targeted by miR-126 correlates with poor prognosis in gastric cancer patients. (PMID: 27754994) Wang J … Zhu Z (Anti-cancer drugs 2017) 3 58
  4. MiR-126 impairs the intestinal barrier function via inhibiting S1PR2 mediated activation of PI3K/AKT signaling pathway. (PMID: 28302479) Chen T … Huang Z (Biochemical and biophysical research communications 2017) 3 58
  5. The association of miR-126-3p, miR-126-5p and miR-664-3p expression profiles with outcomes of patients with metastatic colorectal cancer treated with bevacizumab. (PMID: 28714375) Fiala O … Finek J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR126 Gene

Sources for MIR126 Gene

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